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[post_content] =>
AA analysis is not regularly performed in CAR T-cell experiments due to the complexity and sample volume limitations of traditional methods, but the REBEL device enables rapid analysis, low sample volume requirements and without the need for prior mass spectrometry expertise. Learn how to optimize your cell culture media for enhanced CAR T-cell therapy manufacturing.
[post_title] => Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack-Manufactured CAR T-Cells
[post_excerpt] => This work presented demonstrates a possible correlation between CAR T-cell activation, nutrient metabolism, and efficacy.
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[post_title] => Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry
[post_excerpt] => This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.
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[post_title] => Glucose and Lactate Raman-Based Monitoring With MAVERICK: Performance in Spent Media
[post_excerpt] => MAVERICK provides a plug-and-play, in-line, Raman based PAT solution for monitoring and control of glucose, lactate, and biomass in up to 6 bioreactors. This Application Snapshot shows the results from experiments to demonstrate the selectivity of glucose and lactate measurements from MAVERICK in complex spent media samples from CHO and HEK293 cultures.
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[post_title] => A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
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[post_title] => From comprehensive characterization to monitoring product degradation characteristics
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[post_title] => Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer
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[post_title] => High-Throughput Intact Mass Analysis of mAb Based Therapeutics
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[post_title] => Analysis of Reduced mAbs and ADCs
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[post_title] => Rapid Characterization of Intact mAb-based Biotherapeutics
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[post_title] => ZipChip for profiling and characterization of antibody charge heterogeneity
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[post_title] => Sciex Flexible Solution for MAM with ZipChip
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AA analysis is not regularly performed in CAR T-cell experiments due to the complexity and sample volume limitations of traditional methods, but the REBEL device enables rapid analysis, low sample volume requirements and without the need for prior mass spectrometry expertise. Learn how to optimize your cell culture media for enhanced CAR T-cell therapy manufacturing.
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Application Notes & Snapshots
Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack-Manufactured CAR T-Cells
This work presented demonstrates a possible correlation between CAR T-cell activation, nutrient metabolism, and efficacy.
REBEL
Application Notes & Snapshots
Download
Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry
This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.
ZipChip
Application Notes & Snapshots
Download
Glucose and Lactate Raman-Based Monitoring With MAVERICK: Performance in Spent Media
MAVERICK provides a plug-and-play, in-line, Raman based PAT solution for monitoring and control of glucose, lactate, and biomass in up to 6 bioreactors. This Application Snapshot shows the results from experiments to demonstrate the selectivity of glucose and lactate measurements from MAVERICK in complex spent media samples from CHO and HEK293 cultures.
MAVERICK
Application Notes & Snapshots
Download
A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
ZipChip
Application Notes & Snapshots
Download
From comprehensive characterization to monitoring product degradation characteristics
ZipChip
Application Notes & Snapshots
Download
Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer
ZipChip
Application Notes & Snapshots
Download
High-Throughput Intact Mass Analysis of mAb Based Therapeutics
ZipChip
Application Notes & Snapshots
Download
Analysis of Reduced mAbs and ADCs
ZipChip
Application Notes & Snapshots
Download
Rapid Characterization of Intact mAb-based Biotherapeutics
ZipChip
Application Notes & Snapshots
Download
Quick screening of intact antibody and ADC
ZipChip
Application Notes & Snapshots
Download
ZipChip for profiling and characterization of antibody charge heterogeneity
ZipChip
Application Notes & Snapshots
Download
Sciex Flexible Solution for MAM with ZipChip
ZipChip
Application Notes & Snapshots
Download
At-line spent media analysis is now a reality
To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.
REBEL
Application Notes & Snapshots
Download
Differences in fresh commercially available hybridoma media
REBEL
Application Notes & Snapshots
Download
Select the best CHO media from the start
Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.
REBEL
Application Notes & Snapshots
Download
Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip
ZipChip
Application Notes & Snapshots
Download
Analyze media without removing your mAb on the Rebel
REBEL
Application Notes & Snapshots
Download
Identify variations in dry and liquid CHO media
Running a quick fresh media assay prior to feeding the culture ensures consistency of the media components when scaling up or during the transition between liquid-to-dry media blends.
REBEL
Application Notes & Snapshots
Download
Snapshot: Charge Variant Analysis
ZipChip
Application Notes & Snapshots
Download
Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics
ZipChip
Application Notes & Snapshots
Download
Bioreactor Monitoring via ZipChip
ZipChip
Application Notes & Snapshots
Download
Snapshot: High-Throughput Intact Mass
ZipChip
Application Notes & Snapshots
Download
Snapshot: High Throughput Charge Variant Analysis
ZipChip
Application Notes & Snapshots
Download
Snapshot: Cell Culture Analysis
ZipChip
Application Notes & Snapshots
Download
Don’t sweat your cell media additives
REBEL
Application Notes & Snapshots
Download
Handle non-ionic surfactants in cell media samples with ease
REBEL
Application Notes & Snapshots
Download
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Brochures & Flyers
MAVEN Brochure
MAVEN offers monitoring and control of glucose and lactate concentrations during cell culture and fermentation. Download this brochure to learn more.
MAVEN
Brochures & Flyers
Download
REBEL Spent Media Analysis Kits
The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
REBEL
Brochures & Flyers
Download
MAVERICK Brochure
Real-time bioprocess monitoring and control, right out of the box. In-line measurements of multiple critical parameters across media, across processes, across mammalian cell lines, across scales.
MAVERICK
Brochures & Flyers
Download
A comprehensive CE-ESI MS solution for BioPharma applications
ZipChip
Brochures & Flyers
Download
REBEL Brochure
The REBEL is a novel, dedicated cell culture media analyzer designed for rapid, easy, and efficient amino acid and nutrient analysis.
REBEL
Brochures & Flyers
Download
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Case Studies
Analysis to unravel biosimilarity of therapeutic proteins
ZipChip
Case Studies
Download
Automated monitoring of amino acids in cell culture media
ZipChip
Case Studies
Download
Highly sensitive charge variant analysis of complex biopharmaceuticals
ZipChip
Case Studies
Download
In-depth analysis of top selling biotherapeutics
ZipChip
Case Studies
Download
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Case Studies & Testimonials
Interview: The Key to Unsolved Insights into RNA Characterization?
Recorded at ASMS 2022, Dan Fabris from the University of Connecticut shares his experience with RNA characterization using ZipChip.
ZipChip
Case Studies & Testimonials
Testimonials
Download
Analysis to unravel biosimilarity of therapeutic proteins
ZipChip
Case Studies
Download
Automated monitoring of amino acids in cell culture media
ZipChip
Case Studies
Download
Highly sensitive charge variant analysis of complex biopharmaceuticals
ZipChip
Case Studies
Download
In-depth analysis of top selling biotherapeutics
ZipChip
Case Studies
Download
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[post_title] => Rapid In-Depth Characterization of Biologics by Microchip CE-MS: mAbs, AAVs and Nucleic Acids
[post_excerpt] => Microchip capillary electrophoresis (CE) coupled with mass spectrometry (MS) has revolutionized the characterization of therapeutic modalities in biopharmaceuticals. Here, we present the applications of an integrated workflow that couples the microfluidic CE system (ZipChip) with MS in characterization of biotherapeutics. This was poster A03 at BPS Europe 2024.
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[post_title] => Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis - Mass Spectrometry (CE-MS)
[post_excerpt] => Presenting a novel strategy for characterization of therapeutic peptides was developed based on microchip CE-MS and linkage-specific derivatization. This poster was presented in collaboration with Ningbo University at ASMS 2023 as poster TP544.
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[post_title] => Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
[post_excerpt] => N-glycan profiling is a critical step of biopharmaceuticals analysis as N-glycans play an important part in both activity and safety of monoclonal antibodies and other glycosylated biotherapeutics. This poster was presented at ASMS 2023 as poster MP291.
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[post_title] => Automated Glucose Feeding Based On Online Glucose And Lactate Measurements
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[post_title] => Empowering Process Optimization for a mAb-Expressing CHO Cell Line
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[post_title] => A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS
[post_excerpt] => In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.
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[post_title] => Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
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[post_title] => Glycosylation Profiling of mAB Subunits With CZE-MS
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[post_title] => Fast Chip-CEMS for Characterization of Protein/PTM Changes
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Posters
Rapid In-Depth Characterization of Biologics by Microchip CE-MS: mAbs, AAVs and Nucleic Acids
Microchip capillary electrophoresis (CE) coupled with mass spectrometry (MS) has revolutionized the characterization of therapeutic modalities in biopharmaceuticals. Here, we present the applications of an integrated workflow that couples the microfluidic CE system (ZipChip) with MS in characterization of biotherapeutics. This was poster A03 at BPS Europe 2024.
ZipChip
Posters
Download
Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis – Mass Spectrometry (CE-MS)
Presenting a novel strategy for characterization of therapeutic peptides was developed based on microchip CE-MS and linkage-specific derivatization. This poster was presented in collaboration with Ningbo University at ASMS 2023 as poster TP544.
ZipChip
Posters
Download
Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
N-glycan profiling is a critical step of biopharmaceuticals analysis as N-glycans play an important part in both activity and safety of monoclonal antibodies and other glycosylated biotherapeutics. This poster was presented at ASMS 2023 as poster MP291.
ZipChip
Posters
Download
Automated Glucose Feeding Based On Online Glucose And Lactate Measurements
This poster note describes an automated control strategy for cell growth and biologics production. It leverages MAVEN, a reliable, easy-to-operate, online (sample-free) device for monitoring of glucose and lactate.
MAVEN
Posters
Download
Empowering Process Optimization for a mAb-Expressing CHO Cell Line
Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.
REBEL
Posters
Download
A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS
In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.
ZipChip
Posters
Download
Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.
ZipChip
Posters
Download
Glycosylation Profiling of mAB Subunits With CZE-MS
This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.
ZipChip
Posters
Download
Microchip CE-MS with Integrated Solid Phase Extraction
ZipChip
Posters
Download
Fast Chip-CEMS for Characterization of Protein/PTM Changes
ZipChip
Posters
Download
Characterization of ADCs using ZipChip
ZipChip
Posters
Download
Fast and Efficient Biopharmaceutical Characterization
ZipChip
Posters
Download
Characterization of charge heterogeneity of mAb
ZipChip
Posters
Download
Rapid, Multi-level Analysis of Complex Proteins
ZipChip
Posters
Download
Oligonucleotide Analysis via Microfluidic CE-MS
ZipChip
Posters
Download
Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF
ZipChip
Posters
Download
Native Analysis of Monoclonal Antibodies
ZipChip
Posters
Download
Characterization of Protein/PTM Changes
ZipChip
Posters
Download
Native CE-MS for Biopharmaceutical Characterization
ZipChip
Posters
Download
A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
REBEL
ZipChip
Posters
Download
Bioprocessing of Monoclonal Antibody Based Therapies
ZipChip
Posters
Download
NIBRT Presents Native MS for Charge Variants using ZipChip
ZipChip
Posters
Download
NIBRT Presents ZipChip for Native Charge Heterogeneity
ZipChip
Posters
Download
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Published Articles
The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.
ZipChip
Published Articles
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Identification of AAV capsid proteins
ZipChip
Published Articles
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Characterization of a SRPK1/2 Inhibitor Complex
ZipChip
Published Articles
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Characterizing Covalent CDK Inhibitor Complexes
ZipChip
Published Articles
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Harness the Power of At-Line Spent Media Analysis (BioPharm International)
REBEL
Published Articles
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Rapid Fingerprinting of a Highly Glycosylated Fusion Protein
ZipChip
Published Articles
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Analysis of monosaccharides, oligosaccharides and glycopeptides
ZipChip
Published Articles
Download
Metabolite Profiling Reveals Predictive Biomarkers
ZipChip
Published Articles
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Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples
ZipChip
Published Articles
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Characterizing Antiviral Protein-Inhibitor Complexes
ZipChip
Published Articles
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Characterization of NIST mAb Proteoforms and Glycoforms
ZipChip
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Spent Media Analysis of CHO Grown in an Ammonia-Stressed Parallel Microbioreactor Platform
REBEL
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In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry
ZipChip
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Comparative Elucidation of Cetuximab Heterogeneity on the Intact Protein Level
ZipChip
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Characterization of Protein Assemblies Related to Cancer Proliferation
ZipChip
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Analysis of alkaloids in plant cell cultures
ZipChip
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Safety Data Sheet (SDS)
SDS – ZipChip Standard: Amino Acids
ZipChip
Safety Data Sheet (SDS)
Download
SDS – ZipChip Interface Tray Grease
ZipChip
Safety Data Sheet (SDS)
Download
SDS – ZipChip Acid: Metabolites
ZipChip
Safety Data Sheet (SDS)
Download
SDS – ZipChip BGE: Metabolites
ZipChip
Safety Data Sheet (SDS)
Download
SDS – ZipChip Diluent: Metabolites
ZipChip
Safety Data Sheet (SDS)
Download
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Specification Sheets
MAVEN Specification Sheet
Get all the MAVEN specifications, including measurement range, physical dimensions, and software requirements.
MAVEN
Specification Sheets
Download
MAVERICK Product Specification Sheet
Get all the MAVERICK specifications including applications, physical dimensions, and more.
MAVERICK
Specification Sheets
Download
ZipChip Hardware Specification Sheet
The compact interface seamlessly integrates all fluidics and electronics. Just clip it on your mass spec and off you go!
ZipChip
Specification Sheets
Download
ZipChip Consumables Specification Sheet
Premixed background electrolyte and sample diluent reduce preparation time for your samples. With ZipChip you just dilute and shoot!
ZipChip
Specification Sheets
Download
REBEL Specifications Sheet
Get quantitative identification and analysis on a panel of >30 analytes including key amino acids, biogenic amines, and water soluble vitamins.
REBEL
Specification Sheets
Download
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Tech Notes
Instant Implementation of Raman-based PAT With MAVERICK for Monitoring Glucose and Lactate
MAVERICK is easy to set up and enables instant implementation of PAT generating accurate, precise, linear and selective in-line measurements across a wide range of media used typically in mammalian (including CHO and HEK293 media) cell culture for the production of biotherapeutics.
MAVERICK
Tech Notes
Download
Determining Total Cell Count With MAVERICK Biomass Measurements
MAVERICK provides an in-line, Raman-based PAT solution for monitoring and control of glucose, lactate, and biomass in up to six bioreactors right out of the box.
MAVERICK
Tech Notes
Download
Performance Validation Study
ZipChip
Tech Notes
Download
Using the ZipChip Infusion Function
ZipChip
Tech Notes
Download
Using Field Strength Gradients
ZipChip
Tech Notes
Download
ZipChip and Detergents
ZipChip
Tech Notes
Download
ZipChip Protocols
We have compiled this list of concise protocols and technical notes to help you facilitate high-quality science with ZipChip. Simply log in to our customer support portal to view these files and more.
ZipChip
Tech Notes
Download
Evaluation of Sample Carryover
ZipChip
Tech Notes
Download
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Ready to easily start your bioprocess run?
Get fast, in-line analysis of critical process parameters in minutes. These videos show you how easy it is to set up MAVERICK and start your bioprocess run. MAVERICK is powered by Raman spectroscopy and a purpose-built de novo model that automatically processes spectra from a wide variety of media types and cell lines. There's no modeling or development required. With MAVERICK, you can quickly develop cell culture media and design feeding and control strategies.
Calibrate
Autoclave
Start Bioprocess Run
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Videos
Save Time Using ZipChip
Hear from 908 Devices, Kelly Biggers, Life Sciences Field Sales Manager on how you can save time in your lab and prioritize your time by using ZipChip.
ZipChip
Videos
Watch Video
Protein Characterization With ZipChip
Hear from 908 Devices, Kelly Biggers, Life Sciences Field Sales Manager on the benefits of using ZipChip for protein characterization in your lab.
ZipChip
Videos
Watch Video
Get to Market Faster With MAVERICK
Hear from 908 Devices, Dan Corcoran Life Sciences Field Sales Manager on the feedback received from current customers using MAVERICK in their lab.
MAVERICK
Videos
Watch Video
Bioprocessing International Interview
Bioprocess International interviews with Kevin J. Knopp, CEO of 908 Devices, on our bioprocessing devices, specifically MAVERICK. With MAVERICK, your team can stay at the forefront of Bioprocessing 4.0 and fully harness the advantages of real-time in-line bioprocess analysis and control to get to market faster.
MAVERICK
Videos
Watch Video
MAVERICK Demo: Ready to Go in Minutes
Watch these MAVERICK demos to see how easy it is to start a bioprocess run.
MAVERICK
Videos
Watch Video
MAVERICK: Raman-based Monitoring of Multiple Critical Parameters, Ready to Go in Minutes
MAVERICK is powered by Raman spectroscopy and purpose-built de novo model for simultaneous real-time measurements of multiple key process parameters in mammalian cell cultures without the costs, complexities, and risks of conventional methods.
MAVERICK
Videos
Watch Video
MAVERICK: Monitoring of Multiple Bioprocess Parameters Right Out of the Box
There’s no need to deal with complex empirical calibration models, reagents, or unreliable auto-sampling systems to implement in-line bioreactor monitoring.
MAVERICK
Videos
Watch Video
MAVEN Product Video
If glucose and lactate measurements run your lab’s schedule, it’s time to meet MAVEN.
MAVEN
Videos
Watch Video
REBEL Product Video
REBEL
Videos
Watch Video
Customer Experience: New England Biolabs
ZipChip
Videos
Watch Video
A Conversation with Sciex
ZipChip
Videos
Watch Video
Application Experience: Native Analysis of mAbs and ADCs
ZipChip
Videos
Watch Video
DYK: ZipChip Can See Charge Variants In Degraded Antibodies?
ZipChip
Videos
Watch Video
REBEL Booth Chat
REBEL
Videos
Watch Video
REBEL Demo
REBEL
Videos
Watch Video
ZipChip Poster Chat
ZipChip
Videos
Watch Video
Application Experience: Oligonucleotides
ZipChip
Videos
Watch Video
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About this Webinar
In this webinar, we discuss the implementation of MAVERICK for continuous CHO feed control, including novel feeding approach. While empirical Raman spectroscopy models are convenient due to their 'black box' properties, they may prove impractical and insufficiently robust for deployment as Process Analytical Technology (PAT) solutions in complex upstream bioprocesses. In contrast, the MAVERICK platform, based on Raman technology with a de novo approach, operates as effortlessly as a pH-meter, providing real-time measurements of key process parameters such as glucose, lactate, and biomass.
[post_title] => Instant Implementation of Raman-based Monitoring and Control for Key Upstream Bioprocessing Parameters
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About this Webinar
Drs. Chris Brown and Graziella Piras provide information about a new and transformative means to instantly implement in-line monitoring for multiple key process parameters, right out of the box.
It’s been nearly 20 years since the FDA and EMA published guidelines on process analytical technologies (PAT) to drive the advancement of Biopharma 4.0, with the ultimate aim of predictive control and Quality by Design. Over the years several multivariate optical sensing technologies have demonstrated tremendous promise for in-line continuous monitoring of a range of parameters. These technologies offer the promise of hands-off, non-destructive, and easy-to-integrate multi-parameter analysis with feedback control loop. Yet, they often require substantial expert configuration and set-up time that can take months or years, and substantial expense. In this webinar, review the current state of several optical technology approaches and their associated strengths and limitations. A new platform that greatly accelerates successful implementation of in-line monitoring of key bioprocess parameters is discussed.
Key Takeaways:
- Current state of state-of-the-art in-line upstream bioprocess analytics
- A new solution overcoming major hurdles of implementation of in-line multivariate bioprocess analysis
[post_title] => In-line Monitoring of Bioprocess Analysis Parameters for the 21st Century
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[post_title] => Rapid Clone Screening of Biosimilar Candidates Using Microfluidic CE-MS
[post_excerpt] => In this GEN webinar, our expert speakers, Erin Redman, PhD, and Ruben Cageling, will describe how the ZipChip microfluidic CE-MS technology enables rapid early-stage clone screening for biotherapeutics development. They will present a case study where the ZipChip was used to select clonal cell lines based on their charge variants and glycosylation profile. Furthermore, they will also highlight the new CVA kit, which enabled better separation and sensitivity in charge variant analysis of biotherapeutics.
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[post_title] => Now Starts Now: The Future of Glucose & Lactate Measurement
[post_excerpt] => Learn how MAVEN addresses the challenges of on-line nutrient and metabolite monitoring and control.
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[post_title] => Harness the Power of At-line Spend Media Analysis using the REBEL to Optimize a CHO mAb Fed-batch Process
[post_excerpt] => This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.
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[post_title] => Enabling Faster Feed Strategy Optimization with Rapid Spent Media Analysis and Data Visualization Tools
[post_excerpt] => Learn how to take charge of your bioprocess development via at-line amino acid analysis empowered by a dedicated bioprocess software tool.
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About this Webinar
Faster development cycles, intensified processes, and automation of process control are key initiatives in biotherapeutics manufacturing. However, monitoring critical and time-sensitive process parameters are commonly used for offline analytics, requiring manual intervention.
In this webinar, explore a new, automated approach for optimal growth and production. This new approach leverages sensitive, on-line (sample-free) monitoring of glucose and lactate with automated feed control. Understand its impact on growth/viability, lower toxic metabolite, and improved PQA.
Key Takeaways
- Explore strategies to reduce toxic metabolites, achieve higher yield and improve product quality through continuous monitoring and dynamic control of substrate feeding.
- Discover how selective flow-diffusion technology enables highly sensitive and accurate online measurements of glucose and lactate.
- Learn from case studies in cell culture and fermentation upstream applications.
Meet the Speaker
Nick Randall
As the Bioprocessing Product Manager at 908 Devices, Nick Randall is passionate about empowering and supporting customers at the forefront of biotechnology development. He has ten years of experience as a cross-functional scientist specializing in process and product development, operations, manufacturing, automation, and analytical technologies. Nick attempts to leverage this experience to help develop and launch products with critical-to-life applications.
[post_title] => Benefits of Real-time Analytics to Overcome Common Cell Culture Challenges
[post_excerpt] => MAVEN gives you optimized, automated, don’t-even-sweat-it control of glucose and lactate concentrations in cell culture and fermentation.
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[post_title] => Multi-Component At-Line Cell Culture Media Analysis for Accelerated Process Development of a mAb-Expressing Cell Line
[post_excerpt] => In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.
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[post_title] => Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data
[post_excerpt] => Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.
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[post_name] => biopharma-4-0-finding-opportunities-to-leverage-new-at-line-data
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[post_content] =>
Controlling Essential Amino Acid Levels in CHO Cell Cultures Using A Genome-Scale Nutrient Minimization Forecast Algorithm
Our own Milla Neffling moderates a discussion with three authors of a recent peer-reviewed article in Biotechnology & Bioengineering. The 18-minute discussion ranges from the importance of process modeling to the critical role of new tools like REBEL.
Key Discussion Points:
- How media optimization strategies evolved to help the biopharma industry
- The benefit of genome-scale models
- The importance of input data quality
- The relevance of amino acids and their importance in genome-scale models
Speakers:
Michael Betenbaugh, Ph.D
Professor,
Johns Hopkins University
Yiqun Chen, Ph.D
Graduate Student,
Johns Hopkins University
Ji Young Anderson
Sr. Scientist,
908 Devices
Milla Neffling
Bioprocessing Segment Manager
908 Devices
[post_title] => Process Modeling with Researchers from Johns Hopkins University
[post_excerpt] => Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization
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[post_title] => EPO Separation & Analysis
[post_excerpt] => Straightforward separation and analysis of a highly glycosylated protein
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[post_title] => Ask the Expert: Bioprocess 101 - Cell Culture Media Analysis
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[post_title] => Analysis of inhibitor-protein complexes and small molecules
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[post_title] => Fast Therapeutic Protein Characterization
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[post_title] => In-depth characterization of complex monoclonal antibodies and antibody-drug conjugates with native ZipChip CE-MS
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[post_title] => Streamline Protein Characterization and Profiling with CE-ESI-MS
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About this Webinar
In this webinar, we discuss the implementation of MAVERICK for continuous CHO feed control, including novel feeding approach. While empirical Raman spectroscopy models are convenient due to their 'black box' properties, they may prove impractical and insufficiently robust for deployment as Process Analytical Technology (PAT) solutions in complex upstream bioprocesses. In contrast, the MAVERICK platform, based on Raman technology with a de novo approach, operates as effortlessly as a pH-meter, providing real-time measurements of key process parameters such as glucose, lactate, and biomass.
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Webinars On Demand
Instant Implementation of Raman-based Monitoring and Control for Key Upstream Bioprocessing Parameters
MAVERICK
Webinars On Demand
Watch Webinar
In-line Monitoring of Bioprocess Analysis Parameters for the 21st Century
MAVERICK
Webinars On Demand
Watch Webinar
Rapid Clone Screening of Biosimilar Candidates Using Microfluidic CE-MS
In this GEN webinar, our expert speakers, Erin Redman, PhD, and Ruben Cageling, will describe how the ZipChip microfluidic CE-MS technology enables rapid early-stage clone screening for biotherapeutics development. They will present a case study where the ZipChip was used to select clonal cell lines based on their charge variants and glycosylation profile. Furthermore, they will also highlight the new CVA kit, which enabled better separation and sensitivity in charge variant analysis of biotherapeutics.
ZipChip
Webinars On Demand
Watch Webinar
Now Starts Now: The Future of Glucose & Lactate Measurement
Learn how MAVEN addresses the challenges of on-line nutrient and metabolite monitoring and control.
MAVEN
Webinars On Demand
Watch Webinar
Harness the Power of At-line Spend Media Analysis using the REBEL to Optimize a CHO mAb Fed-batch Process
This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.
REBEL
Webinars On Demand
Watch Webinar
Enabling Faster Feed Strategy Optimization with Rapid Spent Media Analysis and Data Visualization Tools
Learn how to take charge of your bioprocess development via at-line amino acid analysis empowered by a dedicated bioprocess software tool.
REBEL
Webinars On Demand
Watch Webinar
Benefits of Real-time Analytics to Overcome Common Cell Culture Challenges
MAVEN gives you optimized, automated, don’t-even-sweat-it control of glucose and lactate concentrations in cell culture and fermentation.
MAVEN
Webinars On Demand
Watch Webinar
Multi-Component At-Line Cell Culture Media Analysis for Accelerated Process Development of a mAb-Expressing Cell Line
In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.
REBEL
Webinars On Demand
Watch Webinar
Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data
Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.
REBEL
Webinars On Demand
Watch Webinar
Process Modeling with Researchers from Johns Hopkins University
Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization
REBEL
Webinars On Demand
Watch Webinar
EPO Separation & Analysis
Straightforward separation and analysis of a highly glycosylated protein
ZipChip
Webinars On Demand
Watch Webinar
![[Webinar] Bioprocess 101: Cell Culture Media Analysis](https://908devices.com/wp-content/uploads/2022/01/9080151_Bioprocess101-Cell-Culture-Analysis_R1-300x300.jpg)
Ask the Expert: Bioprocess 101 – Cell Culture Media Analysis
REBEL
Webinars On Demand
Watch Webinar
Analysis of inhibitor-protein complexes and small molecules
ZipChip
Webinars On Demand
Watch Webinar
Fast Therapeutic Protein Characterization
ZipChip
Webinars On Demand
Watch Webinar
In-depth characterization of complex monoclonal antibodies and antibody-drug conjugates with native ZipChip CE-MS
ZipChip
Webinars On Demand
Watch Webinar
Streamline Protein Characterization and Profiling with CE-ESI-MS
ZipChip
Webinars On Demand
Watch Webinar
Why Use Capillary Electrophoresis
ZipChip
Webinars On Demand
Watch Webinar
Be a REBEL with Your Cell Media Analytics
REBEL
Webinars On Demand
Watch Webinar
Simultaneous monitoring of amino acids and protein titer
ZipChip
Webinars On Demand
Watch Webinar
Redefine Bioprocess Analytics
REBEL
ZipChip
Webinars On Demand
Watch Webinar
Zip Through the Backlog
ZipChip
Webinars On Demand
Watch Webinar
ZipChip for Rapid and Easy Nanospray Infusions
ZipChip
Webinars On Demand
Watch Webinar
Summary: Streamlined Protein Characterization and Profiling with CE-ESI-MS
ZipChip
Webinars On Demand
Watch Webinar
Rapid, comprehensive biotherapeutics characterization
ZipChip
Webinars On Demand
Watch Webinar
NIBRT presents ZipChip for biopharma characterization
In this webinar NIBRT demonstrates ZipChip’s ease of use and flexibility from the control of upstream processes to downstream biotherapeutics characterisation.
ZipChip
Webinars On Demand
Watch Webinar
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Learn About Advantages Over Traditional Chemometrics Models
Read about the seven reasons why Raman spectroscopy with PLS models is challenging for bioprocess applications. Learn how MAVERICK's purpose-built de novo model eliminates the need for complex empirical calibration models, reagents, or unreliable auto-sampling systems for in-line bioreactor monitoring. This white paper is written in summary of the white paper “De novo Approaches for Bioprocess Parameter Estimation”. Please view the full version for detailed explanations, figures, and references.
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White Papers
De novo Models for Raman: Comparison to and Advantages Over Traditional Chemometrics Models
Learn how the de novo model eliminates the need for complex empirical calibration models, reagents, or unreliable auto-sampling systems for in-line bioreactor monitoring.
MAVERICK
White Papers
Download
‘What’s In Your Media?’ Ebook
Learn about the critical role of cell culture media analysis in biotherapeutics development, including biologics and cell and gene therapies.
REBEL
White Papers
Download
Summary: Characterizing Biotherapeutics Using CE-ESI
ZipChip
White Papers
Download
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