Resource Hub
Application Notes & Snapshots
Poster Note: Bottom-up analysis of progressively larger RNAs by CZE-MS and CZE-MS/MS
This project explores the merits of CZE as a potential alternative to liquid chromatography, as the front-end separation of choice for analyzing progressively larger RNAs with a bottom-up approach.
Poster Note: Multi-Level Expeditious Characterization of AAV Capsid Proteins using ZipChip
This poster note presents a novel approach to complete characterization of capsid viral proteins using microchip CE-MS for the characterization of AAVs.
Poster Note: Rapid Characterization of Oligos Using Microchip CE-MS without Ion-Pairing Reagents
Learn how ZipChip’s ready-to-use oligos BGE solution is free from ion-pairing reagents and makes switching between applications simple and easy.
Application Report: Glucose Control
The online analyser TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.
Application Report: Ethanol Dialysis
The online analyzer TRACE C2 Control allows a rapid and precise determination of the Ethanol concentration in the fermenter.
Application Report: Methanol Dialysis
The online analyzer TRACE C2 Control allows a rapid and precise determination of the methanol concentration in the fermenter and provides the tools for a quick set-up of a feed control strategy
Application Report: Glucose & Lactate (in Small Bioreactors)
The online analyser TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside small bioreactors.
Application Report: Glucose & Lactate
The online analyzer TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.
Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry
This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody-drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.
Rapid characterization of oligonucleotides using microfluidic CE-MS by ZipChip
This application note presents a CE-MS analysis of oligos by a ZipChip coupled to a QExactive HF mass spectrometer. This positive ESI mode method utilizes a MS-friendly background electrolyte (BGE), that eliminates the use of ion-paring agents such as hexafluoro isopropanol or alkyl amines.
Charge variant analysis with ZipChip and maXisII
A ZipChip capillary zone electrophoresis system coupled to Bruker maXis II UHR-QTOF offers an alternative selectivity to separate charge variants prior to MS analysis and affords a more complete intact mass characterization without adding complexity or high salt eluents.
A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
From comprehensive characterization to monitoring product degradation characteristics
Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer
High-Throughput Intact Mass Analysis of mAb Based Therapeutics
RPMI 1640 Medium Analysis with the REBEL: Accuracy and Reproducibility Across Multiple Devices
This extensive fresh media analysis experiment provides an example of the accuracy and reproducibility of the REBEL device obtained with RPMI media.
Screening for Component Diversity in CHO Cell Culture Media
At-line amino acid analysis can speeds up cell culture media and feeding strategy optimization for bioprocess development.
Application Snapshot Booklet Fermentation
Application Snapshot Booklet Cell and Gene Therapy
Application Snapshot Booklet Cell Culture
Application Snapshot Booklet Biologics
Application Snapshot Booklet
Download our full collection of application snapshots, with focuses on biologics, CGT, and fermentation.
How comparable are different vendors’ LB media?
High variations of analyte levels in Terrific broth (TB) media
Investigating the high nutrient variations in Super Optimal Broth
Cultures’ growth rates and productivities may differ when different vendor’s media are used in otherwise identical experiments.
Probing formulation differences in Super Optimal Broth
Analysis of Reduced mAbs and ADCs
Similarities between different vendors’ 2X YT liquid media
Rapid Characterization of Intact mAb-based Biotherapeutics
Quick screening of intact antibody and ADC
Comparing standard microbial media from a single supplier
ZipChip for profiling and characterization of antibody charge heterogeneity
Sciex Flexible Solution for MAM with ZipChip
At-line spent media analysis is now a reality
To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.
Differences in fresh commercially available hybridoma media
Select the best CHO media from the start
Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.
Screening of chemically-defined media for suspension cultures of HEK293 cells
Across four vendors, there was a high variation in the fresh media composition.
Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip
Analyze media without removing your mAb on the Rebel
Identify variations in dry and liquid CHO media
Running a quick fresh media assay prior to feeding the culture ensures consistency of the media components when scaling up or during the transition between liquid-to-dry media blends.
Snapshot: Charge Variant Analysis
Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics
Serum supplemented media analysis is routine with the Rebel
Bioreactor Monitoring via ZipChip
Tease out variations in dry cell culture media
Running a simple media assay prior to feeding your cells can ensure that the composition of the media is what is expected.
Snapshot: High-Throughput Intact Mass
Snapshot: High Throughput Charge Variant Analysis
Snapshot: Cell Culture Analysis
Supplementing RPMI media with fetal bovine serum
Supplementing IMDM media with fetal bovine serum
Conventional and chemically-defined T cell medias
Amino acid contents of Sf9 and Sf21 insect cell media
Knowledge of the insect cell metabolism coupled with an understanding of the amino acid content of the cell media allows for a more informed process development analytics strategy.
Comparing mesenchymal stem cell media with supplements on the Rebel
To ensure consistency when culturing MSCs, researchers should understand what is being added to their media.
Don’t sweat your cell media additives
Handle non-ionic surfactants in cell media samples with ease
Basal cell media with 10% fetal bovine serum
Brochures & Flyers
MAVEN Brochure
MAVEN offers monitoring and control of glucose and lactate concentrations during cell culture and fermentation. Download this brochure to learn more.
REBEL Spent Media Analysis Kits
The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
ZipChip Consumables Guide
Learn how to take the guesswork out of method development with ZipChip. Breeze through your selection in three quick steps.
Hassle-Free Oligo Characterization with ZipChip
The newly released ZipChip® oligos kit provides a simple, sensitive, dilute-and-shoot method for rapid analysis of oligonucleotides, applicable to
various sizes and modifications.
ZipChip Platform Brochure
Download our platform brochure to learn how ZipChip® platform prepares and separates a wide range of biological samples, then electrosprays them into your mass spec for analysis.
A comprehensive CE-ESI MS solution for BioPharma applications
REBEL Brochure
The REBEL is a novel, dedicated cell culture media analyzer designed for rapid, easy, and efficient amino acid and nutrient analysis.
Darwin Flyer
CQAs in 7 Minutes
We make this possible with fast separations and near-instant twiddle-free data analysis. Darwin uses the rich information from both the ZipChip capillary electrophoresis and mass spec domains so you can skip the finicky manual steps typically needed for biotherapeutic analysis.
Case Studies
REBEL + ZipChip help HJB Overcome Scientific Hurdles and Optimize Processes in Biotherapeutic Development
In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
Testimonial – Zachary Kelley – University of Kentucky
Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes
Analysis to unravel biosimilarity of therapeutic proteins
Automated monitoring of amino acids in cell culture media
Highly sensitive charge variant analysis of complex biopharmaceuticals
In-depth analysis of top selling biotherapeutics
Podcasts
Posters
Automated Glucose Feeding Based On Online Glucose And Lactate Measurements
This poster note describes an automated control strategy for cell growth and biologics production. It leverages MAVEN, a reliable, easy-to-operate, online (sample-free) device for monitoring of glucose and lactate.
Process Optimization by the Use of Substrate Feeding Strategies
Online glucose monitoring is possible by using Trace C2 Control system. Feed control without online glucose monitoring causes acetate formation due to overflow metabolism.
Optimized Fed-Batch Fermentation by Use of Online Glucose Measurement
This poster presentation features an integrated multivariate glucose measuring tool combined with software solutions which allow different types of feeding-strategies.
High Frequency Glucose and Lactate Measurements in Multi-Bioreactor Vessels
TRACE C2 is an online analyzer for monitoring and controlling glucose and lactate concentrations in bioreactors. With the extension M4 it is possible to monitor Glucose and Lactate in up to four simultaneous bioprocesses.
Online-Controlling of Glucose in Cultivations and Fermentations
TRACE C2 Control is a new online analyzer for monitoring and controlling of glucose concentrations in bioprocesses. In disturbance reaction experiments and in an E.coli fermentation it can be successfully shown that a reliable control is possible.
Implementation of a New Method for Online Glucose Control in a 10L CHO Bioprocess
This poster shows how glucose concentration can be directly measured based on an enzymatic reaction. This method is then used to control the glucose level in a fed-batch fermentation at a
constant level.
Single-Use Bioreactor for High Density Bacterial Fermentation
Glucose measurement is performed on-line using the TRACE C2 analyser. This allows to follow-up glucose uptake rate and monitor fed batch culture with retro-control on the glucose pump such as maintain glucose level at predefined set point.
Optimization of Scalable rAAV Production for Gene Therapy
This poster showcases spent media analysis leveraging REBEL, which requires only 10 μL per sample and 10 minutes analysis time.
Empowering Process Optimization for a mAb-Expressing CHO Cell Line
Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.
Bottom-Up Analysis of Progressively Larger RNAs by CZE-MS and CZE-MS/MS
In this poster from ASMS 2022, researchers from University of Connecticut and Bruker showed that capillary zone electrophoresis performed on a chip proved to be an effective alternative to liquid chromatography as a front-end separation system to analyze both pure samples and complex digestion mixtures of nucleic acids.
Multi-level Expeditious Characterization of Adeno-associated Virus (AAV) Capsid Proteins Using ZipChip Microfluidic CE Coupled with HRMS
In this poster from ASMS 2022, scientists from Thermo Fisher Scientific and 908 Devices present a novel approach using microchip CE-MS for the characterization of AAVs.
A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS
In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.
Combining μSPE ZipChip CE with PRM-LIVE on a timsTOF Pro for Warp-speed Selectivity Profiling of Deubiquitinase (DUB) Small Molecule Inhibitors
In this ASMS 2022 poster, researchers from Dana Farber Cancer Institute and Harvard Medical School developed a ZipChip-based method for facilitating high-throughput identification
of new small molecule inhibitors.
Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.
CE-MS of Oligonucleotides using a ZipChip
This ASMS 2022 poster from Boehringer Ingelheim explores the use of ZipChip coupled to a high resolution mass spectrometer as an orthogonal method to chromatography for oligonucleotide analysis.
Glycosylation Profiling of mAB Subunits With CZE-MS
This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.
Rapid Characterization of Oligos and Related Impurities Using Microchip CE-MS Without Ion-pairing Reagents
This poster from ASMS 2022 describes a simple & fast method for oligonucleotide characterizations using a Microchip CE-MS platform.
Using CE-HPMS For Accelerated Process Development of a mAb-Expressing Cell Line
The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for at-line amino acid quantitation.
Pushing the Boundaries of Speed and Sensitivity in Proteomics
To overcome sample loading limitations in CE-MS, the poster authors engineered a 1 mm SPE bed within the chip geometry, allowing 100-fold improvements in concentration sensitivity limit for CE-MS.
A Broad Application of Migration Time Indexing and Metabolite Libraries to Evaluate Quantitative Coverage in Microchip CE-MS Metabolomics
In the field of metabolomics, microchip capillary electrophoresis (mCE) has a number of potential advantages over traditional liquid chromatography (LC), including higher throughput due to decreased separation times, increased separation efficiency, and lower required sample volumes.
Dynamic Range Optimization for Amino Acid Quantitation with an Integrated CE-MS Analyzer
The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for amino acid quantitation.
A Microchip CE-MS Based End-to-End Solution for the Analysis of Synthetic Oligonucleotides
This poster showcases a workflow using microchip CE-MS that is coupled with a vendor-neutral informatics platform
as a complete solution for the analysis of synthetic oligos.
Rapid at line quantitation of key nutrients in cell culture media
This poster details the benefits of coupling of miniature mass spectrometry to a microchip capillary electrophoresis platform for characterizing cell media metabolites in fresh and spent media.
Microchip CE-MS with Integrated Solid Phase Extraction
Quantitation of metabolites in classical and customized cell culture media by an integrated CE-MS Analyzer
Quantitation of metabolites in cell culture media by an integrated CE-MS analyzer for upstream process development
Microchip CE-MS of Oligonucleotides: What Can It Separate?
Fast Chip-CEMS for Characterization of Protein/PTM Changes
Characterization of ADCs using ZipChip
Combined Top-down and Bottom-up Proteomics
ZipChip for Glycomics and Glycoproteomics
Fast and Efficient Biopharmaceutical Characterization
Characterization of charge heterogeneity of mAb
Rapid, Multi-level Analysis of Complex Proteins
Oligonucleotide Analysis via Microfluidic CE-MS
Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF
96 Bottles of Beer: Metabolic Profiling of Spent Growth Media
Using genomic and spent media analysis to characterize stressed CHO cultures
Native Analysis of Monoclonal Antibodies
Characterization of Protein/PTM Changes
Native CE-MS for Biopharmaceutical Characterization
A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
Characterizing the Analytical Performance and Reliability of Metabolite Quantitation by an Integrated CE-MS Analyzer
Rapid Analysis of Cell Therapy Media
Quantitation of CHO media nutrients and metabolites in under 180 seconds
Rapid analysis of amino acids, water soluble vitamins, biogenic amines and dipeptides in cell growth media
Rapid at line nutrient profiling from an ammonia stressed CHO cell line
Bioprocessing of Monoclonal Antibody Based Therapies
NIBRT Presents Native MS for Charge Variants using ZipChip
NIBRT Presents ZipChip for Native Charge Heterogeneity
Monitoring Amino Acid Composition of Cell Culture Media
Published Articles
In-Process Analytics are Key to Successful Cell Therapy Process Optimization and Manufacturing
Considerable clinical activity and the approval of several autologous, patient-specific therapies has increased industry demand and has also highlighted bottlenecks in manufacturing workflows.
The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.
Identification of AAV capsid proteins
Characterization of a SRPK1/2 Inhibitor Complex
Detection and Quantification of neurotoxin β-N-methylamino-l-alanine
Characterizing Covalent CDK Inhibitor Complexes
Harness the Power of At-Line Spent Media Analysis (BioPharm International)
Rapid Fingerprinting of a Highly Glycosylated Fusion Protein
Analysis of monosaccharides, oligosaccharides and glycopeptides
Metabolite Profiling Reveals Predictive Biomarkers
Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples
Characterizing Antiviral Protein-Inhibitor Complexes
Characterization of NIST mAb Proteoforms and Glycoforms
Spent Media Analysis of CHO Grown in an Ammonia-Stressed Parallel Microbioreactor Platform
In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry
Comparative Elucidation of Cetuximab Heterogeneity on the Intact Protein Level
Characterization of Protein Assemblies Related to Cancer Proliferation
Analysis of alkaloids in plant cell cultures
Safety Data Sheet (SDS)
SDS – ZipChip Reagents: Oligos
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – Deoxyribonucleic Acid, Unmodified
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Standard: Amino Acids
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Interface Tray Grease
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Reagents: Native Antibodies
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Reagents: Charge Variant – TOF
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip BGE: Intact Antibodies
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Diluent: Intact Antibodies
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Acid: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip BGE: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Diluent: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip BGE: Peptides
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Diluent: Peptides
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Specification Sheets
TRACE C2 Specification Sheet
Get all the TRACE C2 specifications, including measurement range, physical dimensions, and software requirements.
MAVEN Specification Sheet
Get all the MAVEN specifications, including measurement range, physical dimensions, and software requirements.
ZipChip Hardware Specification Sheet
The compact interface seamlessly integrates all fluidics and electronics. Just clip it on your mass spec and off you go!
ZipChip Consumables Specification Sheet
Premixed background electrolyte and sample diluent reduce preparation time for your samples. With ZipChip you just dilute and shoot!
REBEL Specifications Sheet
Get quantitative identification and analysis on a panel of >30 analytes including key amino acids, biogenic amines, and water soluble vitamins.
Tech Notes
How It Works
Performance Validation Study
Using the ZipChip Infusion Function
Using Field Strength Gradients
ZipChip and Detergents
ZipChip Protocols
We have compiled this list of concise protocols and technical notes to help you facilitate high-quality science with ZipChip. Simply log in to our customer support portal to view these files and more.
Evaluation of Sample Carryover
Technical Papers
Tech Note: Glucose & Lactate Dialysis (Low)
These data were compiled in order to give an overview of typical system and sensor performance in the low concentration range using the dialysis-low sampling method. Operational temperature in the bioreactor was set to 37°C.
Tech Note: Glucose & Lactate Dialysis
These data were compiled in order to give an overview of the system and sensor performance in the normal concentration range using the dialysis sampling method.
Tech Note: Pressure Stability of the Dialysis Probe
The TRACE dialysis probe can be safely used in large reactors. Its dialysis membrane does not suffer from higher pressure due to hydrostatic and/ or pressurized conditions.
Tech Note: Interference of Other Sugars on Glucose and Lactate Measurements
Most sugars have no influence on glucose measurement. The only exception is mannose, which shows a low positive interference on the glucose measurement.
Videos
ZipChip Customer Experience: Symphogen
Listen to Dan Bach Kristensen, a principal scientist at Symphogen, as he shares how ZipChip helps him with charge variant separation.
REBEL Customer Experience: Clemson University
Listen to Stephanie Klaubert, a graduate research assistant from Clemson University, as she shares how REBEL helps her with process development and cell culture optimization.
Conference Talk: Power Up Your Process Control (BPI 2022)
Graziella Piras spoke at BPI 2022 about how amino acids can present a goldilocks problem for bioprocessing: too little and they starve; too much and they favor growth over protein production.
Interview: The Unprecedented Potential of CE-MS for Proteomics
Recorded at ASMS 2022, Michael MacCoss from the University of Washington and Will Thompson from 908 Devices discuss how ZipChip is addressing key challenges in proteomics, and its potential in diagnostics, investigating bacterial proteomes, and metabolite analysis.
Interview: The Key to Unsolved Insights into RNA Characterization?
Recorded at ASMS 2022, Dan Fabris from the University of Connecticut shares his experience with RNA characterization using ZipChip.
Interview: Oligonucleotide Analysis with ZipChip at Boehringer Ingelheim
Recorded at ASMS 2022, Vladimir Papov shares his experience with oligo analysis using ZipChip.
Whiteboard Explainer: Avoiding the Stickiness of Oligo Analysis
If you have worked with oligos before, you know this can be a challenging application. Fortunately, ZipChip offers a way to make workflows faster and easier.
MAVEN Product Video
If glucose and lactate measurements run your lab’s schedule, it’s time to meet MAVEN.
REBEL Product Video
Customer Experience: New England Biolabs
A Conversation with Sciex
A Conversation with Bruker
ZipChip. Put your mass into it
Application Experience: Native Analysis of mAbs and ADCs
Application Experience: Detergents
DYK: ZipChip Can See Charge Variants In Degraded Antibodies?
Poster Chat: Spent Media Analysis of CHO
Do You Know ZipChip?
Rapid at-line nutrient profiling from an ammonia stressed CHO cell line
ZipChip Demo
ZipChip Booth Chat
Booth Chat
Demo Video
ZipChip Poster Chat
Application Experience: Oligonucleotides
Rapid analysis of amino acids, water soluble vitamins, biogenic amines and dipeptides in cell growth media
Webinars
Now Starts Now: The Future of Glucose & Lactate Measurement
Learn how MAVEN addresses the challenges of on-line nutrient and metabolite monitoring and control.
Harness the Power of At-Line Spend Media Analysis to Optimize a CHO mAb Fed-Batch Process
This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.
A Versatile Platform for Small Molecules, Intact Proteins & Beyond
ZipChip can be used for applications ranging from proteins and peptides in biopharmaceuticals, to oligonucleotides and AAVs in cell and gene therapy applications.
Multi-Component At-Line Cell Culture Media Analysis
In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.
Power up your process control with rapid at line MS-based key nutrient monitoring
Graziella Piras, bioprocess segment director for 908 Devices, spoke at BPI Europe 2022 on the benefits of at-line nutrient monitoring.
The Critical Role of Cell Culture Media Analysis in CGT Development
Does cell culture analysis matter for CGT development? This short webinar explores what is already known, reviews at-line methods for cell culture media analysis, and shares recent data from two case studies.
Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data
Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.
Process Modeling with Researchers from Johns Hopkins University
Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization
EPO Separation & Analysis
Straightforward separation and analysis of a highly glycosylated protein
Oligo Analysis Simplified: Get Your Answers Faster with Microchip CE-MS
![[Webinar] Bioprocess 101: Cell Culture Media Analysis](https://908devices.com/wp-content/uploads/2022/01/9080151_Bioprocess101-Cell-Culture-Analysis_R1-300x300.jpg)
Ask the Expert: Bioprocess 101 – Cell Culture Media Analysis
Process Intensification: Do You Have All the Data You Need When You Need It?
The need for process intensification and implementation of Bioprocess 4.0 requires extensive real time data acquisition and process modelling. At line MS-based technologies presented here provide key cellular metabolic and protein quality data in real time to support process intensification and modelling.
Simplifying Oligonucleotide Characterization with Microchip CE-MS
In this on-demand webinar, we present a microfluidic capillary zone electrophoresis-based separation coupled with HRAM mass-spectrometry for rapid characterization of oligos in positive ionisation mode.
Analysis of inhibitor-protein complexes and small molecules
Fast Therapeutic Protein Characterization
In-depth characterization of complex monoclonal antibodies and antibody-drug conjugates with native ZipChip CE-MS
Streamline Protein Characterization and Profiling with CE-ESI-MS
The Importance of Cell Media Analysis in Upstream Bioprocess Development
Watch this discussion with experts from industry and academia as they discuss bioprocessing trends relating to cell culture media analysis.
Mass Spectrometry-Based Process Analytical Technologies for Cell Therapies
Why use capillary electrophoresis
Unlocking rapid cell culture media analysis for cell and gene therapy process development
Be a REBEL with Your Cell Media Analytics
Simultaneous monitoring of amino acids and protein titer
Redefine Bioprocess Analytics
Zip Through the Backlog
ZipChip for Rapid and Easy Nanospray Infusions
Summary: Streamlined protein characterization and profiling
Rapid, comprehensive biotherapeutics characterization
Rapid at-line amino acid and nutrient profiling from bioprocess media with the REBEL
How can we accelerate PD analytics?
NIBRT presents ZipChip for biopharma characterization
White Papers
Microchip CE-MS: A Powerful Tool for Biotherapeutic Characterization
To help explain the power of this game-changing technology, we partnered with LCGC on a new ebook that covers the topic in-depth.
‘What’s In Your Media?’ Ebook
Learn about the critical role of cell culture media analysis in biotherapeutics development, including biologics and cell and gene therapies.
Summary: Characterizing Biotherapeutics Using CE-ESI
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