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[post_date] => 2024-09-09 13:14:46
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[post_content] =>
Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis.
This poster was a collaboration with Terumo Blood and Cell Technologies and was part of the poster program at the 2024 ISCT EU Conference.
[post_title] => Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
[post_excerpt] => The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding, characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
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[post_title] => Microchip CE-MS Analysis of Nucleic Acids – From Characterization of Synthetic Oligonucleotides to Sequence Mapping of RNAs
[post_excerpt] => This work will showcase how the ZipChip enables a simple and rapid workflow for the analysis of nucleic acids with noion-pairing reagents needed This poster was highlighted at the 2024 TIDES Conference.
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[post_name] => microchip-ce-ms-analysis-of-nucleic-acids-from-characterization-of-synthetic-oligonucleotides-to-sequence-mapping-of-rnas
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[post_title] => Investigation of Drug-To-Antibody Ratio for FORCE Oligonucleotide Conjugates Using Microchip CE-MS
[post_excerpt] => ZipChip microchip CE-MS resolves DAR species electrophoretically and enables generation of superior MS spectra. This poster was presented as a collaboration with Dyne Therapeutics at ASMS 2023 as poster WP045.
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[post_name] => investigation-of-drug-to-antibody-ratio
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[post_title] => In-depth Characterization of Adeno-Associated Viruses using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
[post_excerpt] => Rapid microchip CE-MS can be utilized for the in-depth characterization of AAVs including viral capsid protein analysis and peptide mapping. This poster was presented as a collaboration with NIBRT at ASMS 2023 as poster WP730.
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[post_name] => in-depth-characterization-of-adeno-associated-viruses
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[post_title] => Rapid In-Depth Characterization of Biologics by Microchip CE-MS: mAbs, AAVs and Nucleic Acids
[post_excerpt] => Microchip capillary electrophoresis (CE) coupled with mass spectrometry (MS) has revolutionized the characterization of therapeutic modalities in biopharmaceuticals. Here, we present the applications of an integrated workflow that couples the microfluidic CE system (ZipChip) with MS in characterization of biotherapeutics. This was poster A03 at BPS Europe 2024.
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[post_name] => rapid-in-depth-characterization-of-biologics
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[post_date] => 2024-03-25 10:10:07
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[post_title] => 5’ mRNA Analysis By Microchip CE-MS Using an Internal Cleavage Motif for RNase H Digestion
[post_excerpt] => The subject of this poster was the investigation of an internal DNA motif to produce a shorter digestion product while simultaneously maintaining the length of the probe at 25nt for hybridization specificity. The shorter oligo results in easier detection using Microchip CE-MS approach. This poster was presented at ASMS 2023 as poster THP575.
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[post_name] => 5-mrna-analysis-by-microchip-ce-ms
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[post_title] => Improved Performance of Phosphopeptides Characterization Using Online Capillary Electrophoresis Coupling with Ion Mobility Mass Spectrometry (CE-IM-MS)
[post_excerpt] => This poster will highlight a novel strategy for characterization of therapeutic peptide that was developed based on microchip CE-MS pure liquid separation and ion mobility gas phase separation, combing with mass spectrometry identification. The poster was presented in collaboration with Ningbo University at ASMS 2023 as poster THP609.
[post_status] => publish
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[post_name] => improved-performance-of-phosphopeptides-characterization
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[post_modified] => 2024-03-25 10:15:12
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[post_date] => 2024-03-25 09:27:20
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[post_title] => Rapid Identification of Conjugation Sites in Antibody Drug Conjugates Using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
[post_excerpt] => CE/MS method is optimized with NISTmAb digest as a reference control. Good MS/MS coverage of NISTmAb is obtained with narrow peak width and fast separation. This poster was presented as a collaboration with Bruker at ASMS 2023 as poster WP041.
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[post_name] => rapid-identification-of-conjugation-sites-in-antibody-drug
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[post_modified] => 2024-03-25 09:28:04
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[post_date] => 2024-03-25 09:13:48
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[post_title] => Conformation of Native Antibody-Drug Conjugate Charge Variants Revealed by Microchip Capillary Electrophoresis Coupled with Trapped Ion Mobility
[post_excerpt] => The combination of microchip capillary electrophoresis and trapped ion mobility enables a rapid, informative method for native monoclonal antibody and antibody-drug conjugate charge variant analysis. This poster was a collaboration with Bruker and NIH and presented at ASMS 2023 as poster WP040.
[post_status] => publish
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[post_name] => conformation-of-native-antibody-drug-conjugate-charge-variants
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[post_modified] => 2024-05-07 14:29:50
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[post_date] => 2024-03-21 11:02:11
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[post_title] => Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis - Mass Spectrometry (CE-MS)
[post_excerpt] => Presenting a novel strategy for characterization of therapeutic peptides was developed based on microchip CE-MS and linkage-specific derivatization. This poster was presented in collaboration with Ningbo University at ASMS 2023 as poster TP544.
[post_status] => publish
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[post_name] => fast-screening-and-characterization-of-therapeutic-peptide
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[post_date] => 2024-03-21 10:52:20
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[post_title] => Continuing the Investigation of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry in the Bottom-Up Characterization of Progressively Larger RNAs
[post_excerpt] => Exploring the merits of capillary-zone electrophoresis (CZE)-mass spectrometry to analyze digestion mixtures of large RNAs and attain sequence information. This poster was presented as a collaboration with UConn and Bruker at ASMS 2023 and was poster TP532.
[post_status] => publish
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[post_name] => continuing-the-investigation-of-microchip-capillary-electrophoresis
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[post_date] => 2024-03-21 10:38:52
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[post_title] => Determination of ATP, ADP, AMP, and Adenosine Levels by Microchip Capillary Electrophoresis Coupled with High Resolution Mass Spectrometry
[post_excerpt] => In this study, we present a novel ZipChip coupled with a QEHF for adenosine nucleotide analysis. This poster was presented at ASMS 2023 as poster TP489.
[post_status] => publish
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[post_name] => determination-of-atp-adp-amp-and-adenosine-levels
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[post_date] => 2024-03-21 10:20:58
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[post_title] => Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS
[post_excerpt] => This poster was presented in collaboration with Protein Metrics and highlights how the ZipChip coupled to HRMS provides a streamlined analytical approach to rapidly assess the heterogeneity of the investigated therapeutic proteins through the comprehensive interrogation of the different charge variants and their intact MS spectra. This poster was presented at ASMS 2023 as poster TP 384.
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[post_name] => sample-to-result-workflow-for-the-investigation-of-biosimilars-vs-innovator-cetuximab
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[post_title] => Peptide Mapping Workflow for Direct Microchip CE-MS Analysis of Biopharmaceuticals
[post_excerpt] => In this study we demonstrated the suitability of a modified digestion workflow for peptide mapping analysis via CE separation. This poster was presented at ASMS 2023 in collaboration with NIBRT. It was poster MP619.
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[post_title] => Combining Capillary Electrophoresis and Trapped Ion Mobility Spectrometry Mass Spectrometry to Analyze Epitranscriptomic Marks Mediating Virus-Host Interactions in Infectious Diseases
[post_excerpt] => This poster evaluates the merits of capillary-zone electrophoresis (CZE)-MS. This poster was presented at ASMS 2023 as a collaboration with UCONN. It was poster MP548.
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[post_type] => resource
[post_mime_type] =>
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[15] => WP_Post Object
(
[ID] => 23779
[post_author] => 15
[post_date] => 2024-03-21 09:38:33
[post_date_gmt] => 2024-03-21 13:38:33
[post_content] =>
[post_title] => Use of Microchip Capillary Electrophoresis – Mass Spectrometry for Automated Rapid Measurement of Enzyme Reaction Kinetics
[post_excerpt] => This approach allows rapid measurement of enzymatic cleavage dynamics in real time. It can be applied to almost any enzyme substrate reaction and is highly tolerable to various buffers, thanks to the CE Chip-MS configuration. This poster was presented at ASMS 2023 with collaborators as poster MP547.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => use-of-microchip-capillary-electrophoresis
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:55:53
[post_modified_gmt] => 2024-03-21 13:55:53
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23779
[menu_order] => 125
[post_type] => resource
[post_mime_type] =>
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)
[16] => WP_Post Object
(
[ID] => 23776
[post_author] => 15
[post_date] => 2024-03-21 09:29:35
[post_date_gmt] => 2024-03-21 13:29:35
[post_content] =>
[post_title] => Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
[post_excerpt] => N-glycan profiling is a critical step of biopharmaceuticals analysis as N-glycans play an important part in both activity and safety of monoclonal antibodies and other glycosylated biotherapeutics. This poster was presented at ASMS 2023 as poster MP291.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rapid-ce-ms-analysis-of-released-n-glycan
[to_ping] =>
[pinged] =>
[post_modified] => 2024-03-21 09:35:32
[post_modified_gmt] => 2024-03-21 13:35:32
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23776
[menu_order] => 128
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[17] => WP_Post Object
(
[ID] => 25226
[post_author] => 29
[post_date] => 2024-07-09 11:04:45
[post_date_gmt] => 2024-07-09 15:04:45
[post_content] =>
Understanding of cell culture metabolism in biologics manufacturing has increased tremendously in the past decade; however, the lack of feasible methods of high coverage, quantitative information on the interplay between nutrients and metabolites has hindered the efforts to fully characterize processes in the different biological phases. Several published models support cell growth phase but lack the kinetic information to be applicable to the phases that follow. We discuss a method for measuring hundreds of metabolites in dozens of pathways that streamlines sample preparation from spent media and cells, enables fast data-analysis times and supports quantitative analysis of key metabolites to gain far richer and more reliable data sources for process characterization, modelling and understanding. The method uses microchip CE/MS and incorporates stable isotope internal standards for both quantitation and migration time indexing. This work explores the information that can be obtained from the extracellular growth media and intracellular metabolites extracted from the CHO cells.
The poster was on display at Bioprocessing Summit, and ESACT #253 in 2024.
[post_title] => In-depth Metabolic Characterization at Different Phases of Cell Culture with a Turnkey CE-ESI-HRMS Workflow
[post_excerpt] => Learn about a turnkey CE-MS metabolomics workflow solution used to characterize media metabolites and intracellular metabolites of CHO bioreactors. The poster was on display at Bioprocessing Summit, and ESACT #253 in 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => correlation-of-soluble-metabolites-with-lactate-switch-observed-in-hek293-culture-using-novel-ce-ms-metabolomics-workflow
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-25 16:13:49
[post_modified_gmt] => 2024-11-25 21:13:49
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25226
[menu_order] => 130
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[post_mime_type] =>
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[filter] => raw
)
[18] => WP_Post Object
(
[ID] => 26149
[post_author] => 15
[post_date] => 2024-10-11 13:20:46
[post_date_gmt] => 2024-10-11 17:20:46
[post_content] =>
Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis. This poster was developed with Terumo Blood and Cell Technologies and was showcased at BPI USA and Advanced Therapies 2024.
[post_title] => Innovations in Analytical Technology for Cell & Gene Therapy Manufacturing
[post_excerpt] => This poster highlights our at-, on-, and in-line analytical solutions that contribute to an enhanced understanding, characterization, and control of bioprocesses in the development and manufacturing of cell and gene therapies.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => innovations-in-analytical-technology-for-cell-gene-therapy-manufacturing
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:32:59
[post_modified_gmt] => 2024-11-18 20:32:59
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=26149
[menu_order] => 132
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[19] => WP_Post Object
(
[ID] => 25218
[post_author] => 29
[post_date] => 2024-07-09 10:54:09
[post_date_gmt] => 2024-07-09 14:54:09
[post_content] =>
The introduction of the ZipChip Intact Antibodies Reagent Kit marked a significant milestone in the ZipChip portfolio, enabling the first tailored solution of charge variant analysis (CVA) of monoclonal antibodies on the CE-MS platform. However, there was room for enhancement in preserving the native conformation of the proteins under analysis, as well as in enhancing the separation between variant peaks. The next generation kits, the Native Antibodies Kit and Charge Variant TOF Kit, significantly improved peak separation and producing spectra more indicative of native protein structures. This was poster # TP642 at ASMS 2024.
[post_title] => Optimized Native Conditions for Charge Variant Analysis Using a Microfluidic CE-MS Platform Yield Higher Quality Data and Enables Analysis of Lower Titer Samples
[post_excerpt] => Learn about the improvements made in the new Charge Variant Analysis kit, compared to the previous Intact Antibodies and Native Antibodies kits. ASMS 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => optimized-native-conditions-for-charge-variant-analysis-using-a-microfluidic-ce-ms-platform-yield-higher-quality-data-and-enables-analysis-of-lower-titer-samples
[to_ping] =>
[pinged] =>
[post_modified] => 2024-09-23 12:16:29
[post_modified_gmt] => 2024-09-23 16:16:29
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25218
[menu_order] => 133
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[20] => WP_Post Object
(
[ID] => 25213
[post_author] => 29
[post_date] => 2024-07-09 10:28:00
[post_date_gmt] => 2024-07-09 14:28:00
[post_content] =>
As the field of bioprocessing continues to mature, there is a need for better analytics applied closer to the bioprocess. We have seen recent advancements in the technology used to measure small molecules within bioreactors (glucose/lactate, amino acids), but there is also a need to directly measure the critical quality attributes of the proteins being produced. To that end, we are assessing the ability of microfluidic CE-ESI-MS to perform charge variant - MS analysis of proteins pulled directly from a bioreactor. We know that excessive salt concentrations can cause band-broadening for this separation, so the key question is whether a desalting step is required, or if a simple dilute and shoot approach can work, and how much information can be obtained. Here we compare a simple dilute and shoot method to a method that buffer exchanges the sample before ZipChip analysis and demonstrates the use of this method for analysis of 4 different bioreactor growth conditions. This poster was on display at ASMS 2024 as poster # TP638.
[post_title] => Charge Variant Analysis of IgGs Directly from Cell Culture Supernatant Using Microfluidic CE-ESI-MS
[post_excerpt] => This poster describes the application of Microfluidic CE-ESI-MS for analyzing protein charge variants directly from a bioreactor. It investigates the feasibility of a "dilute and shoot" approach compared to a buffer exchange method for sample preparation. ASMS 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => charge-variant-analysis-of-iggs-directly-from-cell-culture-supernatant-using-microfluidic-ce-esi-ms
[to_ping] =>
[pinged] =>
[post_modified] => 2024-09-23 12:20:01
[post_modified_gmt] => 2024-09-23 16:20:01
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25213
[menu_order] => 134
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[21] => WP_Post Object
(
[ID] => 25245
[post_author] => 15
[post_date] => 2024-07-09 14:32:05
[post_date_gmt] => 2024-07-09 18:32:05
[post_content] =>
The biopharmaceutical industry is increasingly motivated to improve process control, understanding, and repeatability using process analytical technologies (PAT). More specifically, Raman-based optical, in-line measurement methods have shown promise as a way to monitor critical performance parameters, including glucose and lactate concentrations, in real-time. Recently, this has translated to the implementation of Raman-based glucose feeding strategies to modulate productivity and product quality in Chinese hamster ovary (CHO) cell cultures. The current work implements a novel Raman-based solution that does not require any chemometric models for glucose, lactate and biomass measurements. MAVERICK was directly, without any training in the specific bioprocess, deployed to dynamically control lactate feeding. We compared feeding strategies as means of modulating product quality and improving culture conditions, primarily through decreased ammonia accumulation. This was poster #358 at ESACT 2024 and was also highlighted at the Bioprocessing Summit 2024.
[post_title] => Raman-based Lactate Feeding Impact on Culture Characteristics and Product Quality in Mammalian Cell Cultures
[post_excerpt] => This research explores Raman spectroscopy for real-time glucose monitoring and feeding strategies in CHO cell cultures, aiming to improve product quality.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => raman-based-lactate-feeding-impact-on-culture-characteristics-and-product-quality-in-mammalian-cell-cultures
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-23 14:16:28
[post_modified_gmt] => 2024-08-23 18:16:28
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=25245
[menu_order] => 142
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[22] => WP_Post Object
(
[ID] => 23438
[post_author] => 15
[post_date] => 2024-02-20 17:24:46
[post_date_gmt] => 2024-02-20 22:24:46
[post_content] =>
[post_title] => Improving Cell and Gene Therapy Manufacturing Processes by Automated On-line and In-line Bioprocess Analytical Technologies
[post_excerpt] => Recent advances in cell and gene therapy bioprocess analytical technology regimes, approaches to de novo analytical modeling/calibration of these systems, and how their informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 29. This poster was also on display as #843 at ISCT 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improving-cell-gene-therapy-manufacturing
[to_ping] =>
[pinged] =>
[post_modified] => 2024-07-08 13:01:02
[post_modified_gmt] => 2024-07-08 17:01:02
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=23438
[menu_order] => 146
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[23] => WP_Post Object
(
[ID] => 6117
[post_author] => 20
[post_date] => 2022-06-11 02:59:33
[post_date_gmt] => 2022-06-11 06:59:33
[post_content] =>
[post_title] => Bottom-Up Analysis of Progressively Larger RNAs by CZE-MS and CZE-MS/MS
[post_excerpt] => In this poster from ASMS 2022, researchers from University of Connecticut and Bruker showed that capillary zone electrophoresis performed on a chip proved to be an effective alternative to liquid chromatography as a front-end separation system to analyze both pure samples and complex digestion mixtures of nucleic acids.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-uconn
[to_ping] =>
[pinged] =>
[post_modified] => 2023-12-26 12:43:57
[post_modified_gmt] => 2023-12-26 17:43:57
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6117
[menu_order] => 192
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[24] => WP_Post Object
(
[ID] => 6115
[post_author] => 20
[post_date] => 2022-06-11 02:52:58
[post_date_gmt] => 2022-06-11 06:52:58
[post_content] =>
[post_title] => Multi-level Expeditious Characterization of Adeno-associated Virus (AAV) Capsid Proteins Using ZipChip Microfluidic CE Coupled with HRMS
[post_excerpt] => In this poster from ASMS 2022, scientists from Thermo Fisher Scientific and 908 Devices present a novel approach using microchip CE-MS for the characterization of AAVs.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-thermo
[to_ping] =>
[pinged] =>
[post_modified] => 2023-12-26 12:42:52
[post_modified_gmt] => 2023-12-26 17:42:52
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6115
[menu_order] => 193
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[25] => WP_Post Object
(
[ID] => 6114
[post_author] => 29
[post_date] => 2022-06-11 02:42:23
[post_date_gmt] => 2022-06-11 06:42:23
[post_content] =>
[post_title] => A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS
[post_excerpt] => In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-genentech
[to_ping] =>
[pinged] =>
[post_modified] => 2024-06-26 15:34:54
[post_modified_gmt] => 2024-06-26 19:34:54
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6114
[menu_order] => 194
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[26] => WP_Post Object
(
[ID] => 6113
[post_author] => 20
[post_date] => 2022-06-11 02:37:28
[post_date_gmt] => 2022-06-11 06:37:28
[post_content] =>
[post_title] => Combining μSPE ZipChip CE with PRM-LIVE on a timsTOF Pro for Warp-speed Selectivity Profiling of Deubiquitinase (DUB) Small Molecule Inhibitors
[post_excerpt] => In this ASMS 2022 poster, researchers from Dana Farber Cancer Institute and Harvard Medical School developed a ZipChip-based method for facilitating high-throughput identification
of new small molecule inhibitors.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-dana-farber
[to_ping] =>
[pinged] =>
[post_modified] => 2023-12-26 12:41:30
[post_modified_gmt] => 2023-12-26 17:41:30
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6113
[menu_order] => 195
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[27] => WP_Post Object
(
[ID] => 6112
[post_author] => 20
[post_date] => 2022-06-11 02:30:52
[post_date_gmt] => 2022-06-11 06:30:52
[post_content] =>
[post_title] => Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
[post_excerpt] => In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-fudan
[to_ping] =>
[pinged] =>
[post_modified] => 2023-12-26 12:40:53
[post_modified_gmt] => 2023-12-26 17:40:53
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6112
[menu_order] => 196
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[28] => WP_Post Object
(
[ID] => 6111
[post_author] => 20
[post_date] => 2022-06-11 02:25:34
[post_date_gmt] => 2022-06-11 06:25:34
[post_content] =>
[post_title] => CE-MS of Oligonucleotides using a ZipChip
[post_excerpt] => This ASMS 2022 poster from Boehringer Ingelheim explores the use of ZipChip coupled to a high resolution mass spectrometer as an orthogonal method to chromatography for oligonucleotide analysis.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-boehringer
[to_ping] =>
[pinged] =>
[post_modified] => 2023-12-26 12:39:52
[post_modified_gmt] => 2023-12-26 17:39:52
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6111
[menu_order] => 197
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[29] => WP_Post Object
(
[ID] => 6109
[post_author] => 15
[post_date] => 2022-06-11 02:14:51
[post_date_gmt] => 2022-06-11 06:14:51
[post_content] =>
[post_title] => Rapid Characterization of Oligos and Related Impurities Using Microchip CE-MS without Ion-pairing Reagents
[post_excerpt] => This poster from ASMS 2022 describes a simple & fast method for oligonucleotide characterizations using a Microchip CE-MS platform.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-kulkarni
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 14:18:58
[post_modified_gmt] => 2024-08-01 18:18:58
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6109
[menu_order] => 198
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[30] => WP_Post Object
(
[ID] => 6110
[post_author] => 15
[post_date] => 2022-06-11 02:20:24
[post_date_gmt] => 2022-06-11 06:20:24
[post_content] =>
[post_title] => Glycosylation Profiling of mAB Subunits with CZE-MS
[post_excerpt] => This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-glycosylation-profiling
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-01 14:19:13
[post_modified_gmt] => 2024-08-01 18:19:13
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6110
[menu_order] => 199
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[31] => WP_Post Object
(
[ID] => 6105
[post_author] => 20
[post_date] => 2022-06-10 20:16:47
[post_date_gmt] => 2022-06-11 00:16:47
[post_content] =>
[post_title] => Pushing the Boundaries of Speed and Sensitivity in Proteomics
[post_excerpt] => To overcome sample loading limitations in CE-MS, the poster authors engineered a 1 mm SPE bed within the chip geometry, allowing 100-fold improvements in concentration sensitivity limit for CE-MS.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-thompson
[to_ping] =>
[pinged] =>
[post_modified] => 2023-12-26 12:37:31
[post_modified_gmt] => 2023-12-26 17:37:31
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6105
[menu_order] => 200
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[32] => WP_Post Object
(
[ID] => 6104
[post_author] => 20
[post_date] => 2022-06-10 19:14:29
[post_date_gmt] => 2022-06-10 23:14:29
[post_content] =>
[post_title] => A Broad Application of Migration Time Indexing and Metabolite Libraries to Evaluate Quantitative Coverage in Microchip CE-MS Metabolomics
[post_excerpt] => In the field of metabolomics, microchip capillary electrophoresis (mCE) has a number of potential advantages over traditional liquid chromatography (LC), including higher throughput due to decreased separation times, increased separation efficiency, and lower required sample volumes.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-asms2022-metabolomics-raiche
[to_ping] =>
[pinged] =>
[post_modified] => 2023-12-26 12:36:48
[post_modified_gmt] => 2023-12-26 17:36:48
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=6104
[menu_order] => 201
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[33] => WP_Post Object
(
[ID] => 5998
[post_author] => 20
[post_date] => 2022-05-09 12:26:20
[post_date_gmt] => 2022-05-09 16:26:20
[post_content] =>
[post_title] => A Microchip CE-MS Based End-to-End Solution for the Analysis of Synthetic Oligonucleotides
[post_excerpt] => This poster showcases a workflow using microchip CE-MS that is coupled with a vendor-neutral informatics platform
as a complete solution for the analysis of synthetic oligos.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => a-microchip-ce-ms-based-end-to-end-solution-for-the-analysis-of-synthetic-oligonucleotides
[to_ping] =>
[pinged] =>
[post_modified] => 2023-12-26 12:35:39
[post_modified_gmt] => 2023-12-26 17:35:39
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://908devices.com/?post_type=resource&p=5998
[menu_order] => 208
[post_type] => resource
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[34] => WP_Post Object
(
[ID] => 4938
[post_author] => 20
[post_date] => 2021-11-05 18:59:31
[post_date_gmt] => 2021-11-05 22:59:31
[post_content] =>
[post_title] => Microchip CE-MS with Integrated Solid Phase Extraction
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => zipchip-poster-microchip-cebrms-with-integrated-solid-phase-extraction
[to_ping] =>
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[post_title] => Microchip CE-MS of Oligonucleotides: What Can It Separate?
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[post_title] => Fast Chip-CEMS for Characterization of Protein/PTM Changes
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[post_title] => ZipChip for Glycomics and Glycoproteomics
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[post_title] => Characterization of charge heterogeneity of mAb
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[post_title] => Rapid, Multi-level Analysis of Complex Proteins
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[post_title] => Oligonucleotide Analysis via Microfluidic CE-MS
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[post_title] => 96 Bottles of Beer: Metabolic Profiling of Spent Growth Media
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[post_title] => Native Analysis of Monoclonal Antibodies
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[post_title] => Characterization of Protein/PTM Changes
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[post_title] => A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
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[post_title] => Bioprocessing of Monoclonal Antibody Based Therapies
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[post_title] => NIBRT Presents Native MS for Charge Variants using ZipChip
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[post_title] => Monitoring Amino Acid Composition of Cell Culture Media
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Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis.
This poster was a collaboration with Terumo Blood and Cell Technologies and was part of the poster program at the 2024 ISCT EU Conference.
[post_title] => Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
[post_excerpt] => The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding, characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
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Posters
Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding, characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
MAVEN
MAVERICK
REBEL
ZipChip
Posters
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Microchip CE-MS Analysis of Nucleic Acids – From Characterization of Synthetic Oligonucleotides to Sequence Mapping of RNAs
This work will showcase how the ZipChip enables a simple and rapid workflow for the analysis of nucleic acids with noion-pairing reagents needed This poster was highlighted at the 2024 TIDES Conference.
ZipChip
Posters
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Investigation of Drug-To-Antibody Ratio for FORCE Oligonucleotide Conjugates Using Microchip CE-MS
ZipChip microchip CE-MS resolves DAR species electrophoretically and enables generation of superior MS spectra. This poster was presented as a collaboration with Dyne Therapeutics at ASMS 2023 as poster WP045.
ZipChip
Posters
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In-depth Characterization of Adeno-Associated Viruses using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
Rapid microchip CE-MS can be utilized for the in-depth characterization of AAVs including viral capsid protein analysis and peptide mapping. This poster was presented as a collaboration with NIBRT at ASMS 2023 as poster WP730.
ZipChip
Posters
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Rapid In-Depth Characterization of Biologics by Microchip CE-MS: mAbs, AAVs and Nucleic Acids
Microchip capillary electrophoresis (CE) coupled with mass spectrometry (MS) has revolutionized the characterization of therapeutic modalities in biopharmaceuticals. Here, we present the applications of an integrated workflow that couples the microfluidic CE system (ZipChip) with MS in characterization of biotherapeutics. This was poster A03 at BPS Europe 2024.
ZipChip
Posters
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5’ mRNA Analysis By Microchip CE-MS Using an Internal Cleavage Motif for RNase H Digestion
The subject of this poster was the investigation of an internal DNA motif to produce a shorter digestion product while simultaneously maintaining the length of the probe at 25nt for hybridization specificity. The shorter oligo results in easier detection using Microchip CE-MS approach. This poster was presented at ASMS 2023 as poster THP575.
ZipChip
Posters
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Improved Performance of Phosphopeptides Characterization Using Online Capillary Electrophoresis Coupling with Ion Mobility Mass Spectrometry (CE-IM-MS)
This poster will highlight a novel strategy for characterization of therapeutic peptide that was developed based on microchip CE-MS pure liquid separation and ion mobility gas phase separation, combing with mass spectrometry identification. The poster was presented in collaboration with Ningbo University at ASMS 2023 as poster THP609.
ZipChip
Posters
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Rapid Identification of Conjugation Sites in Antibody Drug Conjugates Using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
CE/MS method is optimized with NISTmAb digest as a reference control. Good MS/MS coverage of NISTmAb is obtained with narrow peak width and fast separation. This poster was presented as a collaboration with Bruker at ASMS 2023 as poster WP041.
ZipChip
Posters
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Conformation of Native Antibody-Drug Conjugate Charge Variants Revealed by Microchip Capillary Electrophoresis Coupled with Trapped Ion Mobility
The combination of microchip capillary electrophoresis and trapped ion mobility enables a rapid, informative method for native monoclonal antibody and antibody-drug conjugate charge variant analysis. This poster was a collaboration with Bruker and NIH and presented at ASMS 2023 as poster WP040.
ZipChip
Posters
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Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis – Mass Spectrometry (CE-MS)
Presenting a novel strategy for characterization of therapeutic peptides was developed based on microchip CE-MS and linkage-specific derivatization. This poster was presented in collaboration with Ningbo University at ASMS 2023 as poster TP544.
ZipChip
Posters
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Continuing the Investigation of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry in the Bottom-Up Characterization of Progressively Larger RNAs
Exploring the merits of capillary-zone electrophoresis (CZE)-mass spectrometry to analyze digestion mixtures of large RNAs and attain sequence information. This poster was presented as a collaboration with UConn and Bruker at ASMS 2023 and was poster TP532.
ZipChip
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Determination of ATP, ADP, AMP, and Adenosine Levels by Microchip Capillary Electrophoresis Coupled with High Resolution Mass Spectrometry
In this study, we present a novel ZipChip coupled with a QEHF for adenosine nucleotide analysis. This poster was presented at ASMS 2023 as poster TP489.
ZipChip
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Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS
This poster was presented in collaboration with Protein Metrics and highlights how the ZipChip coupled to HRMS provides a streamlined analytical approach to rapidly assess the heterogeneity of the investigated therapeutic proteins through the comprehensive interrogation of the different charge variants and their intact MS spectra. This poster was presented at ASMS 2023 as poster TP 384.
ZipChip
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Peptide Mapping Workflow for Direct Microchip CE-MS Analysis of Biopharmaceuticals
In this study we demonstrated the suitability of a modified digestion workflow for peptide mapping analysis via CE separation. This poster was presented at ASMS 2023 in collaboration with NIBRT. It was poster MP619.
ZipChip
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Combining Capillary Electrophoresis and Trapped Ion Mobility Spectrometry Mass Spectrometry to Analyze Epitranscriptomic Marks Mediating Virus-Host Interactions in Infectious Diseases
This poster evaluates the merits of capillary-zone electrophoresis (CZE)-MS. This poster was presented at ASMS 2023 as a collaboration with UCONN. It was poster MP548.
ZipChip
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Use of Microchip Capillary Electrophoresis – Mass Spectrometry for Automated Rapid Measurement of Enzyme Reaction Kinetics
This approach allows rapid measurement of enzymatic cleavage dynamics in real time. It can be applied to almost any enzyme substrate reaction and is highly tolerable to various buffers, thanks to the CE Chip-MS configuration. This poster was presented at ASMS 2023 with collaborators as poster MP547.
ZipChip
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Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
N-glycan profiling is a critical step of biopharmaceuticals analysis as N-glycans play an important part in both activity and safety of monoclonal antibodies and other glycosylated biotherapeutics. This poster was presented at ASMS 2023 as poster MP291.
ZipChip
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In-depth Metabolic Characterization at Different Phases of Cell Culture with a Turnkey CE-ESI-HRMS Workflow
Learn about a turnkey CE-MS metabolomics workflow solution used to characterize media metabolites and intracellular metabolites of CHO bioreactors. The poster was on display at Bioprocessing Summit, and ESACT #253 in 2024.
ZipChip
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Innovations in Analytical Technology for Cell & Gene Therapy Manufacturing
This poster highlights our at-, on-, and in-line analytical solutions that contribute to an enhanced understanding, characterization, and control of bioprocesses in the development and manufacturing of cell and gene therapies.
MAVEN
MAVERICK
REBEL
ZipChip
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Optimized Native Conditions for Charge Variant Analysis Using a Microfluidic CE-MS Platform Yield Higher Quality Data and Enables Analysis of Lower Titer Samples
Learn about the improvements made in the new Charge Variant Analysis kit, compared to the previous Intact Antibodies and Native Antibodies kits. ASMS 2024.
ZipChip
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Charge Variant Analysis of IgGs Directly from Cell Culture Supernatant Using Microfluidic CE-ESI-MS
This poster describes the application of Microfluidic CE-ESI-MS for analyzing protein charge variants directly from a bioreactor. It investigates the feasibility of a “dilute and shoot” approach compared to a buffer exchange method for sample preparation. ASMS 2024.
ZipChip
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Raman-based Lactate Feeding Impact on Culture Characteristics and Product Quality in Mammalian Cell Cultures
This research explores Raman spectroscopy for real-time glucose monitoring and feeding strategies in CHO cell cultures, aiming to improve product quality.
MAVEN
REBEL
ZipChip
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Improving Cell and Gene Therapy Manufacturing Processes by Automated On-line and In-line Bioprocess Analytical Technologies
Recent advances in cell and gene therapy bioprocess analytical technology regimes, approaches to de novo analytical modeling/calibration of these systems, and how their informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 29. This poster was also on display as #843 at ISCT 2024.
MAVEN
MAVERICK
REBEL
ZipChip
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Bottom-Up Analysis of Progressively Larger RNAs by CZE-MS and CZE-MS/MS
In this poster from ASMS 2022, researchers from University of Connecticut and Bruker showed that capillary zone electrophoresis performed on a chip proved to be an effective alternative to liquid chromatography as a front-end separation system to analyze both pure samples and complex digestion mixtures of nucleic acids.
ZipChip
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Multi-level Expeditious Characterization of Adeno-associated Virus (AAV) Capsid Proteins Using ZipChip Microfluidic CE Coupled with HRMS
In this poster from ASMS 2022, scientists from Thermo Fisher Scientific and 908 Devices present a novel approach using microchip CE-MS for the characterization of AAVs.
ZipChip
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A Sensitive and High-Throughput Assay for Analyzing Peptide Exchanged MHCl by High-Resolution Native CZE-MS
In this poster from ASMS 2022, researchers from Genentech describe a sensitive and high-throughput assay using capillary-zone electrophoresis coupled to a high-resolution mass spectrometer for characterizing peptide-exchanged MHCI under native conditions.
ZipChip
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Combining μSPE ZipChip CE with PRM-LIVE on a timsTOF Pro for Warp-speed Selectivity Profiling of Deubiquitinase (DUB) Small Molecule Inhibitors
In this ASMS 2022 poster, researchers from Dana Farber Cancer Institute and Harvard Medical School developed a ZipChip-based method for facilitating high-throughput identification
of new small molecule inhibitors.
ZipChip
Posters
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Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.
ZipChip
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CE-MS of Oligonucleotides using a ZipChip
This ASMS 2022 poster from Boehringer Ingelheim explores the use of ZipChip coupled to a high resolution mass spectrometer as an orthogonal method to chromatography for oligonucleotide analysis.
ZipChip
Posters
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Rapid Characterization of Oligos and Related Impurities Using Microchip CE-MS without Ion-pairing Reagents
This poster from ASMS 2022 describes a simple & fast method for oligonucleotide characterizations using a Microchip CE-MS platform.
ZipChip
Posters
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Glycosylation Profiling of mAB Subunits with CZE-MS
This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.
ZipChip
Posters
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Pushing the Boundaries of Speed and Sensitivity in Proteomics
To overcome sample loading limitations in CE-MS, the poster authors engineered a 1 mm SPE bed within the chip geometry, allowing 100-fold improvements in concentration sensitivity limit for CE-MS.
ZipChip
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A Broad Application of Migration Time Indexing and Metabolite Libraries to Evaluate Quantitative Coverage in Microchip CE-MS Metabolomics
In the field of metabolomics, microchip capillary electrophoresis (mCE) has a number of potential advantages over traditional liquid chromatography (LC), including higher throughput due to decreased separation times, increased separation efficiency, and lower required sample volumes.
ZipChip
Posters
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A Microchip CE-MS Based End-to-End Solution for the Analysis of Synthetic Oligonucleotides
This poster showcases a workflow using microchip CE-MS that is coupled with a vendor-neutral informatics platform
as a complete solution for the analysis of synthetic oligos.
ZipChip
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Microchip CE-MS with Integrated Solid Phase Extraction
ZipChip
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Microchip CE-MS of Oligonucleotides: What Can It Separate?
ZipChip
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Fast Chip-CEMS for Characterization of Protein/PTM Changes
ZipChip
Posters
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Combined Top-down and Bottom-up Proteomics
ZipChip
Posters
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ZipChip for Glycomics and Glycoproteomics
ZipChip
Posters
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Fast and Efficient Biopharmaceutical Characterization
ZipChip
Posters
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Characterization of charge heterogeneity of mAb
ZipChip
Posters
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Rapid, Multi-level Analysis of Complex Proteins
ZipChip
Posters
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Oligonucleotide Analysis via Microfluidic CE-MS
ZipChip
Posters
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Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF
ZipChip
Posters
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96 Bottles of Beer: Metabolic Profiling of Spent Growth Media
ZipChip
Posters
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Native Analysis of Monoclonal Antibodies
ZipChip
Posters
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Characterization of Protein/PTM Changes
ZipChip
Posters
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Native CE-MS for Biopharmaceutical Characterization
ZipChip
Posters
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A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
REBEL
ZipChip
Posters
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Bioprocessing of Monoclonal Antibody Based Therapies
ZipChip
Posters
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NIBRT Presents Native MS for Charge Variants using ZipChip
ZipChip
Posters
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NIBRT Presents ZipChip for Native Charge Heterogeneity
ZipChip
Posters
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Monitoring Amino Acid Composition of Cell Culture Media
ZipChip
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