Resource Hub
Application Notes & Snapshots
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Poster Note: Bottom-up analysis of progressively larger RNAs by CZE-MS and CZE-MS/MS
This project explores the merits of CZE as a potential alternative to liquid chromatography, as the front-end separation of choice for analyzing progressively larger RNAs with a bottom-up approach.
Poster Note: Multi-Level Expeditious Characterization of AAV Capsid Proteins using ZipChip
This poster note presents a novel approach to complete characterization of capsid viral proteins using microchip CE-MS for the characterization of AAVs.
Poster Note: Rapid Characterization of Oligos Using Microchip CE-MS without Ion-Pairing Reagents
Learn how ZipChip’s ready-to-use oligos BGE solution is free from ion-pairing reagents and makes switching between applications simple and easy.
Application Report: Glucose Control
The online analyser TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.
Brochures & Flyers
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MAVEN Brochure
MAVEN offers monitoring and control of glucose and lactate concentrations during cell culture and fermentation. Download this brochure to learn more.
REBEL Spent Media Analysis Kits
The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
MX908 Remote App
Export results, add custom notes, and access support
CBRN History Overview
Chemical warfare agents have evolved greatly over the last 100 years, download this timeline flyer to learn more.
Case Studies
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Case Study: Identifying Smuggled Khat
Suspicious of a possible drug shipment, officers ran the samples in the MX908 Drug Hunter Mission Mode which returned multiple alarms for cathinone, an active drug substance in khat.
REBEL + ZipChip help HJB Overcome Scientific Hurdles and Optimize Processes in Biotherapeutic Development
In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
Aerosolized Fentanyl During Decontamination
Download this case study on Canadian Decon Solutions’ encounter with fentanyl in a vehicle and how the MX908 with Aero provided real-time intel at the point of need.
Analysis Comparison of Fentanyl
Read how the sensitivity of MX908 enables the identification of fentanyl and its analogues down to 0.1%, even in a complex mixture.
Mission Briefs
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Mission Brief: Identify Pesticides at Illegal Marijuana Grows
With the addition of the pesticide capabilities, the MX908 provides critical identification of toxic pesticides in the field, allowing users to act immediately, while keeping themselves safe.
Mission Brief: Novichoks
Review this one sheet on Fourth Generation Agents that the MX908 can detect and identify at trace levels.
Mission Brief: Aerosol
Review the mission brief to learn how MX908 with Aero allows users to detect and identify aerosolized threats at trace levels.
Mission Brief: Fentanyl
Review this one sheet on MX908 detection of fentanyl and its thousands of analogs.
Podcasts
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As heard on Cell Culture Dish
The HazMat Guys Podcast, Part 2: Measuring Aerosols
Listen to Episode 291, Part 2 of the HazMat Guys Podcast on Aerosols. The guys discuss common techniques used measure aerosols and how to keep safe while responding to aerosolized threats.
The HazMat Guys Podcast, Part 1: What are Aerosols?
Listen to Episode 290, Part 1 of the HazMat Guys Podcast to learn more about aerosol threats and the challenges they pose to responders.
A Brief History of Field Technology
The guys introduce themselves and give a brief history of how laboratory technology has evolved for field use since the early 2000’s.
Posters
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Automated Glucose Feeding Based On Online Glucose And Lactate Measurements
This poster describes an automated control strategy for cell growth and biologics production. It leverages MAVEN, a reliable, easy-to-operate, online (sample-free) device for monitoring of glucose and lactate.
Process Optimization by the Use of Substrate Feeding Strategies
Online glucose monitoring is possible by using Trace C2 Control system. Feed control without online glucose monitoring causes acetate formation due to overflow metabolism.
Optimized Fed-Batch Fermentation by Use of Online Glucose Measurement
This poster presentation features an integrated multivariate glucose measuring tool combined with software solutions which allow different types of feeding-strategies.
High Frequency Glucose and Lactate Measurements in Multi-Bioreactor Vessels
TRACE C2 is an online analyzer for monitoring and controlling glucose and lactate concentrations in bioreactors. With the extension M4 it is possible to monitor Glucose and Lactate in up to four simultaneous bioprocesses.
Published Articles
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Prioritizing Officer Safety in the Field as Fentanyl Fatalities Rise
Multi-Mission Threat Detection in Real Time
This article originally appeared in CBNW Magazine.
In-Process Analytics are Key to Successful Cell Therapy Process Optimization and Manufacturing
Considerable clinical activity and the approval of several autologous, patient-specific therapies has increased industry demand and has also highlighted bottlenecks in manufacturing workflows.
The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.
Safety Data Sheet (SDS)
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SDS – ZipChip Reagents: Oligos
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – Deoxyribonucleic Acid, Unmodified
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Standard: Amino Acids
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Interface Tray Grease
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Specification Sheets
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TRACE C2 Specification Sheet
Get all the TRACE C2 specifications, including measurement range, physical dimensions, and software requirements.
MAVEN Specification Sheet
Get all the MAVEN specifications, including measurement range, physical dimensions, and software requirements.
MX908 Specifications for Priority Drugs
With the enhanced selectivity of HPMS, users can conduct field analysis of unknown substances at trace levels to generate actionable intelligence in real time.
MX908 Specifications for Corrections
MX908 provides trace identification (nanogram/invisible level) of many drugs commonly smuggled into corrections facilities.
Tech Notes
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Testimonials
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A Conversation with Michael Gray about Counterfeit Pills
Michael Gray is the CEO of Actus Analytical, Inc., which develops spectroscopy solutions for public safety. Michael and his wife, Nancy, founded The Actus Foundation in 2018, shortly after the death of their daughter, Amanda, who was killed by a poisoning of straight fentanyl at the age of 24.
Hear from Our Users: The Need for Speed in the Lab
Listen to ZipChip and REBEL users from The Dana Farber Cancer Institute, Sartorius, and Amgen discuss the impact of faster workflows in the lab.
A Conversation with Christina Baxter about Fentanyl
Dr. Christina Baxter is the CEO of Emergency Response TIPS, LLC and a partner in Hazard3, LLC which provides practical, evidence-based solutions for emergency response.
A Conversation with Christina Baxter about Aerosol Hazards
Dr. Christina Baxter is the CEO of Emergency Response TIPS, LLC and a partner in Hazard3, LLC which provides practical, evidence-based solutions for emergency response.
Technical Papers
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Tech Note: Glucose & Lactate Dialysis (Low)
These data were compiled in order to give an overview of typical system and sensor performance in the low concentration range using the dialysis-low sampling method. Operational temperature in the bioreactor was set to 37°C.
Tech Note: Glucose & Lactate Dialysis
These data were compiled in order to give an overview of the system and sensor performance in the normal concentration range using the dialysis sampling method.
Tech Note: Pressure Stability of the Dialysis Probe
The TRACE dialysis probe can be safely used in large reactors. Its dialysis membrane does not suffer from higher pressure due to hydrostatic and/ or pressurized conditions.
Tech Note: Interference of Other Sugars on Glucose and Lactate Measurements
Most sugars have no influence on glucose measurement. The only exception is mannose, which shows a low positive interference on the glucose measurement.
Videos
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ZipChip Customer Experience: Symphogen
Listen to Dan Bach Kristensen, a principal scientist at Symphogen, as he shares how ZipChip helps him with charge variant separation.
REBEL Customer Experience: Clemson University
Listen to Stephanie Klaubert, a graduate research assistant from Clemson University, as she shares how REBEL helps her with process development and cell culture optimization.
Conference Talk: Power Up Your Process Control (BPI 2022)
Graziella Piras spoke at BPI 2022 about how amino acids can present a goldilocks problem for bioprocessing: too little and they starve; too much and they favor growth over protein production.
MX Files – Episode 2: Destruction of Evidence
Watch this episode of the MX Files to see how the MX908 identified trace levels of residue left from drug evidence before it was destroyed.
Webinars
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Now Starts Now: The Future of Glucose & Lactate Measurement
Learn how MAVEN addresses the challenges of on-line nutrient and metabolite monitoring and control.
Current Trends in Counterfeit Pills
Watch this on demand webinar as we discuss the importance of identifying controlled substances in the field due to the rise of high potency counterfeit pills.
Harness the Power of At-Line Spend Media Analysis to Optimize a CHO mAb Fed-Batch Process
This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.
A Versatile Platform for Small Molecules, Intact Proteins & Beyond
ZipChip can be used for applications ranging from proteins and peptides in biopharmaceuticals, to oligonucleotides and AAVs in cell and gene therapy applications.
White Papers
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White Paper: Pesticide Detection and Identification at Illegal Marijuana Grows
With pesticides posing an imminent danger for wildlife in the area, responding law enforcement also find themselves potentially exposed to the hazardous chemicals
Microchip CE-MS: A Powerful Tool for Biotherapeutic Characterization
To help explain the power of this game-changing technology, we partnered with LCGC on a new ebook that covers the topic in-depth.
‘What’s In Your Media?’ Ebook
Learn about the critical role of cell culture media analysis in biotherapeutics development, including biologics and cell and gene therapies.
Using MX908 in Investigations and Court
Users can conduct field analysis of unknown substances at trace levels to generate actionable intelligence in real time to assess threat levels, establish probable cause, and prioritize investigatory resources accordingly, all while reducing operator exposure.
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