Resource Hub
Application Notes & Snapshots
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Microchip CE/MS Peptide Mapping Workflow with Trypsin Digestion for the Analysis of Critical Quality Attributes of Monoclonal Antibodies
Peptide mapping is considered the gold standard for the analysis of biopharmaceuticals, including monoclonal antibodies.
Poster Note: Bottom-up analysis of progressively larger RNAs by CZE-MS and CZE-MS/MS
This project explores the merits of CZE as a potential alternative to liquid chromatography, as the front-end separation of choice for analyzing progressively larger RNAs with a bottom-up approach.
Poster Note: Multi-Level Expeditious Characterization of AAV Capsid Proteins using ZipChip
This poster note presents a novel approach to complete characterization of capsid viral proteins using microchip CE-MS for the characterization of AAVs.
Poster Note: Rapid Characterization of Oligos Using Microchip CE-MS without Ion-Pairing Reagents
Learn how ZipChip’s ready-to-use oligos BGE solution is free from ion-pairing reagents and makes switching between applications simple and easy.
Brochures & Flyers
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MAVEN Brochure
MAVEN offers monitoring and control of glucose and lactate concentrations during cell culture and fermentation. Download this brochure to learn more.
REBEL Certified User Training
Get the best user experience with the REBEL at-line spent media analyzer. Our training course is for new and experienced users who want to refresh their REBEL device
operation skills.
REBEL Spent Media Analysis Kits
The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
MX908 Remote App
Export results, add custom notes, and access support
Case Studies
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Case Study: Identifying Smuggled Khat
Suspicious of a possible drug shipment, officers ran the samples in the MX908 Drug Hunter Mission Mode which returned multiple alarms for cathinone, an active drug substance in khat.
REBEL + ZipChip help HJB Overcome Scientific Hurdles and Optimize Processes in Biotherapeutic Development
In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
Aerosolized Fentanyl During Decontamination
Download this case study on Canadian Decon Solutions’ encounter with fentanyl in a vehicle and how the MX908 with Aero provided real-time intel at the point of need.
Analysis Comparison of Fentanyl
Read how the sensitivity of MX908 enables the identification of fentanyl and its analogues down to 0.1%, even in a complex mixture.
Mission Briefs
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Mission Brief: Identify Pesticides at Illegal Marijuana Grows
With the addition of the pesticide capabilities, the MX908 provides critical identification of toxic pesticides in the field, allowing users to act immediately, while keeping themselves safe.
Mission Brief: Novichoks
Review this one sheet on Fourth Generation Agents that the MX908 can detect and identify at trace levels.
Mission Brief: Aerosol
Review the mission brief to learn how MX908 with Aero allows users to detect and identify aerosolized threats at trace levels.
Mission Brief: Fentanyl
Review this one sheet on MX908 detection of fentanyl and its thousands of analogs.
Podcasts
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As heard on Cell Culture Dish
The HazMat Guys Podcast, Part 2: Measuring Aerosols
Listen to Episode 291, Part 2 of the HazMat Guys Podcast on Aerosols. The guys discuss common techniques used measure aerosols and how to keep safe while responding to aerosolized threats.
The HazMat Guys Podcast, Part 1: What are Aerosols?
Listen to Episode 290, Part 1 of the HazMat Guys Podcast to learn more about aerosol threats and the challenges they pose to responders.
A Brief History of Field Technology
The guys introduce themselves and give a brief history of how laboratory technology has evolved for field use since the early 2000’s.
Posters
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Automated Glucose Feeding Based On Online Glucose And Lactate Measurements
This poster note describes an automated control strategy for cell growth and biologics production. It leverages MAVEN, a reliable, easy-to-operate, online (sample-free) device for monitoring of glucose and lactate.
Process Optimization by the Use of Substrate Feeding Strategies
Online glucose monitoring is possible by using Trace C2 Control system. Feed control without online glucose monitoring causes acetate formation due to overflow metabolism.
Optimized Fed-Batch Fermentation by Use of Online Glucose Measurement
This poster presentation features an integrated multivariate glucose measuring tool combined with software solutions which allow different types of feeding-strategies.
High Frequency Glucose and Lactate Measurements in Multi-Bioreactor Vessels
TRACE C2 is an online analyzer for monitoring and controlling glucose and lactate concentrations in bioreactors. With the extension M4 it is possible to monitor Glucose and Lactate in up to four simultaneous bioprocesses.
Published Articles
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Prioritizing Officer Safety in the Field as Fentanyl Fatalities Rise
Multi-Mission Threat Detection in Real Time
This article originally appeared in CBNW Magazine.
In-Process Analytics are Key to Successful Cell Therapy Process Optimization and Manufacturing
Considerable clinical activity and the approval of several autologous, patient-specific therapies has increased industry demand and has also highlighted bottlenecks in manufacturing workflows.
The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.
Safety Data Sheet (SDS)
View AllSpecification Sheets
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MX908 Beacon Spec Sheet
MX908 Beacon remote area monitoring for identification of aerosol and vapor CWA’s and PBA’s.
TRACE C2 Specification Sheet
Get all the TRACE C2 specifications, including measurement range, physical dimensions, and software requirements.
MAVEN Specification Sheet
Get all the MAVEN specifications, including measurement range, physical dimensions, and software requirements.
MAVERICK Product Specification Sheet
Get all the MAVERICK specifications including applications, physical dimensions, and more.
Tech Notes
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Instant Implementation of Raman-based PAT with MAVERICK for Monitoring Glucose and Lactate
MAVERICK is easy to set up and enables instant implementation of PAT generating accurate, precise, linear and selective in-line measurements across a wide range of media used typically in mammalian (including CHO and HEK293 media) cell culture for the production of biotherapeutics.
Determining Total Cell Count with MAVERICK Biomass Measurements
MAVERICK provides an in-line, Raman-based PAT solution for monitoring and control of glucose, lactate, and biomass in up to six bioreactors right out of the box.
On-line Measurement of Glucose and Lactate with Automated Feedback Control
MAVEN answers the urgent need for on-line measurements and automated control of glucose levels, which reduces manual labor, lowers risk of contamination from sampling, decreases risk of human error with feeding, and reduces the stress that cells may experience from variable glucose levels.
Multi-Mission Threat Detection with Handheld HPMS
Testimonials
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ZipChip Customer Experience: Symphogen
Listen to Dan Bach Kristensen, a principal scientist at Symphogen, as he shares how ZipChip helps him with charge variant separation.
A Conversation with Michael Gray about Counterfeit Pills
Michael Gray is the CEO of Actus Analytical, Inc., which develops spectroscopy solutions for public safety. Michael and his wife, Nancy, founded The Actus Foundation in 2018, shortly after the death of their daughter, Amanda, who was killed by a poisoning of straight fentanyl at the age of 24.
Hear from Our Users: The Need for Speed in the Lab
Listen to ZipChip and REBEL users from The Dana Farber Cancer Institute, Sartorius, and Amgen discuss the impact of faster workflows in the lab.
A Conversation with Christina Baxter about Fentanyl
Dr. Christina Baxter is the CEO of Emergency Response TIPS, LLC and a partner in Hazard3, LLC which provides practical, evidence-based solutions for emergency response.
Technical Papers
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Tech Note: Glucose & Lactate Dialysis (Low)
These data were compiled in order to give an overview of typical system and sensor performance in the low concentration range using the dialysis-low sampling method. Operational temperature in the bioreactor was set to 37°C.
Tech Note: Glucose & Lactate Dialysis
These data were compiled in order to give an overview of the system and sensor performance in the normal concentration range using the dialysis sampling method.
Tech Note: Pressure Stability of the Dialysis Probe
The TRACE dialysis probe can be safely used in large reactors. Its dialysis membrane does not suffer from higher pressure due to hydrostatic and/ or pressurized conditions.
Tech Note: Interference of Other Sugars on Glucose and Lactate Measurements
Most sugars have no influence on glucose measurement. The only exception is mannose, which shows a low positive interference on the glucose measurement.
Videos
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MX908 Beacon Product Video
Watch this video to see how MX908 Beacon can be deployed to provide remote area monitoring to provide real-time identification of airborne hazards.
MAVERICK: Raman-based Monitoring of Multiple Critical Parameters, Ready to Go in Minutes
MAVERICK is powered by Raman spectroscopy and purpose-built de novo model for simultaneous real-time measurements of multiple key process parameters in mammalian cell cultures without the costs, complexities, and risks of conventional methods.
MAVERICK: Monitoring of Multiple Bioprocess Parameters Right out of the Box
There’s no need to deal with complex empirical calibration models, reagents, or unreliable auto-sampling systems to implement in-line bioreactor monitoring.
ZipChip Customer Experience: Symphogen
Listen to Dan Bach Kristensen, a principal scientist at Symphogen, as he shares how ZipChip helps him with charge variant separation.
Webinars
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Webinar: Responding to Chemical Warfare and Pharmaceutical Based Agents
A must watch for CBRN first responders! Receive the latest info dangerous chemical threats – chemical warfare and pharmaceutical based agents.
Charge Variant Analysis for Intact Protein Characterization in a Biopharmaceutical Development Lab – Lessons Learned and the Road Ahead
Engineering Functionally Improved CAR T cells with a Multi-Cytokine Backpack Platform with Insights into Metabolism
In-line Monitoring of Bioprocess Analysis Parameters for the 21st Century
White Papers
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White Paper: Area Monitoring for Chemical Warfare and Pharmaceutical Based Agents
Learn more about area monitoring and how MX908 Beacon is the only area monitor on the market to identify chemical warfare agents, etc.
White Paper: Pesticide Detection and Identification at Illegal Marijuana Grows
With pesticides posing an imminent danger for wildlife in the area, responding law enforcement also find themselves potentially exposed to the hazardous chemicals
Microchip CE-MS: A Powerful Tool for Biotherapeutic Characterization
To help explain the power of this game-changing technology, we partnered with LCGC on a new ebook that covers the topic in-depth.
‘What’s In Your Media?’ Ebook
Learn about the critical role of cell culture media analysis in biotherapeutics development, including biologics and cell and gene therapies.
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