ZipChip

Empowering Traditional Mass Spec

The ZipChip™ separations platform uses integrated microfluidic technology to prepare, separate and electrospray biological samples directly into traditional mass spectrometers (MS). In less than 3 minutes per sample, the cost-effective ZipChip system enables analysis of a broad range of matrices from growth media to cell lysates, blood, plasma, urine, and biopharma products. Each chip provides answers on analytes from small molecules up to intact proteins, antibodies and antibody drug conjugates (ADCs). This platform provides better separation quality than most liquid chromatography (LC) instruments – in a fraction of the time – all with full MS identification behind every separations peak.

ZipChip Resources Watch Video

New Technology For Speedy Answers

The ZipChip platform uses cutting-edge microfluidic technology to integrate capillary electrophoresis (CE) and electrospray ionization (ESI) onto each chip. This eliminates junctions between individual components and removes dead volumes that slow and degrade analytical quality in conventional separation techniques. Pick your chip – ZipChip HS for small molecules or ZipChip HR for intact proteins – and off you go.

A Chip With Smarts

Each individual ZipChip has intelligence built in. The system recognizes your ZipChip as soon as it is loaded and will even automatically load run parameters and custom methods based on your preferences. Performance and total runs completed are tracked to ensure reliable results. When used with our premixed assay kits, we’ll even guarantee the lifetime of each chip.

Eliminate The Guesswork

Our premixed background electrolyte consumables further reduce preparation time and minimize opportunities for human error when diluting and analyzing samples. These customized assay kits are manufactured under our ISO-9001 quality system and optimized for your small and intact large molecule sample types.

One Step Prep

A single pre-programmed method works across sample types, typically with electrolyte dilution, as your only step in sample prep. Desalting is automatically taken care of. The ZipChip platform saves time and ensures answers are derived from samples in their native states.

Automated For Productivity

When combined with the autosampler, the ZipChip platform generates dramatic productivity improvements. Users achieve unattended sample runs from sample vials or 96-well plates.   When complete simply change the chip and run another 96.

We Value Your Precious Samples

Each ZipChip needs only a few microliters of sample for analysis, which is great when your development samples are precious. When your lab has high demand, the low-volume and friendly background electrolyte provides analysis that is gentle on your mass spectrometer. The ZipChip platform provides minimum downtime and maximum quantitative stability over time.

ZipChip Resources

ZipChip Platform Brochure

ZipChip Consumables Spec Sheet

ZipChip Hardware Spec Sheet

ZipChip Introduction

Metabolomics Introduction

Proteomics Introduction

Biotherapeutics Introduction

Analysis of Reduced mAbs and Antibody-Drug Conjugates using the ZipChip Platform

Characterizing Biotherapeutics Using CE-ESI

Analysis of Intact Antibodies for Rapid Characterization of mAb-based Biotherapeutics

ZipChip: How It Works

Identification of adeno-associated virus capsid proteins using ZipChip CE/MS

Intact NIST Monoclonal Antibody Characterization — Proteoforms, Glycoforms — using CE-MS and CE-LIF

SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform

A novel integrated strategy for the detection and quantification of the neurotoxin β-N-methylamino-l-alanine in environmental samples

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples Using ZipChip CE-MS

Microfluidic capillary electrophoresis-mass spectrometry for analysis of monosaccharides, oligosaccharides and glycopeptides

Using CE for Separation and Characterization of Intact Monoclonal Antibody Variants

Using CE for Hydrogen Exchange Mass Spectrometry

Characterization of Intact Antibody Drug Conjugate Variants

Poster: A Fully Automated Microchip Capillaray Electrophoresis-ESI-MS System for High Throughput Analysis of Metabolites, Peptides, and Intact Proteins

Poster: Microfluidic Capillary Electrophoresis – Mass Spectrometry for Glycomics and Glycoproteomics

Poster: Fast Chip-CEMS for Characterization of Protein/PTM Changes

Characterization of Antibody Drug Conjugates using Microfluidic CE-MS

Comprehensive amino acid and DBS analysis with a microchip capillary electrophoresis-ESI miniature mass spectrometry platform in 150 seconds

Characterization and quantitation of inhibitor-protein complexes and small molecules using ZipChip

Multi-characterization of proteins in under 5 minutes

Biotherapeutics characterization with CE-ESI MS

Poster: Combined Top-down and Bottom-up Proteomics using Capillary Electrophoresis-Mass Spectrometry

Brochure: A comprehensive CE-ESI MS solution for BioPharma applications

Application Note: Quick screening of intact antibody and antibody- drug conjugates with integrated microfluidic CE MS

Applications

Biotherapeutics

Biotherapeutics
Metabolomics

Metabolomics
Proteomics & Peptide Mapping

Proteomics & Peptide Mapping
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