Posters

Process Optimization by the Use of Substrate Feeding Strategies

Online glucose monitoring is possible by using Trace C2 Control system. Feed control without online glucose monitoring causes acetate formation due to overflow metabolism.

Optimized Fed-Batch Fermentation by Use of Online Glucose Measurement

This poster presentation features an integrated multivariate glucose measuring tool combined with software solutions which allow different types of feeding-strategies.

High Frequency Glucose and Lactate Measurements in Multi-Bioreactor Vessels

TRACE C2 is an online analyzer for monitoring and controlling glucose and lactate concentrations in bioreactors. With the extension M4 it is possible to monitor Glucose and Lactate in up to four simultaneous bioprocesses.

Online-Controlling of Glucose in Cultivations and Fermentations

TRACE C2 Control is a new online analyzer for monitoring and controlling of glucose concentrations in bioprocesses. In disturbance reaction experiments and in an E.coli fermentation it can be successfully shown that a reliable control is possible.

Implementation of a New Method for Online Glucose Control in a 10L CHO Bioprocess

This poster shows how glucose concentration can be directly measured based on an enzymatic reaction. This method is then used to control the glucose level in a fed-batch fermentation at a
constant level.

Single-Use Bioreactor for High Density Bacterial Fermentation: Evaluation of the CELL-tainer® Bioreactor

Single-Use Bioreactor for High Density Bacterial Fermentation

Glucose measurement is performed on-line using the TRACE C2 analyser. This allows to follow-up glucose uptake rate and monitor fed batch culture with retro-control on the glucose pump such as maintain glucose level at predefined set point.

Empowering Process Optimization

Empowering Process Optimization for a mAb-Expressing CHO Cell Line

Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.

CE-HPMS for Accelerated Process Development

Using CE-HPMS For Accelerated Process Development of a mAb-Expressing Cell Line

The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for at-line amino acid quantitation.

Dynamic Range Optimization for Amino Acid Quantification

Dynamic Range Optimization for Amino Acid Quantitation with an Integrated CE-MS Analyzer

The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for amino acid quantitation.

Poster-BPI-West-2022

Rapid at line quantitation of key nutrients in cell culture media

This poster details the benefits of coupling of miniature mass spectrometry to a microchip capillary electrophoresis platform for characterizing cell media metabolites in fresh and spent media.

Webinars

Harness the Power of At-Line Spent Media Analysis

Harness the Power of At-Line Spend Media Analysis to Optimize a CHO mAb Fed-Batch Process

This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.

Multi-Component At-Line Cell Culture Media Analysis

Multi-Component At-Line Cell Culture Media Analysis

In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.

BPI Europe 2022 - Power Up Your Process Control

Power up your process control with rapid at line MS-based key nutrient monitoring

Graziella Piras, bioprocess segment director for 908 Devices, spoke at BPI Europe 2022 on the benefits of at-line nutrient monitoring.

Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data

Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.

Process Modeling with Researchers from Johns Hopkins University

Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization

Process Intensification: Do You Have All the Data You Need When You Need It?

The need for process intensification and implementation of Bioprocess 4.0 requires extensive real time data acquisition and process modelling. At line MS-based technologies presented here provide key cellular metabolic and protein quality data in real time to support process intensification and modelling.

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