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Application Notes & Snapshots
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Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry
This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody-drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.
Rapid characterization of oligonucleotides using microfluidic CE-MS by ZipChip
This application note presents a CE-MS analysis of oligos by a ZipChip coupled to a QExactive HF mass spectrometer. This positive ESI mode method utilizes a MS-friendly background electrolyte (BGE), that eliminates the use of ionparing agents such as hexafluoro isopropanol or alkyl amines.
Charge variant analysis with ZipChip and maXisII
A ZipChip capillary zone electrophoresis system coupled to Bruker maXis II UHR-QTOF offers an alternative selectivity to separate charge variants prior to MS analysis and affords a more complete intact mass characterization without adding complexity or high salt eluents.
A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
Brochures & Flyers
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Case Studies
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REBEL + ZipChip help HJB Overcome Scientific Hurdles and Optimize Processes in Biotherapeutic Development
In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
Aerosolized Fentanyl During Decontamination
Download this case study on Canadian Decon Solutions’ encounter with fentanyl in a vehicle and how the MX908 with Aero provided real-time intel at the point of need.
Analysis Comparison of Fentanyl
Testimonial – Zachary Kelley – University of Kentucky
Mission Briefs
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Podcasts
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As heard on Cell Culture Dish
A Brief History of Field Technology
The guys introduce themselves and give a brief history of how laboratory technology has evolved for field use since the early 2000’s.
Anthrax vs Fentanyl
Get some perspectives on how the “white powder” call has changed dramatically from the anthrax attacks of October 2001 to the synthetic opioid epidemic of more recent years.
Figures of Merit
On the nerdiest show so far, learn some of the scientific terms used to define the performance of analytical technologies and how they apply to the meters you use in the field.
Posters
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Bottom-Up Analysis of Progressively Larger RNAs by CZE-MS and CZE-MS/MS
In this poster from ASMS 2022, researchers from University of Connecticut and Bruker showed that capillary zone electrophoresis performed on a chip proved to be an effective alternative to liquid chromatography as a front-end separation system to analyze both pure samples and complex digestion mixtures of nucleic acids.
Multi-level Expeditious Characterization of Adeno-associated Virus (AAV) Capsid Proteins Using ZipChip Microfluidic CE Coupled with HRMS
In this poster from ASMS 2022, scientists from Thermo Fisher Scientific and 908 Devices present a novel approach using microchip CE-MS for the characterization of AAVs.
A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS
In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.
Combining μSPE ZipChip CE with PRM-LIVE on a timsTOF Pro for Warp-speed Selectivity Profiling of Deubiquitinase (DUB) Small Molecule Inhibitors
In this ASMS 2022 poster, researchers from Dana Farber Cancer Institute and Harvard Medical School developed a ZipChip-based method for facilitating high-throughput identification
of new small molecule inhibitors.
Published Articles
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Prioritizing Officer Safety in the Field as Fentanyl Fatalities Rise
Multi-Mission Threat Detection in Real Time
This article originally appeared in CBNW Magazine.
In-Process Analytics are Key to Successful Cell Therapy Process Optimization and Manufacturing
Considerable clinical activity and the approval of several autologous, patient-specific therapies has increased industry demand and has also highlighted bottlenecks in manufacturing workflows.
The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.
Safety Data Sheet (SDS)
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SDS – ZipChip Reagents: Oligos
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – Deoxyribonucleic Acid, Unmodified
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Standard: Amino Acids
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Interface Tray Grease
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Specification Sheets
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Tech Notes
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Testimonials
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A Conversation with Michael Gray about Counterfeit Pills
Michael Gray is the CEO of Actus Analytical, Inc., which develops spectroscopy solutions for public safety. Michael and his wife, Nancy, founded The Actus Foundation in 2018, shortly after the death of their daughter, Amanda, who was killed by a poisoning of straight fentanyl at the age of 24.
Hear from Our Users: The Need for Speed in the Lab
Listen to ZipChip and REBEL users from The Dana Farber Cancer Institute, Sartorius, and Amgen discuss the impact of faster workflows in the lab.
A Conversation with Christina Baxter about Fentanyl
Dr. Christina Baxter is the CEO of Emergency Response TIPS, LLC and a partner in Hazard3, LLC which provides practical, evidence-based solutions for emergency response.
A Conversation with Christina Baxter about Aerosol Hazards
Dr. Christina Baxter is the CEO of Emergency Response TIPS, LLC and a partner in Hazard3, LLC which provides practical, evidence-based solutions for emergency response.
Videos
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Whiteboard Explainer: Avoiding the Stickiness of Oligo Analysis
If you have worked with oligos before, you know this can be a challenging application. Fortunately, ZipChip offers a way to make workflows faster and easier.
MX908 Product Video
MX Files – Episode 1 – Aerosolized Fentanyl
Join us for this episode of the MX Files featuring Canadian Decon Solutions and a story about an encounter with fentanyl.
Benefits of the MX908 with Aero
Webinars
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Power up your process control with rapid at line MS-based key nutrient monitoring
Graziella Piras, bioprocess segment director for 908 Devices, spoke at BPI Europe 2022 on the benefits of at-line nutrient monitoring.
The Critical Role of Cell Culture Media Analysis in CGT Development
Does cell culture analysis matter for CGT development? This short webinar explores what is already known, reviews at-line methods for cell culture media analysis, and shares recent data from two case studies.
Expert Roundtable: Trends in Illicit Drug Identification
Learn from a panel of law enforcement experts as they discuss challenges in keeping pace with an evolving drug landscape, and how they use new technology to detect and identify drugs in the field.
Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data
Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.
White Papers
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Microchip CE-MS: A Powerful Tool for Biotherapeutic Characterization
To help explain the power of this game-changing technology, we partnered with LCGC on a new ebook that covers the topic in-depth.
‘What’s In Your Media?’ Ebook
Learn about the critical role of cell culture media analysis in biotherapeutics development, including biologics and cell and gene therapies.
Using MX908 in Investigations and Court
Summary: Characterizing Biotherapeutics Using CE-ESI
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