Gain actionable insights with real-time monitoring and control of critical bioprocess parameters to improve product quality and increase process robustness and efficiency.
Measure What Matters,
When It Matters
Real-time measurements in upstream bioprocessing are traditionally limited to just a few parameters such as pH, dissolved oxygen, temperature, and agitation speed. Other critical process parameters such as glucose, lactate, and amino acid concentrations are often based on infrequent manual sampling and at-line or off-line analysis at a core or external lab.
Driven by PAT and the demand for greater efficiency, process development teams need more data closer to the point of need.
Your Choice for Ultimate Bioprocess Monitoring and Control
Our suite of devices provides the data you need, where and when you need it.
Less Data = Greater Risk
Having long gaps between measurements hinders the ability to control a bioprocess. Critical process deviations may go unnoticed and uncorrected for hours or days.
An incomplete picture: The periodic offline glucose data points shown above paint an incomplete picture of glucose concentration trends. By contrast, the online, continuous measurement reveals much more detail and process knowledge.
Hidden process errors: Without frequent spent media analysis, errors like the misincorporation of an amino acid (shown above) would be invisible during process development
Real-time Monitoring Can Make a Big Impact on Your Process
Raman-based, in-line monitoring and control of multiple bioprocessing key process parameters in up to six bioreactors simultaneously.
For Cell Culture Media Analysis
Analyze fresh or spent media and get quantitative reports for amino acids, dipeptides, water soluble vitamins and biogenic amines.
For Glucose & Lactate
Get valuable insights and control from real-time glucose and lactate monitoring without the loss of bioreactor or fermenter volume.
For Methanol or Ethanol
Monitor methanol or ethanol and automatically control substrate feeding in microbial fermentation.
Application Report: Methanol Dialysis
The online analyzer TRACE C2 Control allows a rapid and precise determination of the methanol concentration in the fermenter and provides the tools for a quick set-up of a feed control strategy
MAVEN offers monitoring and control of glucose and lactate concentrations during cell culture and fermentation. Download this brochure to learn more.
Instant Implementation of Raman-based PAT with MAVERICK for Monitoring Glucose and Lactate
MAVERICK is easy to set up and enables instant implementation of PAT generating accurate, precise, linear and selective in-line measurements across a wide range of media used typically in mammalian (including CHO and HEK293 media) cell culture for the production of biotherapeutics.
Empowering Process Optimization for a mAb-Expressing CHO Cell Line
Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.
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