Put Your Mass Into It.

Kick your mass spec into overdrive.

ZipChip® is the new alternative to LC-MS. Based on cutting-edge microfluidic technology it integrates capillary electrophoresis and electrospray ionization into an easy to use system that simply replaces your mass spec’s normal source. But don’t let its size fool you. This small package is built to solve your problems by delivering results for even the most challenging samples.

Show me the science

What’s it for?

Whatcha got? Native biotherapeutic proteins? No problem. Peptide mapping? Great! Small molecules in biofluids? Absolutely!

Not only can ZipChip handle a wide range of sample types, it does so with minimal sample prep and fast analysis times, making your life easier and more productive.

Show me the applications


Suggested Resources:

Videos

Application Experience: Detergents

Keep it simple.

Messing around with fittings and optimizing electrospray isn’t just annoying, it wastes time and is a huge source of variability. ZipChip is simple to set up. The chip simply clicks into place and is automatically positioned for optimal electrospray with no fittings to connect and no further optimization required. That means you can be up and running in a matter of minutes, not hours. 

No fuss, no muss.

ZipChip consumables take the guess work out of method development.  Assay kits contain background electrolyte and sample diluent optimized for each application. Just load the bottle of background electrolyte into the autosampler, prep your samples with the sample diluent, and you’re off!

Suggested Resources

Suggested Resources:

Specifications

Hardware

Specifications

Consumables

Brochures & Flyers

Shift Protocol Overview

Brochures & Flyers

Boost Protocol Overview

Twiddle-free data analysis.

Blast through multiple CQAs in minutes with ZipChip + Darwin.  Our dedicated analysis software uses the rich information from both the ZipChip capillary electrophoresis and mass spec domains so you can skip the finicky manual steps typically needed for biotherapeutic analysis.

Suggested Resources

Suggested Resources:

Brochures & Flyers

CQAs in 7 Minutes

Popular FAQs

  • What is ZipChip?

    ZipChip is a front-end separation device that couples to your mass spectrometer. It joins capillary electrophoresis and electrospray ionization into a plug-and-play chip. There is minimal sample preparation and tiny injection volumes, so there is not much assistance needed by a scientist.

  • Can the ZipChip be used to analyze small and large molecules?

    The beauty of the ZipChip is that you can perform large molecule (e.g., mAb’s) analysis in the morning and transition to small molecule (e.g., amino acids) analysis in the afternoon. It’s that fuss-free! There is no need to change mobile phases or columns to accommodate a new project.

  • Can I use ZipChip to perform Native Charge Variant separations of my mAb?

    Yes! ZipChip performs native charge variant separations by capillary-zone electrophoresis mass spectrometry (CZEMS). Not only can you separate the charge variants (basic lysine 2K and 1K, 0K monomer, and acidic/deamidated species), the selectivity of the mass spectrometer allows you to determine the accurate mass of each species by deconvoluting the charge envelop of each peak.

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Life Sciences Blog

ZipChip Resources

Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics

Bioreactor Monitoring via ZipChip

Snapshot: Charge Variant Analysis

Snapshot: High-Throughput Intact Mass

Snapshot: High Throughput Charge Variant Analysis

Snapshot: Cell Culture Analysis

Analysis of Reduced mAbs and ADCs

Rapid Characterization of Intact mAb-based Biotherapeutics

Quick screening of intact antibody and ADC

Darwin Flyer

Shift Protocol Overview

Boost Protocol Overview

ZipChip Platform Brochure

A comprehensive CE-ESI MS solution for BioPharma applications

Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes

Analysis to unravel biosimilarity of therapeutic proteins

Automated monitoring of amino acids in cell culture media

Highly sensitive charge variant analysis of complex biopharmaceuticals

In-depth analysis of top selling biotherapeutics

Characterization of charge heterogeneity of mAb

Oligonucleotide Analysis via Microfluidic CE-MS

Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF

A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media

Bioprocessing of Monoclonal Antibody Based Therapies

NIBRT Presents Native MS for Charge Variants using ZipChip

NIBRT Presents ZipChip for Native Charge Heterogeneity

Monitoring Amino Acid Composition of Cell Culture Media

Native CE-MS for Biopharmaceutical Characterization

Rapid, Multi-level Analysis of Complex Proteins

96 Bottles of Beer: Metabolic Profiling of Spent Growth Media

Native Analysis of Monoclonal Antibodies

Fast Chip-CEMS for Characterization of Protein/PTM Changes

Characterization of ADCs using ZipChip

Characterization of Protein/PTM Changes

Combined Top-down and Bottom-up Proteomics

ZipChip for Glycomics and Glycoproteomics

ZipChip Protocols

Evaluation of Sample Carryover

ZipChip and Detergents

Using the ZipChip Infusion Function

Using Field Strength Gradients

Performance Validation Study

How It Works

In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry

Comparative Elucidation of Cetuximab Heterogeneity on the Intact Protein Level

Characterization of Protein Assemblies Related to Cancer Proliferation

Analysis of alkaloids in plant cell cultures

Characterizing Antiviral Protein-Inhibitor Complexes

Identification of AAV capsid proteins

Characterization of NIST mAb Proteoforms and Glycoforms

Characterization of a SRPK1/2 Inhibitor Complex

Detection and Quantification of neurotoxin β-N-methylamino-l-alanine

Characterizing Covalent CDK Inhibitor Complexes

Analysis of monosaccharides, oligosaccharides and glycopeptides

Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples

Hardware

Consumables

A conversation with Bruker

ZipChip. Put your mass into it

Do You Know ZipChip?

DYK: ZipChip Can See Charge Variants In Degraded Antibodies?

ZipChip Demo

ZipChip Booth Chat

ZipChip Poster Chat

Application Experience: Oligonucleotides

Application Experience: Native Analysis of mAbs and ADCs

Application Experience: Detergents

Zip Through the Backlog

NIBRT presents ZipChip for biopharma characterization

Rapid, comprehensive biotherapeutics characterization

Simultaneous monitoring of amino acids and protein titer

ZipChip for Rapid and Easy Nanospray Infusions

Summary: Streamlined protein characterization and profiling

Streamline Protein Characterization and Profiling with CE-ESI-MS

Summary: Characterizing Biotherapeutics Using CE-ESI

Analysis of inhibitor-protein complexes and small molecules

Why use capillary electrophoresis

Applications

ZipChip helps you answer key questions about your most important molecules. Whether you’re analyzing biotherapeutic drug products to monitor critical quality attributes or growth media to optimize bioreactor production, ZipChip has an assay for you. From intact charge variant separations to small molecule analysis our assays are fast, sensitive, and provide unique separation abilities – all backed by the power of your mass spectrometer!

Biotherapeutics

Biotherapeutics

Customer Support Portal

The My 908 portal gives scientists quick access to important resources like the latest software upgrades, product guides, and training materials.

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