Resource Hub
Application Notes & Snapshots
Comparing standard microbial media from a single supplier
Application Snapshot Booklet Fermentation
Application Snapshot Booklet Cell and Gene Therapy
Application Snapshot Booklet Cell Culture
Application Snapshot Booklet Biologics
Application Snapshot Booklet
How comparable are different vendors’ LB media?
High variations of analyte levels in Terrific broth (TB) media
Investigating the high nutrient variations in Super Optimal Broth
Cultures’ growth rates and productivities may differ when different vendor’s media are used in otherwise identical experiments.
Probing formulation differences in Super Optimal Broth
Similarities between different vendors’ 2X YT liquid media
Comparing standard microbial media from a single supplier
Be fast and accurate with at-line cell media analysis
At-line spent media analysis is now a reality
To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.
Differences in fresh commercially available hybridoma media
Select the best CHO media from the start
Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.
Screening of chemically-defined media for suspension cultures of HEK293 cells
Across four vendors, there was a high variation in the fresh media composition.
Analyze media without removing your mAb on the Rebel
Identify variations in dry and liquid CHO media
Running a quick fresh media assay prior to feeding the culture ensures consistency of the media components when scaling up or during the transition between liquid-to-dry media blends.
Serum supplemented media analysis is routine with the Rebel
Accelerate process development
Tease out variations in dry cell culture media
Running a simple media assay prior to feeding your cells can ensure that the composition of the media is what is expected.
Are you getting the cell culture media you expected?
Consistency between vendors should not be assumed.
Simply monitor initial vitamin levels
Supplementing RPMI media with fetal bovine serum
Supplementing IMDM media with fetal bovine serum
Conventional and chemically-defined T cell medias
Amino acid contents of Sf9 and Sf21 insect cell media
Knowledge of the insect cell metabolism coupled with an understanding of the amino acid content of the cell media allows for a more informed process development analytics strategy.
Comparing mesenchymal stem cell media with supplements on the Rebel
To ensure consistency when culturing MSCs, researchers should understand what is being added to their media.
Don’t sweat your cell media additives
Handle non-ionic surfactants in cell media samples with ease
Basal cell media with 10% fetal bovine serum
Brochures & Flyers
Podcast
Poster
Quantitation of metabolites in classical and customized cell culture media by an integrated CE-MS Analyzer
Quantitation of metabolites in cell culture media by an integrated CE-MS analyzer
for upstream process development
Using genomic and spent media analysis to characterize stressed CHO cultures
A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
Characterizing the Analytical Performance and Reliability of Metabolite Quantitation by an Integrated CE-MS Analyzer
Rapid Analysis of Cell Therapy Media
Quantitation of CHO media nutrients and metabolites in under 180 seconds
Rapid analysis of amino acids, water soluble vitamins, biogenic amines and dipeptides in cell growth media
Rapid at line nutrient profiling from an ammonia stressed CHO cell line
Published Article
In-Process Analytics are Key to Successful Cell Therapy Process Optimization and Manufacturing
Cellular therapies are an increasingly viable therapeutic option for many indications, particularly for patients who have exhausted traditional treatments. Considerable clinical activity and the approval of several autologous, patient-specific therapies has increased industry demand and has also highlighted bottlenecks in manufacturing workflows.
Spent Media Analysis of CHO Grown in an Ammonia-Stressed Parallel Microbioreactor Platform
Specification Sheet
Videos
Webinar
Ask the Expert: Bioprocess 101 – Cell Culture Media Analysis
Process Intensification: Do You Have All the Data You Need When You Need It?
The need for process intensification and implementation of Bioprocess 4.0 requires extensive real time data acquisition and process modelling. At line MS-based technologies presented here provide key cellular metabolic and protein quality data in real time to support process intensification and modelling.
Conference Talk: 2021 Industrializing Cell-Based Meats & Seafood Summit
The Importance of Cell Media Analysis in Upstream Bioprocess Development
Mass Spectrometry-Based Process Analytical Technologies for Cell Therapies
Unlocking rapid cell culture media analysis for cell and gene therapy process development
Be a REBEL with Your Cell Media Analytics
Redefine Bioprocess Analytics
Rapid at-line amino acid and nutrient profiling from bioprocess media with the REBEL
How can we accelerate PD analytics?
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