Put Your Mass Into It.

Kick your mass spec into overdrive.

ZipChip® is the new alternative to LC-MS. Based on cutting-edge microfluidic technology it integrates capillary electrophoresis and electrospray ionization into an easy to use system that simply replaces your mass spec’s normal source. But don’t let its size fool you. This small package is built to solve your problems by delivering results for even the most challenging samples.

Show me the science

What’s it for?

Whatcha got? Native biotherapeutic proteins? No problem. Peptide mapping? Great! Small molecules in biofluids? Absolutely!

Not only can ZipChip handle a wide range of sample types, it does so with minimal sample prep and fast analysis times, making your life easier and more productive.

Show me the applications


Keep it simple.

Messing around with fittings and optimizing electrospray isn’t just annoying, it wastes time and is a huge source of variability. ZipChip is simple to set up. The chip simply clicks into place and is automatically positioned for optimal electrospray with no fittings to connect and no further optimization required. That means you can be up and running in a matter of minutes, not hours. 

No fuss, no muss.

ZipChip consumables take the guess work out of method development.  Assay kits contain background electrolyte and sample diluent optimized for each application. Just load the bottle of background electrolyte into the autosampler, prep your samples with the sample diluent, and you’re off!

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Twiddle-free data analysis.

Blast through multiple CQAs in minutes with ZipChip + Darwin.  Our dedicated analysis software uses the rich information from both the ZipChip capillary electrophoresis and mass spec domains so you can skip the finicky manual steps typically needed for biotherapeutic analysis.

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Popular FAQs

  • What is ZipChip?

    ZipChip is a front-end separation device that couples to your mass spectrometer. It joins capillary electrophoresis and electrospray ionization into a plug-and-play chip. There is minimal sample preparation and tiny injection volumes, so there is not much assistance needed by a scientist.

  • Can the ZipChip be used to analyze small and large molecules?

    The beauty of the ZipChip is that you can perform large molecule (e.g., mAb’s) analysis in the morning and transition to small molecule (e.g., amino acids) analysis in the afternoon. It’s that fuss-free! There is no need to change mobile phases or columns to accommodate a new project.

  • Can I use ZipChip to perform Native Charge Variant separations of my mAb?

    Yes! ZipChip performs native charge variant separations by capillary-zone electrophoresis mass spectrometry (CZEMS). Not only can you separate the charge variants (basic lysine 2K and 1K, 0K monomer, and acidic/deamidated species), the selectivity of the mass spectrometer allows you to determine the accurate mass of each species by deconvoluting the charge envelop of each peak.

ZipChip Resources

Customer Experience: New England Biolabs

A conversation with Sciex

A conversation with Bruker

ZipChip. Put your mass into it

Do You Know ZipChip?

DYK: ZipChip Can See Charge Variants In Degraded Antibodies?

ZipChip Demo

ZipChip Booth Chat

ZipChip Poster Chat

Application Experience: Oligonucleotides

Application Experience: Native Analysis of mAbs and ADCs

Application Experience: Detergents

Zip Through the Backlog

NIBRT presents ZipChip for biopharma characterization

Rapid, comprehensive biotherapeutics characterization

Simultaneous monitoring of amino acids and protein titer

ZipChip for Rapid and Easy Nanospray Infusions

Summary: Streamlined protein characterization and profiling

Streamline Protein Characterization and Profiling with CE-ESI-MS

Summary: Characterizing Biotherapeutics Using CE-ESI

Analysis of inhibitor-protein complexes and small molecules

Why use capillary electrophoresis

Applications

ZipChip helps you answer key questions about your most important molecules. Whether you’re analyzing biotherapeutic drug products to monitor critical quality attributes or growth media to optimize bioreactor production, ZipChip has an assay for you. From intact charge variant separations to small molecule analysis our assays are fast, sensitive, and provide unique separation abilities – all backed by the power of your mass spectrometer!

Customer Support Portal

The My 908 portal gives scientists quick access to important resources like the latest software upgrades, product guides, and training materials.

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Log in to the My 908 Customer Support Portal