In-line Bioprocess Analysis


Real-time, in-line bioprocess analysis and control, right out of the box. Measurements of multiple critical parameters across media, across processes, across mammalian cell lines, across scales.

Measurement Module
In-line Immersion Probe
Maverick Hub

All In-line Gain, No Modeling Pain

MAVERICK is powered by Raman spectroscopy and a purpose-built De Novo Model. The De Novo Model is explicitly built on media chemistries and device physics, not on empirical data. It automatically interprets the spectra and quantifies process parameters enabling simultaneous measurements of glucose, lactate, and total biomass. This is achieved without the costs, complexities, and risks associated with conventional Process Analytical Technology (PAT) methods. There is no need to grapple with complex empirical models, reagents, or unreliable auto-sampling systems to implement in-line bioprocess analysis.

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PAT Made Easy

While in-line process analytical technology (PATs) offer many benefits, adoption has been hindered by technical challenges, integration issues, and significant implementation costs.

MAVERICK addresses all these issues, ushering in an era of accessible, continuous monitoring of multiple parameters. With MAVERICK, your team can stay at the forefront of Bioprocessing 4.0 and fully harness the advantages of real-time in-line bioprocess analysis (bioreactor monitoring) and control. Intuitive setup and user-friendly interface means there is no training barrier to overcome.

Instant Raman, Ready in Minutes

MAVERICK offers all the advantages of Raman-based process analytical technology (PAT) without the cost and complexities associated with developing “black box” empirical calibration models, required by conventional process spectroscopy-based methods. While it can take months and a dedicated team of experts to build and validate a robust empirical calibration model—MAVERICK only takes a simple two-point probe calibration to begin monitoring multiple key process parameters in most types of bioreactors. Just take it out of the box, and you’re already halfway through the setup process.

You are ready to monitor multiple process parameters in only four steps

Take MAVERICK out of the box and connect components

Perform two-point calibration with the standard

Autoclave the probe body with the bioreactor

Reconnect the probe

The calibration model requires revalidation for any significant change in process conditions.

Unbox the instrument and connect the components

Calibrate and standardize probe optics

Autoclave the probe with bioreactor

Reconnect the probe and prepare the bioreactor runs

Collect Raman spectra from multiple bioreactor runs

Extract samples and collect reference measurements

Build multivariate empirical calibration model

Validate model performance

Multiplex Flex

Up to six measurement modules can be connected to a single MAVERICK hub. Independently monitor process conditions and control feeds in multiple bioreactors, in real-time, simultaneously. Save valuable bench space and increase efficiency.

Walk-Away Automation

Control feeding pumps directly or relay the measurements to an existing automation or data acquisition system. Integration is simplified with analog and digital connectivity via Ethernet or OPC UA. Optional remote monitoring allows you to securely check on your bioreactors from anywhere, anytime, 24/7.

Easy to Learn, Easy to Use

MAVERICK hardware and software have been meticulously designed with the user in mind. No previous experience with Raman spectroscopy or chemometric modeling required. The Hub features a high-resolution color touchscreen, CFR 21 Part 11 compliance ready software, and a highly intuitive user interface. In-line bioprocess analysis made easy.

Data Visualization with JMP Software

MAVERICK users with access to the JMP statistical software package are able to expedite time-course data visualization and compare runs. MAVERICK users can download the add-in tool from the 908 Devices customer support portal or visit the JMP site to obtain a JMP software trial.

MAVERICK data files are rich in data from in-line measurements of glucose, lactate and biomass. The values in g/L, biomass units are provided in 1-minute intervals.

Visualize time-course data for glucose, lactate, and biomass and compare runs.

Consumables & Services

Replacement immersion probes, calibration standards, IQOQ, and service plans are available to keep your new favorite process analytical technology tool in tip-top shape.

How Will You Use MAVERICK?

With MAVERICK you get in-line, real-time, and robust bioreactor monitoring of multiple key process parameters in biopharmaceutical manufacturing of monoclonal antibodies, recombinant proteins, and viral vectors utilizing CHO and HEK293 cell lines in a variety of media types.

Customer Support Portal

The My 908 portal gives scientists quick access to important resources like the latest software upgrades, product guides, and training materials.

Frequently Asked Questions

What applications can MAVERICK be used for?

MAVERICK is intended for bioprocessing applications in process development and biopharmaceutical manufacturing, enabling cell culture automation in biologic production for CHO or HEK293 mammalian cell line and media. For example, MAVERICK can help optimize viral vector titer in lentiviral vector production, AAV production, and other viral vector manufacturing applications.

Which cell lines and cell culture media does MAVERICK work with?

MAVERICK works with CHO and HEK293 cell lines and media.

Which bioreactors are compatible with MAVERICK?

MAVERICK autoclavable immersion probe is 220 mm long with 12 mm outside diameter, making it compatible with most 250 mL to 10L bioreactors. The PG 13.5 compression fitting interfaces with the standard bioreactor sensor ports and enables adjustment of the immersion depth (minimum 40 mm immersion depth is required).

I simultaneously operate more than one bioreactor. Can I multiplex MAVERICK to multiple vessels?

Yes. Each MAVERICK Hub connects and controls up to six Measurement Modules, supporting up to six individually or jointly operated bioreactors. Unlike other process Raman spectroscopy analyzers that employ optical switches or multi-channel design, MAVERICK preserves operational redundancy in multi-bioreactor applications.

How is MAVERICK calibrated?

The probe is calibrated using the two standards in the Calibration Kit. Calibration is performed prior to autoclaving the probe, before each bioreactor run. Each probe has a built-in memory chip that stores its calibration coefficients and verifies that the correct probe was re-attached post-sterilization.

How does the feedback control loop automate substrate feeding based on in-line measurements?

On-board analog/digital controller offers optional direct control of feed pumps. Alternatively, the measured values can be sent to an existing bioreactor controller, SCADA, or data acquisition system via Analog outputs or OPC UA protocol.

How are probes sterilized?

Probe barrels are autoclavable or steam sterilizable and should be replaced after 10 autoclave cycles to ensure the probe maintains its integrity.

Why doesn’t MAVERICK require the development of multivariate models to correlate Raman spectra to cell culture process parameters?

Normally, interpreting the spectrum from Raman spectroscopy requires the development of empirical multivariate calibration models (chemometric modeling) specific to analytes of interest. This requires multiple bioreactor runs to acquire real-time spectral data, manually collect numerous samples from the bioreactors for at-line/off-line analysis, and then utilize statistical analysis to correlate the Raman spectra to the at-line/off-line measurements. Naturally, this process is very time consuming, expensive, and complicated, making Raman-based bioprocess monitoring inaccessible to most biopharma labs.

MAVERICK purpose-built De Novo Model does not need to be trained on empirical process data. The model quantifies analyte concentration by accurately inferring peaks, associated with the analytes of interest based on a priori knowledge and the baseline from water, other mixture components, and instrumentation in the spectra.

Is MAVERICK available outside the United States, and do you provide global technical support?

MAVERICK devices and support are available for purchase directly from 908 Devices in North America and Europe, and through a network of distributors globally.

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