Application Notes & Snapshots

Application Snapshot Booklet Fermentation

Application Snapshot Booklet Cell and Gene Therapy

Application Snapshot Booklet Cell Culture

Application Snapshot Booklet Biologics

Application Snapshot Booklet

How comparable are different vendors’ LB media?

High variations of analyte levels in Terrific broth (TB) media

Investigating the high nutrient variations in Super Optimal Broth

Cultures’ growth rates and productivities may differ when different vendor’s media are used in otherwise identical experiments.

Probing formulation differences in Super Optimal Broth

Similarities between different vendors’ 2X YT liquid media

Comparing standard microbial media from a single supplier

At-line spent media analysis is now a reality

To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.

Differences in fresh commercially available hybridoma media

Select the best CHO media from the start

Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.

Screening of chemically-defined media for suspension cultures of HEK293 cells

Across four vendors, there was a high variation in the fresh media composition.

Analyze media without removing your mAb on the Rebel

Identify variations in dry and liquid CHO media

Running a quick fresh media assay prior to feeding the culture ensures consistency of the media components when scaling up or during the transition between liquid-to-dry media blends.

Serum supplemented media analysis is routine with the Rebel

Tease out variations in dry cell culture media

Running a simple media assay prior to feeding your cells can ensure that the composition of the media is what is expected.

Supplementing RPMI media with fetal bovine serum

Supplementing IMDM media with fetal bovine serum

Conventional and chemically-defined T cell medias

Amino acid contents of Sf9 and Sf21 insect cell media

Knowledge of the insect cell metabolism coupled with an understanding of the amino acid content of the cell media allows for a more informed process development analytics strategy.

Comparing mesenchymal stem cell media with supplements on the Rebel

To ensure consistency when culturing MSCs, researchers should understand what is being added to their media.

Don’t sweat your cell media additives

Handle non-ionic surfactants in cell media samples with ease

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Basal cell media with 10% fetal bovine serum

Webinars

The Critical Role of Cell Culture Media Analysis in Cell & Gene Therapies Development

Does cell culture analysis matter for CGT development? This short webinar explores what is already known, reviews at-line methods for cell culture media analysis, and shares recent data from two case studies.

Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data

Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.

Process Modeling with Researchers from Johns Hopkins University

Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization

Ask the Expert: Bioprocess 101 – Cell Culture Media Analysis

Process Intensification: Do You Have All the Data You Need When You Need It?

The need for process intensification and implementation of Bioprocess 4.0 requires extensive real time data acquisition and process modelling. At line MS-based technologies presented here provide key cellular metabolic and protein quality data in real time to support process intensification and modelling.

Conference Talk: 2021 Industrializing Cell-Based Meats & Seafood Summit

The Importance of Cell Media Analysis in Upstream Bioprocess Development

Mass Spectrometry-Based Process Analytical Technologies for Cell Therapies

Unlocking rapid cell culture media analysis for cell and gene therapy process development

Be a REBEL with Your Cell Media Analytics

Redefine Bioprocess Analytics

Rapid at-line amino acid and nutrient profiling from bioprocess media with the REBEL

How can we accelerate PD analytics?

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