The XplorIR Quantification Package provides hazmat responders with the capability to not only identify thousands of gases and vapors, but also quantify them in real-time on scene. This represents the only device of it's kind which can accurately detect, identify, and quantify, thousands of gases in seconds. With this unmatched capability, responders are able to respond swiftly to assess atmospheric conditions and make rapid decisions on PPE selection, exposure potential, mitigation techniques, and influence tactical considerations.
[post_title] => XplorIR Quantification
[post_excerpt] => Read this application note to learn about XplorIR quantification package which allows users to measure the concentration of a hazardous gas or vapor and part-per-million (ppm) levels.
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[post_modified] => 2024-08-14 10:27:14
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[post_date] => 2024-06-14 09:24:15
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Responders to hazardous materials incidents face significant risks from flammable atmospheres. To manage this threat, teams use structural firefighting gear, SCBA, and various sensors, including LEL sensors, for initial reconnaissance and subsequent entries. However, traditional Catalytic Bead LEL sensors can be inaccurate due to calibration issues with different gases and a limited scope, creating more safety risk. The XplorIR® device allows responders to identify the specific gas or vapor detected. This enables real-time adjustments to the sensor readings, improving safety by reducing the need for action levels, speeding up leak identification, and enhancing overall mitigation efforts.
[post_title] => XplorIR and LEL Sensors for Hazmat Response
[post_excerpt] => Learn about the integration of XplorIR's gas identification capabilities with the common air monitoring tool of the LEL sensor.
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[post_name] => xplorir-and-lel-sensors-for-hazmat-response
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[post_date] => 2024-06-14 09:24:16
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Colorimetric tubes have been a standard in the downrange toolkits of many first responders. Despite their widespread use, they are plagued by high error rates, significant cross-sensitivities, and an inability to conduct continuous gas monitoring. The XplorIR significantly reduces the reliance on individual colorimetric tubes. The XplorIR is the only FTIR analyzer that can provide continuous gas monitoring at operationally relevant concentrations while uniquely identifying over 5600 chemicals and up to 6 components simultaneously within a gas mixture.
[post_title] => Are Colorimetric Tubes Becoming Obsolete for HazMat/CBRN Response
[post_excerpt] => Learn how the XplorIR revolutionizes gas detection by eliminating the drawbacks of traditional colorimetric tubes.
[post_status] => publish
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[post_name] => are-colorimetric-tubes-obsolete-hazmat
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In emergency response, 4-gas or 5-gas air monitors with oxygen sensors ensure sufficient O2 levels for both responder safety and proper function of Catalytic Bead LEL sensors. However, a drop in O2 below 19.5% is considered IDLH by OSHA, signaling the need for supplied air respirators. Even a small decrease in O2 can indicate a large presence of contaminants, as a 0.1% drop in O2 can represent around 5,000 ppm of an unknown substance. If the XplorIR® device is used with these monitors, it can detect contaminants at much lower levels (25-50 ppm) compared to the O2 sensor, enhancing safety and reducing the risk of exposure to potentially dangerous gas clouds. XplorIR'[SW1] s capability to identify over 5,600 gases and vapors at levels well under the detection ability of O2 sensors provides an added layer of safety during reconnaissance operations.
[SW1]only need registered mark on the first mention of product.
[post_title] => XplorIR Solves Oxygen Displacement for Hazmat Response
[post_excerpt] => Learn how XplorIR identifies contaminants lower than an O2 sensor, and why it is deployed with gas monitors during recon entry.
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[post_name] => o2-displacement-and-xplorir
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[post_modified] => 2024-11-01 15:21:27
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[post_date] => 2024-09-10 15:24:09
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In this application note, by using a combination of analytical tools including REBEL and MAVEN, we were able to gain unique insights that allowed us to perform a data-driven optimization of a bioprocess and reach the process development goals with regards to titer, toxic metabolite profiles, and viability. REBEL, an amino acid analyzer streamlines bioprocess optimization by providing rapid, at-line spent-media analysis. It helps optimize nutrient feeding, control toxic metabolites, and improve cell viability, resulting in higher yields, including a 30% titer increase in one case.
[post_title] => Data-driven CHO Bioprocess Optimization and Scale-up with At-line Intelligence of Key Media Components
[post_excerpt] => Accelerate your process development with the fast, at-line REBEL analyzer, which provides amino acid analysis in minutes. Rapid analysis minimizes the time between bioprocess development experiments, helping you optimize nutrient feeding and control toxic metabolite production.
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[post_date] => 2024-06-14 09:24:16
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Learn how XplorIR accurately identifies toxic gases that can give your air monitors false readings or inhibit accurate measurements.
Carbon monoxide (CO) electrochemical sensors, commonly used in 4 or 5-gas air monitors, can give inaccurate readings due to cross-sensitivity with other gases and vapors. Inexperienced operators may incorrectly assume that any CO reading indicates the presence of CO, which can be dangerous.. XplorIR® can complement CO sensors by identifying not only CO but also many of these cross-sensitive gases, improving the accuracy of readings and enhancing responder safety. This pairing ensures a more reliable assessment of hazardous environments.
For reconnaissance teams at hazardous materials incidents, responders typically use a combination of 4-gas monitors, PID sensors, gamma detectors, temperature guns, and colorimetric papers. However, these tools have limitations due to cross-sensitivity issues, leading to potentially inaccurate readings and less reliable risk assessments. The XplorIR® offers a significant improvement by providing real-time identification of gases and vapors, reducing the problem of false readings and enabling more accurate risk assessments. By incorporating XplorIR, responders can more quickly and safely determine the presence of specific hazards, such as Hydrogen Fluoride or Carbon Dioxide, making it an essential addition to standard reconnaissance toolbox.
[post_title] => Building Your Recon Toolbox
[post_excerpt] => Learn how the XplorIR is a logical addition to your set of recon tools.
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[post_name] => building-your-recon-toolbox
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[post_modified] => 2024-11-01 15:37:27
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[post_date] => 2024-06-14 09:24:17
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Photo Ionization Detectors (PIDs) are valuable tools for detecting a broad range of chemicals by measuring ionized gas samples with ultraviolet light. However, PIDs face limitations in accuracy due to their reliance on calibration standards and the need for gas-specific correction factors, which require knowing the identity of the gas. The XplorIR® addresses this challenge by providing real-time gas and vapor identification, enabling operators to apply the correct PID correction factors for more accurate readings and assess toxic risks based on specific contaminants. This advancement significantly enhances risk assessment and response efficiency, allowing for quicker and more accurate identification of hazards and sources, and making XplorIR a major improvement in emergency response technology since the introduction of the PID in the 1970s.
[post_title] => Expanding Your Toolbox: Pairing Your PID with FTIR
[post_excerpt] => Learn about PID entry methods and how continuous air monitoring with XplorIR can identify unknown gases in the hotzone.
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[post_name] => detect-and-identify-with-pid-and-ftir
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[post_modified] => 2024-11-01 15:42:34
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This app note discusses the challenges faced by emergency responders when dealing with mixed chemical products in the field. It highlights the limitations of existing chemical identification technologies and introduces our innovative approach with the XplorIR to identify up to 6 gas components within complex mixtures.
[post_title] => Breaking New Ground: Gas Mixture Analysis with XplorIR
[post_excerpt] => Learn how the XplorIR identifies mixed chemical products and overcomes current chemical detection challenges through its ability to identify up to 6 gas components within complex mixtures.
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[post_name] => breaking-new-ground-gas-mixture-analysis-with-xplorir
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[post_date] => 2024-06-10 09:36:50
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AA analysis is not regularly performed in CAR T-cell experiments due to the complexity and sample volume limitations of traditional methods, but the REBEL device enables rapid analysis, low sample volume requirements and without the need for prior mass spectrometry expertise. Learn how to optimize your cell culture media for enhanced CAR T-cell therapy manufacturing.
This study explores the relationship between CAR T-cell activation, nutrient metabolism, and treatment efficacy. It highlights differences in amino acid (AA) concentrations in spent media between potent CAR T-cell phenotypes and less-active, exhausted ones. By using novel multi-cytokine backpacks (MCBs) in cell culture, the research aims to enhance T-cell manufacturing, focusing on the metabolic profiles linked to different phenotypes. The analysis revealed that certain AAs, such as alanine and glycine, accumulated during culture while others, like arginine, were consumed, indicating active metabolic pathways. With automated quantitation and low sample volume requirements, REBEL facilitated efficient AA quantification, underscoring its potential for optimizing CAR T-cell culture media. Overall, the findings suggest that understanding AA dynamics could improve CAR T-cell therapies.
[post_title] => Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack-Manufactured CAR T-Cells
[post_excerpt] => With automated quantitation and low sample volume requirements, the REBEL device enables rapid AA analysis compared to the many complexities in traditional analysis methods.
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[post_name] => amino-acid-analysis-indicates-metabolic-differences-in-multi-cytokine-backpack-manufactured-car-t-cells
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[post_modified] => 2024-11-03 17:08:26
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[post_date] => 2024-11-15 15:04:30
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ZipChip CE-MS was employed to assess mAb quality attributes directly from spent media, requiring only simple dilution without additional preparation. This technique facilitated daily monitoring of molecular weight, charge, and glycoform heterogeneity in mAbs produced in bioreactors with different glucose feeding strategies. Results showed improved product quality attributes from continuous glucose feeding compared to those produced with bolus glucose feeding, demonstrating ZipChip’s potential as a simple and effective tool for real-time monitoring of product quality in bioprocess development.
ZipChip CE-MS was used to analyze biosimilar mAb candidates, resolving charge variants and glycoforms with high sensitivity and short run times. This approach enabled rapid characterization of critical quality attributes, such as glycosylation and charge modifications, from early-stage cell line candidates. By providing detailed insights into post-translational modifications in a single assay, ZipChip facilitated efficient selection of mAbs closely matching the originator's quality profile, accelerating biosimilar development.
MAVERICK enables real-time monitoring of critical process parameters like glucose, lactate, and biomass in bioprocesses without the need for complex setups or prior modeling. Unlike traditional Raman spectroscopy methods that require extensive configuration and expert knowledge, MAVERICK offers a plug-and-play solution that can be implemented quickly and effectively across various cell lines and culture media. The system utilizes a de novo algorithm that works straight out of the box, measuring both static and dynamic parameters during bioprocess runs. Results from experiments with CHO and HEK293 cell cultures demonstrated that MAVERICK provides accurate readings that align closely with at-line measurements. The technology simplifies the monitoring process and helps ensure optimal cell culture conditions, enhancing overall product quality and yield. Overall, MAVERICK represents a significant advancement in in-line process analytical technology (PAT) for biomanufacturing.
[post_title] => Instant PAT Implementation with Raman-based MAVERICK
[post_excerpt] => Learn about instant PAT implementation, where MAVERICK was used to monitor critical process parameters to create measurement chemometric models.
[post_status] => publish
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[post_name] => instant-pat-implementation-with-raman-based-maverick
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[post_modified] => 2024-11-08 12:19:58
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[post_date] => 2024-02-09 11:43:11
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This document discusses the critical roles of glucose and lactate in bioprocessing, emphasizing the benefits of real-time monitoring using MAVEN. Traditional sampling methods limit process insight, but MAVEN allows for continuous measurement and control of these parameters, enhancing bioprocess characterization and management. The experiments demonstrated that a continuous glucose feeding strategy improves cell culture viability and product quality compared to daily bolus feeding. In particular, MAVEN prevented culture crashes and reduced high-mannose glycan levels in monoclonal antibodies, which can influence efficacy and stability. Overall, MAVEN facilitates more precise control and optimization of bioprocesses, leading to improved outcomes.
[post_title] => Continuous Monitoring and Control of Glucose and Lactate with MAVEN: Impact on Cell Culture Performance and Protein Quality
[post_excerpt] => Traditional sampling methods limit process insight, but MAVEN allows for continuous measurement and control of these parameters, enhancing bioprocess optimization.
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[post_name] => maven-monitoring-glucose-lactate-cell-culture-quality
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[post_title] => Real-time Monitoring of Key Bioprocess Parameters Using MAVERICK In-line Device in Culture Biosciences’ Cloud-connected Bioreactors
[post_excerpt] => Bioprocessing 4.0 aims to leverage advanced digital technologies, automation, and data-driven approaches to transform biopharmaceutical production. The data generated utilizing Culture Bioscience’s bioreactors, cloud-based controllers and software console together with MAVERICK, a novel Raman spectroscopy powered in-line PAT device, was found to track closely with off-line measurements for multiple critical process parameters. The use of PAT in bioreactors provides in-line, continuous data about cell culture conditions, thereby enhancing process understanding and enabling precise bioprocess monitoring and control.
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[post_name] => maverick-application-notes-and-snapshots-real-time-monitoring-of-key-bioprocess
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[post_title] => Microchip CE/MS Peptide Mapping Workflow with Trypsin Digestion for the Analysis of Critical Quality Attributes of Monoclonal Antibodies
[post_excerpt] => Peptide mapping is considered the gold standard for the analysis of biopharmaceuticals, including monoclonal antibodies.
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[post_name] => zipchip-appnote-ls-zc-an-0020
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[post_title] => Glucose Control
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.
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[post_name] => application-report-glucose-control
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[post_title] => Ethanol Dialysis
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of the Ethanol concentration in the fermenter.
[post_status] => publish
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[post_name] => trace-c2-application-report-ethanol
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[post_title] => Methanol Dialysis
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of the methanol concentration in the fermenter and provides the tools for a quick set-up of a feed control strategy
[post_status] => publish
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[post_title] => Glucose & Lactate (in Small Bioreactors)
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside small bioreactors.
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[post_title] => Glucose & Lactate
[post_excerpt] => The online analyzer TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.
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[post_title] => Why are Fentanyl and Fake Pills so Deadly
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[post_title] => Rapid characterization of oligonucleotides using microfluidic CE-MS by ZipChip
[post_excerpt] => This application note presents a CE-MS analysis of oligos by a ZipChip coupled to a QExactive HF mass spectrometer. This positive ESI mode method utilizes a MS-friendly background electrolyte (BGE), that eliminates the use of ion-paring agents such as hexafluoro isopropanol or alkyl amines.
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[post_title] => Charge variant analysis with ZipChip and maXisII
[post_excerpt] => A ZipChip capillary zone electrophoresis system coupled to Bruker maXis II UHR-QTOF offers an alternative selectivity to separate charge variants prior to MS analysis and affords a more complete intact mass characterization without adding complexity or high salt eluents.
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[post_title] => Glucose and Lactate Raman-Based Monitoring with MAVERICK: Performance in Spent Media
[post_excerpt] => MAVERICK provides a plug-and-play, in-line, Raman based PAT solution for monitoring and control of glucose, lactate, and biomass in up to 6 bioreactors. This Application Snapshot shows the results from experiments to demonstrate the selectivity of glucose and lactate measurements from MAVERICK in complex spent media samples from CHO and HEK293 cultures.
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[post_title] => A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
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[post_title] => From comprehensive characterization to monitoring product degradation characteristics
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[post_name] => zipchip-native-charge-variant-analysis-of-biotherapeutics-using-zipchip-ce-esi-ms
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[post_title] => Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer
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[post_content] =>
[post_title] => High-Throughput Intact Mass Analysis of mAb Based Therapeutics
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[post_title] => RPMI 1640 Medium Analysis with the REBEL: Accuracy and Reproducibility Across Multiple Devices
[post_excerpt] => This extensive fresh media analysis experiment provides an example of the accuracy and reproducibility of the REBEL device obtained with RPMI media.
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[post_title] => Screening for Component Diversity in CHO Cell Culture Media
[post_excerpt] => At-line amino acid analysis can speeds up cell culture media and feeding strategy optimization for bioprocess development.
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[post_title] => High variations of analyte levels in Terrific broth (TB) media
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[post_title] => Application Snapshot Booklet Cell and Gene Therapy
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[post_content] =>
[post_title] => How comparable are different vendors' LB media?
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[post_title] => Investigating the high nutrient variations in Super Optimal Broth
[post_excerpt] => Cultures’ growth rates and productivities may differ when different vendor’s media are used in otherwise identical experiments.
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[post_title] => Probing formulation differences in Super Optimal Broth
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[post_title] => Analysis of Reduced mAbs and ADCs
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[post_title] => Similarities between different vendors’ 2X YT liquid media
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[post_title] => ZipChip for profiling and characterization of antibody charge heterogeneity
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[post_title] => Sciex Flexible Solution for MAM with ZipChip
[post_excerpt] =>
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[post_name] => zipchip_app-note_sciex-charge-variant-liability-analysis-using-the-sciex-flexible-solution-for-mam
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[post_title] => At-line spent media analysis is now a reality
[post_excerpt] => To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.
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[post_title] => Differences in fresh commercially available hybridoma media
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[post_status] => publish
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[post_name] => rebel_app-note_fresh-commercially-available-hybridoma-media
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[post_content] =>
[post_title] => Select the best CHO media from the start
[post_excerpt] => Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.
[post_status] => publish
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[post_name] => select-the-best-cho
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[post_title] => Screening of chemically-defined media for suspension cultures of HEK293 cells
[post_excerpt] => Across four vendors, there was a high variation in the fresh media composition.
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[post_content] =>
[post_title] => Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip
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[post_date] => 2019-10-02 16:11:47
[post_date_gmt] => 2019-10-02 20:11:47
[post_content] =>
[post_title] => Analyze Media without Removing Your mAb on the Rebel
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => analyze-media-without-removing-your-mab-on-the-rebel
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[post_date] => 2019-08-08 17:24:30
[post_date_gmt] => 2019-08-08 21:24:30
[post_content] =>
[post_title] => Identify variations in dry and liquid CHO media
[post_excerpt] => Running a quick fresh media assay prior to feeding the culture ensures consistency of the media components when scaling up or during the transition between liquid-to-dry media blends.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => identify-variations-in-dry-and-liquid-cho-media
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[post_modified] => 2024-05-07 16:03:23
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[post_date] => 2020-06-16 19:57:47
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[post_title] => Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics
[post_excerpt] =>
[post_status] => publish
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[post_date] => 2019-10-02 16:17:00
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[post_content] =>
[post_title] => Serum supplemented media analysis is routine with the Rebel
[post_excerpt] =>
[post_status] => publish
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[post_name] => serum-supplemented-media-analysis-is-routine-with-the-rebel
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[post_date] => 2020-07-31 20:21:21
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[post_content] =>
[post_title] => Supplementing IMDM media with fetal bovine serum
[post_excerpt] =>
[post_status] => publish
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[ping_status] => closed
[post_password] =>
[post_name] => rebel_app-note_supplementing-imdm-media-with-different-amounts-of-fetal-bovine-serum
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[post_content] =>
[post_title] => Supplementing RPMI Media with Fetal Bovine Serum
[post_excerpt] =>
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[post_name] => rebel_app-note_supplementing-rpmi-media-with-different-amounts-of-fetal-bovine-serum
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[post_date] => 2020-07-31 20:12:38
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[post_content] =>
[post_title] => Conventional and chemically-defined T cell medias
[post_excerpt] =>
[post_status] => publish
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[post_name] => rebel-app-note-conventional-and-chemically-defined-t-cell-medias
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[post_date_gmt] => 2020-07-31 22:52:21
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[post_title] => Amino acid contents of Sf9 and Sf21 insect cell media
[post_excerpt] => Knowledge of the insect cell metabolism coupled with an understanding of the amino acid content of the cell media allows for a more informed process development analytics strategy.
[post_status] => publish
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[post_title] => Comparing Mesenchymal Stem Cell Media with Supplements on the Rebel
[post_excerpt] => To ensure consistency when culturing MSCs, researchers should understand what is being added to their media.
[post_status] => publish
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[post_name] => rebel-applications-comparing-mesenchymal-stem-cell-media
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[post_content] =>
[post_title] => Don’t sweat your cell media additives
[post_excerpt] =>
[post_status] => publish
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[post_title] => Handle Non-ionic Surfactants in Cell Media Samples with Ease
[post_excerpt] =>
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[post_title] => Basal Cell Media with 10% Fetal Bovine Serum
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[post_date] => 2024-08-14 10:27:13
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[post_content] =>
The XplorIR Quantification Package provides hazmat responders with the capability to not only identify thousands of gases and vapors, but also quantify them in real-time on scene. This represents the only device of it's kind which can accurately detect, identify, and quantify, thousands of gases in seconds. With this unmatched capability, responders are able to respond swiftly to assess atmospheric conditions and make rapid decisions on PPE selection, exposure potential, mitigation techniques, and influence tactical considerations.
In this flyer, learn how you can optimize the performance of your REBEL device with a preventive maintenance plan. There are various parts for the REBEL device and with routine maintenance, you can keep your device running efficiently with optimal analysis. We offer a few options for service plans to support your needs.
Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
1.REBEL Autosampler Sample Needle
Routine PM replacement and alignment of the autosampler needle will reduce chances of leaks, clogs, and potential missed injections during analysis.
2.REBEL Autosampler Sample Syringe
The autosampler syringe is responsible for all the fluidic movement and precise sampling within the REBEL. Over time the seals within the syringe can wear resulting in leaks and lowered analysis precision of fluidic transfer/sample loads.
3.REBEL Gas System Inlet Filter*
Annual PM replacement of the air inlet carbon and HEPA filters is to ensure optimal performance for the gas handling system in the REBEL. If not replaced the filters become less efficient and could result in poor analysis performance and contamination of more expensive components
*Access this on the back of the REBEL
4.REBEL Waste System Filter*
A particulate filter included in the waste system within the REBEL is to prevent material from entering the membranes of the waste pump. Routine replacement prevents clogging and decreased waste removal performance.
*Access underneath outer panels of the REBEL
5.REBEL MS Detector Inlet*
Detector Inlet is the entrance to the mass spectrometer of the REBEL device. Routine maintenance can reduce the chance of clogging, detection issues, and fouling. During PM, the performance of the vacuum system is evaluated along with alignment and detector performance.
*Access underneath outer panels of the REBEL
REBEL “STANDARD” SERVICE PM PLAN
REBEL PREMIUM SERVICE PLAN
Tech support (via email/phone)
Yes (Priority)
Yes (Highest priority)
Software updates (bug fixes)
Yes
Yes
Software upgrades (applicable features)
Yes
Yes
Replacement parts/repair labor
Yes
Yes
Preventative maintenance & IQ/OQ
Once per year
Once per year
On-site application support
Up to two visits included per year
Up to two visits included per year
Certified training
No
One free of charge* per year
Discount on single SMA kit purchase
No
7% through coverage period
Multi-year service plans
Yes
Yes
*For multi-year Premium plan, one free of charge Certified Training is on annual “use it or lose it” basis.
[post_title] => Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
[post_excerpt] => Learn how you can optimize the performance of REBEL with a preventive maintenance plan and see what is included.
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[1] => WP_Post Object
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[post_date] => 2024-07-09 13:02:58
[post_date_gmt] => 2024-07-09 17:02:58
[post_content] =>
Combining Terumo BCT's Quantum Flex platform with 908 Devices’ MAVEN will help cell therapy manufacturers reduce time-consuming manual steps that increase manufacturing costs and risks. It will also help advance the development of life-saving cell and gene therapies by providing insights into and control of one of the largest components of cell therapy development and manufacturing.
908 Devices MAVEN:
Automated monitoring of glucose and lactate on the Quantum Flex Cell Expansion System
Knowing what is happening inside your bioreactor is critical for cell expansion
Glucose and lactate concentrations can serve as leading indicators of the health and growth kinetics of your cells. When considered alongside perfusion rate, these metabolic indicators can help optimize media usage and harvest time. Quantum Flex paired with MAVEN from 908 Devices brings you continuous monitoring of glucose and lactate levels inside your bioreactor.
MAVEN integrates easily with Quantum Flex. The device clamps securely to the Quantum Flex bag pole, and a single-use diffusion flow cell is sterile-welded into the waste line of the Quantum Flex Cell Expansion Set.
Only the small glucose and lactate molecules from the bioreactor medium diffuse through a semi-permeable membrane inside the flow cell, moving into a transport buffer solution. The solution travels through the tubing to a biosensor inside MAVEN.
MAVEN analyzes the glucose and lactate concentrations. Results are available in near-real time and can be read on your computer using installed software.
Glucose measurement range: From 0.01 to 40 g/L concentration
Lactate measurement range: From 0.05 to 10 g/L concentration
Sensor operating life: 5,000 measurements or 30 days
[post_title] => Automated Monitoring on the Quantum Flex
[post_excerpt] => Learn how Terumo Blood and Cell Technologies' Quantum Flex cell expansion system and 908 Devices' MAVEN can work together to help your cells thrive and optimize your cell expansion process.
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[comment_status] => closed
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[post_date] => 2024-06-18 07:03:19
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This flyer describes the XplorIR's new identification with simultaneous quantification capability. The XplorIR can identify over 5,600 gases/vapors with extreme selectivity within seconds. With the new quantification package, the XplorIR can now quantify nearly 5,000 gases/vapors at parts-per-million (ppm) levels. This is done without any calibration required.
XplorIR Quantification Package
Simultaneously Identify and Quantify Hazardous Gases and Vapors
It’s one thing to know if a hazardous gas or vapor is present at an incident, and another to know what the product is. But what if you could also know how much of the hazard exists in the atmosphere? That requires quantification, and the XplorIR® now provides this critical piece of information.
The XplorIR, based on Fourier transform infrared (FTIR) spectroscopy, can identify over 5,600 gases/vapors with extreme selectivity within seconds. With the new quantification package, the XplorIR can now quantify nearly 5,000 gases/vapors at parts-per-million (ppm) levels. This is done without any calibration required.
FTIR measurements are inherently quantitative, and the spectral response is linear with respect to product concentration. Using a reference library based on known chemical concentrations, the XplorIR can determine the ppm of a product captured within its 2-meter gas cell and report that concentration along with the product identity.
Once the concentration is known, it can easily be compared to the Immediately Dangerous to Life and Health (ILDH) level of the product within the XplorIR software. This allows you to make rapid tactical decisions about remediation and decon with just a few button clicks.
Going further, the XplorIR uses a proprietary, automated process which combines molecular functional groups with measured spectra to estimate quantitative data for nearly all library entries. This extends the quantitative capabilities from a few hundred compounds to several thousand. With its ability to identify and quantify up to 6 mixture components at one time, the XplorIR is a game-changer for chemical response scenarios such as clandestine labs and other situations involving complex gas and vapor environments.
Key Attributes
The only handheld device for rapid trace detection and identification of pesticides at nanogram levels, in the field
Trace capability allows for exterior packaging sampling, reducing exposure risk
Provides actionable data at the point of need with results in less than a minute
Identify numerous pesticides by name to guide clean up efforts and keep personnel on site safe
Developed in partnership with the United States Forest Service (USFS)
Traditional first-entry meters only detect the presence of gases downrange, without accurately identifying their specific chemical compounds. During an explosion at a clandestine meth lab, learn how the XplorIR provides positive gas identification of over 5600 chemicals, even in complex gas mixtures.
It is 2:00 A.M. and your agency has just been dispatched to an explosion at a home in a heavily populated residential area
Once the resulting flames have been extinguished, your recon team performs an initial site assessment. While LEL readings are relatively low, CO and PID readings are extremely high. Neighbors complain of acrid odors and difficulty breathing. It seems you have just stepped into a clandestine meth lab, and you need answers… FAST!
Such incidents are far too common for first responders and mitigating them requires actionable intelligence on the myriad toxic gases and vapors filling the atmosphere. While multi-gas meters and PIDs play a critical role in these scenarios, such first entry devices don’t provide the gas and vapor identification capability required to tell the whole story. That’s where the XplorIR® comes in.
The hand-held XplorIR gas and vapor system can identify over 5,600 chemical products in seconds downrange
And with its sophisticated atmospheric compensation and mixture analysis algorithms, the XplorIR can report up to 6 compounds within the dirtiest of environments with minimal operator interaction. And when expert help is needed in the middle of the night, reach back scientists are on call to review the XplorIR data you upload to the cloud using the TeamLeader app on your smartphone.
Hazardous Chemicals
Chemical Warfare Agents
TICs
Nerve Agents
TOMs
Blister Agents
VOCs
Choking Agents
And many more toxic products
Whether a complex toxic gas release is nefarious or unintentional, the next time your agency is called to secure public and environmental safety, be prepared with the XplorIR. It will definitely save time, and it just might save lives.
[post_title] => XplorIR: Gas Identification for Rapid Response
[post_excerpt] => Learn how the XplorIR provides positive gas identification during an explosion at a clandestine meth lab.
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[post_name] => threat-brief-xplorir-mixture-analysis
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[post_date] => 2024-04-24 13:27:24
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[post_content] =>
Faster Bioprocess Data Visualization
Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers rich, time-course data visualization in less than a minute for run and sample comparisons. Download from our customer support portal and visit JMP.com.
REBEL
Sample comparison, and time-course data visualization from multiple samples, for all analytes, in an instant.
[post_title] => Faster Bioprocess Data Visualization
[post_excerpt] => Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers data visualization in less than a minute for run and sample comparisons.
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[post_name] => faster-bioprocess-data-visualization
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[post_modified] => 2024-08-14 16:26:04
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[post_date] => 2023-01-16 17:15:33
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[post_content] =>
NOW STARTS NOW
MAVEN
ON-LINE MONITORING AND REAL-TIME CONTROL OF GLUCOSE AND LACTATE
MEET MAVEN
OPTIMIZED, AUTOMIZED, DON’T-EVEN-SWEAT-IT GLUCOSE AND LACTATE CONTROL.
Monitoring and control of glucose and lactate concentrations during cell culture and fermentation are critical to achieve optimal process efficiency and productivity for effortless realization of PAT strategies. Real time insights into cellular metabolism are invaluable for media optimization and development of feeding and control strategies.
Detect and react to process changes in real time with on-line monitoring of glucose and lactate as often as every 2 minutes.
Develop advanced process control strategies and identify opportunities for process improvement with up to 720 glucose lactate data points per day.
Preserve precious bioreactor material and reduce process contamination risk with sample-free analysis based on the proprietary selective flow diffusion method.
Reliable and precise biosensor-based measurement technology ensures that optimal glucose concentration can be maintained, even at very low levels.
Reusable and single-use probes and flow cells make it easy to integrate MAVEN with most types and sizes of upstream systems in both the PD lab and GMP manufacturing.
Control the feeding pump directly with the integrated PID controller or easily connect with existing process automation systems via OPC UA, Analog or Serial outputs.
DESIGNED WITH FEATURES TO MAKE YOUR DAY
KNOW EXACTLY WHAT’S HAPPENING IN YOUR BIOREACTOR, MAINTAIN CONTROL OF YOUR PROCESS, AND KEEP YOUR CELLS HAPPY.
Unlike in manual or automated sampling, measurements are performed without any loss of bioreactor volume and without increased risk of process contamination.
Glucose and lactate molecules from the medium diffuse through the semi-permeable membrane into the transport buffer solution circulated between the probe and measuring cell.
HIGHLY PRECISE AND ROBUST BIOSENSORS
The biosensor’s enzymatic recognition and selectivity for glucose and lactate generates an electrical signal proportional to concentration of targeted analytes.
— Sensor type: Enzyme-based electrochemical biosensor — Glucose measurement range: From 0.01 to 40 g/L concentration
— Lactate measurement range: From 0.05 to 10 g/L concentration — Replaceable biosensor service life: 5,000 measurements or 30 days
BE A REBEL AND REAP THE REWARDS.
Combine REBEL’s at-line analysis of amino acids and vitamins with MAVEN’s on-line monitoring and control of glucose and lactate to get unambiguous answers where and when you need them.
HOW WILL YOU USE MAVEN?
MONITOR GLUCOSE AND LACTATE IN YOUR BIOREACTOR IN REAL-TIME. REFINE FEEDING STRATEGIES ON THE FLY.
MAVEN LOVES TO COLLABORATE
LIKE A GOOD LAB PARTNER, MAVEN EASILY INTEGRATES WITH YOUR EXISTING OR NEW UPSTREAM PROCESS DEVELOPMENT OR GMP MANUFACTURING SYSTEMS.
Compatible with Most Bioreactors and Fermenters
Automation Included
Advanced Connectivity
SUDDENLY, YOU'RE THE BOSS OF YOUR BIOREACTOR
Tight control of glucose-lactate concentrations enables development and implementation of dynamic feeding strategies to optimize cellular metabolisms leading to higher productivity and improved quality of biotherapeutics.
[post_title] => MAVEN Brochure
[post_excerpt] => MAVEN offers monitoring and control of glucose and lactate concentrations during cell culture and fermentation. Download this brochure to learn more.
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[post_date] => 2024-08-19 09:20:53
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[post_content] =>
With ongoing focus on the opioid crisis, synthetic opioids such a fentanyl have garnered much attention in the public eye. One emerging class of synthetic opioids, known as nitazenes, are increasing in appearance in the illicit drug market. Nitazenes can be 25 times more toxic than fentanyl and are often found in low concentrations mixed with substances or disguised as prescription pills.
While many bulk chemical detectors may have various nitazenes in their library, they are unlikely to identify these synthetic opioids in the field due to the low concentrations. The capability to identify these powerful synthetic opioids at trace levels (invisible to the eye/nanogram level) is more important than ever before to further investigations while keeping officers safe.
MX908 Advantages
Excellent target coverage of nitazenes and other synthetic opioids
Identification of mixed street drugs such as heroin, cocaine, meth, fentanyl, and nitazenes
Sampling of exterior packaging limits exposure risk to officers
No sample preparation, results in less than 60 seconds
Reachback services for data analysis by 908 Devices Forensic Chemists
“This tool (MX908) not only enhances the safety for our deputies but also significantly decreases the time between seizing a substance and confirming its identity. Our ability to act swiftly means a safer community and more efficient use of our resources.” -COUNTY SHERIFF AND MX908 CUSTOMER
The increasing size of the illegal marijuana market has given rise to an increasing number of trespass cannabis cultivation throughout the world. The heavy use of toxic pesticides by these illegal growers has had significant impact on the environment and wildlife. Many of these pesticides are so toxic, they are heavily restricted or even completely banned by many governments. In addition to the threat these pesticides pose to the environment, they also pose a great threat to responding law enforcement and agencies tasked with dismantling these operations.
With the addition of the pesticide capabilities, the MX908 provides critical identification of toxic pesticides in the field, allowing users to act immediately, while keeping themselves safe. Whether it be on site at an illegal marijuana grow, or at the border identifying smuggled pesticides, the MX908 provides accurate identification of pesticides at trace levels, in a handheld device, for the first time ever.
MX908 Advantages
The only handheld device for rapid trace detection and identification of pesticides at nanogram levels, in the field
Trace capability allows for exterior packaging sampling, reducing exposure risk
Provides actionable data at the point of need with results in less than a minute
Identify numerous pesticides by name to guide clean up efforts and keep personnel on site safe
Developed in partnership with the United States Forest Service (USFS)
Pesticide Targets
Aldicarb
Diazinon
Carbaryl
Imidacloprid
Carbofuran
Malathion
Chlorpyrifos
Methamidophos
A single drop of Carbofuran is enough to kill an adult human. Here a ~1 liter bottle is found at a trespass grow site.
Identifying containers and crop sprayers that have pesticides present reduce the cost of clean up and keep responders safe.
[post_title] => Identify Pesticides at Illegal Marijuana Grows
[post_excerpt] => With the addition of the pesticide capabilities, the MX908 provides critical identification of toxic pesticides in the field, allowing users to act immediately, while keeping themselves safe.
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[post_content] =>
Ensuring User Success with 908 Devices
REBEL Certified User Training
Get the best user experience with the REBEL at-line spent media analyzer. This training course is for new and experienced users who want to refresh their REBEL device operation skills.
The REBEL certified training includes:
Two day in-person instructor-led training at your facility for up to 3 people
Program highlights: REBEL introduction, sample handling and preparation, best practices for operating the REBEL, data handling and processing
Training materials: REBEL Spent Media Analysis consumable kit and extra materials used in the training program
[post_title] => REBEL Certified User Training
[post_excerpt] => Get the best user experience with the REBEL at-line spent media analyzer. Our training course is for new and experienced users who want to refresh their REBEL device
operation skills.
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Cool and Confident
The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
HASSLE-FREE PURCHASING AND SHIPPING OPTIONS
Choose the purchasing style that suits your lab:
One-time: Order one or more kits at full price for shipment.
Subscription: Order 6 or 12 kits at a time, shipped to you on a schedule you choose.
– Buy the 6-kit subscription, 5% discount
– Buy the 12-kit subscription, 10% discount
Thoughtful shipping: No matter how you buy, every kit ships overnight with proper packing to keep critical components chilled between 2-8° C at all times. Buy with a subscription to keep a steady stream of shipments flowing to your lab, without filling up valuable refrigerator space.
ABOUT THE KIT
Comprehensive package: Each kit includes BGE, diluent, a REBEL chip, standards, and microwell plates.
Packed for 200 runs: Make your buying decision based on kit consumption and your upcoming projects.
[post_title] => REBEL Spent Media Analysis Kits
[post_excerpt] => The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
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[post_content] =>
MX908 Remote App
Export Results, Add Custom Notes, and Access Support
DOWNLOAD THE APP
Get the MX908 Remote App on Google Play or the App Store
STEP 1
Pair the MX908 with a phone or tablet
STEP 2
Send reports, add custom notes and access support with the touch of a button
[post_title] => MX908 Remote App
[post_excerpt] => Download this flyer to learn more about the remote app now available for MX908. The MX908 remote app is available for download on Google Play or Apple App Store.
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[post_date] => 2022-03-25 11:24:22
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[post_content] =>
History of CWA Development & Use
The Evolution of CBRN Threats
Chemical warfare agents have evolved greatly over the last 100 years. Choking and blistering agents were the first to be developed and used broadly in combat. More recently, the development of 3rd and 4th generation agents as well as the use of Pharmaceutical-Based Agents have widely replaced them as the weapons of choice in modern conflict.
Modern Threat Detection
The Evolution of CBRN Technology
As CWAs evolved, detection technologies have evolved with them. Enabling warfighters to detect and identify evolving threats with greater accuracy, closer to the front lines.
Choosing a CWA detector that provides broad coverage of likely threats is critical for success. The MX908 is able to detect and identify 2nd, 3rd, and 4th Generation agents, as well as emerging Pharmaceutical Based Agents, and more. The MX908 provides operators with a tool that can change with emerging threats and evolve to meet future needs.
[post_title] => CBRN History Overview
[post_excerpt] => Chemical warfare agents have evolved greatly over the last 100 years, download this timeline flyer to learn more.
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Third-generation chemical warfare (CW) agents (binary G series and VX) were developed for their lethality, stability, and ease of weaponization. These have been the focus of CBRNE detection and protective equipment by US and NATO forces, which are well trained and equipped to counter these traditional CW agents.
Unfortunately, chemical warfare agents have continued to evolve. Russian developed fourth generation agents represent the latest evolution in the CW landscape. These A-Series Agents, also known as Novichoks, were employed in 2019 in Salisbury, UK in the attempted assassination of the Skripals, and, most recently, in 2020 in an assassination attempt of Russian opposition leader Alexei Navalny. Current global conflicts have increased the concern over use of chemical warfare agents.
Responding to A-Series CW Agents
A-Series agents, potent acetylcholinesterase inhibitors with signs and symptoms similar to traditional G- and V-Series nerve agents, were designed with specific knowledge of existing NATO detection and protective equipment, and ultimately, the goal of countering those detection and protection methods. They tend to be oily liquids which produce little to no vapors. They pose significant cross-contamination and exposure risks due to a combination of high potency and environmental persistence, and consequently a small release can rapidly become a large-area hazard. Due to their increased potency they often require higher antidote doses and can create additional vapor hazards when improperly decontaminated.
Traditional CBRNE detection equipment was designed to detect vapors which are characteristic of G-series and even VX agents, and have not yet evolved to detect or identify A-Series agents. This capability gap poses significant challenges to essential CBRNE tasks such as detection, determining limits of contamination, establishing control zones, selecting decontamination solutions, and verifying decontamination procedures to regenerate combat power in contaminated environments. The US Department of Health and Human Services issued emergency response guidelines for these agents in 2019, where they noted that, “There is a limited fielded capability within hazardous materials teams to detect, characterize, and identify FGAs.” These limitations are also true for traditional military forces.
Responding Pharmaceutical Based Agents
Synthetic opioids such as fentanyl pose a similar risk to nerve agents with their potency and potential lethality. These are often referred to as pharmaceutical based agents (PBAs). While not unique to Russia, these agents were first deliberately weaponized during the Moscow theater crisis where more than 100 people died from respiratory arrest after a PBA mixture was disseminated in aerosol form. Synthetic opioids are readily available through global illicit supply chains and are also synthesized by state actors. There are hundreds to thousands of potential PBA options, none of which are detected by traditional CBRNE detection technology during an aerosol dispersal event.
Aerosols are a fine suspension of liquids or solids in the air. They behave like gases yet are unable to be detected, much less identified, by fielded vapor detectors. This makes aerosolization an incredibly effective deployment method for CWAs and PBAs.
Detection Technology that can Detect and Identify A-Series Agents and PBAs
The MX908 handheld mass spectrometer is the only device able to detect and identify both A-Series Agents and PBAs at trace levels in solid, liquid, vapor, and aerosol forms. Easy to swap sampling modules enable the device to quickly switch from one sample type to another.
As a result, FGA and PBA hazards can now be detected on surfaces and in the air in under 60 seconds regardless of their mode of dissemination. Extensive third-party testing has shown detection efficiencies at or below the toxicologically relevant levels of most agents with a false negative rate of .6% when challenged with A-Series agents of varying purities on operationally relevant surfaces. Advanced software using predictive analytics further expands the detection capability of PBAs by increasing the effective library size to thousands of synthetic opioids.
The MX908 detects and identifies a broad range of priority drugs at trace levels in seconds.
The MX908 has the capability to detect and identify both A-Series Agents and PBAs in solid, liquid, vapor, and aerosol forms
[post_title] => Operational Impact of Fourth Generation Agents and Pharmaceutical Based Agents
[post_excerpt] => The MX908 handheld mass spectrometer is the only device able to detect and identify both A-Series Agents and PBAs at trace levels in solid, liquid, vapor, and aerosol forms.
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Real-Time Threats Real-Time Detection
MX908
MX908 is a multi-mission, handheld mass spectrometer utilized by elite responders conducting chemical, explosive, priority drug, and hazmat operations around the world.
MX908: A CRITICAL TOOL IN THE RESPONDER TOOLKIT
MX908® detects compounds at trace levels and combines unparalleled sensitivity and selectivity, providing users with confident results and actionable intelligence other handheld technologies cannot. The power of high-pressure mass spectrometry™ (HPMS) accurately discriminates priority threats from the broad range of interferents that lead to false alarms with other commonly used technologies.
DETECT AND IDENTIFY CHEMICALS IN ANY PHASE
With the MX908, one device can analyze any sample you encounter regardless of size or phase of matter. This flexibility combined with the MX908 expanding target list ensures that responders have a device that can evolve with new and emerging threats.
MULTI-MODE THREAT DETECTION
MX908 EXCELS WITH SAMPLES ACROSS THE LANDSCAPE
MX908 EXCELS WITH A BROAD RANGE OF SAMPLES AND CONCENTRATIONS
The MX908 is powered by high-pressure mass spectrometry (HPMS) technology, which enables responders to detect and identify chemical hazards from bulk to true trace concentrations. MX908 is up to 1 million times more sensitive than commonly used Raman and FT-IR technologies. Depend on high-fidelity trace and bulk identification, for point detection or remote area monitoring, all with one device
YOUR MISSION DEFINES YOUR MODE
Based on your specific mission objectives, choose an MX908 Mission Mode that leverages specialized software and hardware configurations to optimize performance for hunting certain chemical classes.
DRUG HUNTER
Methamphetamine
Cocaine
Fentanyl and 2000+ Fentanyl Analogs
Heroin
Cannabinoids
Cathinones
And More…
Identify narcotics in low concentration mixtures (well below 5%)
Establish trace chemical evidence linkages for interdiction, checkpoint operations, and more
Improve officer safety with limited exposure risk
Fentanyl Classifier provides coverage for 2000+ fentanyl analogs
Add case information with the MX908 remote application
CW HUNTER
Novichoks or A-series Agents
Legacy Warfare Agents (G, V, and H-series)
Pharmaceutical Based Agents (including fentanyl, carfentanil, and remifentanil)
Only field deployable detector for trace identification of Novichoks
Only field deployable detector for identification of aerosolized threats
Quantify chemical warfare agents in real time
Identifying Novichoks and other CWAs by name is essential for decontamination and medical response
Allow for broad threat coverage in any state with a single device
Remote area monitoring with MX908 Beacon
EXPLOSIVE HUNTER
Homemade Explosives
Military Explosives
Commercial Explosives
Precursors
Identify trace explosive residues
Identify explosives by name to guide response
Analyze samples safely with no threat of igniting sensitive materials
Identify aerosolized chemical threats dispersed from IEDs and other munitions
Establish trace chemical evidence linkages for checkpoint operations, HME lab response, and more
Our ZipChip CVA kit takes the guesswork out of method development. Characterizing your samples with ZipChip capillary electrophoresis coupled to your high-resolution MS, you're able to assess charge heterogeneity, identify basic and acidic variants, acquire accurate mass information, and profile glycoforms, all in a single analysis.
Get more data and streamline your Charge Variant Analysis workflow with ZipChip CVA kit
Easy sample prep and rapid analysis
Little-to-no method development
High performance analysis with full charge variant separation and peak identification
Comparable profiles to commonly used CVA techniques with the added power of mass spec characterization
Dilute Sample and Prepare BGE
Load Sample into ZipChip
Run the CVA on ZipChip-MS
Get straight to it.
Our preconfigured ZipChip CVA kit takes the guesswork out of method development.
SEAMLESS WORKFLOW
ZipChip-MS peak profile is comparable to Capillary Isoelectric Focusing (CiEF), Cation Exchange Chromatography (CEX), and Capillary Zone Electrophoresis (CZE-UV) and delivers seamless workflow for identification of detected unknown variant peaks.
STREAMLINED DESIGN
Analyze multiple biotherapeutic protein CQAs in a single assay - gain the ability to clearly separate and identify acidic and basic species and assess the glycosylation profile.
OPTIMIZED FOR YOU
Characterize a variety of monoclonal antibodies (mAbs) and other biotherapeutic proteins with the ZipChip CVA kit without having to reoptimize your method.
ZipChip CVA Consumables
ZipChip CVA consumables provide everything you need for analysis with no method development and minimal sample prep.
Name
Contents
Sample per kit
Part No.
CVA Assay Kit
CVA Background Electrolyte (BGE), Diluent, and Additive
From complex biologics to small molecules, ZipChip has an assay kit for you.
Take the Guesswork Out of Method Development
3 Easy Steps to Selection
1. Application
2. Chip
3. Kit
Assay kits come with background electrolyte and sample diluent that’s optimized for each application. Just put the bottle of background electrolyte in the autosampler, prep your samples with the sample diluent and you’re off.
1. The Application
From large to small molecule, ZipChip’s got you covered.
Protein Characterization: ZipChip is a one-stop shop for CQA’s—from charge variant analysis to peptide mapping. You’ll get high-resolution separation coupled to MS with simple, streamlined workflows.
Metabolomics: Quickly analyze small polar analytes from a variety of matrices, or monitor dynamic levels of metabolites in real time. Sample prep is quick and easy and results are ready in minutes.
Oligonucleotides: The characterization of nucleic acid-based drugs like oligonucleotides isn’t easy. ZipChip can offer some advantage over LC separations, particularly variations due to charge or shape.
Small Molecules: Analysis is easy and fast with ZipChip. Simply dilute and shoot; there’s no labeling or derivatization. Small polar analyte assays take as little as 2 minutes. Add internal standards for full quantitation on a variety of analytes.
2. The Chips
Choose from a range of chip options to optimize your workflow. Each chip can be used up to 125 injections.
HS: High Speed chip enables fastest separations. Matching BGE kits: Intact Antibody, Peptides, or Metabolites.
HR: High Resolution chip for applications demanding maximum separation capacities. Matching BGE kits: Intact Antibody, Peptides, or Metabolites.
HSN: High Speed chip for fast native protein analysis. Matching BGE kits: Native Antibodies or Charge Variant Analysis.
HRN: High Resolution chip with ultimate separation for native protein analysis. Matching BGE kits: Native Antibodies, or Charge Variant Analysis.
HSB: High Speed Bare Glass chip for high throughput separations. For example: fast oligonucleotides analysis. Matching BGE kit example: Oligos BGE.
HRB: High Resolution Bare Glass chip for high resolution separation of negatively charged analytes such as oligonucleotides. Matching BGE kit example: Oligos BGE.
3. BGE Kits
Background electrolyte (BGE) and sample diluent reduce preparation time for your samples. With ZipChip you just dilute and shoot!
Charge Variant Analysis: Formulated to provide excellent charge variant separations and MS sensitivity for antibodies and other proteins on all mass spectrometers.
Native Antibodies: Excellent charge variant separation of antibodies and other constructs to generate native spectra.
Peptides: Fast, efficient separations of protein digests and peptides utilizing low pH.
Metabolites: Streamlined sample prep and high-speed analysis for small molecules in denaturing conditions at low pH.
Oligonucleotides: Rapid analysis of oligonucleotides without the use of ion-pairing agents.
Ordering Information
ZipChip Assay Kits*
Part Number
Samples Per Kit
Charge Variant Analysis Kit
850-00052
625
Native Antibody Assay
850-00048
625
Metabolites Assat
850-00033
625
Peptide Assay
850-00034
625
Oligos Assay
850-00066
625
Oligos Starter
850-00067
250 Tests
*All kits contain BGE and diluent, and chips need to be ordered separately. The exception is the oligos starter kit which contains BGE, Diluent, chips and a standard.
Chips
Part Number
Chips Per Box
Injections Per Chip
HS
810-00195
5
125
HR
810-00194
5
125
HSN
810-00230
5
125
HRN
810-00227
5
125
HSB
810-00237
5
125
HRB
810-00239
5
125
[post_title] => ZipChip Consumables Guide
[post_excerpt] => Learn how to take the guesswork out of method development with ZipChip. Breeze through your selection in three quick steps.
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HASSLE FREE
Oligo characterization with ZipChip
The newly released ZipChip® oligos kit provides a simple, sensitive, dilute-and-shoot method for rapid analysis of oligonucleotides, applicable to various sizes and modifications.
Benefits:
High-resolution accurate mass identification and quantitation with CE-MS
No ion-pairing agents; no instrument contamination
Orthogonal to LC-based separation
Analysis in minutes with simple sample prep
Part Name
Contents
Samples per kit
Part No.
ZipChip Oligos Starter Kit
Oligos Background electrolyte (BGE) x 2 Diluent x 2 HRB Chip x 2 Oligo standard
250
850-00067
ZipChip Oligos Kit
Oligos BGE x 5 Diluent x 5
625
850-00066
HSB Chip
High Speed Bare Glass Chip (HSB) x 5
625
810-00237
HRB Chip
High Resolution Bare Glass Chip (HRB) x 5
625
810-00239
ZipChip Oligos Standard
20 mer DNA Primer
-
445-02281
Rapid Characterization of Oligos
Separation of Modified ssRNAs
Electropherogram showing separation of biotinylated, glycosylated and phosphorylated 20 mers from the corresponding unmodified 20 mer RNA standard
Rapid characterization of ssRNA with no method development
Base Peak Electropherogram for 20mer unmodified ssRNA standards (left) along with the raw mass spectrum (right).
RAMAN-BASED MONITORING OF MULTIPLE CRITICAL PARAMETERS, READY TO GO IN MINUTES.
MEET MAVERICK
THE ONLY PLUG-AND-PLAY, READY IN MINUTES, IN-LINE MULTIPARAMETER PAT PLATFORM
MAVERICK is powered by Raman spectroscopy and purpose-built de novo model for simultaneous real-time measurements of multiple key process parameters in mammalian cell cultures without the costs, complexities, and risks of conventional methods. There’s no need to deal with complex empirical calibration models, reagents, or unreliable auto-sampling systems to implement in-line bioreactor monitoring.
It’s all in-line gain, with no modeling pain.
Monitoring of multiple bioprocess parameters right out of the box.
Walk-away automation with integrated analog and digital feed controllers and optional secure remote monitoring.
Parallel and continuous monitoring of up to six bioreactors from a single hub.
Analog and OPC UA communication options for plug-and-play integration with automation and data acquisition systems.
Straightforward validation process and CFR 21 part 11 compliance-ready software enable seamless method tech transfer
MAVERICK’s de novo model will continue to evolve, with additional process parameters that can be added through software upgrades
INSTANT INSIGHTS WITH DE NOVO MODEL
QUANTIFICATION OF GLUCOSE, LACTATE AND TOTAL BIOMASS IN CELL CULTURE WITHOUT “BLACK BOX” EMPIRICAL RAMAN CALIBRATION MODELS
Raman spectrum is collected from the bioreactor
Spectrum analyzed and interpreted in real-time by de novo model
Process parameters are quantified and displayed automatically
A SIX BIOREACTOR MULTIPLEX FLEX
EASILY MONITOR AND CONTROL UP TO SIX BIOREACTORS SIMULTANEOUSLY
Control feeding pumps directly or send the measured parameters to an existing automation system
Securely monitor your bioprocess from anywhere with optional remote monitoring via a web browser
INSTANTLY ENHANCE UNDERSTANDING AND CONTROL OF YOUR BIOPROCESS
MEASURE AND CONTROL GLUCOSE CONCENTRATION
Dynamic control of feeding, enabled by real-time glucose measurements, helps optimize cell growth and productivity while minimizing accumulation of toxic metabolites and ensuring product quality
MONITOR LACTATE CONCENTRATION
Continuously monitoring lactate concentration is crucial to prevent potentially toxic effects that can compromise productivity and product quality
TRACK TOTAL BIOMASS
Tracking the biomass trend over the cell culture duration provides valuable insights on cell growth for process optimization and detection of deviations
TAKE IT OUT OF THE BOX AND YOU'RE HALFWAY DONE WITH THE SETUP PROCESS
BIOPROCESS INSIGHTS AT YOUR FINGERTIPS
Take your understanding of bioprocess to the next level by combining real time process insights offered by MAVERICK and at line spent media analysis provided by REBEL.
EVERYTHING YOU NEED TO GET STARTED
OPTICAL IMMERSION PROBE
— Autoclavable probe compatible with standard bioreactor ports
— Automatic probe identification and compliance traceability
— Magnetic probe coupling ensures secure attachment and proper alignment
— No optical isolation of bioreactor required
MEASUREMENT MODULE
— Autonomous operation — Optional direct control of feed pumps — Compact footprint — Electrical interrupt switch for enhanced operator safety
HUB
— Simultaneous control of up to six measurement modules
— Data transfer over Ethernet or OPC UA
High-resolution, color touchscreen interface supports:
— User authentication
— System configuration and operation
— Guided calibration of immersion probes
— Viewing system status, monitoring of real-time measurements and trends
SOFTWARE
— CFR 21 part 11 compliance ready
— Optional remote monitoring from any web browser
— Access to Raman spectral data
CALIBRATION KITS AND ACCESSORIES
— Two-point probe calibration standards
— Probe stand for convenient calibration and probe storage on the bench
[post_title] => MAVERICK Brochure
[post_excerpt] => Real-time bioprocess monitoring and control, right out of the box. In-line measurements of multiple critical parameters across media, across processes, across mammalian cell lines, across scales.
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ZipChip leverages microfluidic-based Capillary Electrophoresis (CE) and electrospray ionization technology to simplify sample preparation, perform high-resolution separations with reduced analysis times, and directly introduce samples into a Thermo Fisher Scientific, Bruker, or Sciex mass spectrometer. Achieve faster results with the ZipChip CE-MS device.
CE-MS DEVICE
ZipChip
ACCELERATE YOUR MS CHARACTERIZATION
Rapid protein characterization and metabolomic analysis with microfluidic technology for highly efficient separations of complex samples.
BIOLOGICAL CHARACTERIZATION
IN MINUTES
GIVE YOUR MASS SPEC SOME ZIP
The ZipChip® platform prepares and separates a wide range of biological samples, then electrosprays them into your mass spec for analysis. Just clip it on. The process takes as little as a few minutes, and it results in better separation quality than most LCs in a fraction of the time. Simple workflows and multiple kit options cover a host of biotherapeutic, metabolomic, and proteomic applications.
EASY ON SAMPLES
Now the kicker. ZipChip plays well with your mass spec and your proteins. Gentle sample prep reagents preserve structural integrity without denaturing or unfolding proteins for fully native mass spectra. No need to remove detergents or desalt. Negative and neutrals are trashed. Only positive analytes head out for cleaner mass spectra and more identified peaks.
EFFICIENCY WITH ADVANCED
MICROCHIP TECHNOLOGY
WITH ZIPCHIP YOU GET THE DATA FASTER, AND BECAUSE OF THAT YOU CAN MAKE QUICK DECISIONS
Associate scientist at Amgen
Easy as 1-2-3
Pick an application, a chip, and a kit. After simply loading the premixed background electrolyte and sample into the autosampler, pop in a ZipChip, and hit run. Use vials or 96-well plates.
It’s hands-off from there. Smart chips tell the system which method to use based on your preferences. Samples are automatically loaded, separated, and electrosprayed. Integrated software cues the mass spec to start analysis.
Efficient Separations
Microfluidic technology integrates capillary electrophoresis (CE) and electrospray ionization (ESI) on the ZipChip. Junctions and dead volumes don’t exist so analytical quality stays high, and no injection bias improves repeatability.
1. Pick your application, kit, and chip
2. Simple sample prep
3. Load reagent and chip, then run
IT'S ALL IN THE CHIP
FROM LARGE TO SMALL MOLECULES,
ZIPCHIP’S GOT YOU COVERED
Protein Characterization:
ZipChip is a one-stop shop for CQAs—with streamlined CE MS workflows for Charge Variant Analysis of basic and acidic species, Rapid Intact Mass Analysis, Subunit Analysis, and Peptide Mapping for deeper characterization.
Oligonucleotides:
The characterization of nucleic acid-based drugs like oligonucleotides isn’t easy. ZipChip can offer some advantage over LC separations, such as no ion-pairing agents to contaminate the instrument
Small Molecules
Analysis is easy and fast with ZipChip. Simply dilute and shoot; there’s no labeling or derivatization. Small polar analyte assays take as little as 2 minutes. Add internal standards for full quantitation on a variety of analytes.
Metabolomics:
Detect, identify and quantitate small polar analytes from a variety of matrices like cell lysates or growth media and monitor dynamic levels of metabolites in real time. Sample prep is quick and easy and results are ready in minutes.
Chemical Warfare Agents (CWAs) continue to evolve from Chlorine gas in World War I to G-series agents in the 1930s and novel agents used in the UK in 2018. Technology must evolve with these threats to ensure responders can quickly and safely act to protect the public. MX908 has expanded its CW Hunter Mode to include A-series agents, also known as Fourth Generation Agents (FGAs) or Novichoks.
Developed to avoid existing detection technologies, Novichok agents are more persistent than other nerve agents and at least as toxic as VX; some estimate as high as 8 times as toxic. There is a significant risk of cross contamination, so secondary exposures can be just as deadly and difficult to identify. Potential delayed onset of symptoms makes early detection even more critical to minimize casualties, limit the spread of contamination, and conduct appropriate decontamination.
MX908 ADVANTAGES
The only field-deployable tool for rapid trace detection and identification of A-230, A-232 and A-234 at low nanogram levels
Includes a wide range of other CWAs including GA, GB, GD, GF, HD, VX and additional V-series agents (VE, VM, VLX, VS, RVX/CVX and VX acid)
Results in 60 seconds to expedite response and increase public and responder safety
Independently tested by MRI Global; results available on request
CW HUNTER MODE:
NOVICHOKS
For more information: Fourth Generation Agents: Reference Guide, January 2019 This new fourth generation agent guidance from CHEMM makes clear the need for trace detection tools that are adaptable, reliable and ready. https://apps.dtic.mil/sti/citations/AD1066891
Source: Chemical Hazards Emergency Medical Management (CHEMM), U.S. Department of Health and Human Service
In upstream bioprocessing, cell culture media development is a key area of focus, and monitoring of the media all the way through manufacturing is critical. Understanding the relationship between cell culture media components and the cells they support can ultimately impact the process Key Performance Indicators (KPIs) and Critical Quality Attributes (CQAs). Analysis of key media components such as amino acids, vitamins, and the metabolites produced as a result of cell growth is beneficial at all stages of process development, including
cell line development, media QC, and media development. This information provides insight not just on media composition and performance, but also on clone selection, feed strategy, optimal harvest time, product quality, and more. The need for more process intensification and process modeling requires frequent real time data that can easily be used for deeper monitoring and control.
Ultimately, having greater insight offers more opportunities to positively impact CQAs and KPIs to create products faster, more cost effectively, and with greater therapeutic success.
GETTING RESULTS ISN'T ALWAYS EASY
Process development groups don’t always have the analytical tools or resources to gain in-depth process understanding. Sending samples to on-site or off-site core labs can take days to weeks and can be costly.
MEET THE
REBEL
The REBEL is a novel, dedicated cell culture media analyzer designed for rapid, easy, and efficient amino acid and nutrient analysis. Combining award winning design with 908 Devices proven capillary electrophoresis and high-pressure mass spectrometry technologies, the REBEL provides process development scientists access to critical data at-line, any time.
ANALYSIS IN 4 EASY STEPS
PULL A SAMPLE
Pull a sample from your bioreactor, shake flask, or well plate. The REBEL only needs 10µL.
SPIN & DILUTE
Spin out your cells and dilute. That’s as complicated as it gets.
LOAD YOUR SAMPLES
Load your samples, reagents, and calibrants.
GENERATE RESULTS
Hit start, get results. Results can quickly be reviewed in a simple report.
REBEL
BENEFITS
EASY TO OPERATE
Designed for simplicity.
MINIMAL SAMPLE PREPARATION
Pull a sample from your bioreactor, shake flask or well plate, then spin out your cells and dilute.
NO MORE WAITING FOR RESULTS
Fully processed at line report for 30+ components in under 10 minutes.
DATA INTEGRATION
For easy data alignment and interpretation with third-party platforms.
A COMPREHENSIVE PANEL TO MEET YOUR NEEDS
THE REBEL SCREENS FOR OVER 30 ANALYTES IN EVERY RUN, ALL IN UNDER 10 MINUTES
AMINO ACIDS
Alanine
Alanyl-Glutamine
Arginine
Asparagine
Aspartic Acid
Cystine
Glutamic Acid
Glutamine
Glycine
Histidine
Isoleucine
Leucine
Lysine
Methionine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Serine
Threonine
Tryptophan
Tyrosine
Valine
VITAMINS
Choline
Nicotinamide
Pyridoxal
Pyridoxine
Thiamine
AMINES
β-Alanine
Citrulline
GABA
Hydroxyproline
Methyl-Histidine
Sarcosine
KNOW WHAT'S IN YOUR MEDIA
Understanding which key nutrients are present in your cell culture media is critical to media screening and optimization efforts. In this experiment, nine commercial CHO media were measured using the REBEL in a media screening evaluation (Figure 1). The amino acid profile reveals high diversity in nutrient composition across the media panel. With the REBEL you can measure key nutrients such as amino acids in both fresh and spent media at-line in real time to gain deeper insight into your process and obtain high titer faster.
CHO MEDIA SCREENING
Analyzed using a simple 100x dilution with 20 replicates.
Figure 1. Diversity of nutrient composition in a panel of chemically defined CHO media.
REBEL measures over 30 analytes including all amino acids, certain vitamins, and bio amines. Plotted here are a subset of amino acids including all essential ones and others in 9 different CHO media. This comparison shows that the concentration of several amino acids such as serine and arginine, two potentially important amino acids for cell growth and protein production, varies widely between the media tested here while other amino acids are more consistent between media.
COMPACT WITHOUT COMPROMISE
The REBEL delivers high method accuracy and reproducibility, ensuring confidence in results. In a spiking experiment, 17 analytes with known concentrations were added into a chemically defined medium and measured using the REBEL. Values obtained with REBEL showed high accuracy (values were within +/- 20% of expected values) and high analytical precision (%RSDs were between 7 to 16%) as demonstrated in Figure 2.
AMINCO ACID RECOVERY IN CHO MEDIUM
Figure 2. Recovery of analyte concentration using the REBEL analyzer. 17 analytes (Sigma AAS18 amino acid standard) were spiked at 1mM and cystine at 0.5mM, into a commercial chemically defined medium in triplicate and measured four times on the REBEL (total of 12 replicates). All analytes were between 93 –118% of expected values.
HOW WILL YOU USE
REBEL?
MONITOR AMINO ACIDS AND VITAMINS THROUGHOUT YOUR BIOREACTOR TIME COURSE. REFINE FEEDING STRATEGIES ON THE FLY. CORRELATE MEDIA SELECTION TO PRODUCT QUALITY AND YIELD.
Expanded Capability for Toxic Aerosol Detection and Identification
The MX908® Aero enables operators to detect and identify aerosolized threats—such as Chemical Warfare Agents (CWAs) and Pharmaceutical-based Agents (PBAs) —which represent a critical gap in existing trace chemical detection solutions.
An aerosol is a suspension of fine solid or liquid particles which maintain the physical properties of their solid or liquid state but behave like a vapor. This combination of physical state and vapor-like behavior make traditional vapor detectors ineffective against aerosol threats. The Aero leverages proven MX908 sampling technologies and analysis mechanics to address this unique threat.
MX908 ADVANTAGES
The only field-deployable tool available now for rapid trace detection and identification of aerosol threats.
Simultaneous monitoring, detection, and identification of both vapor and aerosol threats.
Flexible sampling modules for easy transition from trace solid and liquid sampling to vapor and aerosol sampling.
Optional accessory can be quickly deployed to fielded units or be purchased with new MX908 devices.
Target Group
Targets
A-series agents (Novichoks)
A-230, A-232, A-234
V-series agents
VE, VM, VS, VX, VX Acid RVX/CVX
G-series agents
GA, GB, GD, GF
Blister agents
HD
Fast-acting incapacitating agents
Fentanyl and analogs (2000+), U-series, AH-7921
Lachrymatory agents
Capsaicin
AERO
The MX908 Aero can detect aerosol particulates dispersed from an explosive device.
An operator using the MX908 can conduct post-blast analysis on-site with the Aero.
MX908 with Drug Hunter Mode future-proofs the device against the ever-changing fentanyl landscape. Novel predictive classification algorithms enable alerts in minutes to previously undetectable threats, setting the MX908 apart from library-based tools.
MX908 ADVANTAGES
Identification of most drugs of abuse
Detection of 2,000+ novel fentanyl analogs
No library updates required
Detection of trace fentanyls within bulk cutting agents (street cut drugs)
Immunity to benign cutting agents such as lactose
Simultaneous identification of mixed street drugs such as heroin, cocaine or methamphetamine with trace fentanyls
Exterior package sampling limits exposure risk
Results in 60 seconds to expedite mitigation or prosecution
No sample prep required for heroin
Electronic records preserve data integrity
“We have been using the MX908 for the past few months and it has already proven to be a tremendous asset in the field for maintaining Officer safety while being able to detect trace elements of multiple drugs in as short as 20-30 seconds.”
Patrick Glynn, Lieutenant Det., Commander, Quincy, MA PD
DRUG HUNTER MODE:
FENTANYL
Minimize exposure risk with exterior package sampling.
MX908’s predictive classification algorithms can recognize the molecular structure of more than 2000 previously undetectable fentanyl analogs.
In this flyer, learn how you can optimize the performance of your REBEL device with a preventive maintenance plan. There are various parts for the REBEL device and with routine maintenance, you can keep your device running efficiently with optimal analysis. We offer a few options for service plans to support your needs.
Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
1.REBEL Autosampler Sample Needle
Routine PM replacement and alignment of the autosampler needle will reduce chances of leaks, clogs, and potential missed injections during analysis.
2.REBEL Autosampler Sample Syringe
The autosampler syringe is responsible for all the fluidic movement and precise sampling within the REBEL. Over time the seals within the syringe can wear resulting in leaks and lowered analysis precision of fluidic transfer/sample loads.
3.REBEL Gas System Inlet Filter*
Annual PM replacement of the air inlet carbon and HEPA filters is to ensure optimal performance for the gas handling system in the REBEL. If not replaced the filters become less efficient and could result in poor analysis performance and contamination of more expensive components
*Access this on the back of the REBEL
4.REBEL Waste System Filter*
A particulate filter included in the waste system within the REBEL is to prevent material from entering the membranes of the waste pump. Routine replacement prevents clogging and decreased waste removal performance.
*Access underneath outer panels of the REBEL
5.REBEL MS Detector Inlet*
Detector Inlet is the entrance to the mass spectrometer of the REBEL device. Routine maintenance can reduce the chance of clogging, detection issues, and fouling. During PM, the performance of the vacuum system is evaluated along with alignment and detector performance.
*Access underneath outer panels of the REBEL
REBEL “STANDARD” SERVICE PM PLAN
REBEL PREMIUM SERVICE PLAN
Tech support (via email/phone)
Yes (Priority)
Yes (Highest priority)
Software updates (bug fixes)
Yes
Yes
Software upgrades (applicable features)
Yes
Yes
Replacement parts/repair labor
Yes
Yes
Preventative maintenance & IQ/OQ
Once per year
Once per year
On-site application support
Up to two visits included per year
Up to two visits included per year
Certified training
No
One free of charge* per year
Discount on single SMA kit purchase
No
7% through coverage period
Multi-year service plans
Yes
Yes
*For multi-year Premium plan, one free of charge Certified Training is on annual “use it or lose it” basis.
Lithium-ion batteries are prevalent in our society and used in everything from electric vehicles to personal devices. Disposal of used batteries represents a challenge, as even old or partially charged devices present deflagration hazards if exposed to heat, puncture, or other forms of perturbation. A method for decommissioning Li-ion batteries is to immerse them in a brine solution, which ostensibly de-energizes the electrical cells such that the batteries can be transported and discarded safely. However, this process is not trivial for remediation personnel as it results in the liberation of numerous gases that are highly toxic and flammable. As such, having a means to detect and identify these gases and to determine when they are no longer present is crucial to the decommissioning process.
In a recent case study, an agency was contracted to decommission numerous types of batteries including Li-ion cells and other electrical components that had been damaged in a large- scale fire event. The agency planned to deploy the brine solution method but was also interested in testing its efficacy and learning what gaseous components may be generated. Batteries were soaked in 55-gallon drums and smaller containers, and gaseous samples were extracted from headspaces using Tedlar bags. Initial air monitoring of the headspaces yielded some interesting and unexpected results, which prompted the need for additional gas identification.
The agency’s approach was to use ThreatID™, a portable analyzer for identifying powders, liquids, gas, vapors, and complex mixtures based on Fourier transform infrared (FTIR) technology.
The remnants of an exploded li-ion battery. Source: PETER PEREIRA/The Standard-Times
The ThreatID can identify over 27,600 hazardous chemicals, including over 5,600 gases at low parts-per-million (ppm) levels, in less than 1 minute. A certified instructor was on-site for the endeavor to conduct the measurements and report results back to technical experts. From the headspace sampling, the ThreatID primarily identified methane and ammonia.
Reachback personnel confirmed the results and even identified some very minute components through detailed spectral data review. These additional materials included acetylene, formaldehyde, ethene, and even some unidentifiable substances. The ThreatID gas-phase results were confirmed on-site using colorimetric tubes which detected methane, ammonia, and formaldehyde.
Interestingly, the presence of ammonia and volatile organic compounds (VOCs) was not expected based on initial supposition and readings from basic air monitors. Headspace analyses showed that even after the batteries were deemed “safe,” toxic and flammable materials continued to off-gas. The study proved that after a fire or other disastrous event when batteries are inactive, they may still pose significant hazards and must be properly monitored. By rapidly identifying the liberating gases and using secondary technologies to confirm them, the correct hazard associations can be made and greatly accelerate the time scale of future decommissioning projects.
This event was a success by demonstrating that the brine solution method must be further optimized to fully decommission Li-ion and other battery types to render them safe for transport and disposal. Without FTIR gas identification, the clean-up effort would have been plagued with uncertainties and require significantly more time to properly remediate the lurking potential hazards.
Reachback Spectral Interpretation for sample CNB018a, matching Methane.
Hundreds of ThreatIDs have been deployed by the U.S. Postal Inspection Service for their Dangerous Mail Program. Learn why USPIS chose the ThreatID for advanced screening and detection; distinguishing it from other FTIR technologies.
Ever since anthrax spores were mailed to high value targets in late 2001 and resulted in five deaths and 17 infections of American citizens1, the United States Postal Inspection Service (USPIS) has been concerned about suspicious substances being sent within envelopes and packages. But the USPIS mission of protecting America’s mail has a long history.
Though the Department of Homeland Security (DHS) is the largest U.S. federal law enforcement agency, USPIS is its oldest.1,4 248 years ago, on August 7, 1775, Postmaster General Benjamin Franklin handed a paycheck to the first USPIS Surveyor William Goddard in Philadelphia, Pennsylvania.4 The USPIS has been carrying out its critical duties program ever since, most recently under the auspices of the Dangerous Mail Investigation (DMI) program.
Key to this program has been the adoption of advanced screening and detection technologies to expedite the analysis of potential threat materials in mailed containers.5 Such threats can include actual or hoax biological agents, illicit drugs, or numerous other types of suspicious substances. To that end, the USPIS adopted field-portable Fourier transform infrared (FTIR) technology in 2005 owing to its ease of use and desirable form factor. More recently, as part of a technology refresh initiative, the agency updated its chemical identification fleet with the ThreatID™. Currently, 225 ThreatID systems are deployed by the USPIS at strategic locations around the country.
ThreatID is a portable FTIR analyzer which can identify over 27,600 products including common household materials, hazardous chemicals, explosives, drugs, and much more in less than one minute. Measuring a substance is as simple as placing a minute grain of solid or drop of liquid onto the diamond sensor and following the on-screen prompts.
However, these technical features were not the only aspects the USPIS considered when procuring the ThreatID. As important was the unique level of support provided to the agency.
When inspectors are trained, they receive a tailored program which incorporates the ThreatID into their concept of operations (CONOPS). Specifically, the training addresses how FTIR should be used within the context of other technologies employed by the inspectors during threat assessment. These technologies parallel those used in hazardous materials response including pH paper, radiation detectors, multi-gas monitors, and even biological agent screening tests. USPS Publication 52 documentation on Hazardous, Restricted, and Perishable Mail1 was programmed into the ThreatID software for direct on-board access at the system’s result screen. Service is also paramount, 24/7/365 access is provided to its scientists and engineers for device troubleshooting and spectral data review when they are needed most. Furthermore, the TeamLeader mobile application, a standard no-cost offering to all our customers, fits nicely with the USPS goal of
exploring “cloud capabilities in support of targeting and detection efforts” as part of the DMI initiative.
The ThreatID is a critical component of the USPIS mail protection mission. As part of a tiered screening approach, the ThreatID has proven to be an effective means of protecting USPIS employees and its customers. The agency responds to approximately 2,500 mail inspection calls per year. Though not all calls require a physical response, the ThreatID provides peace of mind to all who encounter suspicious substances, especially when the threat of legitimate attacks still looms in our unsettled world. As a law enforcement arm of the U.S. government, the USPIS can impose strict penalties onto offenders including fines or prosecution. Having the most advanced technologies in hand, these efforts are conducted with more speed and confidence than ever before. Benjamin Franklin would indeed be proud.
References:
Publication 52 – Hazardous, Restricted, and Perishable Mail Standard, pe.usps.com/text/pub52/index.htm, Accessed November 7, 2023.
www.fbi.gov/history/famous-cases/amerithrax-or-anthraxinvestigation, Accessed November 7, 2023.
www.dhs.gov/dhs-law-enforcement-overview, Accessed November 7, 2023.
www.uspis.gov/about/history-of-uspis, accessed November 7, 2023.
U.S. Postal Service Strategy: Combating Illicit Drugs in the Mail, September 2020 Report, www.uspis.gov/combating-illicit-drugsin-the-mail, Accessed November 7, 2023.SU103_AGHS.pdf, Revision 23 August 2018.
[post_title] => ThreatID Case Study: United States Postal Inspection Service
[post_excerpt] => Learn why USPIS chose the ThreatID for advanced screening and detection, distinguishing it from other FTIR technologies.
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Customs organizations are tasked with protecting the border as well as managing the safety and security of passengers, imports, exports and mail centers. It’s a huge operation for every country. Drug detection and seizures are a large aspect of any customs organization. In fact, the New Zealand Customs Service (NZCS) was responsible for responding to nearly 4,300 drug incidents1 in 2023, seizing more than 3,805 kilograms of cocaine, 2,190 kilograms of methamphetamine and 567.8 kilograms of ecstasy.
When faced with dangerous substances and other challenges in the field, customs officers need quick and accurate information about the substances they are handling. Which is why the NZCS turned to 908 Devices’ MX908 trace detection and identification tool. The MX908 is capable of analyzing solid, liquid, vapor and aerosol threats – from street drugs to chemical spills to explosives
These three examples in particular stand out as exemplary use cases.
Case 1 - Narcotics Identification
Suspected Narcotics Identified with Drug Hunter
Drug traffickers go to huge lengths to conceal their contraband, wrapping substances in seemingly innocuous containers, jamming them into the walls of vehicles and more. While multiple technologies, including X-Ray, are deployed to uncover these hiding spots, they can’t tell officers exactly what the packages contain. It’s imperative to verify the substances inside to ensure officer safety and stop illicit drugs from entering their borders.
In one notable instance, NZCS officers identified goods crossing the border that appeared to be multiple large containers of waterproofing material. However, due to suspicious activity, the items were flagged for secondary inspection. The team needed to confirm the presence of illegal substances while maintaining the safety of officers during the search.
Two officers deployed the MX908, swabbing areas of concern—including the bucket handles—which are the most common areas for trace levels of narcotics to be found. Each analysis returned a positive result for methamphetamine, a Schedule II controlled substance that’s highly addictive. The containers were carefully taken apart and numerous extremely small packages of methamphetamine were removed from the waterproofing material, and thereby confiscated. In the words of the NZCS, “the ability of the MX908 to obtain clear and consistent results further encouraged our officers to locate the previously unseen and undetected illicit drugs
Case 2 - Chemical Detection
Identifying Toxic Industrial Chemicals
A freight carrier close to the airport spilled, and an unknown substance that was suspected to be a noxious chemical prompted a response. The NZCS was called in to investigate, however given the proximity to the airport and possible hazards to officers, extreme caution was needed to collect a physical sample. Time was of the essence, and the freight carrier logs were being combed through, but not nearly fast enough to determine the type of substance and remediation protocol.
NZCS officers arrived onsite equipped with the MX908, utilizing the trace vapor capability. A specialist officer donned personal protective equipment and entered the spill site. The MX908 positively identified the presence of dimethylformamide, a solvent for chemical reactions that can impact the eyes, skin, lungs, liver and heart during prolonged exposure. This positive identification enabled officers to properly secure the spill site and implement remediation efforts. The freighter manifest confirmed dimethylformamide, and the spill was contained. The rapid, trace analysis of the MX908 enabled officers to access this information quickly with a high degree of confidence and expedite clean-up.
Case 3 - Explosives Identification
Analyzing Possible Explosives
Bomb threats are always taken seriously, so when a law enforcement agency was contacted by a concerned individual about an abandoned package at a place of worship, the NZCS was called to identify the package. Given the proximity of the venue to public areas, it was ideal to avoid having to evacuate the area, if possible, in order to mitigate undue stress on the public.
The MX908 was again dispatched, this time utilizing the Explosives Hunter Mission Mode, which detects trace levels of military and commercial grade explosives, homemade explosives and relevant precursors. The item was tested with minimal disruption to the package and site, and returned negative results. This gave the agencies involved comfort in mitigating the perceived risk and the ability to downgrade the cordon. This succinct information and inter-agency coordination also enabled officers to clear the scene and move on to their next duties.
Result
Whether using trace identification features for drug traffickers, deploying vapor capabilities to analyze threats or implementing the explosive functionality to assess risk to the public, the NZCS has seen tremendous benefit from 908 Devices' MX908. This multi-mission handheld tool empowers swift response with confidence, helps protect officers and ensures greater public safety and well-being.
Special thanks to the New Zealand Customs Service for their contribution to this Case Study
[post_title] => Trace Drug Identification at the Border: 3 Scenarios from the New Zealand Customs Service
[post_excerpt] => Whether using trace identification features for drug traffickers, deploying vapor capabilities to analyze threats or implementing the explosive functionality to assess risk to the public, the New Zealand Customs Service has seen tremendous benefit from 908 Devices' MX908.
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[post_date] => 2024-01-25 09:17:49
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[post_content] =>
On average, the U.S. Postal Service processes and delivers 421.4 million pieces of mail each day. In fiscal year 2023 (October 2022- August 2023), the United States Postal Inspection Service (USPIS) made 5,014 seizures, of drug substances in U.S. mail. That is an average of nearly 14 seizures per day. The most commonly seized substances were:
Substance
Number of Seizures
Quantity of Substance Seized
Cocaine
1,727
5,393 lbs
Meth
1,607
7,189 lbs
Synthetic Opioids (Fentanyl)
1,554
4,038 lbs
Heroin
126
99 lbs
There are many employees and individuals at risk of exposure to these dangerous substances as mail is processed, handled, and delivered. Substances contained within those packages and envelopes are at risk of being dispersed on the surface of packaging materials, mail handling equipment, or in the air. In 2001, this type of threat was brought to light as anthrax attacks within the United States, delivered by ordinary mail, claimed the lives of five individuals. More recently, in November 2023, suspicious letters containing fentanyl were sent to U.S. voting centers and government buildings in six separate states.
Situation
A task force of federal, state, and local officers were investigating individuals and locations suspected of receiving packages containing illicit substances. They began surveillance on a house known to law enforcement to be a drop spot for packages that would later be collected by a neighbor.
After surveillance, officers set up a controlled delivery of the package to the residence. Officers conducted a stop of the vehicle and began to investigate the package. Suspecting the package contained a controlled substance, the officers used a K-9 which did not alert for any substance. This presented a challenge to law enforcement since they did not have a warrant to open the package. Officers had immediate access to optical chemical identification tools but were unable to utilize them since there was no visible material on the package.
Solution
The officers also had access to an MX908 and decided to test the outside of the package for trace residues of controlled substances. Officers swabbed the outside of the packaging focusing on the seals of the package, as these are the most likely areas for residues to collect. The swabs were analyzed using the MX908 Drug Hunter Mission Mode and returned a result of Cocaine. The presence of cocaine on the outside of the package allowed officers to obtain a warrant to open the package. The package was then opened and 2 lunchboxes were recovered, both containing 1 kilogram of cocaine.
Result
In the above scenario, the material inside the package was cocaine, which is not surprising given it was the most seized drug by the USPIS in FY23. However, it could have just as easily been fentanyl. Fentanyl in any form poses a major risk to health and safety due to its highly toxic nature. The average lethal dose of fentanyl and carfentanil are 2 milligrams and 0.02 milligrams respectively. These materials may be easily aerosolized while opening and handling packages or envelopes. In an envelope or package, fentanyl or its analogs could be found in various amounts and may pose a serious threat without being visible. The MX908 can identify fentanyl and its analogs at levels of tens of nanograms or 10,000 times less than the lethal dose of fentanyl and 100 times less than the lethal dose of carfentanil.
In a mail screening operation, this means that a user could quickly and easily determine whether a package or packages contain a dangerous substance by analyzing the air in a controlled processing area or by swabbing the outside of packages. Identification of trace drug substances, whether aerosolized or deposited on the outside of mail and packages, enables users to take appropriate actions and keep employees and first responders safe when handling these materials.
[post_title] => Identifying Dangerous Materials in Mail
[post_excerpt] => Learn what are the commonly seized substances in everyday mail and how our MX908 is utilized as a screening tool to keep employees safe from harmful substance exposures. A simple swab of a package can reveal the contents inside.
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[post_date] => 2023-10-30 15:22:42
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[post_title] => Identifying a Synthetic Cannabinoid Imbedded in Paper
[post_excerpt] => Read our latest case study on how MX908 aids correctional staff to proactively identify drugs at nanogram levels via trace detection on difficult samples, such as drugs imbedded in paper.
[post_status] => publish
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[post_title] => Identifying Smuggled Khat
[post_excerpt] => Suspicious of a possible drug shipment, officers ran the samples in the MX908 Drug Hunter Mission Mode which returned multiple alarms for cathinone, an active drug substance in khat.
[post_status] => publish
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[post_title] => REBEL + ZipChip help HJB Overcome Scientific Hurdles and Optimize Processes in Biotherapeutic Development
[post_excerpt] => In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
[post_status] => publish
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[post_date] => 2021-10-26 12:26:35
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[post_content] =>
[post_title] => Aerosolized Fentanyl During Decontamination
[post_excerpt] => Download this case study on Canadian Decon Solutions' encounter with fentanyl in a vehicle and how the MX908 with Aero provided real-time intel at the point of need.
[post_status] => publish
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[post_content] =>
[post_title] => Analysis Comparison of Fentanyl
[post_excerpt] => Read how the sensitivity of MX908 enables the identification of fentanyl and its analogues down to 0.1%, even in a complex mixture.
[post_status] => publish
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[post_title] => Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes
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[post_title] => Analysis to unravel biosimilarity of therapeutic proteins
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[post_name] => analysis-to-unravel-biosimilarity-of-therapeutic-proteins
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[post_title] => Automated monitoring of amino acids in cell culture media
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[post_title] => Highly sensitive charge variant analysis of complex biopharmaceuticals
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[post_title] => In-depth analysis of top selling biotherapeutics
[post_excerpt] =>
[post_status] => publish
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[post_name] => in-depth-analysis-of-top-selling-biotherapeutics-with-zipchip
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[post_date] => 2024-06-14 09:24:15
[post_date_gmt] => 2024-06-14 13:24:15
[post_content] =>
Lithium-ion batteries are prevalent in our society and used in everything from electric vehicles to personal devices. Disposal of used batteries represents a challenge, as even old or partially charged devices present deflagration hazards if exposed to heat, puncture, or other forms of perturbation. A method for decommissioning Li-ion batteries is to immerse them in a brine solution, which ostensibly de-energizes the electrical cells such that the batteries can be transported and discarded safely. However, this process is not trivial for remediation personnel as it results in the liberation of numerous gases that are highly toxic and flammable. As such, having a means to detect and identify these gases and to determine when they are no longer present is crucial to the decommissioning process.
In a recent case study, an agency was contracted to decommission numerous types of batteries including Li-ion cells and other electrical components that had been damaged in a large- scale fire event. The agency planned to deploy the brine solution method but was also interested in testing its efficacy and learning what gaseous components may be generated. Batteries were soaked in 55-gallon drums and smaller containers, and gaseous samples were extracted from headspaces using Tedlar bags. Initial air monitoring of the headspaces yielded some interesting and unexpected results, which prompted the need for additional gas identification.
The agency’s approach was to use ThreatID™, a portable analyzer for identifying powders, liquids, gas, vapors, and complex mixtures based on Fourier transform infrared (FTIR) technology.
The remnants of an exploded li-ion battery. Source: PETER PEREIRA/The Standard-Times
The ThreatID can identify over 27,600 hazardous chemicals, including over 5,600 gases at low parts-per-million (ppm) levels, in less than 1 minute. A certified instructor was on-site for the endeavor to conduct the measurements and report results back to technical experts. From the headspace sampling, the ThreatID primarily identified methane and ammonia.
Reachback personnel confirmed the results and even identified some very minute components through detailed spectral data review. These additional materials included acetylene, formaldehyde, ethene, and even some unidentifiable substances. The ThreatID gas-phase results were confirmed on-site using colorimetric tubes which detected methane, ammonia, and formaldehyde.
Interestingly, the presence of ammonia and volatile organic compounds (VOCs) was not expected based on initial supposition and readings from basic air monitors. Headspace analyses showed that even after the batteries were deemed “safe,” toxic and flammable materials continued to off-gas. The study proved that after a fire or other disastrous event when batteries are inactive, they may still pose significant hazards and must be properly monitored. By rapidly identifying the liberating gases and using secondary technologies to confirm them, the correct hazard associations can be made and greatly accelerate the time scale of future decommissioning projects.
This event was a success by demonstrating that the brine solution method must be further optimized to fully decommission Li-ion and other battery types to render them safe for transport and disposal. Without FTIR gas identification, the clean-up effort would have been plagued with uncertainties and require significantly more time to properly remediate the lurking potential hazards.
Reachback Spectral Interpretation for sample CNB018a, matching Methane.
Cell therapy manufacturing continues to advance through innovation in bioreactor design, and the integration of process analytical technology (PAT) to monitor, control, and improve processes. Real-time and in-line and on-line monitoring of key metabolic parameters, such as glucose and lactate, enables improved control strategies for optimized cell culture. This, in turn, leads to more reliable and cost-effective manufacturing, ultimately helping make therapies more accessible to patients in need. Discover how the synergy between automated cell expansion systems and real-time analyzers revolutionizes cell culture processes.
This poster, developed in partnership with Quantum Flex and Terumo Blood and Cell Technologies, was featured at Advanced Therapies 2024.
[post_title] => Advancing Cell Therapy Manufacturing with Bioreactor and Bioprocess Control Solutions
[post_excerpt] => Discover how the synergy between automated cell expansion systems and real-time analyzers revolutionizes cell culture processes. This poster was featured at Advanced Therapies 2024.
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[post_name] => advancing-cell-therapy-manufacturing-with-bioreactor-and-bioprocess-control-solutions
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Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis.
This poster was a collaboration with Terumo Blood and Cell Technologies and was part of the poster program at the 2024 ISCT EU Conference.
[post_title] => Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
[post_excerpt] => The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding, characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
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[post_title] => Optimization of Scalable rAAV Production for Gene Therapy – Utilizing At-Line Amino Acid Measurements for Bioprocess
[post_excerpt] => The REBEL device enabled data-driven bioprocess development for rAAV manufacturing in HEK293 cells by accurately and precisely quantitating amino acids, leading to deeper process understanding. This poster was a collaboration with MIT and highlighted at the following 2024 Conferences-ASGCT, ISCT, ISCT EU and ESACT.
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[post_date] => 2024-05-23 19:04:45
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[post_content] =>
[post_title] => In-Line and On-Line Monitoring of Key Cell Culture Parameters for Robust Cell and Gene Therapy Bioprocess
[post_excerpt] => The instant PAT implementation with MAVERICK, versatility, and sensitivity of MAVEN and point of need availability of amino acids analysis with REBEL, enable deeper knowledge and actionable information of Cell and GeneTherapy bioprocesses. Further, the devices informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization and control. This poster was highlighted at the 2024 ASGCT Conference.
[post_status] => publish
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[post_name] => in-line-and-on-line-monitoring-of-key-cell-culture-parameters-for-robust-cell-and-gene-therapy-bioprocess
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[post_title] => Microchip CE-MS Analysis of Nucleic Acids – From Characterization of Synthetic Oligonucleotides to Sequence Mapping of RNAs
[post_excerpt] => This work will showcase how the ZipChip enables a simple and rapid workflow for the analysis of nucleic acids with noion-pairing reagents needed This poster was highlighted at the 2024 TIDES Conference.
[post_status] => publish
[comment_status] => closed
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[post_name] => microchip-ce-ms-analysis-of-nucleic-acids-from-characterization-of-synthetic-oligonucleotides-to-sequence-mapping-of-rnas
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[post_title] => Investigation of Drug-To-Antibody Ratio for FORCE Oligonucleotide Conjugates Using Microchip CE-MS
[post_excerpt] => ZipChip microchip CE-MS resolves DAR species electrophoretically and enables generation of superior MS spectra. This poster was presented as a collaboration with Dyne Therapeutics at ASMS 2023 as poster WP045.
[post_status] => publish
[comment_status] => closed
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[post_name] => investigation-of-drug-to-antibody-ratio
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[post_content] =>
[post_title] => In-depth Characterization of Adeno-Associated Viruses using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
[post_excerpt] => Rapid microchip CE-MS can be utilized for the in-depth characterization of AAVs including viral capsid protein analysis and peptide mapping. This poster was presented as a collaboration with NIBRT at ASMS 2023 as poster WP730.
[post_status] => publish
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[post_name] => in-depth-characterization-of-adeno-associated-viruses
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[post_modified] => 2024-03-25 09:56:23
[post_modified_gmt] => 2024-03-25 13:56:23
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[7] => WP_Post Object
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[ID] => 23966
[post_author] => 29
[post_date] => 2024-04-01 13:05:13
[post_date_gmt] => 2024-04-01 17:05:13
[post_content] =>
[post_title] => Rapid In-Depth Characterization of Biologics by Microchip CE-MS: mAbs, AAVs and Nucleic Acids
[post_excerpt] => Microchip capillary electrophoresis (CE) coupled with mass spectrometry (MS) has revolutionized the characterization of therapeutic modalities in biopharmaceuticals. Here, we present the applications of an integrated workflow that couples the microfluidic CE system (ZipChip) with MS in characterization of biotherapeutics. This was poster A03 at BPS Europe 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rapid-in-depth-characterization-of-biologics
[to_ping] =>
[pinged] =>
[post_modified] => 2024-05-07 16:06:30
[post_modified_gmt] => 2024-05-07 20:06:30
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[8] => WP_Post Object
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[ID] => 23963
[post_author] => 29
[post_date] => 2024-04-01 12:35:51
[post_date_gmt] => 2024-04-01 16:35:51
[post_content] =>
[post_title] => Know Your Process: On-line and At-line Analytics for Upstream Bioprocess Key Nutrients
[post_excerpt] => Bioprocess development requires analytics to monitor critical process parameters. This poster discusses two discuss two key technologies to characterize, optimize and control bioprocess. In 2024, this poster has been highlighted at BPI Europe and BPS Europe.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => know-your-process-on-line-and-at-line-analytics
[to_ping] =>
[pinged] =>
[post_modified] => 2024-10-22 13:09:38
[post_modified_gmt] => 2024-10-22 17:09:38
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[9] => WP_Post Object
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[ID] => 23826
[post_author] => 15
[post_date] => 2024-03-25 10:02:00
[post_date_gmt] => 2024-03-25 14:02:00
[post_content] =>
[post_title] => Raman-based In-line Monitoring of Key Process Parameters in Mammalian Bioprocesses without the Need for Chemometric Model Building
[post_excerpt] => This poster describes a new technology called MAVERICK that uses Raman spectroscopy for continuous monitoring of mammalian cell cultures, specifically those using CHO and HEK293 cells. In 2024 this poster has been highlighted at BPI US West, BPS Europe, BPI Europe, BPI USA and most recently Advanced Therapies.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => raman-based-in-line-monitoring-of-key-process-parameters-in-mammalian
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:35:31
[post_modified_gmt] => 2024-11-18 20:35:31
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[guid] => https://908devices.com/?post_type=resource&p=23826
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[10] => WP_Post Object
(
[ID] => 23828
[post_author] => 32
[post_date] => 2024-03-25 10:10:07
[post_date_gmt] => 2024-03-25 14:10:07
[post_content] =>
[post_title] => 5’ mRNA Analysis By Microchip CE-MS Using an Internal Cleavage Motif for RNase H Digestion
[post_excerpt] => The subject of this poster was the investigation of an internal DNA motif to produce a shorter digestion product while simultaneously maintaining the length of the probe at 25nt for hybridization specificity. The shorter oligo results in easier detection using Microchip CE-MS approach. This poster was presented at ASMS 2023 as poster THP575.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => 5-mrna-analysis-by-microchip-ce-ms
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-26 14:32:16
[post_modified_gmt] => 2024-03-26 18:32:16
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23828
[menu_order] => 110
[post_type] => resource
[post_mime_type] =>
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[11] => WP_Post Object
(
[ID] => 23830
[post_author] => 15
[post_date] => 2024-03-25 10:15:07
[post_date_gmt] => 2024-03-25 14:15:07
[post_content] =>
[post_title] => Improved Performance of Phosphopeptides Characterization Using Online Capillary Electrophoresis Coupling with Ion Mobility Mass Spectrometry (CE-IM-MS)
[post_excerpt] => This poster will highlight a novel strategy for characterization of therapeutic peptide that was developed based on microchip CE-MS pure liquid separation and ion mobility gas phase separation, combing with mass spectrometry identification. The poster was presented in collaboration with Ningbo University at ASMS 2023 as poster THP609.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improved-performance-of-phosphopeptides-characterization
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-25 10:15:12
[post_modified_gmt] => 2024-03-25 14:15:12
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23830
[menu_order] => 111
[post_type] => resource
[post_mime_type] =>
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[12] => WP_Post Object
(
[ID] => 23832
[post_author] => 15
[post_date] => 2024-03-25 10:20:12
[post_date_gmt] => 2024-03-25 14:20:12
[post_content] =>
[post_title] => Amino Acid Quantitation in Over 50 Mammalian Cell Culture Media with an Integrated CE-MS Analyzer
[post_excerpt] => Characterizing cell culture nutrients such as amino acids in growth media is critical for maximizing cell growth and improving key quality attributes of the cells. This poster was presented at ASMS 2023 as poster THP625.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => amino-acid-quantitation-in-over-50-mammalian-cell-culture-media
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 14:18:02
[post_modified_gmt] => 2024-08-01 18:18:02
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23832
[menu_order] => 112
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[post_mime_type] =>
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[13] => WP_Post Object
(
[ID] => 23820
[post_author] => 15
[post_date] => 2024-03-25 09:27:20
[post_date_gmt] => 2024-03-25 13:27:20
[post_content] =>
[post_title] => Rapid Identification of Conjugation Sites in Antibody Drug Conjugates Using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
[post_excerpt] => CE/MS method is optimized with NISTmAb digest as a reference control. Good MS/MS coverage of NISTmAb is obtained with narrow peak width and fast separation. This poster was presented as a collaboration with Bruker at ASMS 2023 as poster WP041.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rapid-identification-of-conjugation-sites-in-antibody-drug
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-25 09:28:04
[post_modified_gmt] => 2024-03-25 13:28:04
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23820
[menu_order] => 113
[post_type] => resource
[post_mime_type] =>
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[14] => WP_Post Object
(
[ID] => 23818
[post_author] => 29
[post_date] => 2024-03-25 09:13:48
[post_date_gmt] => 2024-03-25 13:13:48
[post_content] =>
[post_title] => Conformation of Native Antibody-Drug Conjugate Charge Variants Revealed by Microchip Capillary Electrophoresis Coupled with Trapped Ion Mobility
[post_excerpt] => The combination of microchip capillary electrophoresis and trapped ion mobility enables a rapid, informative method for native monoclonal antibody and antibody-drug conjugate charge variant analysis. This poster was a collaboration with Bruker and NIH and presented at ASMS 2023 as poster WP040.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => conformation-of-native-antibody-drug-conjugate-charge-variants
[to_ping] =>
[pinged] =>
[post_modified] => 2024-05-07 14:29:50
[post_modified_gmt] => 2024-05-07 18:29:50
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[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23818
[menu_order] => 114
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[15] => WP_Post Object
(
[ID] => 23798
[post_author] => 15
[post_date] => 2024-03-21 11:02:11
[post_date_gmt] => 2024-03-21 15:02:11
[post_content] =>
[post_title] => Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis - Mass Spectrometry (CE-MS)
[post_excerpt] => Presenting a novel strategy for characterization of therapeutic peptides was developed based on microchip CE-MS and linkage-specific derivatization. This poster was presented in collaboration with Ningbo University at ASMS 2023 as poster TP544.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => fast-screening-and-characterization-of-therapeutic-peptide
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 11:02:12
[post_modified_gmt] => 2024-03-21 15:02:12
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23798
[menu_order] => 115
[post_type] => resource
[post_mime_type] =>
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[16] => WP_Post Object
(
[ID] => 23796
[post_author] => 15
[post_date] => 2024-03-21 10:52:20
[post_date_gmt] => 2024-03-21 14:52:20
[post_content] =>
[post_title] => Continuing the Investigation of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry in the Bottom-Up Characterization of Progressively Larger RNAs
[post_excerpt] => Exploring the merits of capillary-zone electrophoresis (CZE)-mass spectrometry to analyze digestion mixtures of large RNAs and attain sequence information. This poster was presented as a collaboration with UConn and Bruker at ASMS 2023 and was poster TP532.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => continuing-the-investigation-of-microchip-capillary-electrophoresis
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 14:18:20
[post_modified_gmt] => 2024-08-01 18:18:20
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23796
[menu_order] => 116
[post_type] => resource
[post_mime_type] =>
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[17] => WP_Post Object
(
[ID] => 23794
[post_author] => 15
[post_date] => 2024-03-21 10:38:52
[post_date_gmt] => 2024-03-21 14:38:52
[post_content] =>
[post_title] => Determination of ATP, ADP, AMP, and Adenosine Levels by Microchip Capillary Electrophoresis Coupled with High Resolution Mass Spectrometry
[post_excerpt] => In this study, we present a novel ZipChip coupled with a QEHF for adenosine nucleotide analysis. This poster was presented at ASMS 2023 as poster TP489.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => determination-of-atp-adp-amp-and-adenosine-levels
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 14:18:43
[post_modified_gmt] => 2024-08-01 18:18:43
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23794
[menu_order] => 117
[post_type] => resource
[post_mime_type] =>
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[18] => WP_Post Object
(
[ID] => 23789
[post_author] => 15
[post_date] => 2024-03-21 10:26:35
[post_date_gmt] => 2024-03-21 14:26:35
[post_content] =>
[post_title] => Amino Acid Quantitation of Cell Culture Media Matrices via an Integrated CE-MS Analyzer
[post_excerpt] => Optimization of cell culture media and process conditions are critical for achieving optimal cell growth, productivity, and product quality. This poster was presented at ASMS 2023 as poster TP 398.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => amino-acid-quantitation-of-cell-culture-media
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 10:33:40
[post_modified_gmt] => 2024-03-21 14:33:40
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23789
[menu_order] => 118
[post_type] => resource
[post_mime_type] =>
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[19] => WP_Post Object
(
[ID] => 23787
[post_author] => 15
[post_date] => 2024-03-21 10:20:58
[post_date_gmt] => 2024-03-21 14:20:58
[post_content] =>
[post_title] => Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS
[post_excerpt] => This poster was presented in collaboration with Protein Metrics and highlights how the ZipChip coupled to HRMS provides a streamlined analytical approach to rapidly assess the heterogeneity of the investigated therapeutic proteins through the comprehensive interrogation of the different charge variants and their intact MS spectra. This poster was presented at ASMS 2023 as poster TP 384.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => sample-to-result-workflow-for-the-investigation-of-biosimilars-vs-innovator-cetuximab
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 10:20:58
[post_modified_gmt] => 2024-03-21 14:20:58
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23787
[menu_order] => 119
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
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[20] => WP_Post Object
(
[ID] => 23785
[post_author] => 15
[post_date] => 2024-03-21 10:15:48
[post_date_gmt] => 2024-03-21 14:15:48
[post_content] =>
[post_title] => Peptide Mapping Workflow for Direct Microchip CE-MS Analysis of Biopharmaceuticals
[post_excerpt] => In this study we demonstrated the suitability of a modified digestion workflow for peptide mapping analysis via CE separation. This poster was presented at ASMS 2023 in collaboration with NIBRT. It was poster MP619.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => peptide-mapping-workflow-for-direct-microchip
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 10:15:49
[post_modified_gmt] => 2024-03-21 14:15:49
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23785
[menu_order] => 120
[post_type] => resource
[post_mime_type] =>
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[21] => WP_Post Object
(
[ID] => 23781
[post_author] => 15
[post_date] => 2024-03-21 09:57:40
[post_date_gmt] => 2024-03-21 13:57:40
[post_content] =>
[post_title] => Combining Capillary Electrophoresis and Trapped Ion Mobility Spectrometry Mass Spectrometry to Analyze Epitranscriptomic Marks Mediating Virus-Host Interactions in Infectious Diseases
[post_excerpt] => This poster evaluates the merits of capillary-zone electrophoresis (CZE)-MS. This poster was presented at ASMS 2023 as a collaboration with UCONN. It was poster MP548.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => combining-capillary-electrophoresis-and-trapped-ion-mobility-spectrometry-mass-spectrometry
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:57:41
[post_modified_gmt] => 2024-03-21 13:57:41
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23781
[menu_order] => 121
[post_type] => resource
[post_mime_type] =>
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[22] => WP_Post Object
(
[ID] => 23779
[post_author] => 15
[post_date] => 2024-03-21 09:38:33
[post_date_gmt] => 2024-03-21 13:38:33
[post_content] =>
[post_title] => Use of Microchip Capillary Electrophoresis – Mass Spectrometry for Automated Rapid Measurement of Enzyme Reaction Kinetics
[post_excerpt] => This approach allows rapid measurement of enzymatic cleavage dynamics in real time. It can be applied to almost any enzyme substrate reaction and is highly tolerable to various buffers, thanks to the CE Chip-MS configuration. This poster was presented at ASMS 2023 with collaborators as poster MP547.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => use-of-microchip-capillary-electrophoresis
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:55:53
[post_modified_gmt] => 2024-03-21 13:55:53
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23779
[menu_order] => 122
[post_type] => resource
[post_mime_type] =>
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[23] => WP_Post Object
(
[ID] => 24540
[post_author] => 29
[post_date] => 2024-05-23 13:58:57
[post_date_gmt] => 2024-05-23 17:58:57
[post_content] =>
[post_title] => Optimization of Scalable rAAV Production for Gene Therapy – Leveraging At-Line Amino AcidMeasurements for Bioprocess Modeling-Driven Approaches
[post_excerpt] => Spent media analysis from an at-line analyzer, the REBEL, was used to further understanding of AAV production process and identify correlation between key nutrient consumptions and capsid titers in fed-batch and continuous processes. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 43.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => scalable-aav-production-gene-therapy
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 12:39:26
[post_modified_gmt] => 2024-08-01 16:39:26
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=24540
[menu_order] => 124
[post_type] => resource
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[24] => WP_Post Object
(
[ID] => 23776
[post_author] => 15
[post_date] => 2024-03-21 09:29:35
[post_date_gmt] => 2024-03-21 13:29:35
[post_content] =>
[post_title] => Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
[post_excerpt] => N-glycan profiling is a critical step of biopharmaceuticals analysis as N-glycans play an important part in both activity and safety of monoclonal antibodies and other glycosylated biotherapeutics. This poster was presented at ASMS 2023 as poster MP291.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rapid-ce-ms-analysis-of-released-n-glycan
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:35:32
[post_modified_gmt] => 2024-03-21 13:35:32
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=23776
[menu_order] => 125
[post_type] => resource
[post_mime_type] =>
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[25] => WP_Post Object
(
[ID] => 26486
[post_author] => 15
[post_date] => 2024-11-26 16:19:49
[post_date_gmt] => 2024-11-26 21:19:49
[post_content] =>
Process intensification in biomanufacturing often involves increasing cell densities and product titers, which can lead to increased glucose consumption and potential accumulation of toxic metabolites. High glucose concentrations can also negatively impact protein quality attributes. To address these challenges, we developed MAVERICK, a novel Raman-based PAT approach that enables real-time monitoring and control of CHO cell cultures without the need for prior model building. This versatile approach can be applied across various cell lines, media systems, reactor scales, and culture modes. By implementing a continuous dynamic feeding strategy guided by MAVERICK, we can enhance process performance and improve protein quality attributes like glycosylation, glycation, and charge variants.
MAVERICK, a novel Raman-based PAT technology, was showcased at the ECI Integrated Continuous Biomanufacturing Conference 2024. This technology allows for immediate monitoring of critical process parameters like glucose, lactate, and biomass without the need for extensive preliminary work or model building. By implementing a continuous glucose feeding strategy guided by MAVERICK, researchers were able to significantly improve process titer, cell-specific productivity, and protein quality attributes. This straightforward approach highlights the potential of MAVERICK to revolutionize biomanufacturing processes.
[post_title] => Novel Approach for Instant Implementation of Raman-based PAT with Integrated Real-Time Process Control
[post_excerpt] => The innovative technology of Maverick allows for immediate monitoring of critical process parameters like glucose, lactate, and biomass without the need for extensive preliminary work or model building.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => novel-approach-for-instant-implementation-of-raman-based-pat-with-integrated-real-time-process-control
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-26 16:19:49
[post_modified_gmt] => 2024-11-26 21:19:49
[post_content_filtered] =>
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[guid] => https://908devices.com/?post_type=resource&p=26486
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[26] => WP_Post Object
(
[ID] => 25226
[post_author] => 29
[post_date] => 2024-07-09 11:04:45
[post_date_gmt] => 2024-07-09 15:04:45
[post_content] =>
Understanding of cell culture metabolism in biologics manufacturing has increased tremendously in the past decade; however, the lack of feasible methods of high coverage, quantitative information on the interplay between nutrients and metabolites has hindered the efforts to fully characterize processes in the different biological phases. Several published models support cell growth phase but lack the kinetic information to be applicable to the phases that follow. We discuss a method for measuring hundreds of metabolites in dozens of pathways that streamlines sample preparation from spent media and cells, enables fast data-analysis times and supports quantitative analysis of key metabolites to gain far richer and more reliable data sources for process characterization, modelling and understanding. The method uses microchip CE/MS and incorporates stable isotope internal standards for both quantitation and migration time indexing. This work explores the information that can be obtained from the extracellular growth media and intracellular metabolites extracted from the CHO cells.
The poster was on display at Bioprocessing Summit, and ESACT #253 in 2024.
[post_title] => In-depth Metabolic Characterization at Different Phases of Cell Culture with a Turnkey CE-ESI-HRMS Workflow
[post_excerpt] => Learn about a turnkey CE-MS metabolomics workflow solution used to characterize media metabolites and intracellular metabolites of CHO bioreactors. The poster was on display at Bioprocessing Summit, and ESACT #253 in 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => correlation-of-soluble-metabolites-with-lactate-switch-observed-in-hek293-culture-using-novel-ce-ms-metabolomics-workflow
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-25 16:13:49
[post_modified_gmt] => 2024-11-25 21:13:49
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[guid] => https://908devices.com/?post_type=resource&p=25226
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[27] => WP_Post Object
(
[ID] => 26149
[post_author] => 15
[post_date] => 2024-10-11 13:20:46
[post_date_gmt] => 2024-10-11 17:20:46
[post_content] =>
Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis. This poster was developed with Terumo Blood and Cell Technologies and was showcased at BPI USA and Advanced Therapies 2024.
[post_title] => Innovations in Analytical Technology for Cell & Gene Therapy Manufacturing
[post_excerpt] => This poster highlights our at-, on-, and in-line analytical solutions that contribute to an enhanced understanding, characterization, and control of bioprocesses in the development and manufacturing of cell and gene therapies.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => innovations-in-analytical-technology-for-cell-gene-therapy-manufacturing
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:32:59
[post_modified_gmt] => 2024-11-18 20:32:59
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=26149
[menu_order] => 129
[post_type] => resource
[post_mime_type] =>
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[28] => WP_Post Object
(
[ID] => 25218
[post_author] => 29
[post_date] => 2024-07-09 10:54:09
[post_date_gmt] => 2024-07-09 14:54:09
[post_content] =>
The introduction of the ZipChip Intact Antibodies Reagent Kit marked a significant milestone in the ZipChip portfolio, enabling the first tailored solution of charge variant analysis (CVA) of monoclonal antibodies on the CE-MS platform. However, there was room for enhancement in preserving the native conformation of the proteins under analysis, as well as in enhancing the separation between variant peaks. The next generation kits, the Native Antibodies Kit and Charge Variant TOF Kit, significantly improved peak separation and producing spectra more indicative of native protein structures. This was poster # TP642 at ASMS 2024.
[post_title] => Optimized Native Conditions for Charge Variant Analysis Using a Microfluidic CE-MS Platform Yield Higher Quality Data and Enables Analysis of Lower Titer Samples
[post_excerpt] => Learn about the improvements made in the new Charge Variant Analysis kit, compared to the previous Intact Antibodies and Native Antibodies kits. ASMS 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => optimized-native-conditions-for-charge-variant-analysis-using-a-microfluidic-ce-ms-platform-yield-higher-quality-data-and-enables-analysis-of-lower-titer-samples
[to_ping] =>
[pinged] =>
[post_modified] => 2024-09-23 12:16:29
[post_modified_gmt] => 2024-09-23 16:16:29
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25218
[menu_order] => 130
[post_type] => resource
[post_mime_type] =>
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)
[29] => WP_Post Object
(
[ID] => 25213
[post_author] => 29
[post_date] => 2024-07-09 10:28:00
[post_date_gmt] => 2024-07-09 14:28:00
[post_content] =>
As the field of bioprocessing continues to mature, there is a need for better analytics applied closer to the bioprocess. We have seen recent advancements in the technology used to measure small molecules within bioreactors (glucose/lactate, amino acids), but there is also a need to directly measure the critical quality attributes of the proteins being produced. To that end, we are assessing the ability of microfluidic CE-ESI-MS to perform charge variant - MS analysis of proteins pulled directly from a bioreactor. We know that excessive salt concentrations can cause band-broadening for this separation, so the key question is whether a desalting step is required, or if a simple dilute and shoot approach can work, and how much information can be obtained. Here we compare a simple dilute and shoot method to a method that buffer exchanges the sample before ZipChip analysis and demonstrates the use of this method for analysis of 4 different bioreactor growth conditions. This poster was on display at ASMS 2024 as poster # TP638.
[post_title] => Charge Variant Analysis of IgGs Directly from Cell Culture Supernatant Using Microfluidic CE-ESI-MS
[post_excerpt] => This poster describes the application of Microfluidic CE-ESI-MS for analyzing protein charge variants directly from a bioreactor. It investigates the feasibility of a "dilute and shoot" approach compared to a buffer exchange method for sample preparation. ASMS 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => charge-variant-analysis-of-iggs-directly-from-cell-culture-supernatant-using-microfluidic-ce-esi-ms
[to_ping] =>
[pinged] =>
[post_modified] => 2024-09-23 12:20:01
[post_modified_gmt] => 2024-09-23 16:20:01
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25213
[menu_order] => 131
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[30] => WP_Post Object
(
[ID] => 25249
[post_author] => 15
[post_date] => 2024-07-09 18:00:38
[post_date_gmt] => 2024-07-09 22:00:38
[post_content] =>
Raman spectroscopy offers relatively non-invasive access to the estimation of critical quality attributes and parameters in bioprocesses. Current approaches to predicting these parameters rely heavily on latent variable/regularized empirical calibration methods, with partial least-squares (PLS) being the most dominant. Although one advantage of these approaches is that they require zero detailed understanding of the underlying system (physics/chemistry/biology), there are several significant disadvantages to modelling bioprocess under these frameworks. This was poster #391 at ESACT 2024.
[post_title] => De Novo Approaches for Bioprocess Parameter Estimation Using Raman Spectroscopy
[post_excerpt] => This research proposes a novel method for real-time bioprocess parameter prediction with de novo models using Raman spectroscopy. Unlike traditional methods, this approach requires no training data and offers a priori performance estimates.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => de-novo-approaches-for-bioprocess-parameter-estimation-using-raman-spectroscopy
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-09 18:00:39
[post_modified_gmt] => 2024-07-09 22:00:39
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25249
[menu_order] => 137
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[31] => WP_Post Object
(
[ID] => 25246
[post_author] => 15
[post_date] => 2024-07-09 14:48:37
[post_date_gmt] => 2024-07-09 18:48:37
[post_content] =>
The power of Raman spectroscopy for bioprocess monitoring is well-known , but the expertise required to develop ROBUST and SUSTAINABLE multivariate models is a massive impediment. Our goal was to develop an in-line device, termed MAVERICK, that provides immediate value for glucose, lactate and biomass estimation without the need for cumbersome model training/re-training with an ease-of-use similar to that of a pH probe. This was poster # 390 at ESACT 2024.
[post_title] => New Era of Real-time Bioprocess Monitoring and Control –Raman-based Direct Measurements with De Novo Model
[post_excerpt] => MAVERICK offers real-time bioprocess monitoring of glucose, lactate, and biomass through a Raman-based sensor, eliminating the need for complex setup and training data.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => new-era-of-real-time-bioprocess-monitoring-and-control-raman-based-direct-measurements-with-de-novo-model
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-09 14:48:38
[post_modified_gmt] => 2024-07-09 18:48:38
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25246
[menu_order] => 138
[post_type] => resource
[post_mime_type] =>
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[filter] => raw
)
[32] => WP_Post Object
(
[ID] => 25245
[post_author] => 15
[post_date] => 2024-07-09 14:32:05
[post_date_gmt] => 2024-07-09 18:32:05
[post_content] =>
The biopharmaceutical industry is increasingly motivated to improve process control, understanding, and repeatability using process analytical technologies (PAT). More specifically, Raman-based optical, in-line measurement methods have shown promise as a way to monitor critical performance parameters, including glucose and lactate concentrations, in real-time. Recently, this has translated to the implementation of Raman-based glucose feeding strategies to modulate productivity and product quality in Chinese hamster ovary (CHO) cell cultures. The current work implements a novel Raman-based solution that does not require any chemometric models for glucose, lactate and biomass measurements. MAVERICK was directly, without any training in the specific bioprocess, deployed to dynamically control lactate feeding. We compared feeding strategies as means of modulating product quality and improving culture conditions, primarily through decreased ammonia accumulation. This was poster #358 at ESACT 2024 and was also highlighted at the Bioprocessing Summit 2024.
[post_title] => Raman-based Lactate Feeding Impact on Culture Characteristics and Product Quality in Mammalian Cell Cultures
[post_excerpt] => This research explores Raman spectroscopy for real-time glucose monitoring and feeding strategies in CHO cell cultures, aiming to improve product quality.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => raman-based-lactate-feeding-impact-on-culture-characteristics-and-product-quality-in-mammalian-cell-cultures
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-23 14:16:28
[post_modified_gmt] => 2024-08-23 18:16:28
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25245
[menu_order] => 139
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[33] => WP_Post Object
(
[ID] => 25242
[post_author] => 15
[post_date] => 2024-07-09 14:23:13
[post_date_gmt] => 2024-07-09 18:23:13
[post_content] =>
Biologics production development for intensified processes aims to achieve desired product quality attributes and high productivity. Running multiple micro-bioreactors in parallel enables expedited optimization, but low microbioreactor volumes limit the media available for daily sampling for analysis. Cell culture media (CCM) optimization can be a lengthy and complex process involving multiple DOEs. Fast, at the point-of-need, analytical tools with only minimal sample consumption, are required to assess key-nutrient consumption and provide feedback to enable feed strategy optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
[post_title] => Data-driven Feed Strategy Optimization and Scale-up of mAb-expressing CHO Cell Line Bioprocess
[post_excerpt] => This poster explores utilizing micro-bioreactors for expedited biologics production development, highlighting challenges with limited sample volume for media analysis and proposing real-time, point-of-need analytical tools for efficient CCM optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => data-driven-feed-strategy-optimization-and-scale-up-of-mab-expressing-cho-cell-line-bioprocess
[to_ping] =>
[pinged] =>
[post_modified] => 2024-10-02 13:40:29
[post_modified_gmt] => 2024-10-02 17:40:29
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25242
[menu_order] => 140
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[34] => WP_Post Object
(
[ID] => 25192
[post_author] => 15
[post_date] => 2024-07-08 15:11:04
[post_date_gmt] => 2024-07-08 19:11:04
[post_content] =>
Through the work highlighted in this poster we found that when the manufactured cells are antigen-stimulated, CAR/VIPRa T-cells become significantly more energetic. In contrast, CAR T-cells become less energetic and more glycolytic, which are known features of T-cell exhaustion. Further, metabolic assessment with multiple methods produced findings that correlated with this assessment, such oxygen consumption and certain amino acid levels in spent media. Finally, CAR T-cell activity, potency, and cytotoxicity assessments showed a correlation with anti-tumor activity. Together, this work demonstrates that distinct metabolic features allow CAR/VIPRa T cells, when antigen-stimulated, to have enhanced functions against tumors. Developed in partnership with Emory University and the Winship Cancer Institute, this poster has made waves at the 2024 ISCT & ISCT EU Conference, the ESACT Conference, and Advanced Therapies 2024.
[post_title] => Spent Media Analysis Aids in Determining Metabolic Mechanisms of Superior CAR T-Cell Products
[post_excerpt] => As the use of CAR T-cell therapies advances, testing different CAR T-cells, and associating metabolic characteristics to well-performing, desired phenotypes of CAR T-cells enables optimization of CAR constructs and manufacturing processes.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => spent-media-analysis-aids-in-determining-metabolic-mechanisms-of-superior-car-t-cell-products
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:37:35
[post_modified_gmt] => 2024-11-18 20:37:35
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25192
[menu_order] => 141
[post_type] => resource
[post_mime_type] =>
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[filter] => raw
)
[35] => WP_Post Object
(
[ID] => 25189
[post_author] => 15
[post_date] => 2024-07-08 14:47:24
[post_date_gmt] => 2024-07-08 18:47:24
[post_content] =>
This poster highlights the HEK-mediated adeno-associated virus (AAV) production process and the development of an open-source production platform incorporating a chemically defined serum-free medium. Initial attempts using an open-source CHO-medium resulted in cell aggregation, slow growth, and an inability to transfect and produce AAV. Therefore, we explored creating an HEK-friendly medium and process conducive to healthy cell growth, transfection, and vector production. Nutrient consumption rates were studied to elucidate metabolic activity associated with AAV production. This poster was #835 at ISCT 2024
[post_title] => Open-sourced Production Platform for Raav in HEK Data-driven Cell Culture Media Optimization
[post_excerpt] => This poster highlights the HEK-mediated adeno-associated virus (AAV) production process and the development of an open-source production platform incorporating a chemically defined serum-free medium.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => open-sourced-production-platform-for-raav-in-hek-data-driven-cell-culture-media-optimization
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-08 14:47:25
[post_modified_gmt] => 2024-07-08 18:47:25
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25189
[menu_order] => 142
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[36] => WP_Post Object
(
[ID] => 23438
[post_author] => 15
[post_date] => 2024-02-20 17:24:46
[post_date_gmt] => 2024-02-20 22:24:46
[post_content] =>
[post_title] => Improving Cell and Gene Therapy Manufacturing Processes by Automated On-line and In-line Bioprocess Analytical Technologies
[post_excerpt] => Recent advances in cell and gene therapy bioprocess analytical technology regimes, approaches to de novo analytical modeling/calibration of these systems, and how their informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 29. This poster was also on display as #843 at ISCT 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improving-cell-gene-therapy-manufacturing
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-08 13:01:02
[post_modified_gmt] => 2024-07-08 17:01:02
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23438
[menu_order] => 143
[post_type] => resource
[post_mime_type] =>
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[37] => WP_Post Object
(
[ID] => 23435
[post_author] => 29
[post_date] => 2024-02-20 17:15:13
[post_date_gmt] => 2024-02-20 22:15:13
[post_content] =>
[post_title] => Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack - Manufactured CAR T-Cells
[post_excerpt] => Novel reagents that aid in the consistent manufacturing of
Novel reagents that aid in consistent manufacturing of CAR T-cells with well-defined phenotypes are needed to improve treatment outcomes in patients. View poster #17 from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => multi-cytokine-backpack-car-t-cells
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 11:11:58
[post_modified_gmt] => 2024-08-01 15:11:58
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23435
[menu_order] => 144
[post_type] => resource
[post_mime_type] =>
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[38] => WP_Post Object
(
[ID] => 23432
[post_author] => 15
[post_date] => 2024-02-20 17:03:02
[post_date_gmt] => 2024-02-20 22:03:02
[post_content] =>
[post_title] => Optimization of Cell Culture Media and Culture Conditions for HEK293 for Improved Cell Growth and Reduced Cell Clumping for the Effective Production of Viral Vectors
[post_excerpt] => This study demonstrates the power of at-line cell culture analyzers such as the REBEL to gain process understanding quickly to adjust media components for improved cell culture performance. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 18.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improved-cell-growth-production-viral-vectors
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:09:37
[post_modified_gmt] => 2024-03-21 13:09:37
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23432
[menu_order] => 145
[post_type] => resource
[post_mime_type] =>
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)
[39] => WP_Post Object
(
[ID] => 7689
[post_author] => 29
[post_date] => 2023-02-27 11:46:37
[post_date_gmt] => 2023-02-27 16:46:37
[post_content] =>
[post_title] => Automated Glucose Feeding Based On Online Glucose And Lactate Measurements
[post_excerpt] => This poster note describes an automated control strategy for cell growth and biologics production. It leverages MAVEN, a reliable, easy-to-operate, online (sample-free) device for monitoring of glucose and lactate.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => maven-poster-bpi-west-2023
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-29 09:59:39
[post_modified_gmt] => 2024-07-29 13:59:39
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=7689
[menu_order] => 146
[post_type] => resource
[post_mime_type] =>
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[40] => WP_Post Object
(
[ID] => 7158
[post_author] => 15
[post_date] => 2022-11-30 20:16:00
[post_date_gmt] => 2022-12-01 01:16:00
[post_content] =>
[post_title] => Process Optimization by the Use of Substrate Feeding Strategies
[post_excerpt] => Online glucose monitoring is possible by using Trace C2 Control system. Feed control without online glucose monitoring causes acetate formation due to overflow metabolism.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => trace-c2-poster-process-optimization-by-the-use-of-substrate-feeding-strategies
[to_ping] =>
[pinged] =>
[post_modified] => 2024-04-03 18:38:25
[post_modified_gmt] => 2024-04-03 22:38:25
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=7158
[menu_order] => 147
[post_type] => resource
[post_mime_type] =>
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[filter] => raw
)
[41] => WP_Post Object
(
[ID] => 7156
[post_author] => 15
[post_date] => 2022-11-30 20:03:35
[post_date_gmt] => 2022-12-01 01:03:35
[post_content] =>
[post_title] => Optimized Fed-Batch Fermentation by Use of Online Glucose Measurement
[post_excerpt] => This poster presentation features an integrated multivariate glucose measuring tool combined with software solutions which allow different types of feeding-strategies.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => trace-c2-poster-optimized-fed-batch
[to_ping] =>
[pinged] =>
[post_modified] => 2024-04-03 18:40:24
[post_modified_gmt] => 2024-04-03 22:40:24
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=7156
[menu_order] => 148
[post_type] => resource
[post_mime_type] =>
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[filter] => raw
)
[42] => WP_Post Object
(
[ID] => 7153
[post_author] => 15
[post_date] => 2022-11-30 19:53:12
[post_date_gmt] => 2022-12-01 00:53:12
[post_content] =>
[post_title] => High Frequency Glucose and Lactate Measurements in Multi-Bioreactor Vessels
[post_excerpt] => TRACE C2 is an online analyzer for monitoring and controlling glucose and lactate concentrations in bioreactors. With the extension M4 it is possible to monitor Glucose and Lactate in up to four simultaneous bioprocesses.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => trace-c2-poster-high-frequency-glucose-and-lactate
[to_ping] =>
[pinged] =>
[post_modified] => 2024-04-03 18:42:31
[post_modified_gmt] => 2024-04-03 22:42:31
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=7153
[menu_order] => 149
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[43] => WP_Post Object
(
[ID] => 7151
[post_author] => 15
[post_date] => 2022-11-30 19:44:36
[post_date_gmt] => 2022-12-01 00:44:36
[post_content] =>
[post_title] => Online-Controlling of Glucose in Cultivations and Fermentations
[post_excerpt] => TRACE C2 Control is a new online analyzer for monitoring and controlling of glucose concentrations in bioprocesses. In disturbance reaction experiments and in an E.coli fermentation it can be successfully shown that a reliable control is possible.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => trace-c2-poster-online-controlling-of-glucose
[to_ping] =>
[pinged] =>
[post_modified] => 2024-04-03 18:43:23
[post_modified_gmt] => 2024-04-03 22:43:23
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=7151
[menu_order] => 150
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[44] => WP_Post Object
(
[ID] => 7149
[post_author] => 15
[post_date] => 2022-11-30 19:33:56
[post_date_gmt] => 2022-12-01 00:33:56
[post_content] =>
[post_title] => Implementation of a New Method for Online Glucose Control in a 10L CHO Bioprocess
[post_excerpt] => This poster shows how glucose concentration can be directly measured based on an enzymatic reaction. This method is then used to control the glucose level in a fed-batch fermentation at a
constant level.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => trace-c2-poster-online-glucose-control
[to_ping] =>
[pinged] =>
[post_modified] => 2024-04-03 19:14:31
[post_modified_gmt] => 2024-04-03 23:14:31
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=7149
[menu_order] => 151
[post_type] => resource
[post_mime_type] =>
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[filter] => raw
)
[45] => WP_Post Object
(
[ID] => 7144
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[post_date] => 2022-11-30 19:05:04
[post_date_gmt] => 2022-12-01 00:05:04
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[post_title] => Single-Use Bioreactor for High Density Bacterial Fermentation
[post_excerpt] => Glucose measurement is performed on-line using the TRACE C2 analyzer. This allows to follow-up glucose uptake rate and monitor fed batch culture with retro-control on the glucose pump such as maintain glucose level at predefined set point.
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[post_title] => Optimization of Scalable rAAV Production for Gene Therapy
[post_excerpt] => This poster showcases spent media analysis leveraging REBEL, which requires only 10 μL per sample and 10 minutes analysis time.
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[post_name] => rebel-ps-13
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[post_content] =>
[post_title] => Empowering Process Optimization for a mAb-Expressing CHO Cell Line
[post_excerpt] => Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.
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[post_content] =>
[post_title] => Bottom-Up Analysis of Progressively Larger RNAs by CZE-MS and CZE-MS/MS
[post_excerpt] => In this poster from ASMS 2022, researchers from University of Connecticut and Bruker showed that capillary zone electrophoresis performed on a chip proved to be an effective alternative to liquid chromatography as a front-end separation system to analyze both pure samples and complex digestion mixtures of nucleic acids.
[post_status] => publish
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[post_title] => Multi-level Expeditious Characterization of Adeno-associated Virus (AAV) Capsid Proteins Using ZipChip Microfluidic CE Coupled with HRMS
[post_excerpt] => In this poster from ASMS 2022, scientists from Thermo Fisher Scientific and 908 Devices present a novel approach using microchip CE-MS for the characterization of AAVs.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-thermo
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[post_date] => 2022-06-11 02:42:23
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[post_content] =>
[post_title] => A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS
[post_excerpt] => In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.
[post_status] => publish
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[post_content] =>
[post_title] => Combining μSPE ZipChip CE with PRM-LIVE on a timsTOF Pro for Warp-speed Selectivity Profiling of Deubiquitinase (DUB) Small Molecule Inhibitors
[post_excerpt] => In this ASMS 2022 poster, researchers from Dana Farber Cancer Institute and Harvard Medical School developed a ZipChip-based method for facilitating high-throughput identification
of new small molecule inhibitors.
[post_status] => publish
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[post_content] =>
[post_title] => Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
[post_excerpt] => In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.
[post_status] => publish
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[post_content] =>
[post_title] => CE-MS of Oligonucleotides using a ZipChip
[post_excerpt] => This ASMS 2022 poster from Boehringer Ingelheim explores the use of ZipChip coupled to a high resolution mass spectrometer as an orthogonal method to chromatography for oligonucleotide analysis.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-boehringer
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[post_content] =>
[post_title] => Rapid Characterization of Oligos and Related Impurities Using Microchip CE-MS without Ion-pairing Reagents
[post_excerpt] => This poster from ASMS 2022 describes a simple & fast method for oligonucleotide characterizations using a Microchip CE-MS platform.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-kulkarni
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[post_date] => 2022-06-11 02:20:24
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[post_content] =>
[post_title] => Glycosylation Profiling of mAB Subunits with CZE-MS
[post_excerpt] => This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-glycosylation-profiling
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[post_modified] => 2024-08-01 14:19:13
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[post_date] => 2022-06-10 20:16:47
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[post_content] =>
[post_title] => Pushing the Boundaries of Speed and Sensitivity in Proteomics
[post_excerpt] => To overcome sample loading limitations in CE-MS, the poster authors engineered a 1 mm SPE bed within the chip geometry, allowing 100-fold improvements in concentration sensitivity limit for CE-MS.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-thompson
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[post_modified] => 2023-12-26 12:37:31
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[post_date] => 2022-06-10 19:14:29
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[post_content] =>
[post_title] => A Broad Application of Migration Time Indexing and Metabolite Libraries to Evaluate Quantitative Coverage in Microchip CE-MS Metabolomics
[post_excerpt] => In the field of metabolomics, microchip capillary electrophoresis (mCE) has a number of potential advantages over traditional liquid chromatography (LC), including higher throughput due to decreased separation times, increased separation efficiency, and lower required sample volumes.
[post_status] => publish
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[post_name] => zipchip-poster-asms2022-metabolomics-raiche
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[post_title] => A Microchip CE-MS Based End-to-End Solution for the Analysis of Synthetic Oligonucleotides
[post_excerpt] => This poster showcases a workflow using microchip CE-MS that is coupled with a vendor-neutral informatics platform
as a complete solution for the analysis of synthetic oligos.
[post_status] => publish
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[post_title] => Microchip CE-MS with Integrated Solid Phase Extraction
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[post_status] => publish
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[post_name] => zipchip-poster-microchip-cebrms-with-integrated-solid-phase-extraction
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[post_content] =>
[post_title] => Microchip CE-MS of Oligonucleotides: What Can It Separate?
[post_excerpt] =>
[post_status] => publish
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[post_name] => zipchip-poster-microchip-ce-ms-of-oligonucleotides-what-can-it-separate
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[post_title] => Fast Chip-CEMS for Characterization of Protein/PTM Changes
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[post_status] => publish
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[post_name] => poster-fast-chip-cems-characterization-proteinptm-changes
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[post_date] => 2017-10-05 17:52:35
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[post_content] =>
[post_title] => Combined Top-down and Bottom-up Proteomics
[post_excerpt] =>
[post_status] => publish
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[post_name] => poster-combined-top-bottom-proteomics-using-capillary-electrophoresis-mass-spectrometry
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[post_content] =>
[post_title] => ZipChip for Glycomics and Glycoproteomics
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[post_status] => publish
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[post_name] => poster-microfluidic-capillary-electrophoresis-mass-spectrometry-glycomics-glycoproteomics
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[post_title] => Fast and Efficient Biopharmaceutical Characterization
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[post_name] => zipchip_poster_2019-cesi-symposium
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[post_content] =>
[post_title] => Characterization of charge heterogeneity of mAb
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[post_status] => publish
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[post_name] => zipchip_poster_sciex_characterization-of-charge-heterogeneity-of-mab
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[post_title] => Rapid, Multi-level Analysis of Complex Proteins
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[post_content] =>
[post_title] => Oligonucleotide Analysis via Microfluidic CE-MS
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[post_name] => zipchip_oligonucleotide-analysis-via-microfluidic-ce-ms
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[post_title] => Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF
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[post_title] => 96 Bottles of Beer: Metabolic Profiling of Spent Growth Media
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[post_title] => Using genomic and spent media analysis to characterize stressed CHO cultures
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[post_title] => Native Analysis of Monoclonal Antibodies
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[post_title] => Characterization of Protein/PTM Changes
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[post_title] => Native CE-MS for Biopharmaceutical Characterization
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[post_title] => A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
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[post_title] => Bioprocessing of Monoclonal Antibody Based Therapies
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[post_date] => 2019-11-05 13:38:52
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[post_title] => NIBRT Presents Native MS for Charge Variants using ZipChip
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[post_name] => casss-nibrt-presents-native-ms-for-charge-variants-using-zipchip
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[post_title] => NIBRT Presents ZipChip for Native Charge Heterogeneity
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[post_name] => asms-nibrt-presents-zipchip-for-native-charge-heterogeneity
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[post_date] => 2019-10-17 16:59:46
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[post_title] => Monitoring Amino Acid Composition of Cell Culture Media
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[post_name] => c-media-using-microfluidic-ce-ms
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[post_date] => 2024-11-25 10:49:05
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[post_content] =>
Cell therapy manufacturing continues to advance through innovation in bioreactor design, and the integration of process analytical technology (PAT) to monitor, control, and improve processes. Real-time and in-line and on-line monitoring of key metabolic parameters, such as glucose and lactate, enables improved control strategies for optimized cell culture. This, in turn, leads to more reliable and cost-effective manufacturing, ultimately helping make therapies more accessible to patients in need. Discover how the synergy between automated cell expansion systems and real-time analyzers revolutionizes cell culture processes.
This poster, developed in partnership with Quantum Flex and Terumo Blood and Cell Technologies, was featured at Advanced Therapies 2024.
908 Devices expanded its chemical detection capabilities by acquiring RedWave Technology, combining its high-pressure mass spectrometry (HPMS) expertise with RedWave’s advanced Fourier-transform infrared (FTIR) technology. This acquisition creates a more comprehensive solution for detecting and identifying chemicals across various scenarios, from field forensics to hazardous material response. The move also opens new opportunities for cross-selling, shared training, and customer support, positioning 908 Devices as a key player in both public safety and military markets.
[post_title] => Catching a RedWave
[post_excerpt] => Explore how 908 Devices' acquisition of RedWave Technology is revolutionizing chemical detection with advanced mass spectrometry and FTIR solutions, expanding capabilities for public safety and military applications.
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The novel 13C tracer-based metabolomics method using microfluidic capillary electrophoresis-mass spectrometry (CE-MS) enables rapid and accurate analysis of isotopomer patterns in proteinogenic amino acids from minimal sample sizes, revealing central carbon metabolism and amino acid biosynthesis pathways in microbes such as Methanothermobacter thermautotrophicus. This method, utilizing a ZipChip CE system and an Orbitrap Fusion Tribrid mass spectrometer, demonstrated high sensitivity and precision, detecting metabolic pathways and fluxes even under biomass-restricted conditions. The approach also highlights the presence of alternative enzymes and biosynthesis pathways not captured by existing public databases, thus enhancing the prediction and understanding of microbial metabolic and genetic capabilities.
Download Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product. For products where multiple SDS are available, please check the part number and concentration.
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Download Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product. For products where multiple SDS are available, please check the part number and concentration.
[post_title] => The HazMat Guys Podcast, Part 2: Measuring Aerosols
[post_excerpt] => Listen to Episode 291, Part 2 of the HazMat Guys Podcast on Aerosols. The guys discuss common techniques used to measure aerosols and how to keep safe while responding to aerosolized threats.
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[post_title] => The HazMat Guys Podcast, Part 1: What are Aerosols?
[post_excerpt] => Listen to Episode 290, Part 1 of the HazMat Guys Podcast to learn more about aerosol threats and the challenges they pose to responders.
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[post_title] => Raman-based In-line Monitoring of Key Process Parameters in Mammalian Bioprocesses without the Need for Chemometric Model Building
[post_excerpt] => This poster describes a new technology called MAVERICK that uses Raman spectroscopy for continuous monitoring of mammalian cell cultures, specifically those using CHO and HEK293 cells. In 2024 this poster has been highlighted at BPI US West, BPS Europe, BPI Europe, BPI USA and most recently Advanced Therapies.
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[post_title] => 5’ mRNA Analysis By Microchip CE-MS Using an Internal Cleavage Motif for RNase H Digestion
[post_excerpt] => The subject of this poster was the investigation of an internal DNA motif to produce a shorter digestion product while simultaneously maintaining the length of the probe at 25nt for hybridization specificity. The shorter oligo results in easier detection using Microchip CE-MS approach. This poster was presented at ASMS 2023 as poster THP575.
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[post_title] => Improved Performance of Phosphopeptides Characterization Using Online Capillary Electrophoresis Coupling with Ion Mobility Mass Spectrometry (CE-IM-MS)
[post_excerpt] => This poster will highlight a novel strategy for characterization of therapeutic peptide that was developed based on microchip CE-MS pure liquid separation and ion mobility gas phase separation, combing with mass spectrometry identification. The poster was presented in collaboration with Ningbo University at ASMS 2023 as poster THP609.
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[post_name] => improved-performance-of-phosphopeptides-characterization
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[post_date] => 2024-03-25 10:20:12
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[post_title] => Amino Acid Quantitation in Over 50 Mammalian Cell Culture Media with an Integrated CE-MS Analyzer
[post_excerpt] => Characterizing cell culture nutrients such as amino acids in growth media is critical for maximizing cell growth and improving key quality attributes of the cells. This poster was presented at ASMS 2023 as poster THP625.
[post_status] => publish
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[post_name] => amino-acid-quantitation-in-over-50-mammalian-cell-culture-media
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[post_date] => 2024-03-25 09:27:20
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[post_title] => Rapid Identification of Conjugation Sites in Antibody Drug Conjugates Using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
[post_excerpt] => CE/MS method is optimized with NISTmAb digest as a reference control. Good MS/MS coverage of NISTmAb is obtained with narrow peak width and fast separation. This poster was presented as a collaboration with Bruker at ASMS 2023 as poster WP041.
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[post_name] => rapid-identification-of-conjugation-sites-in-antibody-drug
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[post_date] => 2024-03-25 09:13:48
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[post_title] => Conformation of Native Antibody-Drug Conjugate Charge Variants Revealed by Microchip Capillary Electrophoresis Coupled with Trapped Ion Mobility
[post_excerpt] => The combination of microchip capillary electrophoresis and trapped ion mobility enables a rapid, informative method for native monoclonal antibody and antibody-drug conjugate charge variant analysis. This poster was a collaboration with Bruker and NIH and presented at ASMS 2023 as poster WP040.
[post_status] => publish
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[post_name] => conformation-of-native-antibody-drug-conjugate-charge-variants
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[post_date] => 2024-03-21 11:02:11
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[post_title] => Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis - Mass Spectrometry (CE-MS)
[post_excerpt] => Presenting a novel strategy for characterization of therapeutic peptides was developed based on microchip CE-MS and linkage-specific derivatization. This poster was presented in collaboration with Ningbo University at ASMS 2023 as poster TP544.
[post_status] => publish
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[post_name] => fast-screening-and-characterization-of-therapeutic-peptide
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[post_title] => Continuing the Investigation of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry in the Bottom-Up Characterization of Progressively Larger RNAs
[post_excerpt] => Exploring the merits of capillary-zone electrophoresis (CZE)-mass spectrometry to analyze digestion mixtures of large RNAs and attain sequence information. This poster was presented as a collaboration with UConn and Bruker at ASMS 2023 and was poster TP532.
[post_status] => publish
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[post_name] => continuing-the-investigation-of-microchip-capillary-electrophoresis
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[post_date] => 2024-03-21 10:38:52
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[post_title] => Determination of ATP, ADP, AMP, and Adenosine Levels by Microchip Capillary Electrophoresis Coupled with High Resolution Mass Spectrometry
[post_excerpt] => In this study, we present a novel ZipChip coupled with a QEHF for adenosine nucleotide analysis. This poster was presented at ASMS 2023 as poster TP489.
[post_status] => publish
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[post_name] => determination-of-atp-adp-amp-and-adenosine-levels
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[18] => WP_Post Object
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[post_date] => 2024-03-21 10:26:35
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[post_title] => Amino Acid Quantitation of Cell Culture Media Matrices via an Integrated CE-MS Analyzer
[post_excerpt] => Optimization of cell culture media and process conditions are critical for achieving optimal cell growth, productivity, and product quality. This poster was presented at ASMS 2023 as poster TP 398.
[post_status] => publish
[comment_status] => closed
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[post_name] => amino-acid-quantitation-of-cell-culture-media
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[post_modified] => 2024-03-21 10:33:40
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[19] => WP_Post Object
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[ID] => 23787
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[post_date] => 2024-03-21 10:20:58
[post_date_gmt] => 2024-03-21 14:20:58
[post_content] =>
[post_title] => Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS
[post_excerpt] => This poster was presented in collaboration with Protein Metrics and highlights how the ZipChip coupled to HRMS provides a streamlined analytical approach to rapidly assess the heterogeneity of the investigated therapeutic proteins through the comprehensive interrogation of the different charge variants and their intact MS spectra. This poster was presented at ASMS 2023 as poster TP 384.
[post_status] => publish
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[post_name] => sample-to-result-workflow-for-the-investigation-of-biosimilars-vs-innovator-cetuximab
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[post_modified] => 2024-03-21 10:20:58
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[20] => WP_Post Object
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[ID] => 23785
[post_author] => 15
[post_date] => 2024-03-21 10:15:48
[post_date_gmt] => 2024-03-21 14:15:48
[post_content] =>
[post_title] => Peptide Mapping Workflow for Direct Microchip CE-MS Analysis of Biopharmaceuticals
[post_excerpt] => In this study we demonstrated the suitability of a modified digestion workflow for peptide mapping analysis via CE separation. This poster was presented at ASMS 2023 in collaboration with NIBRT. It was poster MP619.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => peptide-mapping-workflow-for-direct-microchip
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[post_modified] => 2024-03-21 10:15:49
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[21] => WP_Post Object
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[ID] => 23781
[post_author] => 15
[post_date] => 2024-03-21 09:57:40
[post_date_gmt] => 2024-03-21 13:57:40
[post_content] =>
[post_title] => Combining Capillary Electrophoresis and Trapped Ion Mobility Spectrometry Mass Spectrometry to Analyze Epitranscriptomic Marks Mediating Virus-Host Interactions in Infectious Diseases
[post_excerpt] => This poster evaluates the merits of capillary-zone electrophoresis (CZE)-MS. This poster was presented at ASMS 2023 as a collaboration with UCONN. It was poster MP548.
[post_status] => publish
[comment_status] => closed
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[post_name] => combining-capillary-electrophoresis-and-trapped-ion-mobility-spectrometry-mass-spectrometry
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[post_modified] => 2024-03-21 09:57:41
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[22] => WP_Post Object
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[ID] => 23779
[post_author] => 15
[post_date] => 2024-03-21 09:38:33
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[post_content] =>
[post_title] => Use of Microchip Capillary Electrophoresis – Mass Spectrometry for Automated Rapid Measurement of Enzyme Reaction Kinetics
[post_excerpt] => This approach allows rapid measurement of enzymatic cleavage dynamics in real time. It can be applied to almost any enzyme substrate reaction and is highly tolerable to various buffers, thanks to the CE Chip-MS configuration. This poster was presented at ASMS 2023 with collaborators as poster MP547.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => use-of-microchip-capillary-electrophoresis
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[post_modified] => 2024-03-21 09:55:53
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[23] => WP_Post Object
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[ID] => 24540
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[post_date] => 2024-05-23 13:58:57
[post_date_gmt] => 2024-05-23 17:58:57
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[post_title] => Optimization of Scalable rAAV Production for Gene Therapy – Leveraging At-Line Amino AcidMeasurements for Bioprocess Modeling-Driven Approaches
[post_excerpt] => Spent media analysis from an at-line analyzer, the REBEL, was used to further understanding of AAV production process and identify correlation between key nutrient consumptions and capsid titers in fed-batch and continuous processes. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 43.
[post_status] => publish
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[post_name] => scalable-aav-production-gene-therapy
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[post_modified] => 2024-08-01 12:39:26
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[24] => WP_Post Object
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[ID] => 23776
[post_author] => 15
[post_date] => 2024-03-21 09:29:35
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[post_title] => Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
[post_excerpt] => N-glycan profiling is a critical step of biopharmaceuticals analysis as N-glycans play an important part in both activity and safety of monoclonal antibodies and other glycosylated biotherapeutics. This poster was presented at ASMS 2023 as poster MP291.
[post_status] => publish
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[post_name] => rapid-ce-ms-analysis-of-released-n-glycan
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[post_modified] => 2024-03-21 09:35:32
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[25] => WP_Post Object
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[ID] => 26486
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[post_date] => 2024-11-26 16:19:49
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