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Application Notes & Snapshots
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Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry
This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody-drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.
Rapid characterization of oligonucleotides using microfluidic CE-MS by ZipChip
This application note presents a CE-MS analysis of oligos by a ZipChip coupled to a QExactive HF mass spectrometer. This positive ESI mode method utilizes a MS-friendly background electrolyte (BGE), that eliminates the use of ionparing agents such as hexafluoro isopropanol or alkyl amines.
TN 53 – Charge variant analysis with ZipChip and maXisII
A ZipChip capillary zone electrophoresis system coupled to Bruker maXis II UHR-QTOF offers an alternative selectivity to separate charge variants prior to MS analysis and affords a more complete intact mass characterization without adding complexity or high salt eluents.
A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
Brochures & Flyers
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ZipChip Consumables Guide
Learn how to take the guesswork out of method development with ZipChip. Breeze through your selection in three quick steps.
Hassle-Free Oligo Characterization with ZipChip
The newly released ZipChip® oligos kit provides a simple, sensitive, dilute-and-shoot method for rapid analysis of oligonucleotides, applicable to
various sizes and modifications.
ZipChip Platform Brochure
Download our platform brochure to learn how ZipChip® platform prepares and separates a wide range of biological samples, then electrosprays them into your mass spec for analysis.
A comprehensive CE-ESI MS solution for BioPharma applications
Case Study
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Podcast
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As heard on Cell Culture Dish
A Brief History of Field Technology
The guys introduce themselves and give a brief history of how laboratory technology has evolved for field use since the early 2000’s.
Anthrax vs Fentanyl
Get some perspectives on how the “white powder” call has changed dramatically from the anthrax attacks of October 2001 to the synthetic opioid epidemic of more recent years.
Figures of Merit
On the nerdiest show so far, learn some of the scientific terms used to define the performance of analytical technologies and how they apply to the meters you use in the field.
Poster
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Microchip CE-MS with Integrated Solid Phase Extraction
Quantitation of metabolites in classical and customized cell culture media by an integrated CE-MS Analyzer
Quantitation of metabolites in cell culture media by an integrated CE-MS analyzer
for upstream process development
Microchip CE-MS of Oligonucleotides: What Can It Separate?
Published Article
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In-Process Analytics are Key to Successful Cell Therapy Process Optimization and Manufacturing
Cellular therapies are an increasingly viable therapeutic option for many indications, particularly for patients who have exhausted traditional treatments. Considerable clinical activity and the approval of several autologous, patient-specific therapies has increased industry demand and has also highlighted bottlenecks in manufacturing workflows.
The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.
Identification of AAV capsid proteins
Characterization of a SRPK1/2 Inhibitor Complex
Specification Sheet
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Tech Note
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Videos
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Webinar
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Ask the Expert: Bioprocess 101 – Cell Culture Media Analysis
Detecting Solids, Liquids, Vapors … and Aerosols?
Case Studies on Field Identification of Controlled Substances
Process Intensification: Do You Have All the Data You Need When You Need It?
The need for process intensification and implementation of Bioprocess 4.0 requires extensive real time data acquisition and process modelling. At line MS-based technologies presented here provide key cellular metabolic and protein quality data in real time to support process intensification and modelling.
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