All In-line Gain, No Modeling Pain
MAVERICK is powered by Raman spectroscopy and a purpose-built De Novo Model. The De Novo Model is explicitly built on media chemistries and device physics, not on empirical data. It automatically interprets the spectra and quantifies process parameters enabling simultaneous measurements of glucose, lactate, and total biomass. This is achieved without the costs, complexities, and risks associated with conventional Process Analytical Technology (PAT) methods. There is no need to grapple with complex empirical models, reagents, or unreliable auto-sampling systems to implement in-line bioprocess analysis.
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PAT Made Easy
While in-line PATs offer many benefits, adoption has been hindered by technical challenges, integration issues, and significant implementation costs.
MAVERICK addresses all these issues, ushering in an era of accessible, continuous monitoring of multiple parameters. With MAVERICK, your team can stay at the forefront of Bioprocessing 4.0 and fully harness the advantages of real-time in-line bioprocess analysis (bioreactor monitoring) and control. Intuitive setup and user-friendly interface means there is no training barrier to overcome.
MAVERICK Setup: Less than 1 day
You are ready to monitor multiple process parameters in only four steps
Conventional Raman Setup: 18 to 60 months
The calibration model requires revalidation for any significant change in process conditions.
Up to six measurement modules can be connected to a single MAVERICK hub. Independently monitor process conditions and control feeds in multiple bioreactors, in real-time, simultaneously. Save valuable bench space and increase efficiency.
Easy to Learn, Easy to Use
MAVERICK hardware and software have been meticulously designed with the user in mind. No previous experience with Raman spectroscopy or chemometric modeling required. The Hub features a high-resolution color touchscreen, CFR 21 Part 11 compliance ready software, and a highly intuitive user interface. In-line bioprocess analysis made easy.
How Will You Use MAVERICK?
With MAVERICK you get in-line, real-time, and robust bioreactor monitoring of multiple key process parameters in biopharmaceutical manufacturing of monoclonal antibodies, recombinant proteins, and viral vectors utilizing CHO and HEK293 cell lines in a variety of media types.
Consumables & Services
Replacement immersion probes, calibration standards, IQOQ, and service plans are available to keep your new favorite PAT tool in tip-top shape.
Real-time bioprocess monitoring and control, right out of the box. In-line measurements of multiple critical parameters across media, across processes, across mammalian cell lines, across scales.
Instant Implementation of Raman-based PAT with MAVERICK for Monitoring Glucose and Lactate
MAVERICK is easy to set up and enables instant implementation of PAT generating accurate, precise, linear and selective in-line measurements across a wide range of media used typically in mammalian (including CHO and HEK293 media) cell culture for the production of biotherapeutics.
Determining Total Cell Count with MAVERICK Biomass Measurements
MAVERICK provides an in-line, Raman-based PAT solution for monitoring and control of glucose, lactate, and biomass in up to six bioreactors right out of the box.
MAVERICK Product Specification Sheet
Get all the MAVERICK specifications including applications, physical dimensions, and more.
Frequently Asked Questions
What applications can MAVERICK be used for?
MAVERICK is intended for bioprocessing applications in process development and biopharmaceutical manufacturing, enabling cell culture automation in biologic production for CHO or HEK293 mammalian cell line and media. For example, MAVERICK can help optimize viral vector titer in lentiviral vector production, AAV production, and other viral vector manufacturing applications.
Which cell lines and cell culture media does MAVERICK work with?
MAVERICK works with CHO and HEK293 cell lines and media.
Which bioreactors are compatible with MAVERICK?
MAVERICK autoclavable immersion probe is 220 mm long with 12 mm outside diameter, making it compatible with most 250 mL to 10L bioreactors. The PG 13.5 compression fitting interfaces with the standard bioreactor sensor ports and enables adjustment of the immersion depth (minimum 40 mm immersion depth is required).
I simultaneously operate more than one bioreactor. Can I multiplex MAVERICK to multiple vessels?
Yes. Each MAVERICK Hub connects and controls up to six Measurement Modules, supporting up to six individually or jointly operated bioreactors. Unlike other process Raman spectroscopy analyzers that employ optical switches or multi-channel design, MAVERICK preserves operational redundancy in multi-bioreactor applications.
How is MAVERICK calibrated?
The probe is calibrated using the two standards in the Calibration Kit. Calibration is performed prior to autoclaving the probe, before each bioreactor run. Each probe has a built-in memory chip that stores its calibration coefficients and verifies that the correct probe was re-attached post-sterilization.
How does the feedback control loop automate substrate feeding based on in-line measurements?
On-board analog/digital controller offers optional direct control of feed pumps. Alternatively, the measured values can be sent to an existing bioreactor controller, SCADA, or data acquisition system via Analog outputs or OPC UA protocol.
How are probes sterilized?
Probe barrels are autoclavable or steam sterilizable and should be replaced after 10 autoclave cycles to ensure the probe maintains its integrity.
Why doesn’t MAVERICK require the development of multivariate models to correlate Raman spectra to cell culture process parameters?
Normally, interpreting the spectrum from Raman spectroscopy requires the development of empirical multivariate calibration models (chemometric modeling) specific to analytes of interest. This requires multiple bioreactor runs to acquire real-time spectral data, manually collect numerous samples from the bioreactors for at-line/off-line analysis, and then utilize statistical analysis to correlate the Raman spectra to the at-line/off-line measurements. Naturally, this process is very time consuming, expensive, and complicated, making Raman-based bioprocess monitoring inaccessible to most biopharma labs.
MAVERICK purpose-built De Novo Model does not need to be trained on empirical process data. The model quantifies analyte concentration by accurately inferring peaks, associated with the analytes of interest based on a priori knowledge and the baseline from water, other mixture components, and instrumentation in the spectra.
Is MAVERICK available outside the United States, and do you provide global technical support?
MAVERICK devices and support are available for purchase directly from 908 Devices in North America and Europe, and through a network of distributors globally.
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