In-line Monitoring of Bioprocess Analysis Parameters for the 21st Century

Drs. Chris Brown and Graziella Piras provide information about a new and transformative means to instantly implement in-line monitoring for multiple key process parameters, right out of the box. 

It’s been nearly 20 years since the FDA and EMA published guidelines on process analytical technologies (PAT) to drive the advancement of Biopharma 4.0, with the ultimate aim of predictive control and Quality by Design. Over the years several multivariate optical sensing technologies have demonstrated tremendous promise for in-line continuous monitoring of a range of parameters. These technologies offer the promise of hands-off, non-destructive, and easy-to-integrate multi-parameter analysis with feedback control loop. Yet, they often require substantial expert configuration and set-up time that can take months or years, and substantial expense. In this webinar, review the current state of several optical technology approaches and their associated strengths and limitations. A new platform that greatly accelerates successful implementation of in-line monitoring of key bioprocess parameters is discussed.

  • Current state of state-of-the-art in-line upstream bioprocess analytics
  • A new solution overcoming major hurdles of implementation of in-line multivariate bioprocess analysis

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