ZipChip - 908 Devices

Kick your mass spec into overdrive.

ZipChip^® is the new alternative to LC-MS. Based on cutting-edge microfluidic technology it integrates capillary electrophoresis and electrospray ionization into an easy to use system that simply replaces your mass spec’s normal source. But don’t let its size fool you. This small package is built to solve your problems by delivering results for even the most challenging samples.

What’s it for?

Whatcha got? Native biotherapeutic proteins? No problem. Peptide mapping? Great! Small molecules in biofluids? Absolutely!

Not only can ZipChip handle a wide range of sample types, it does so with minimal sample prep and fast analysis times, making your life easier and more productive.

Keep it simple.

Messing around with fittings and optimizing electrospray isn’t just annoying, it wastes time and is a huge source of variability. ZipChip is simple to set up. The chip simply clicks into place and is automatically positioned for optimal electrospray with no fittings to connect and no further optimization required. That means you can be up and running in a matter of minutes, not hours.

No fuss, no muss.

ZipChip consumables take the guess work out of method development. Assay kits contain background electrolyte and sample diluent optimized for each application. Just load the bottle of background electrolyte into the autosampler, prep your samples with the sample diluent, and you’re off!

Suggested Resources

Snapshot: Fast Charge Variant Analysis

Snapshot: High-Throughput Intact Mass

Snapshot: Cell Culture Analysis

Analysis of Reduced mAbs and ADCs

Rapid Characterization of Intact mAb-based Biotherapeutics

Quick screening of intact antibody and ADC

Shift Protocol Flyer

Boost Protocol Flyer

ZipChip Platform Brochure

A comprehensive CE-ESI MS solution for BioPharma applications

In-depth analysis of top selling biotherapeutics

ASMS: NIBRT Presents ZipChip for Native Charge Heterogeneity

CASSS: NIBRT Presents Native MS for Charge Variants using ZipChip

Monitoring Amino Acid Composition of Cell Culture Media

Native CE-MS for Biopharmaceutical Characterization

Rapid, Multi-level Analysis of Complex Proteins

96 Bottles of Beer: Metabolic Profiling of Spent Growth Media

Native Analysis of Monoclonal Antibodies

Fast Chip-CEMS for Characterization of Protein/PTM Changes

Characterization of ADCs using ZipChip

Characterization of Protein/PTM Changes

Combined Top-down and Bottom-up Proteomics

ZipChip for Glycomics and Glycoproteomics

ZipChip Protocols

Evaluation of Sample Carryover

ZipChip and Detergents

Using the ZipChip Infusion Function

Using Field Strength Gradients

Performance Validation Study

ZipChip: How It Works

Characterization of Protein Assemblies Related to Cancer Proliferation

Analysis of alkaloids in plant cell cultures

Characterizing Antiviral Protein-Inhibitor Complexes

Identification of AAV capsid proteins

Characterization of NIST mAb Proteoforms and Glycoforms

Characterization of a SRPK1/2 Inhibitor Complex

Detection and Quantification of neurotoxin β-N-methylamino-l-alanine

Characterizing Covalent CDK Inhibitor Complexes

Analysis of monosaccharides, oligosaccharides and glycopeptides

Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples

Hardware

Consumables

ZipChip. Put your mass into it

DYK: ZipChip Can See Charge Variants In Degraded Antibodies?

Application Experience: Native Analysis of mAbs and ADCs with ZipChip

Application Experience: Detergents

NIBRT presents ZipChip for biopharma characterization

Rapid, comprehensive biotherapeutics characterization

Simultaneous monitoring of amino acids and protein titer

ZipChip for Rapid and Easy Nanospray Infusions

Summary: Streamlined protein characterization and profiling

Streamline Protein Characterization and Profiling with CE-ESI-MS

Summary: Characterizing Biotherapeutics Using CE-ESI

Analysis of inhibitor-protein complexes and small molecules

Why use capillary electrophoresis

Applications

ZipChip helps you answer key questions about your most important molecules. Whether you’re analyzing biotherapeutic drug products to monitor critical quality attributes or growth media to optimize bioreactor production, ZipChip has an assay for you. From intact charge variant separations to small molecule analysis our assays are fast, sensitive, and provide unique separation abilities – all backed by the power of your mass spectrometer!

Put Your Mass Into It.

Kick your mass spec into overdrive.

What’s it for?

Videos

Application Experience: Detergents

Keep it simple.