Application Notes & Snapshots

ZipChip_AppNote_Thermo-Quick-Screening

Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry

This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody-drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.

Rapid characterization of oligonucleotides using microfluidic CE-MS by ZipChip

This application note presents a CE-MS analysis of oligos by a ZipChip coupled to a QExactive HF mass spectrometer. This positive ESI mode method utilizes a MS-friendly background electrolyte (BGE), that eliminates the use of ionparing agents such as hexafluoro isopropanol or alkyl amines.

ZipChip_AppNote

TN 53 – Charge variant analysis with ZipChip and maXisII

A ZipChip capillary zone electrophoresis system coupled to Bruker maXis II UHR-QTOF offers an alternative selectivity to separate charge variants prior to MS analysis and affords a more complete intact mass characterization without adding complexity or high salt eluents.

ZipChip App Note 8.5

A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics

Native charge variant analysis of biotherapeutics using ZipChip CE-ESI-MS: From comprehensive characterization to monitoring product degradation characteristics

Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer

High-Throughput Intact Mass Analysis of mAb Based Therapeutics

Analysis of Reduced mAbs and ADCs

Rapid Characterization of Intact mAb-based Biotherapeutics

Quick screening of intact antibody and ADC

ZipChip for profiling and characterization of antibody charge heterogeneity

Sciex Flexible Solution for MAM with ZipChip

Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip

Snapshot: Charge Variant Analysis

Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics

Bioreactor Monitoring via ZipChip

Snapshot: High-Throughput Intact Mass

Snapshot: High Throughput Charge Variant Analysis

Snapshot: Cell Culture Analysis

Poster

Microchip CE
MS with Integrated Solid Phase Extraction

poster_oligos_thumb

Microchip CE-MS of Oligonucleotides: What Can It Separate?

Fast Chip-CEMS for Characterization of Protein/PTM Changes

Characterization of ADCs using ZipChip

Combined Top-down and Bottom-up Proteomics

ZipChip for Glycomics and Glycoproteomics

Fast and Efficient Biopharmaceutical Characterization

Characterization of charge heterogeneity of mAb

Rapid, Multi-level Analysis of Complex Proteins

Oligonucleotide Analysis via Microfluidic CE-MS

Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF

96 Bottles of Beer: Metabolic Profiling of Spent Growth Media

Native Analysis of Monoclonal Antibodies

Characterization of Protein/PTM Changes

Native CE-MS for Biopharmaceutical Characterization

A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media

Bioprocessing of Monoclonal Antibody Based Therapies

NIBRT Presents Native MS for Charge Variants using ZipChip

NIBRT Presents ZipChip for Native Charge Heterogeneity

Monitoring Amino Acid Composition of Cell Culture Media

email Subscribe to Our Newsletter Signup to receive new product updates, technical tips and more.