Streamlining mAb Quality Assessment Throughout the Bioprocess with ZipChip-MS

About this Webinar

Understanding how bioprocess changes impact product quality is crucial for successful biopharmaceutical development. However, frequent data collection across the entire bioprocess can be a significant challenge for analytical teams.

This webinar explores a streamlined solution for acquiring critical mAb quality attributes, including charge variant profiles, sequence identity, glycosylation profiles, and glycation levels. We will demonstrate a simple “dilute-and-shoot” analysis utilizing ZipChip capillary electrophoresis coupled with high-resolution mass spectrometry.

Furthermore, we will present a case study comparing CHO fed-batch processes with traditional daily bolus glucose feeding and a 2g/L dynamic glucose feed strategy, enabled by MAVEN monitoring and control. This study highlights the clear impact of process feeding strategies on product quality profiles.

Presenters

• Erin Redman, PhD, Principal Scientist, 908 Devices
• Graziella Piras, PhD, Senior Director of Strategic Marketing, Life Science, 908 Devices

Key Takeaways:

• Streamline mAb product quality assessment throughout bioprocess runs.
• Gain insights into charge variant profiles, sequence identity, glycosylation profiles, and glycation levels.
• Understand the link between process feeding strategies and product quality.
• Learn how bioprocess monitoring enables control, such as stabilizing glucose levels at 2g/L via MAVEN control to reduce glycation.
• Explore the benefits of both off-line analytical and on-line process analytical technology (PAT) solutions.
• Discover the efficiency of the dilute-and-shoot ZipChip-MS CVA workflow for frequent measurements.