Put Your Mass Into It.

Kick your mass spec into overdrive.

ZipChip^® is a front-end separation platform for your mass spectrometer that lets you measure multiple critical quality attributes (CQAs) in a single assay. Just clip it on. ZipChip uses a cutting edge combination of capillary electrophoresis (CE) and electrospray ionization (ESI) to make fast, high-efficiency analysis possible for even the most challenging samples and answers the complex questions other techniques can’t.

Take Me To The Applications Show Me The Science

Roll with the pace.

As demand in the lab increases, ZipChip helps you step up the pace. Max out efficiency with little to no sample prep and 3-minute separations. ZipChip takes on challenging analytes like small molecule isomers and intact protein variants. And don’t worry about detergents, they’re no big deal for ZipChip.

Suggested Resources

Suggested Resources:

Videos

Application Experience: Detergents

Keeping it simple.

ZipChip is simple to set up and easily integrates into existing lab workflows. Pick an application. Pick a chip and a kit. And off you go. The proprietary microfabrication technology on each chip simplifies the rest:

No capillaries to coat
No MS alignment needed
No small connections
No junction issues
No channel flushing between runs
No carryover issues

No fuss, no muss.

ZipChip consumables help take the guess work out of method development. Mix and match chips and kits to fit your application needs. Change applications with a quick chip swap and be up and running again in under 30 minutes.

Suggested Resources

Suggested Resources:

Specifications

ZipChip Hardware Spec Sheet

Specifications

ZipChip Consumables Spec Sheet

Specifications

Shift Protocol Flyer

Specifications

Boost Protocol Flyer

Cool new stuff.

Boost your data. Give your mass spec 20X higher sensitivity.

Perform near-native analysis on your standard QE. And even your Lumos.

ZipChip Resources

Shift Protocol Flyer

Boost Protocol Flyer

ZipChip Platform Brochure

ZipChip Hardware Spec Sheet

ZipChip Consumables Spec Sheet

ZipChip Introduction

Metabolomics Introduction

Proteomics Introduction

Biotherapeutics Introduction

Streamlined Protein Characterization and Profiling with CE–ESI–MS

Using the ZipChip Infusion Function

Using Field Strength Gradients to Enhance ZipChip Analysis

ZipChip Performance Validation Study

Analysis of Reduced mAbs and Antibody-Drug Conjugates using the ZipChip Platform

Characterizing Biotherapeutics Using CE-ESI

Analysis of Intact Antibodies for Rapid Characterization of mAb-based Biotherapeutics

ZipChip: How It Works

Advances in Mass Spectrometry-Based Glycomics

Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein

Identification of adeno-associated virus capsid proteins using ZipChip CE/MS

Intact NIST Monoclonal Antibody Characterization — Proteoforms, Glycoforms — using CE-MS and CE-LIF

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform

A novel integrated strategy for the detection and quantification of the neurotoxin β-N-methylamino-l-alanine in environmental samples

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples Using ZipChip CE-MS

Microfluidic capillary electrophoresis-mass spectrometry for analysis of monosaccharides, oligosaccharides and glycopeptides

Using CE for Separation and Characterization of Intact Monoclonal Antibody Variants

Using CE for Hydrogen Exchange Mass Spectrometry

Characterization of Intact Antibody Drug Conjugate Variants

Native Microchip CE-MS for In-Depth Biopharmaceutical Characterization

Rapid, Multi-level Analysis of Complex Proteins by Microchip Capillary Electrophoresis-ESI-MS

Characterization of Protein/PTM Changes by Chip Capillary Electrophoresis Mass Spectrometry

Native Analysis of Monoclonal Antibodies by Microchip Capillary Electrophoresis-ESI-MS

96 Bottles of Beer: Metabolic Profiling of Spent Growth Media Using Rapid, High Throughput Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry

Microchip Capillary Electrophoresis-ESI-MS for Rapid, Multi-level Analysis of Complex Proteins

A Fully Automated Microchip Capillary Electrophoresis-ESI-MS System for High Throughput Analysis of Metabolites, Peptides, and Intact Proteins

Microfluidic Capillary Electrophoresis – Mass Spectrometry for Glycomics and Glycoproteomics

Fast Chip-CEMS for Characterization of Protein/PTM Changes

Characterization of Antibody Drug Conjugates using Microfluidic CE-MS

Comprehensive amino acid and DBS analysis with a microchip capillary electrophoresis-ESI miniature mass spectrometry platform in 150 seconds

Application Experience: Native Analysis of mAbs and ADCs with ZipChip

Application Experience: Detergents

ZipChip. Put your mass into it

Simultaneous CE-MS monitoring of amino acid and protein titer in the bioreactor

Ditch Your Syringe Pump: Use ZipChip for Rapid and Easy Nanospray Infusions

Streamline Protein Characterization and Profiling with CE-ESI-MS

Why use capillary electrophoresis

Native Analysis of Monoclonal Antibodies with ZipChip

Characterization and quantitation of inhibitor-protein complexes and small molecules using ZipChip

Multi-characterization of proteins in under 5 minutes

Biotherapeutics characterization with CE-ESI MS

Combined Top-down and Bottom-up Proteomics using Capillary Electrophoresis-Mass Spectrometry

Brochure: A comprehensive CE-ESI MS solution for BioPharma applications

Application Note: Quick screening of intact antibody and antibody- drug conjugates with integrated microfluidic CE MS

Applications

ZipChip helps you answer key questions about your most important molecules. Whether you’re analyzing biotherapeutic drug products to monitor critical quality attributes or growth media to optimize bioreactor production, ZipChip has an assay for you. From intact charge variant separations to small molecule analysis our assays are fast, sensitive, and provide unique separation abilities – all backed by the power of your mass spectrometer!

Biotherapeutics

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