Data-driven Feed Strategy Optimization and Scale-up of mAb-expressing CHO Cell Line Bioprocess
This poster explores utilizing micro-bioreactors for expedited biologics production development, highlighting challenges with limited sample volume for media analysis and proposing real-time, point-of-need analytical tools for efficient CCM optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
Biologics production development for intensified processes aims to achieve desired product quality attributes and high productivity. Running multiple micro-bioreactors in parallel enables expedited optimization, but low microbioreactor volumes limit the media available for daily sampling for analysis. Cell culture media (CCM) optimization can be a lengthy and complex process involving multiple DOEs. Fast, at the point-of-need, analytical tools with only minimal sample consumption, are required to assess key-nutrient consumption and provide feedback to enable feed strategy optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
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