Posters

Poster Note: Bottom-up analysis of progressively larger RNAs by CZE-MS and CZE-MS/MS

This project explores the merits of CZE as a potential alternative to liquid chromatography, as the front-end separation of choice for analyzing progressively larger RNAs with a bottom-up approach.

Poster Note: Multi-Level Expeditious Characterization of AAV Capsid Proteins using ZipChip

This poster note presents a novel approach to complete characterization of capsid viral proteins using microchip CE-MS for the characterization of AAVs.

Poster Note: Rapid Characterization of Oligos Using Microchip CE-MS without Ion-Pairing Reagents

Learn how ZipChip’s ready-to-use oligos BGE solution is free from ion-pairing reagents and makes switching between applications simple and easy.

Process Optimization by the Use of Substrate Feeding Strategies

Online glucose monitoring is possible by using Trace C2 Control system. Feed control without online glucose monitoring causes acetate formation due to overflow metabolism.

Optimized Fed-Batch Fermentation by Use of Online Glucose Measurement

This poster presentation features an integrated multivariate glucose measuring tool combined with software solutions which allow different types of feeding-strategies.

High Frequency Glucose and Lactate Measurements in Multi-Bioreactor Vessels

TRACE C2 is an online analyzer for monitoring and controlling glucose and lactate concentrations in bioreactors. With the extension M4 it is possible to monitor Glucose and Lactate in up to four simultaneous bioprocesses.

Online-Controlling of Glucose in Cultivations and Fermentations

TRACE C2 Control is a new online analyzer for monitoring and controlling of glucose concentrations in bioprocesses. In disturbance reaction experiments and in an E.coli fermentation it can be successfully shown that a reliable control is possible.

Implementation of a New Method for Online Glucose Control in a 10L CHO Bioprocess

This poster shows how glucose concentration can be directly measured based on an enzymatic reaction. This method is then used to control the glucose level in a fed-batch fermentation at a
constant level.

Single-Use Bioreactor for High Density Bacterial Fermentation: Evaluation of the CELL-tainer® Bioreactor

Single-Use Bioreactor for High Density Bacterial Fermentation

Glucose measurement is performed on-line using the TRACE C2 analyser. This allows to follow-up glucose uptake rate and monitor fed batch culture with retro-control on the glucose pump such as maintain glucose level at predefined set point.

Optimization of Scalable rAAV

Optimization of Scalable rAAV Production for Gene Therapy

This poster showcases spent media analysis leveraging REBEL, which requires only 10 μL per sample and 10 minutes analysis time.

Empowering Process Optimization

Empowering Process Optimization for a mAb-Expressing CHO Cell Line

Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.

ASMS2022 ThP362 Poster

Bottom-Up Analysis of Progressively Larger RNAs by CZE-MS and CZE-MS/MS

In this poster from ASMS 2022, researchers from University of Connecticut and Bruker showed that capillary zone electrophoresis performed on a chip proved to be an effective alternative to liquid chromatography as a front-end separation system to analyze both pure samples and complex digestion mixtures of nucleic acids.

ASMS2022 ThP360 Poster

Multi-level Expeditious Characterization of Adeno-associated Virus (AAV) Capsid Proteins Using ZipChip Microfluidic CE Coupled with HRMS

In this poster from ASMS 2022, scientists from Thermo Fisher Scientific and 908 Devices present a novel approach using microchip CE-MS for the characterization of AAVs.

ASMS2022 WP233 Poster

A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS

In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.

ASMS2022 WP144 Poster

Combining μSPE ZipChip CE with PRM-LIVE on a timsTOF Pro for Warp-speed Selectivity Profiling of Deubiquitinase (DUB) Small Molecule Inhibitors

In this ASMS 2022 poster, researchers from Dana Farber Cancer Institute and Harvard Medical School developed a ZipChip-based method for facilitating high-throughput identification
of new small molecule inhibitors.

ASMS2022 WP044 Poster

Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers

In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.

ASMS2022 WP396 Poster

CE-MS of Oligonucleotides using a ZipChip

This ASMS 2022 poster from Boehringer Ingelheim explores the use of ZipChip coupled to a high resolution mass spectrometer as an orthogonal method to chromatography for oligonucleotide analysis.

ASMS2022 TP025 Poster

Glycosylation Profiling of mAB Subunits With CZE-MS

This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.

Rapid Characterization of Oligos and Related Impurities Using Microchip CE-MS Without Ion-pairing Reagents

This poster from ASMS 2022 describes a simple & fast method for oligonucleotide characterizations using a Microchip CE-MS platform.

CE-HPMS for Accelerated Process Development

Using CE-HPMS For Accelerated Process Development of a mAb-Expressing Cell Line

The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for at-line amino acid quantitation.

Pushing the Boundaries of Speed and Sensitivity in Proteomics

To overcome sample loading limitations in CE-MS, the poster authors engineered a 1 mm SPE bed within the chip geometry, allowing 100-fold improvements in concentration sensitivity limit for CE-MS.

ASMS2022 MP347 Poster

A Broad Application of Migration Time Indexing and Metabolite Libraries to Evaluate Quantitative Coverage in Microchip CE-MS Metabolomics

In the field of metabolomics, microchip capillary electrophoresis (mCE) has a number of potential advantages over traditional liquid chromatography (LC), including higher throughput due to decreased separation times, increased separation efficiency, and lower required sample volumes.

Dynamic Range Optimization for Amino Acid Quantification

Dynamic Range Optimization for Amino Acid Quantitation with an Integrated CE-MS Analyzer

The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for amino acid quantitation.

A Microchip CE-MS Based End-to-End Solution for the Analysis of Synthetic Oligonucleotides

This poster showcases a workflow using microchip CE-MS that is coupled with a vendor-neutral informatics platform
as a complete solution for the analysis of synthetic oligos.

Poster-BPI-West-2022

Rapid at line quantitation of key nutrients in cell culture media

This poster details the benefits of coupling of miniature mass spectrometry to a microchip capillary electrophoresis platform for characterizing cell media metabolites in fresh and spent media.

Microchip CE-MS with Integrated Solid Phase Extraction

Quantitation of metabolites in classical and customized cell culture media by an integrated CE-MS Analyzer

Quantitation of metabolites in cell culture media by an integrated CE-MS analyzer for upstream process development

Microchip CE-MS of Oligonucleotides: What Can It Separate?

Fast Chip-CEMS for Characterization of Protein/PTM Changes

Characterization of ADCs using ZipChip

Combined Top-down and Bottom-up Proteomics

ZipChip for Glycomics and Glycoproteomics

Fast and Efficient Biopharmaceutical Characterization

Characterization of charge heterogeneity of mAb

Rapid, Multi-level Analysis of Complex Proteins

Oligonucleotide Analysis via Microfluidic CE-MS

Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF

96 Bottles of Beer: Metabolic Profiling of Spent Growth Media

Using genomic and spent media analysis to characterize stressed CHO cultures

Native Analysis of Monoclonal Antibodies

Characterization of Protein/PTM Changes

Native CE-MS for Biopharmaceutical Characterization

A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media

Characterizing the Analytical Performance and Reliability of Metabolite Quantitation by an Integrated CE-MS Analyzer

Rapid Analysis of Cell Therapy Media

Quantitation of CHO media nutrients and metabolites in under 180 seconds

Rapid analysis of amino acids, water soluble vitamins, biogenic amines and dipeptides in cell growth media

Rapid at line nutrient profiling from an ammonia stressed CHO cell line

Bioprocessing of Monoclonal Antibody Based Therapies

NIBRT Presents Native MS for Charge Variants using ZipChip

NIBRT Presents ZipChip for Native Charge Heterogeneity

Monitoring Amino Acid Composition of Cell Culture Media

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