The International Foundation Process Analytical Chemistry is a world-wide, not-for-profit organization dedicated to the advancement of Process Analytical Technology and Chemistry.
The organization provides a dynamic platform for the interaction of ideas and sharing of information between industry, research institutions, government agencies, and the manufacturers/suppliers of Process Analytical Chemistry and Technology. The ultimate goal is to understand and control the manufacturing process.
Look for Us in Booth 511 with Culture Bioscience
Process Analytical Technology is one of the most exciting and important advanced technology areas meeting both the current challenges, as well as the future needs of the industry. Each year the IFPAC Scientific Board consisting of industry, regulatory, and academic leaders works collaboratively to create a comprehensive program that addresses important mainstay topics, as well as the latest trends, technologies, and applications.
Learn more about this conference.
We are Joining Culture Bioscience at Booth 511
We look forward to highlighting real-time monitoring of key bioprocess parameters using MAVERICK in-line device in Culture Biosciences’ cloud-connected bioreactors.
Read about it before you arrive.
Advanced Biomanufacturing Technology & Innovation Stream
Profiling of complex metabolite panels in bioprocess development and optimization with micro-scale separations and mass spectrometry for PAT
The value of metabolite profiling and metabolomics in bioprocess development and optimization has been extensively discussed and demonstrated in the literature. Studies have shown that such approaches are critical to further understand cell metabolism to achieve higher productivities and process robustness through cell engineering and media/feed development/optimization. However these approaches are hindered by the complexity of applying mass spectroscopy type analysis in the bioprocessing lab.
In this talk we’ll discuss contemporary approaches for rapid at-line quantitative media characterization across highly multiplexed panels. The capabilities of miniature MS systems for at line panel assays, and deeper characterization with rapid high performance MS methods will be reviewed.
Smart Sensors in Bio-Processing Stream
Raman-based bioprocess control with generalizable de novo modeling
Raman technology has enjoyed increasing attention for bioprocess process parameter and product characterization. The appeal of a simple optical in-situ probe for multi-parameter evaluation is obvious, but the OPEX associated with robust multivariate model development often dwarfs the expense of the hardware itself. Considerable expertise is required in the nuances of the spectroscopic modality, the interplay of chemistry, physics and environmental factors, not to mention the details of multivariate model development and validation. This has limited adoption of raman technology to later stages of process development under the expert supervision of specialist PAT groups, which also greatly limits the amount of early-phase process diversity data that can be acquired to inform later-stage development.
In this talk we’ll discuss recent advances in a raman platform built to scale from early phase PD to GMP implementation, and facilitate both monitoring and control. This initiative necessitated the development of de novo data analytic approaches with far greater agility than traditional empirical multivariate calibration approaches, to generalize across cell lines, media systems, and reactor scales. In this talk we’ll discuss the key elements of de novo approaches from a foundational and practical perspective, along with their advantages and as importantly, limitations. Case studies from multiple cell lines, media systems and scales will be leveraged to highlight figures of merit. We’ll also discuss the opportunity to integrate metabolic and process engineering models with raman-based de novo methods for even more productive process understanding.
Our latest device MAVERICK enables real-time in-line bioprocess analysis (bioreactor monitoring) and control. Monitor key process parameters in up to six bioreactors simultaneously. Experience Process Analytical Technology (PAT) made easy.