Continuous Monitoring and Control of Glucose and Lactate With MAVEN: Impact on Cell Culture Performance and Protein Quality

Glucose and lactate are critical process parameters in bioprocessing. Measuring these parameters is part of every bioprocess run, but often the measurements are limited to daily sampling, leaving much granularity of the bioprocess uncovered. Monitoring glucose and lactate automatically, in real-time, supports bioprocess characterization with enhanced process understanding and enables proactive management of cell culture. In this application note, we describe the monitoring of glucose and lactate using MAVEN, an on-line, biosensor-based device with an in-situ sample probe and real-time measurements.