Continuous Monitoring and Control of Glucose and Lactate with MAVEN: Impact on Cell Culture Performance and Protein Quality

Traditional sampling methods limit process insight, but MAVEN allows for continuous measurement and control of these parameters, enhancing bioprocess optimization.

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This document discusses the critical roles of glucose and lactate in bioprocessing, emphasizing the benefits of real-time monitoring using MAVEN. Traditional sampling methods limit process insight, but MAVEN allows for continuous measurement and control of these parameters, enhancing bioprocess characterization and management. The experiments demonstrated that a continuous glucose feeding strategy improves cell culture viability and product quality compared to daily bolus feeding. In particular, MAVEN prevented culture crashes and reduced high-mannose glycan levels in monoclonal antibodies, which can influence efficacy and stability. Overall, MAVEN facilitates more precise control and optimization of bioprocesses, leading to improved outcomes.