A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
Native charge variant analysis of biotherapeutics using ZipChip CE-ESI-MS: From comprehensive characterization to monitoring product degradation characteristics
Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer
High-Throughput Intact Mass Analysis of mAb Based Therapeutics
Analysis of Reduced mAbs and ADCs
Rapid Characterization of Intact mAb-based Biotherapeutics
Quick screening of intact antibody and ADC
ZipChip for profiling and characterization of antibody charge heterogeneity
Sciex Flexible Solution for MAM with ZipChip
Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip
Snapshot: Charge Variant Analysis
Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics
Bioreactor Monitoring via ZipChip
Snapshot: High-Throughput Intact Mass
Snapshot: High Throughput Charge Variant Analysis
Snapshot: Cell Culture Analysis
Comparing standard microbial media from a single supplier
Application Snapshot Booklet Fermentation
Application Snapshot Booklet Cell and Gene Therapy
Application Snapshot Booklet Biologics
How comparable are different vendors’ LB media?
High variations of analyte levels in Terrific broth (TB) media
Investigating the high nutrient variations in Super Optimal Broth
Cultures’ growth rates and productivities may differ when different vendor’s media are used in otherwise identical experiments.
Probing formulation differences in Super Optimal Broth
Similarities between different vendors’ 2X YT liquid media
Comparing standard microbial media from a single supplier
Be fast and accurate with at-line cell media analysis
At-line spent media analysis is now a reality
To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.
Differences in fresh commercially available hybridoma media
Select the best CHO media from the start
Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.
Screening of chemically-defined media for suspension cultures of HEK293 cells
Across four vendors, there was a high variation in the fresh media composition.
Analyze media without removing your mAb on the Rebel
Identify variations in dry and liquid CHO media
Running a quick fresh media assay prior to feeding the culture ensures consistency of the media components when scaling up or during the transition between liquid-to-dry media blends.
Serum supplemented media analysis is routine with the Rebel
Accelerate process development
Tease out variations in dry cell culture media
Running a simple media assay prior to feeding your cells can ensure that the composition of the media is what is expected.
Are you getting the cell culture media you expected?
Consistency between vendors should not be assumed.
Simply monitor initial vitamin levels
Supplementing RPMI media with fetal bovine serum
Supplementing IMDM media with fetal bovine serum
Conventional and chemically-defined T cell medias
Amino acid contents of Sf9 and Sf21 insect cell media
Knowledge of the insect cell metabolism coupled with an understanding of the amino acid content of the cell media allows for a more informed process development analytics strategy.
Comparing mesenchymal stem cell media with supplements on the Rebel
To ensure consistency when culturing MSCs, researchers should understand what is being added to their media.
Don’t sweat your cell media additives
Handle non-ionic surfactants in cell media samples with ease
Basal cell media with 10% fetal bovine serum
Testimonial – Zachary Kelley – University of Kentucky
Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes
Analysis to unravel biosimilarity of therapeutic proteins
Automated monitoring of amino acids in cell culture media
Highly sensitive charge variant analysis of complex biopharmaceuticals
In-depth analysis of top selling biotherapeutics
A comprehensive CE-ESI MS solution for BioPharma applications
Boost Protocol Overview
Get 20X higher sensitivity and see more charge variants than ever before!
Shift Protocol Overview
Our new Shifter Protocol allows you to analyze charge variants on your standard Thermo Scientific QE and Lumos instruments
CQAs in 7 Minutes
We make this possible with fast separations and near-instant twiddle-free data analysis. Darwin uses the rich information from both the ZipChip capillary electrophoresis and mass spec domains so you can skip the finicky manual steps typically needed for biotherapeutic analysis.
Fast Chip-CEMS for Characterization of Protein/PTM Changes
Characterization of ADCs using ZipChip
Combined Top-down and Bottom-up Proteomics
ZipChip for Glycomics and Glycoproteomics
Fast and Efficient Biopharmaceutical Characterization
Characterization of charge heterogeneity of mAb
Rapid, Multi-level Analysis of Complex Proteins
Oligonucleotide Analysis via Microfluidic CE-MS
Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF
96 Bottles of Beer: Metabolic Profiling of Spent Growth Media
Using genomic and spent media analysis to characterize stressed CHO cultures
Native Analysis of Monoclonal Antibodies
Characterization of Protein/PTM Changes
Native CE-MS for Biopharmaceutical Characterization
A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
Characterizing the Analytical Performance and Reliability of Metabolite Quantitation by an Integrated CE-MS Analyzer
Rapid Analysis of Cell Therapy Media
Rapid analysis of amino acids, water soluble vitamins, biogenic amines and dipeptides in cell growth media
Rapid at line nutrient profiling from an ammonia stressed CHO cell line
Bioprocessing of Monoclonal Antibody Based Therapies
NIBRT Presents Native MS for Charge Variants using ZipChip
NIBRT Presents ZipChip for Native Charge Heterogeneity
Monitoring Amino Acid Composition of Cell Culture Media
Identification of AAV capsid proteins
Characterization of a SRPK1/2 Inhibitor Complex
Detection and Quantification of neurotoxin β-N-methylamino-l-alanine
Characterizing Covalent CDK Inhibitor Complexes
Rapid Fingerprinting of a Highly Glycosylated Fusion Protein
Analysis of monosaccharides, oligosaccharides and glycopeptides
Metabolite Profiling Reveals Predictive Biomarkers
Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples
Characterizing Antiviral Protein-Inhibitor Complexes
Characterization of NIST mAb Proteoforms and Glycoforms
Spent Media Analysis of CHO Grown in an Ammonia-Stressed Parallel Microbioreactor Platform
In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry
Comparative Elucidation of Cetuximab Heterogeneity on the Intact Protein Level
Characterization of Protein Assemblies Related to Cancer Proliferation
Analysis of alkaloids in plant cell cultures
Quantification of metabolites in
chemically defined media:
an example of method
accuracy and reproducibility
How It Works
Performance Validation Study
Using the ZipChip Infusion Function
Using Field Strength Gradients
ZipChip and Detergents
We have compiled this list of concise protocols and technical notes to help you facilitate high-quality science with ZipChip. Simply log in to our customer support portal to view these files and more.
Evaluation of Sample Carryover
REBEL Product Video
Customer Experience: New England Biolabs
A Conversation with Sciex
A Conversation with Bruker
ZipChip. Put your mass into it
Application Experience: Native Analysis of mAbs and ADCs
Application Experience: Detergents
DYK: ZipChip Can See Charge Variants In Degraded Antibodies?
Do You Know ZipChip?
ZipChip Booth Chat
ZipChip Poster Chat
Application Experience: Oligonucleotides
Analysis of inhibitor-protein complexes and small molecules
Fast Therapeutic Protein Characterization
In-depth characterization of complex monoclonal antibodies and antibody-drug conjugates with native ZipChip CE-MS
Streamline Protein Characterization and Profiling with CE-ESI-MS
The Importance of Cell Media Analysis in Upstream Bioprocess Development
Mass Spectrometry-Based Process Analytical Technologies for Cell Therapies
Why use capillary electrophoresis
Unlocking rapid cell culture media analysis for cell and gene therapy process development
Be a REBEL with Your Cell Media Analytics
Simultaneous monitoring of amino acids and protein titer
Redefine Bioprocess Analytics
Zip Through the Backlog
ZipChip for Rapid and Easy Nanospray Infusions
Summary: Streamlined protein characterization and profiling
Rapid, comprehensive biotherapeutics characterization
Rapid at-line amino acid and nutrient profiling from bioprocess media with the Rebel
How can we accelerate PD analytics?
NIBRT presents ZipChip for biopharma characterization
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