Real-time Monitoring of Key Bioprocess Parameters Using MAVERICK In-line Device in Culture Biosciences’ Cloud-connected Bioreactors

Bioprocessing 4.0 aims to leverage advanced digital technologies, automation, and data-driven approaches to transform biopharmaceutical production. The data generated utilizing Culture Bioscience’s bioreactors, cloud-based controllers and software console together with MAVERICK, a novel Raman spectroscopy powered in-line PAT device, was found to track closely with off-line measurements for multiple critical process parameters. The use of PAT in bioreactors provides in-line, continuous data about cell culture conditions, thereby enhancing process understanding and enabling precise bioprocess monitoring and control.