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Application Notes & Snapshots

Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry
This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody-drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.

Rapid characterization of oligonucleotides using microfluidic CE-MS by ZipChip
This application note presents a CE-MS analysis of oligos by a ZipChip coupled to a QExactive HF mass spectrometer. This positive ESI mode method utilizes a MS-friendly background electrolyte (BGE), that eliminates the use of ionparing agents such as hexafluoro isopropanol or alkyl amines.

Charge variant analysis with ZipChip and maXisII
A ZipChip capillary zone electrophoresis system coupled to Bruker maXis II UHR-QTOF offers an alternative selectivity to separate charge variants prior to MS analysis and affords a more complete intact mass characterization without adding complexity or high salt eluents.

A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics

From comprehensive characterization to monitoring product degradation characteristics

Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer

High-Throughput Intact Mass Analysis of mAb Based Therapeutics

Analysis of Reduced mAbs and ADCs

Rapid Characterization of Intact mAb-based Biotherapeutics

Quick screening of intact antibody and ADC

ZipChip for profiling and characterization of antibody charge heterogeneity

Sciex Flexible Solution for MAM with ZipChip

Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip

Snapshot: Charge Variant Analysis

Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics

Bioreactor Monitoring via ZipChip

Snapshot: High-Throughput Intact Mass

Snapshot: High Throughput Charge Variant Analysis

Snapshot: Cell Culture Analysis
Brochures & Flyers

ZipChip Consumables Guide
Learn how to take the guesswork out of method development with ZipChip. Breeze through your selection in three quick steps.

Hassle-Free Oligo Characterization with ZipChip
The newly released ZipChip® oligos kit provides a simple, sensitive, dilute-and-shoot method for rapid analysis of oligonucleotides, applicable to
various sizes and modifications.

ZipChip Platform Brochure
Download our platform brochure to learn how ZipChip® platform prepares and separates a wide range of biological samples, then electrosprays them into your mass spec for analysis.

A comprehensive CE-ESI MS solution for BioPharma applications

Darwin Flyer
Case Studies

Testimonial – Zachary Kelley – University of Kentucky

Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes

Analysis to unravel biosimilarity of therapeutic proteins

Automated monitoring of amino acids in cell culture media

Highly sensitive charge variant analysis of complex biopharmaceuticals

In-depth analysis of top selling biotherapeutics
Posters

A Microchip CE-MS Based End-to-End Solution for the Analysis of Synthetic Oligonucleotides
This poster showcases a workflow using microchip CE-MS that is coupled with a vendor-neutral informatics platform
as a complete solution for the analysis of synthetic oligos.

Microchip CE-MS with Integrated Solid Phase Extraction

Microchip CE-MS of Oligonucleotides: What Can It Separate?

Fast Chip-CEMS for Characterization of Protein/PTM Changes

Characterization of ADCs using ZipChip

Combined Top-down and Bottom-up Proteomics

ZipChip for Glycomics and Glycoproteomics

Fast and Efficient Biopharmaceutical Characterization

Characterization of charge heterogeneity of mAb

Rapid, Multi-level Analysis of Complex Proteins

Oligonucleotide Analysis via Microfluidic CE-MS

Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF

96 Bottles of Beer: Metabolic Profiling of Spent Growth Media

Native Analysis of Monoclonal Antibodies

Characterization of Protein/PTM Changes

Native CE-MS for Biopharmaceutical Characterization

A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media

Bioprocessing of Monoclonal Antibody Based Therapies

NIBRT Presents Native MS for Charge Variants using ZipChip

NIBRT Presents ZipChip for Native Charge Heterogeneity
Monitoring Amino Acid Composition of Cell Culture Media
Published Articles

The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.

Identification of AAV capsid proteins

Characterization of a SRPK1/2 Inhibitor Complex

Detection and Quantification of neurotoxin β-N-methylamino-l-alanine

Characterizing Covalent CDK Inhibitor Complexes

Rapid Fingerprinting of a Highly Glycosylated Fusion Protein

Analysis of monosaccharides, oligosaccharides and glycopeptides

Metabolite Profiling Reveals Predictive Biomarkers

Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples

Characterizing Antiviral Protein-Inhibitor Complexes

Characterization of NIST mAb Proteoforms and Glycoforms

In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry

Comparative Elucidation of Cetuximab Heterogeneity on the Intact Protein Level

Characterization of Protein Assemblies Related to Cancer Proliferation

Analysis of alkaloids in plant cell cultures
Safety Data Sheet (SDS)

SDS – ZipChip Reagents: Oligos
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – Deoxyribonucleic Acid, Unmodified
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip Standard: Amino Acids
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip Interface Tray Grease
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip Reagents: Native Antibodies
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip Reagents: Charge Variant – TOF
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip BGE: Intact Antibodies
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip Diluent: Intact Antibodies
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip Acid: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip BGE: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip Diluent: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip BGE: Peptides
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.

SDS – ZipChip Diluent: Peptides
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Specification Sheets
Tech Notes

How It Works

Performance Validation Study

Using the ZipChip Infusion Function

Using Field Strength Gradients

ZipChip and Detergents

ZipChip Protocols
We have compiled this list of concise protocols and technical notes to help you facilitate high-quality science with ZipChip. Simply log in to our customer support portal to view these files and more.

Evaluation of Sample Carryover
Videos

Whiteboard Explainer: Avoiding the Stickiness of Oligo Analysis
If you have worked with oligos before, you know this can be a challenging application. Fortunately, ZipChip offers a way to make workflows faster and easier.

Customer Experience: New England Biolabs

A Conversation with Sciex

A Conversation with Bruker

ZipChip. Put your mass into it

Application Experience: Native Analysis of mAbs and ADCs

Application Experience: Detergents

DYK: ZipChip Can See Charge Variants In Degraded Antibodies?

Do You Know ZipChip?

ZipChip Demo

ZipChip Booth Chat

ZipChip Poster Chat

Application Experience: Oligonucleotides
Webinars

EPO Separation & Analysis
Straightforward separation and analysis of a highly glycosylated protein

Oligo Analysis Simplified: Get Your Answers Faster with Microchip CE-MS

Simplifying Oligonucleotide Characterization with Microchip CE-MS
In this on-demand webinar, we present a microfluidic capillary zone electrophoresis-based separation coupled with HRAM mass-spectrometry for rapid characterization of oligos in positive ionisation mode.

Analysis of inhibitor-protein complexes and small molecules

Fast Therapeutic Protein Characterization

In-depth characterization of complex monoclonal antibodies and antibody-drug conjugates with native ZipChip CE-MS

Streamline Protein Characterization and Profiling with CE-ESI-MS

Why use capillary electrophoresis

Simultaneous monitoring of amino acids and protein titer

Redefine Bioprocess Analytics

Zip Through the Backlog

ZipChip for Rapid and Easy Nanospray Infusions

Summary: Streamlined protein characterization and profiling

Rapid, comprehensive biotherapeutics characterization

NIBRT presents ZipChip for biopharma characterization
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