Application Notes & Snapshots

Application Report: Glucose Control

Application Report: Glucose Control

The online analyser TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.

Application Report: Ethanol Dialysis

Application Report: Ethanol Dialysis

The online analyzer TRACE C2 Control allows a rapid and precise determination of the Ethanol concentration in the fermenter.

Application Report: Methanol Dialysis

The online analyzer TRACE C2 Control allows a rapid and precise determination of the methanol concentration in the fermenter and provides the tools for a quick set-up of a feed control strategy

Application Report: Glucose and Lactate (in Small Bioreactors)

Application Report: Glucose & Lactate (in Small Bioreactors)

The online analyser TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside small bioreactors.

Application Report: Glucose & Lactate

Application Report: Glucose & Lactate

The online analyzer TRACE C2 Control allows a rapid and precise determination of glucose and lactate concentrations inside the bioreactor.

Glucose and Lactate Raman-Based Monitoring with MAVERICK: Performance in Spent Media

MAVERICK provides a plug-and-play, in-line, Raman based PAT solution for monitoring and control of glucose, lactate, and biomass in up to 6 bioreactors. This Application Snapshot shows the results from experiments to demonstrate the selectivity of glucose and lactate measurements from MAVERICK in complex spent media samples from CHO and HEK293 cultures.

Posters

Maven Poster Note

Automated Glucose Feeding Based On Online Glucose And Lactate Measurements

This poster note describes an automated control strategy for cell growth and biologics production. It leverages MAVEN, a reliable, easy-to-operate, online (sample-free) device for monitoring of glucose and lactate.

Process Optimization by the Use of Substrate Feeding Strategies

Online glucose monitoring is possible by using Trace C2 Control system. Feed control without online glucose monitoring causes acetate formation due to overflow metabolism.

Optimized Fed-Batch Fermentation by Use of Online Glucose Measurement

This poster presentation features an integrated multivariate glucose measuring tool combined with software solutions which allow different types of feeding-strategies.

High Frequency Glucose and Lactate Measurements in Multi-Bioreactor Vessels

TRACE C2 is an online analyzer for monitoring and controlling glucose and lactate concentrations in bioreactors. With the extension M4 it is possible to monitor Glucose and Lactate in up to four simultaneous bioprocesses.

Online-Controlling of Glucose in Cultivations and Fermentations

TRACE C2 Control is a new online analyzer for monitoring and controlling of glucose concentrations in bioprocesses. In disturbance reaction experiments and in an E.coli fermentation it can be successfully shown that a reliable control is possible.

Implementation of a New Method for Online Glucose Control in a 10L CHO Bioprocess

This poster shows how glucose concentration can be directly measured based on an enzymatic reaction. This method is then used to control the glucose level in a fed-batch fermentation at a
constant level.

Single-Use Bioreactor for High Density Bacterial Fermentation: Evaluation of the CELL-tainer® Bioreactor

Single-Use Bioreactor for High Density Bacterial Fermentation

Glucose measurement is performed on-line using the TRACE C2 analyser. This allows to follow-up glucose uptake rate and monitor fed batch culture with retro-control on the glucose pump such as maintain glucose level at predefined set point.

Empowering Process Optimization

Empowering Process Optimization for a mAb-Expressing CHO Cell Line

Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.

CE-HPMS for Accelerated Process Development

Using CE-HPMS For Accelerated Process Development of a mAb-Expressing Cell Line

The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for at-line amino acid quantitation.

Dynamic Range Optimization for Amino Acid Quantification

Dynamic Range Optimization for Amino Acid Quantitation with an Integrated CE-MS Analyzer

The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for amino acid quantitation.

Poster-BPI-West-2022

Rapid at line quantitation of key nutrients in cell culture media

This poster details the benefits of coupling of miniature mass spectrometry to a microchip capillary electrophoresis platform for characterizing cell media metabolites in fresh and spent media.

Webinars

In-line Monitoring of Bioprocess Analysis Parameters for the 21st Century

Now Starts Now: MAVEN Webinar

Now Starts Now: The Future of Glucose & Lactate Measurement

Learn how MAVEN addresses the challenges of on-line nutrient and metabolite monitoring and control.

Harness the Power of At-Line Spent Media Analysis

Reduce Process Development Timelines and Improve Productivity

This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.

Enabling Faster Feed Strategy Optimization with Rapid Spent Media Analysis and Data Visualization Tools

Lower Costs, Accelerate Productivity and Time-to-Market with Fast Analytical Tools

Learn how to take charge of your bioprocess development via at-line amino acid analysis empowered by a dedicated bioprocess software tool.

Multi-Component At-Line Cell Culture Media Analysis

Know your Cells Nutrient Requirements and Accelerate Media Development Timelines

In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.

BPI Europe 2022 - Power Up Your Process Control

Add the Missing Pieces to your Predictive Model with Rapid Amino Acid Profiling

Graziella Piras, bioprocess segment director for 908 Devices, spoke at BPI Europe 2022 on the benefits of at-line nutrient monitoring.

Add the Missing Pieces to your Predictive Model for Smarter DOEs

Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.

Process Modeling with Researchers from Johns Hopkins University

Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization

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