Empowering Traditional Mass Spec

The ZipChip™ separations platform uses integrated microfluidic technology to prepare, separate and electrospray biological samples directly into traditional mass spectrometers (MS). In less than 3 minutes per sample, the cost-effective ZipChip system enables analysis of a broad range of matrices from growth media to cell lysates, blood, plasma, urine, and biopharma products. Each chip provides answers on analytes from small molecules up to intact proteins, antibodies and antibody drug conjugates (ADCs). This platform provides better separation quality than most liquid chromatography (LC) instruments – in a fraction of the time – all with full MS identification behind every separations peak.

ZipChip Resources Watch Video

New Technology For Speedy Answers

The ZipChip platform uses cutting-edge microfluidic technology to integrate capillary electrophoresis (CE) and electrospray ionization (ESI) onto each chip. This eliminates junctions between individual components and removes dead volumes that slow and degrade analytical quality in conventional separation techniques. Pick your chip – ZipChip HS for small molecules or ZipChip HR for intact proteins – and off you go.

A Chip With Smarts

Each individual ZipChip has intelligence built in. The system recognizes your ZipChip as soon as it is loaded and will even automatically load run parameters and custom methods based on your preferences. Performance and total runs completed are tracked to ensure reliable results. When used with our premixed assay kits, we’ll even guarantee the lifetime of each chip.

Eliminate The Guesswork

Our premixed background electrolyte consumables further reduce preparation time and minimize opportunities for human error when diluting and analyzing samples. These customized assay kits are manufactured under our ISO-9001 quality system and optimized for your small and intact large molecule sample types.

One Step Prep

A single pre-programmed method works across sample types, typically with electrolyte dilution, as your only step in sample prep. Desalting is automatically taken care of. The ZipChip platform saves time and ensures answers are derived from samples in their native states.

Automated For Productivity

When combined with the autosampler, the ZipChip platform generates dramatic productivity improvements. Users achieve unattended sample runs from sample vials or 96-well plates.   When complete simply change the chip and run another 96.

We Value Your Precious Samples

Each ZipChip needs only a few microliters of sample for analysis, which is great when your development samples are precious. When your lab has high demand, the low-volume and friendly background electrolyte provides analysis that is gentle on your mass spectrometer. The ZipChip platform provides minimum downtime and maximum quantitative stability over time.

ZipChip Resources

Application Experience: Native Analysis of mAbs and ADCs with ZipChip

Application Experience: Detergents

ZipChip. Put your mass into it

Streamline Protein Characterization and Profiling with CE-ESI-MS

Why use capillary electrophoresis

Native Analysis of Monoclonal Antibodies with ZipChip

Characterization and quantitation of inhibitor-protein complexes and small molecules using ZipChip

Multi-characterization of proteins in under 5 minutes

Biotherapeutics characterization with CE-ESI MS


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