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Application Notes & Snapshots

Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry
This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody-drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.

A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics

From comprehensive characterization to monitoring product degradation characteristics

Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer

High-Throughput Intact Mass Analysis of mAb Based Therapeutics

Analysis of Reduced mAbs and ADCs

Rapid Characterization of Intact mAb-based Biotherapeutics

Quick screening of intact antibody and ADC

ZipChip for profiling and characterization of antibody charge heterogeneity

Sciex Flexible Solution for MAM with ZipChip

Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip

Snapshot: Charge Variant Analysis

Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics

Bioreactor Monitoring via ZipChip

Snapshot: High-Throughput Intact Mass

Snapshot: High Throughput Charge Variant Analysis

Snapshot: Cell Culture Analysis
Brochures & Flyers

MAVEN Brochure
MAVEN offers monitoring and control of glucose and lactate concentrations during cell culture and fermentation. Download this brochure to learn more.

ZipChip Platform Brochure
Download our platform brochure to learn how ZipChip® platform prepares and separates a wide range of biological samples, then electrosprays them into your mass spec for analysis.

A comprehensive CE-ESI MS solution for BioPharma applications

Darwin Flyer
Case Studies
Posters

Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.

Glycosylation Profiling of mAB Subunits With CZE-MS
This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.

Microchip CE-MS with Integrated Solid Phase Extraction

Fast Chip-CEMS for Characterization of Protein/PTM Changes

Characterization of ADCs using ZipChip

Fast and Efficient Biopharmaceutical Characterization

Characterization of charge heterogeneity of mAb

Rapid, Multi-level Analysis of Complex Proteins

Oligonucleotide Analysis via Microfluidic CE-MS

Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF

Native Analysis of Monoclonal Antibodies

Characterization of Protein/PTM Changes

Native CE-MS for Biopharmaceutical Characterization

A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media

Characterizing the Analytical Performance and Reliability of Metabolite Quantitation by an Integrated CE-MS Analyzer

Bioprocessing of Monoclonal Antibody Based Therapies

NIBRT Presents Native MS for Charge Variants using ZipChip

NIBRT Presents ZipChip for Native Charge Heterogeneity
Published Articles

The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.

Identification of AAV capsid proteins

Characterization of a SRPK1/2 Inhibitor Complex

Characterizing Covalent CDK Inhibitor Complexes

Harness the Power of At-Line Spent Media Analysis (BioPharm International)

Rapid Fingerprinting of a Highly Glycosylated Fusion Protein

Analysis of monosaccharides, oligosaccharides and glycopeptides

Metabolite Profiling Reveals Predictive Biomarkers

Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples

Characterizing Antiviral Protein-Inhibitor Complexes

Characterization of NIST mAb Proteoforms and Glycoforms

In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry

Comparative Elucidation of Cetuximab Heterogeneity on the Intact Protein Level

Characterization of Protein Assemblies Related to Cancer Proliferation

Analysis of alkaloids in plant cell cultures
Safety Data Sheet (SDS)
Specification Sheets

MAVEN Specification Sheet
Get all the MAVEN specifications, including measurement range, physical dimensions, and software requirements.

ZipChip Hardware Specification Sheet
The compact interface seamlessly integrates all fluidics and electronics. Just clip it on your mass spec and off you go!

ZipChip Consumables Specification Sheet
Premixed background electrolyte and sample diluent reduce preparation time for your samples. With ZipChip you just dilute and shoot!
Tech Notes

Performance Validation Study

Using the ZipChip Infusion Function

Using Field Strength Gradients

ZipChip and Detergents

ZipChip Protocols
We have compiled this list of concise protocols and technical notes to help you facilitate high-quality science with ZipChip. Simply log in to our customer support portal to view these files and more.

Evaluation of Sample Carryover
Videos
Interview: The Key to Unsolved Insights into RNA Characterization?
Recorded at ASMS 2022, Dan Fabris from the University of Connecticut shares his experience with RNA characterization using ZipChip.

MAVEN Product Video
If glucose and lactate measurements run your lab’s schedule, it’s time to meet MAVEN.

Customer Experience: New England Biolabs

A Conversation with Sciex

Application Experience: Native Analysis of mAbs and ADCs

DYK: ZipChip Can See Charge Variants In Degraded Antibodies?

ZipChip Poster Chat

Application Experience: Oligonucleotides
Webinars

Now Starts Now: The Future of Glucose & Lactate Measurement
Learn how MAVEN addresses the challenges of on-line nutrient and metabolite monitoring and control.

Benefits of Real-time Analytics to Overcome Common Cell Culture Challenges
MAVEN gives you optimized, automated, don’t-even-sweat-it control of glucose and lactate concentrations in cell culture and fermentation.

EPO Separation & Analysis
Straightforward separation and analysis of a highly glycosylated protein

Analysis of inhibitor-protein complexes and small molecules

Fast Therapeutic Protein Characterization

In-depth characterization of complex monoclonal antibodies and antibody-drug conjugates with native ZipChip CE-MS

Streamline Protein Characterization and Profiling with CE-ESI-MS

Why use capillary electrophoresis

Be a REBEL with Your Cell Media Analytics

Simultaneous monitoring of amino acids and protein titer

Redefine Bioprocess Analytics

Zip Through the Backlog

ZipChip for Rapid and Easy Nanospray Infusions

Summary: Streamlined protein characterization and profiling

Rapid, comprehensive biotherapeutics characterization

NIBRT presents ZipChip for biopharma characterization
White Papers
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