Bioprocess Online Webinar
Webinar Date: Tuesday, April 9, 2024
Webinar Time: 11 AM EST / 8 AM PST
Although empirical Raman spectroscopy models are convenient because of the ‘black box’ design, they may prove impractical. In complex upstream bioprocesses, you may find that these are insufficiently robust for deployment as Process Analytical Technology (PAT) solutions. However, the MAVERICK platform, utilizes Raman technology with a de novo approach. This operates as effortlessly as a pH-meter, providing real-time measurements of key process parameters such as glucose, lactate, and biomass. Additionally, it offers access to top-notch, complete-spectrum Raman data, facilitating comprehensive bioprocess development.
Register today for the upcoming BioProcess Online Webinar to learn more and join the discussion.
The first part of the webinar explains how MAVERICK employs physics-based de novo model for real-time monitoring and control of upstream process parameters.
In the second part of the webinar, learn how this technology was readily deployed in CHO cell cultures monitoring and control without any bioprocess-specific model building. We implemented a strategy of continuous dynamic feeding to enhance process performance and circumvent conditions recognized to adversely impact product quality.
Key Takeaways:
- MAVERICK, a novel Raman spectroscopy -based PAT solution that can be easily deployed without bioprocess-specific model building
- Operational mechanism of MAVERICK and foundation of its measurement
- Example of implementing MAVERICK for continuous CHO feed control, including novel feeding approach
Meet the Speakers
Dr. Stephen Driscoll
Senior Scientist, Algorithms
908 Devices
Dr. Stephen Driscoll is a senior scientist at 908 Devices, specializing in the development and application of multivariate algorithms. He obtained his PhD from Dalhousie University, where he studied under the guidance of Professor Peter Wentzell. During his doctoral research, Dr. Driscoll focused on the advancement of algorithms and evaluation techniques for multivariate chemical subspace estimation. With a strong foundation in mathematical modeling and algorithm development, Dr. Driscoll now applies his expertise at 908 Devices. He continues to push the boundaries of multivariate analysis by further refining existing algorithms and spearheading the development of novel approaches.
Dr. Stephanie Klaubert
Senior Scientist, Bioreactor Operations
908 Devices
Dr. Stephanie Klaubert is a senior scientist at 908 Devices, focusing on bioreactor operations. She obtained her PhD from Clemson University under the advisement of Dr. Sarah W. Harcum, where her research explored modalities of productivity and critical quality attributes in fed-batch Chinese Hamster Ovary (CHO) cell cultures. At 908 Devices, Dr. Klaubert conducts bioreactor experimentation to demonstrate the capabilities of various novel on-line, in-line, and at-line process analytical technology (PAT) devices.