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[post_date] => 2024-09-10 15:24:09
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[post_content] =>
In this application note, by using a combination of analytical tools including REBEL and MAVEN, we were able to gain unique insights that allowed us to perform a data-driven optimization of a bioprocess and reach the process development goals with regards to titer, toxic metabolite profiles, and viability. REBEL, an amino acid analyzer streamlines bioprocess optimization by providing rapid, at-line spent-media analysis. It helps optimize nutrient feeding, control toxic metabolites, and improve cell viability, resulting in higher yields, including a 30% titer increase in one case.
[post_title] => Data-driven CHO Bioprocess Optimization and Scale-up with At-line Intelligence of Key Media Components
[post_excerpt] => Accelerate your process development with the fast, at-line REBEL analyzer, which provides amino acid analysis in minutes. Rapid analysis minimizes the time between bioprocess development experiments, helping you optimize nutrient feeding and control toxic metabolite production.
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[post_date] => 2024-06-10 09:36:50
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AA analysis is not regularly performed in CAR T-cell experiments due to the complexity and sample volume limitations of traditional methods, but the REBEL device enables rapid analysis, low sample volume requirements and without the need for prior mass spectrometry expertise. Learn how to optimize your cell culture media for enhanced CAR T-cell therapy manufacturing.
This study explores the relationship between CAR T-cell activation, nutrient metabolism, and treatment efficacy. It highlights differences in amino acid (AA) concentrations in spent media between potent CAR T-cell phenotypes and less-active, exhausted ones. By using novel multi-cytokine backpacks (MCBs) in cell culture, the research aims to enhance T-cell manufacturing, focusing on the metabolic profiles linked to different phenotypes. The analysis revealed that certain AAs, such as alanine and glycine, accumulated during culture while others, like arginine, were consumed, indicating active metabolic pathways. With automated quantitation and low sample volume requirements, REBEL facilitated efficient AA quantification, underscoring its potential for optimizing CAR T-cell culture media. Overall, the findings suggest that understanding AA dynamics could improve CAR T-cell therapies.
[post_title] => Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack-Manufactured CAR T-Cells
[post_excerpt] => With automated quantitation and low sample volume requirements, the REBEL device enables rapid AA analysis compared to the many complexities in traditional analysis methods.
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[post_title] => RPMI 1640 Medium Analysis with the REBEL: Accuracy and Reproducibility Across Multiple Devices
[post_excerpt] => This extensive fresh media analysis experiment provides an example of the accuracy and reproducibility of the REBEL device obtained with RPMI media.
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[post_title] => Screening for Component Diversity in CHO Cell Culture Media
[post_excerpt] => At-line amino acid analysis can speeds up cell culture media and feeding strategy optimization for bioprocess development.
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[post_title] => High variations of analyte levels in Terrific broth (TB) media
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[post_title] => Application Snapshot Booklet Cell and Gene Therapy
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[post_title] => How comparable are different vendors' LB media?
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[post_title] => Investigating the high nutrient variations in Super Optimal Broth
[post_excerpt] => Cultures’ growth rates and productivities may differ when different vendor’s media are used in otherwise identical experiments.
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[post_title] => Probing formulation differences in Super Optimal Broth
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[post_title] => Similarities between different vendors’ 2X YT liquid media
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[post_title] => At-line spent media analysis is now a reality
[post_excerpt] => To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.
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[post_name] => at-line-spent-media-analysis-is-now-a-reality
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[post_title] => Differences in fresh commercially available hybridoma media
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[post_name] => rebel_app-note_fresh-commercially-available-hybridoma-media
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[post_title] => Select the best CHO media from the start
[post_excerpt] => Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.
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[post_title] => Screening of chemically-defined media for suspension cultures of HEK293 cells
[post_excerpt] => Across four vendors, there was a high variation in the fresh media composition.
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[post_title] => Amino acid contents of Sf9 and Sf21 insect cell media
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In this application note, by using a combination of analytical tools including REBEL and MAVEN, we were able to gain unique insights that allowed us to perform a data-driven optimization of a bioprocess and reach the process development goals with regards to titer, toxic metabolite profiles, and viability. REBEL, an amino acid analyzer streamlines bioprocess optimization by providing rapid, at-line spent-media analysis. It helps optimize nutrient feeding, control toxic metabolites, and improve cell viability, resulting in higher yields, including a 30% titer increase in one case.
[post_title] => Data-driven CHO Bioprocess Optimization and Scale-up with At-line Intelligence of Key Media Components
[post_excerpt] => Accelerate your process development with the fast, at-line REBEL analyzer, which provides amino acid analysis in minutes. Rapid analysis minimizes the time between bioprocess development experiments, helping you optimize nutrient feeding and control toxic metabolite production.
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Application Notes & Snapshots
Data-driven CHO Bioprocess Optimization and Scale-up with At-line Intelligence of Key Media Components
Accelerate your process development with the fast, at-line REBEL analyzer, which provides amino acid analysis in minutes. Rapid analysis minimizes the time between bioprocess development experiments, helping you optimize nutrient feeding and control toxic metabolite production.
Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack-Manufactured CAR T-Cells
With automated quantitation and low sample volume requirements, the REBEL device enables rapid AA analysis compared to the many complexities in traditional analysis methods.
RPMI 1640 Medium Analysis with the REBEL: Accuracy and Reproducibility Across Multiple Devices
This extensive fresh media analysis experiment provides an example of the accuracy and reproducibility of the REBEL device obtained with RPMI media.
Screening for Component Diversity in CHO Cell Culture Media
At-line amino acid analysis can speeds up cell culture media and feeding strategy optimization for bioprocess development.
High variations of analyte levels in Terrific broth (TB) media
Application Snapshot Booklet Cell and Gene Therapy
How comparable are different vendors’ LB media?
Investigating the high nutrient variations in Super Optimal Broth
Cultures’ growth rates and productivities may differ when different vendor’s media are used in otherwise identical experiments.
Probing formulation differences in Super Optimal Broth
Similarities between different vendors’ 2X YT liquid media
At-line spent media analysis is now a reality
To elevate process development decisions to real-time, researchers require new analytical platforms that simplify analysis and accelerate delivery of actionable intelligence.
Differences in fresh commercially available hybridoma media
Select the best CHO media from the start
Performing your own quick assays of the media you receive ensures consistency in the cell media fed to your cells.
Screening of chemically-defined media for suspension cultures of HEK293 cells
Across four vendors, there was a high variation in the fresh media composition.
Analyze Media without Removing Your mAb on the Rebel
Identify variations in dry and liquid CHO media
Running a quick fresh media assay prior to feeding the culture ensures consistency of the media components when scaling up or during the transition between liquid-to-dry media blends.
Serum supplemented media analysis is routine with the Rebel
Supplementing IMDM media with fetal bovine serum
Supplementing RPMI Media with Fetal Bovine Serum
Conventional and chemically-defined T cell medias
Amino acid contents of Sf9 and Sf21 insect cell media
Knowledge of the insect cell metabolism coupled with an understanding of the amino acid content of the cell media allows for a more informed process development analytics strategy.
Comparing Mesenchymal Stem Cell Media with Supplements on the Rebel
To ensure consistency when culturing MSCs, researchers should understand what is being added to their media.
Don’t sweat your cell media additives
Handle Non-ionic Surfactants in Cell Media Samples with Ease
Basal Cell Media with 10% Fetal Bovine Serum
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In this flyer, learn how you can optimize the performance of your REBEL device with a preventive maintenance plan. There are various parts for the REBEL device and with routine maintenance, you can keep your device running efficiently with optimal analysis. We offer a few options for service plans to support your needs.
Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
1. REBEL Autosampler Sample Needle
Routine PM replacement and alignment of the autosampler needle will reduce chances of leaks, clogs, and potential missed injections during analysis.
2. REBEL Autosampler Sample Syringe
The autosampler syringe is responsible for all the fluidic movement and precise sampling within the REBEL. Over time the seals within the syringe can wear resulting in leaks and lowered analysis precision of fluidic transfer/sample loads.
3. REBEL Gas System Inlet Filter*
Annual PM replacement of the air inlet carbon and HEPA filters is to ensure optimal performance for the gas handling system in the REBEL. If not replaced the filters become less efficient and could result in poor analysis performance and contamination of more expensive components
*Access this on the back of the REBEL
4. REBEL Waste System Filter*
A particulate filter included in the waste system within the REBEL is to prevent material from entering the membranes of the waste pump. Routine replacement prevents clogging and decreased waste removal performance.
*Access underneath outer panels of the REBEL
5. REBEL MS Detector Inlet*
Detector Inlet is the entrance to the mass spectrometer of the REBEL device. Routine maintenance can reduce the chance of clogging, detection issues, and fouling. During PM, the performance of the vacuum system is evaluated along with alignment and detector performance.
*Access underneath outer panels of the REBEL
REBEL “STANDARD”
SERVICE PM PLAN REBEL PREMIUM
SERVICE PLAN Tech support (via email/phone) Yes (Priority) Yes (Highest priority) Software updates (bug fixes) Yes Yes Software upgrades
(applicable features) Yes Yes Replacement parts/repair labor Yes Yes Preventative
maintenance & IQ/OQ Once per year Once per year On-site
application support Up to two visits included per year Up to two visits included per year Certified training No One free of charge* per year Discount on single
SMA kit purchase No 7% through coverage period Multi-year service plans Yes Yes
*For multi-year Premium plan, one free of charge Certified Training is on annual “use it or lose it” basis.
[post_title] => Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
[post_excerpt] => Learn how you can optimize the performance of REBEL with a preventive maintenance plan and see what is included.
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Faster Bioprocess Data Visualization
Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers rich, time-course data visualization in less than a minute for run and sample comparisons. Download from our customer support portal and visit JMP.com.
REBEL
Sample comparison, and time-course data visualization from multiple samples, for all analytes, in an instant.
MAVERICK
Visualize time course data for glucose, lactate, and biomass and compare runs. Values are provided in 1-minute intervals.
MAVEN
Visualize time course data for glucose and lactate, and display the glucose feed-pump speed for run duration to compare runs.
Data Visualization for Actionable Insights
MAVEN data output from device
MAVEN data output with JMP add-in tool
[post_title] => Faster Bioprocess Data Visualization
[post_excerpt] => Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers data visualization in less than a minute for run and sample comparisons.
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Ensuring User Success with 908 Devices
REBEL Certified User Training
Get the best user experience with the REBEL at-line spent media analyzer. This training course is for new and experienced users who want to refresh their REBEL device operation skills.
The REBEL certified training includes:
- Two day in-person instructor-led training at your facility for up to 3 people
- Program highlights: REBEL introduction, sample handling and preparation, best practices for operating the REBEL, data handling and processing
- Training materials: REBEL Spent Media Analysis consumable kit and extra materials used in the training program
- Certificate of completion
[post_title] => REBEL Certified User Training
[post_excerpt] => Get the best user experience with the REBEL at-line spent media analyzer. Our training course is for new and experienced users who want to refresh their REBEL device
operation skills.
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Cool and Confident
The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
HASSLE-FREE PURCHASING
AND SHIPPING OPTIONS
Choose the purchasing style that suits your lab:
- One-time: Order one or more kits at full price for shipment.
- Subscription: Order 6 or 12 kits at a time, shipped to you on a schedule you choose.
– Buy the 6-kit subscription, 5% discount
– Buy the 12-kit subscription, 10% discount
- Thoughtful shipping: No matter how you buy, every kit ships overnight with proper packing to keep critical components chilled between 2-8° C at all times. Buy with a subscription to keep a steady stream of shipments flowing to your lab, without filling up valuable refrigerator space.
ABOUT THE KIT
- Comprehensive package: Each kit includes BGE, diluent, a REBEL chip, standards, and microwell plates.
- Packed for 200 runs: Make your buying decision based on kit consumption and your upcoming projects.
[post_title] => REBEL Spent Media Analysis Kits
[post_excerpt] => The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
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BOOST YOUR BIOPROCESS
CELL CULTURE MEDIA ANALYSIS IN MINUTES, NOT WEEKS
CELL CULTURE MEDIA ANALYSIS MATTERS
In upstream bioprocessing, cell culture media development is a key area of focus, and monitoring of the media all the way through manufacturing is critical. Understanding the relationship between cell culture media components and the cells they support can ultimately impact the process Key Performance Indicators (KPIs) and Critical Quality Attributes (CQAs). Analysis of key media components such as amino acids, vitamins, and the metabolites produced as a result of cell growth is beneficial at all stages of process development, including
cell line development, media QC, and media development. This information provides insight not just on media composition and performance, but also on clone selection, feed strategy, optimal harvest time, product quality, and more. The need for more process intensification and process modeling requires frequent real time data that can easily be used for deeper monitoring and control.
Ultimately, having greater insight offers more opportunities to positively impact CQAs and KPIs to create products faster, more cost effectively, and with greater therapeutic success.
GETTING RESULTS ISN'T ALWAYS EASY
Process development groups don’t always have the analytical tools or resources to gain in-depth process understanding. Sending samples to on-site or off-site core labs can take days to weeks and can be costly.
MEET THE
REBEL
The REBEL is a novel, dedicated cell culture media analyzer designed for rapid, easy, and efficient amino acid and nutrient analysis. Combining award winning design with 908 Devices proven capillary electrophoresis and high-pressure mass spectrometry technologies, the REBEL provides process development scientists access to critical data at-line, any time.
ANALYSIS IN 4 EASY STEPS
PULL A SAMPLE
Pull a sample from your bioreactor, shake flask, or well plate. The REBEL only needs 10µL.
SPIN & DILUTE
Spin out your cells and dilute. That’s as complicated as it gets.
LOAD YOUR SAMPLES
Load your samples, reagents, and calibrants.
GENERATE RESULTS
Hit start, get results. Results can quickly be reviewed in a simple report.
REBEL
BENEFITS
EASY TO OPERATE
Designed for simplicity.
MINIMAL SAMPLE PREPARATION
Pull a sample from your bioreactor, shake flask or well plate, then spin out your cells and dilute.
NO MORE WAITING FOR RESULTS
Fully processed at line report for 30+ components in under 10 minutes.
DATA INTEGRATION
For easy data alignment and interpretation with third-party platforms.
A COMPREHENSIVE PANEL TO MEET YOUR NEEDS
THE REBEL SCREENS FOR OVER 30 ANALYTES IN EVERY RUN, ALL IN UNDER 10 MINUTES
AMINO ACIDS
- Alanine
- Alanyl-Glutamine
- Arginine
- Asparagine
- Aspartic Acid
- Cystine
- Glutamic Acid
- Glutamine
- Glycine
- Histidine
- Isoleucine
- Leucine
- Lysine
- Methionine
- Isoleucine
- Leucine
- Lysine
- Methionine
- Phenylalanine
- Serine
- Threonine
- Tryptophan
- Tyrosine
- Valine
VITAMINS
- Choline
- Nicotinamide
- Pyridoxal
- Pyridoxine
- Thiamine
AMINES
- β-Alanine
- Citrulline
- GABA
- Hydroxyproline
- Methyl-Histidine
- Sarcosine
KNOW WHAT'S IN YOUR MEDIA
Understanding which key nutrients are present in your cell culture media is critical to media screening and optimization efforts. In this experiment, nine commercial CHO media were measured using the REBEL in a media screening evaluation (Figure 1). The amino acid profile reveals high diversity in nutrient composition across the media panel. With the REBEL you can measure key nutrients such as amino acids in both fresh and spent media at-line in real time to gain deeper insight into your process and obtain high titer faster.
CHO MEDIA SCREENING
Analyzed using a simple 100x dilution with 20 replicates.
Figure 1. Diversity of nutrient composition in a panel of chemically defined CHO media.
REBEL measures over 30 analytes including all amino acids, certain vitamins, and bio amines. Plotted here are a subset of amino acids including all essential ones and others in 9 different CHO media. This comparison shows that the concentration of several amino acids such as serine and arginine, two potentially important amino acids for cell growth and protein production, varies widely between the media tested here while other amino acids are more consistent between media.
COMPACT WITHOUT COMPROMISE
The REBEL delivers high method accuracy and reproducibility, ensuring confidence in results. In a spiking experiment, 17 analytes with known concentrations were added into a chemically defined medium and measured using the REBEL. Values obtained with REBEL showed high accuracy (values were within +/- 20% of expected values) and high analytical precision (%RSDs were between 7 to 16%) as demonstrated in Figure 2.
AMINCO ACID RECOVERY IN CHO MEDIUM
Figure 2. Recovery of analyte concentration using the REBEL analyzer. 17 analytes (Sigma AAS18 amino acid standard) were spiked at 1mM and cystine at 0.5mM, into a commercial chemically defined medium in triplicate and measured four times on the REBEL (total of 12 replicates). All analytes were between 93 –118% of expected values.
HOW WILL YOU USE
REBEL?
MONITOR AMINO ACIDS AND VITAMINS THROUGHOUT YOUR BIOREACTOR TIME COURSE. REFINE FEEDING STRATEGIES ON THE FLY. CORRELATE MEDIA SELECTION TO PRODUCT QUALITY AND YIELD.
[post_title] => REBEL Brochure
[post_excerpt] => The REBEL is a novel, dedicated cell culture media analyzer designed for rapid, easy, and efficient amino acid and nutrient analysis.
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In this flyer, learn how you can optimize the performance of your REBEL device with a preventive maintenance plan. There are various parts for the REBEL device and with routine maintenance, you can keep your device running efficiently with optimal analysis. We offer a few options for service plans to support your needs.
Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
1. REBEL Autosampler Sample Needle
Routine PM replacement and alignment of the autosampler needle will reduce chances of leaks, clogs, and potential missed injections during analysis.
2. REBEL Autosampler Sample Syringe
The autosampler syringe is responsible for all the fluidic movement and precise sampling within the REBEL. Over time the seals within the syringe can wear resulting in leaks and lowered analysis precision of fluidic transfer/sample loads.
3. REBEL Gas System Inlet Filter*
Annual PM replacement of the air inlet carbon and HEPA filters is to ensure optimal performance for the gas handling system in the REBEL. If not replaced the filters become less efficient and could result in poor analysis performance and contamination of more expensive components
*Access this on the back of the REBEL
4. REBEL Waste System Filter*
A particulate filter included in the waste system within the REBEL is to prevent material from entering the membranes of the waste pump. Routine replacement prevents clogging and decreased waste removal performance.
*Access underneath outer panels of the REBEL
5. REBEL MS Detector Inlet*
Detector Inlet is the entrance to the mass spectrometer of the REBEL device. Routine maintenance can reduce the chance of clogging, detection issues, and fouling. During PM, the performance of the vacuum system is evaluated along with alignment and detector performance.
*Access underneath outer panels of the REBEL
REBEL “STANDARD”
SERVICE PM PLAN REBEL PREMIUM
SERVICE PLAN Tech support (via email/phone) Yes (Priority) Yes (Highest priority) Software updates (bug fixes) Yes Yes Software upgrades
(applicable features) Yes Yes Replacement parts/repair labor Yes Yes Preventative
maintenance & IQ/OQ Once per year Once per year On-site
application support Up to two visits included per year Up to two visits included per year Certified training No One free of charge* per year Discount on single
SMA kit purchase No 7% through coverage period Multi-year service plans Yes Yes
*For multi-year Premium plan, one free of charge Certified Training is on annual “use it or lose it” basis.
[post_title] => Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
[post_excerpt] => Learn how you can optimize the performance of REBEL with a preventive maintenance plan and see what is included.
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Brochures & Flyers
Optimize Your REBEL’s Performance with a Preventive Maintenance Plan
Learn how you can optimize the performance of REBEL with a preventive maintenance plan and see what is included.
Faster Bioprocess Data Visualization
Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers data visualization in less than a minute for run and sample comparisons.
REBEL Certified User Training
Get the best user experience with the REBEL at-line spent media analyzer. Our training course is for new and experienced users who want to refresh their REBEL device
operation skills.
REBEL Spent Media Analysis Kits
The REBEL Spent Media Analysis (SMA) kit is designed to give you all the consumable components needed to run your samples quickly and move your projects forward faster.
REBEL Brochure
The REBEL is a novel, dedicated cell culture media analyzer designed for rapid, easy, and efficient amino acid and nutrient analysis.
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[post_content] =>
Getting life-changing biologics to patients ASAP
HJB’s goal is to overcome scientific and technical hurdles that inhibit patients’ access to life-changing biologics. To do that, they aim to provide high quality, holistic, and reliable services to innovative biopharma companies.
So how exactly do they hit that lofty goal? The contract development and manufacturing organization (CDMO) based in Zhejiang, China, employs cutting-edge technology that substantially accelerates R&D processes, reduces costs, and fast-tracks commercialization. They offer biopharma clients access to complete, flexible, and reliable development and manufacturing services that include cell line development, bioprocess development, analytical method development, formulation development and GMP manufacturing for all clinical phases and commercial production.
Overcoming hurdles in cell culture media analysis
CHALLENGE: The waiting game
Prior to HJB’s integration of the REBEL™ cell culture media analyzer into their processes, the upstream process development team, led by Vice President Lisa Zheng, sent media samples off to HJB’s analytical sciences group for amino acid analysis. But relying on another team for results meant they were waiting to make decisions and take next steps in their media development processes.
In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
SOLUTION: Answers at-line, anytime
Lisa’s team purchased a REBEL and set it up right next to their bioreactors. They found the device space-friendly and easy to install. Consumables were easy to maintain, and operation was so simple that even their non-technical analysts could conduct analysis. Samples were measured quickly, and with results in less than 10 minutes, scientists were making decisions in near-real time. REBEL is now used routinely for quick analysis to support accelerated media and process improvements.
CONCLUSION: A new milestone in productivity
Because REBEL lets the upstream process development group analyze many samples in a short period of time, the group accumulates a large amount of amino acid data just through daily testing. This lets them quickly investigate deviations during product development, carry out process development/optimization based on REBEL data, and better understand the impacts on culture performance and Product Quality Attributes (PQAs) from process parameter changes.
REBEL was also key in helping HJB accelerate media and process development, which is essential for the development of highly intensified, continuous cell culture perfusion. Earlier this year, the company announced that its continuous perfusion cell culture platform has achieved industry-leading volumetric productivity of greater than 6 g/L per day while maintaining process and product quality attributes in a state of control for a 4-week culture.
“REBEL can analyze a large number of samples in a short period of time to provide valuable data to accelerate cell culture process development. Rather than obtaining amino acid profiles after the run is completed, REBEL provides real-time data for us to make process decisions while the experiments are in progress to maximize successful outcomes.”
-Dr. Christopher Hwang, CTO of HJB
Overcoming hurdles in cell culture media analysis
CHALLENGE: A fair share of challenges with LC
Liming Shi is the VP in charge of the Analytical Science and Quality Control Departments, and responsible for Product & Process Development Operation. HJB’s Analytical Science Department develops and optimizes analytical methods, and provides analytical support for cell lines upstream, downstream, and formulation process development. The group applies the most advanced analytical techniques to perform large molecule characterization, including analysis of mAbs, ADCs, and bispecific antibodies.
Liming’s team was looking for difficult-to-separate charge variants, which is a challenge with LC-based separations. They were also bumping into UHPLC challenges, such as poor separation and analysis with limited sample volumes. Furthermore, their UHPLC-MS separation and analysis had a turn-around time that was too long.
SOLUTION: In comes ZipChip
In their search for analytical tools that could provide higher-quality data and get them to results faster, the Analytical Services team put ZipChip® straight to work.
Because ZipChip enables rapid measurement of Critical Quality Attributes (CQAs) of native and intact monoclonal antibodies (mAbs), the team used it to characterize intact mAbs and assess the root cause of increases in acidic and basic variants under stress at high temperature. The antibody was analyzed at multiple levels, including its intact state under native conditions and subunit and peptide levels. They used the same ZipChip system and method for both analyses, and were able to determine charge heterogeneity speciation and identification in under 10 minutes. This new workflow was 100 times faster with less prep compared to conventional LC, which required them to harvest fractions.
It was also easy to start integrating ZipChip into their other laboratory workflows as minimal method development was needed for different types of proteins. The team noted this was a big benefit when it came to analysis of native proteins.
Liming Shi -
VP of Analytical Science and Quality Control Departments, Product & Process Development Operation
“ZipChip is a capable platform for multiple CQA assays, and for charge variant analysis it is very straightforward to get separation and identification information with minimal method development needed for different types of proteins, especially for the analysis in native conditions. The sample preparation is simple and straightforward, and the sample requirements are at nanogram levels.”
CONCLUSION: ZipChip + MS goes mainstream
The Analytical Science and Quality Control groups at HJB now have ZipChip systems coupled to their Q Exactive and other Thermo Fisher Scientific mass specs. They’ve adopted ZipChip into their intact antibody analysis workflows (denatured and native conditions) and their subunit and peptide mapping analysis as it gives them very clear and in-depth information on antibody molecules. One of the stand-out features in Liming’s opinion is having an online platform that provides straightforward separation and identification of charge variants based on different mechanisms.
The Analytical Science team recently published their work using ZipChip in Analytical Biochemistry, Volume 625, 15 July 2021, 114214: Characterization and monitoring of charge variants of a recombinant monoclonal antibody using microfluidic capillary electrophoresis-mass spectrometry.
[post_title] => REBEL + ZipChip help HJB Overcome Scientific Hurdles and Optimize Processes in Biotherapeutic Development
[post_excerpt] => In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
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Getting life-changing biologics to patients ASAP
HJB’s goal is to overcome scientific and technical hurdles that inhibit patients’ access to life-changing biologics. To do that, they aim to provide high quality, holistic, and reliable services to innovative biopharma companies.
So how exactly do they hit that lofty goal? The contract development and manufacturing organization (CDMO) based in Zhejiang, China, employs cutting-edge technology that substantially accelerates R&D processes, reduces costs, and fast-tracks commercialization. They offer biopharma clients access to complete, flexible, and reliable development and manufacturing services that include cell line development, bioprocess development, analytical method development, formulation development and GMP manufacturing for all clinical phases and commercial production.
Overcoming hurdles in cell culture media analysis
CHALLENGE: The waiting game
Prior to HJB’s integration of the REBEL™ cell culture media analyzer into their processes, the upstream process development team, led by Vice President Lisa Zheng, sent media samples off to HJB’s analytical sciences group for amino acid analysis. But relying on another team for results meant they were waiting to make decisions and take next steps in their media development processes.
In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
SOLUTION: Answers at-line, anytime
Lisa’s team purchased a REBEL and set it up right next to their bioreactors. They found the device space-friendly and easy to install. Consumables were easy to maintain, and operation was so simple that even their non-technical analysts could conduct analysis. Samples were measured quickly, and with results in less than 10 minutes, scientists were making decisions in near-real time. REBEL is now used routinely for quick analysis to support accelerated media and process improvements.
CONCLUSION: A new milestone in productivity
Because REBEL lets the upstream process development group analyze many samples in a short period of time, the group accumulates a large amount of amino acid data just through daily testing. This lets them quickly investigate deviations during product development, carry out process development/optimization based on REBEL data, and better understand the impacts on culture performance and Product Quality Attributes (PQAs) from process parameter changes.
REBEL was also key in helping HJB accelerate media and process development, which is essential for the development of highly intensified, continuous cell culture perfusion. Earlier this year, the company announced that its continuous perfusion cell culture platform has achieved industry-leading volumetric productivity of greater than 6 g/L per day while maintaining process and product quality attributes in a state of control for a 4-week culture.
“REBEL can analyze a large number of samples in a short period of time to provide valuable data to accelerate cell culture process development. Rather than obtaining amino acid profiles after the run is completed, REBEL provides real-time data for us to make process decisions while the experiments are in progress to maximize successful outcomes.”
-Dr. Christopher Hwang, CTO of HJB
Overcoming hurdles in cell culture media analysis
CHALLENGE: A fair share of challenges with LC
Liming Shi is the VP in charge of the Analytical Science and Quality Control Departments, and responsible for Product & Process Development Operation. HJB’s Analytical Science Department develops and optimizes analytical methods, and provides analytical support for cell lines upstream, downstream, and formulation process development. The group applies the most advanced analytical techniques to perform large molecule characterization, including analysis of mAbs, ADCs, and bispecific antibodies.
Liming’s team was looking for difficult-to-separate charge variants, which is a challenge with LC-based separations. They were also bumping into UHPLC challenges, such as poor separation and analysis with limited sample volumes. Furthermore, their UHPLC-MS separation and analysis had a turn-around time that was too long.
SOLUTION: In comes ZipChip
In their search for analytical tools that could provide higher-quality data and get them to results faster, the Analytical Services team put ZipChip® straight to work.
Because ZipChip enables rapid measurement of Critical Quality Attributes (CQAs) of native and intact monoclonal antibodies (mAbs), the team used it to characterize intact mAbs and assess the root cause of increases in acidic and basic variants under stress at high temperature. The antibody was analyzed at multiple levels, including its intact state under native conditions and subunit and peptide levels. They used the same ZipChip system and method for both analyses, and were able to determine charge heterogeneity speciation and identification in under 10 minutes. This new workflow was 100 times faster with less prep compared to conventional LC, which required them to harvest fractions.
It was also easy to start integrating ZipChip into their other laboratory workflows as minimal method development was needed for different types of proteins. The team noted this was a big benefit when it came to analysis of native proteins.
Liming Shi -
VP of Analytical Science and Quality Control Departments, Product & Process Development Operation
“ZipChip is a capable platform for multiple CQA assays, and for charge variant analysis it is very straightforward to get separation and identification information with minimal method development needed for different types of proteins, especially for the analysis in native conditions. The sample preparation is simple and straightforward, and the sample requirements are at nanogram levels.”
CONCLUSION: ZipChip + MS goes mainstream
The Analytical Science and Quality Control groups at HJB now have ZipChip systems coupled to their Q Exactive and other Thermo Fisher Scientific mass specs. They’ve adopted ZipChip into their intact antibody analysis workflows (denatured and native conditions) and their subunit and peptide mapping analysis as it gives them very clear and in-depth information on antibody molecules. One of the stand-out features in Liming’s opinion is having an online platform that provides straightforward separation and identification of charge variants based on different mechanisms.
The Analytical Science team recently published their work using ZipChip in Analytical Biochemistry, Volume 625, 15 July 2021, 114214: Characterization and monitoring of charge variants of a recombinant monoclonal antibody using microfluidic capillary electrophoresis-mass spectrometry.
[post_title] => REBEL + ZipChip help HJB Overcome Scientific Hurdles and Optimize Processes in Biotherapeutic Development
[post_excerpt] => In their search to accelerate R&D and reduce costs, HJB discovered the power of REBEL and ZipChip.
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[post_date] => 2024-09-09 13:14:46
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[post_content] =>
Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis.
This poster was a collaboration with Terumo Blood and Cell Technologies and was part of the poster program at the 2024 ISCT EU Conference.
[post_title] => Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
[post_excerpt] => The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding, characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
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[post_name] => enhancing-cell-and-gene-therapy-manufacturing-processes-by-in-line-on-line-and-at-line-bioprocess-analytical-technologies
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[post_date] => 2024-05-23 19:23:12
[post_date_gmt] => 2024-05-23 23:23:12
[post_content] =>
[post_title] => Optimization of Scalable rAAV Production for Gene Therapy – Utilizing At-Line Amino Acid Measurements for Bioprocess
[post_excerpt] => The REBEL device enabled data-driven bioprocess development for rAAV manufacturing in HEK293 cells by accurately and precisely quantitating amino acids, leading to deeper process understanding. This poster was a collaboration with MIT and highlighted at the following 2024 Conferences-ASGCT, ISCT, ISCT EU and ESACT.
[post_status] => publish
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[post_name] => optimization-of-scalable-raav-production-for-gene-therapy-utilizing-at-line-amino-acid-measurements-for-bioprocess
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[post_date] => 2024-05-23 19:04:45
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[post_content] =>
[post_title] => In-Line and On-Line Monitoring of Key Cell Culture Parameters for Robust Cell and Gene Therapy Bioprocess
[post_excerpt] => The instant PAT implementation with MAVERICK, versatility, and sensitivity of MAVEN and point of need availability of amino acids analysis with REBEL, enable deeper knowledge and actionable information of Cell and GeneTherapy bioprocesses. Further, the devices informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization and control. This poster was highlighted at the 2024 ASGCT Conference.
[post_status] => publish
[comment_status] => closed
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[post_name] => in-line-and-on-line-monitoring-of-key-cell-culture-parameters-for-robust-cell-and-gene-therapy-bioprocess
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[post_modified] => 2024-07-29 09:55:27
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[post_author] => 29
[post_date] => 2024-04-01 12:35:51
[post_date_gmt] => 2024-04-01 16:35:51
[post_content] =>
[post_title] => Know Your Process: On-line and At-line Analytics for Upstream Bioprocess Key Nutrients
[post_excerpt] => Bioprocess development requires analytics to monitor critical process parameters. This poster discusses two discuss two key technologies to characterize, optimize and control bioprocess. In 2024, this poster has been highlighted at BPI Europe and BPS Europe.
[post_status] => publish
[comment_status] => closed
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[post_password] =>
[post_name] => know-your-process-on-line-and-at-line-analytics
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[post_modified] => 2024-10-22 13:09:38
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[post_date] => 2024-03-25 10:20:12
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[post_content] =>
[post_title] => Amino Acid Quantitation in Over 50 Mammalian Cell Culture Media with an Integrated CE-MS Analyzer
[post_excerpt] => Characterizing cell culture nutrients such as amino acids in growth media is critical for maximizing cell growth and improving key quality attributes of the cells. This poster was presented at ASMS 2023 as poster THP625.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => amino-acid-quantitation-in-over-50-mammalian-cell-culture-media
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[post_modified] => 2024-08-01 14:18:02
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[5] => WP_Post Object
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[post_author] => 15
[post_date] => 2024-03-21 10:26:35
[post_date_gmt] => 2024-03-21 14:26:35
[post_content] =>
[post_title] => Amino Acid Quantitation of Cell Culture Media Matrices via an Integrated CE-MS Analyzer
[post_excerpt] => Optimization of cell culture media and process conditions are critical for achieving optimal cell growth, productivity, and product quality. This poster was presented at ASMS 2023 as poster TP 398.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => amino-acid-quantitation-of-cell-culture-media
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[6] => WP_Post Object
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[ID] => 24540
[post_author] => 29
[post_date] => 2024-05-23 13:58:57
[post_date_gmt] => 2024-05-23 17:58:57
[post_content] =>
[post_title] => Optimization of Scalable rAAV Production for Gene Therapy – Leveraging At-Line Amino AcidMeasurements for Bioprocess Modeling-Driven Approaches
[post_excerpt] => Spent media analysis from an at-line analyzer, the REBEL, was used to further understanding of AAV production process and identify correlation between key nutrient consumptions and capsid titers in fed-batch and continuous processes. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 43.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => scalable-aav-production-gene-therapy
[to_ping] =>
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[post_modified] => 2024-08-01 12:39:26
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[7] => WP_Post Object
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[ID] => 26149
[post_author] => 15
[post_date] => 2024-10-11 13:20:46
[post_date_gmt] => 2024-10-11 17:20:46
[post_content] =>
Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis. This poster was developed with Terumo Blood and Cell Technologies and was showcased at BPI USA and Advanced Therapies 2024.
[post_title] => Innovations in Analytical Technology for Cell & Gene Therapy Manufacturing
[post_excerpt] => This poster highlights our at-, on-, and in-line analytical solutions that contribute to an enhanced understanding, characterization, and control of bioprocesses in the development and manufacturing of cell and gene therapies.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => innovations-in-analytical-technology-for-cell-gene-therapy-manufacturing
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:32:59
[post_modified_gmt] => 2024-11-18 20:32:59
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[8] => WP_Post Object
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[ID] => 25245
[post_author] => 15
[post_date] => 2024-07-09 14:32:05
[post_date_gmt] => 2024-07-09 18:32:05
[post_content] =>
The biopharmaceutical industry is increasingly motivated to improve process control, understanding, and repeatability using process analytical technologies (PAT). More specifically, Raman-based optical, in-line measurement methods have shown promise as a way to monitor critical performance parameters, including glucose and lactate concentrations, in real-time. Recently, this has translated to the implementation of Raman-based glucose feeding strategies to modulate productivity and product quality in Chinese hamster ovary (CHO) cell cultures. The current work implements a novel Raman-based solution that does not require any chemometric models for glucose, lactate and biomass measurements. MAVERICK was directly, without any training in the specific bioprocess, deployed to dynamically control lactate feeding. We compared feeding strategies as means of modulating product quality and improving culture conditions, primarily through decreased ammonia accumulation. This was poster #358 at ESACT 2024 and was also highlighted at the Bioprocessing Summit 2024.
[post_title] => Raman-based Lactate Feeding Impact on Culture Characteristics and Product Quality in Mammalian Cell Cultures
[post_excerpt] => This research explores Raman spectroscopy for real-time glucose monitoring and feeding strategies in CHO cell cultures, aiming to improve product quality.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => raman-based-lactate-feeding-impact-on-culture-characteristics-and-product-quality-in-mammalian-cell-cultures
[to_ping] =>
[pinged] =>
[post_modified] => 2024-08-23 14:16:28
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[9] => WP_Post Object
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[ID] => 25242
[post_author] => 15
[post_date] => 2024-07-09 14:23:13
[post_date_gmt] => 2024-07-09 18:23:13
[post_content] =>
Biologics production development for intensified processes aims to achieve desired product quality attributes and high productivity. Running multiple micro-bioreactors in parallel enables expedited optimization, but low microbioreactor volumes limit the media available for daily sampling for analysis. Cell culture media (CCM) optimization can be a lengthy and complex process involving multiple DOEs. Fast, at the point-of-need, analytical tools with only minimal sample consumption, are required to assess key-nutrient consumption and provide feedback to enable feed strategy optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
[post_title] => Data-driven Feed Strategy Optimization and Scale-up of mAb-expressing CHO Cell Line Bioprocess
[post_excerpt] => This poster explores utilizing micro-bioreactors for expedited biologics production development, highlighting challenges with limited sample volume for media analysis and proposing real-time, point-of-need analytical tools for efficient CCM optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => data-driven-feed-strategy-optimization-and-scale-up-of-mab-expressing-cho-cell-line-bioprocess
[to_ping] =>
[pinged] =>
[post_modified] => 2024-10-02 13:40:29
[post_modified_gmt] => 2024-10-02 17:40:29
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[10] => WP_Post Object
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[ID] => 25192
[post_author] => 15
[post_date] => 2024-07-08 15:11:04
[post_date_gmt] => 2024-07-08 19:11:04
[post_content] =>
Through the work highlighted in this poster we found that when the manufactured cells are antigen-stimulated, CAR/VIPRa T-cells become significantly more energetic. In contrast, CAR T-cells become less energetic and more glycolytic, which are known features of T-cell exhaustion. Further, metabolic assessment with multiple methods produced findings that correlated with this assessment, such oxygen consumption and certain amino acid levels in spent media. Finally, CAR T-cell activity, potency, and cytotoxicity assessments showed a correlation with anti-tumor activity. Together, this work demonstrates that distinct metabolic features allow CAR/VIPRa T cells, when antigen-stimulated, to have enhanced functions against tumors. Developed in partnership with Emory University and the Winship Cancer Institute, this poster has made waves at the 2024 ISCT & ISCT EU Conference, the ESACT Conference, and Advanced Therapies 2024.
[post_title] => Spent Media Analysis Aids in Determining Metabolic Mechanisms of Superior CAR T-Cell Products
[post_excerpt] => As the use of CAR T-cell therapies advances, testing different CAR T-cells, and associating metabolic characteristics to well-performing, desired phenotypes of CAR T-cells enables optimization of CAR constructs and manufacturing processes.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => spent-media-analysis-aids-in-determining-metabolic-mechanisms-of-superior-car-t-cell-products
[to_ping] =>
[pinged] =>
[post_modified] => 2024-11-18 15:37:35
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[ID] => 25189
[post_author] => 15
[post_date] => 2024-07-08 14:47:24
[post_date_gmt] => 2024-07-08 18:47:24
[post_content] =>
This poster highlights the HEK-mediated adeno-associated virus (AAV) production process and the development of an open-source production platform incorporating a chemically defined serum-free medium. Initial attempts using an open-source CHO-medium resulted in cell aggregation, slow growth, and an inability to transfect and produce AAV. Therefore, we explored creating an HEK-friendly medium and process conducive to healthy cell growth, transfection, and vector production. Nutrient consumption rates were studied to elucidate metabolic activity associated with AAV production. This poster was #835 at ISCT 2024
[post_title] => Open-sourced Production Platform for Raav in HEK Data-driven Cell Culture Media Optimization
[post_excerpt] => This poster highlights the HEK-mediated adeno-associated virus (AAV) production process and the development of an open-source production platform incorporating a chemically defined serum-free medium.
[post_status] => publish
[comment_status] => closed
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[post_name] => open-sourced-production-platform-for-raav-in-hek-data-driven-cell-culture-media-optimization
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[post_modified] => 2024-07-08 14:47:25
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[post_date] => 2024-02-20 17:24:46
[post_date_gmt] => 2024-02-20 22:24:46
[post_content] =>
[post_title] => Improving Cell and Gene Therapy Manufacturing Processes by Automated On-line and In-line Bioprocess Analytical Technologies
[post_excerpt] => Recent advances in cell and gene therapy bioprocess analytical technology regimes, approaches to de novo analytical modeling/calibration of these systems, and how their informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 29. This poster was also on display as #843 at ISCT 2024.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
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[post_name] => improving-cell-gene-therapy-manufacturing
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[post_date] => 2024-02-20 17:15:13
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[post_content] =>
[post_title] => Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack - Manufactured CAR T-Cells
[post_excerpt] => Novel reagents that aid in the consistent manufacturing of
Novel reagents that aid in consistent manufacturing of CAR T-cells with well-defined phenotypes are needed to improve treatment outcomes in patients. View poster #17 from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference.
[post_status] => publish
[comment_status] => closed
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[post_password] =>
[post_name] => multi-cytokine-backpack-car-t-cells
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[post_modified] => 2024-08-01 11:11:58
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[post_date] => 2024-02-20 17:03:02
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[post_content] =>
[post_title] => Optimization of Cell Culture Media and Culture Conditions for HEK293 for Improved Cell Growth and Reduced Cell Clumping for the Effective Production of Viral Vectors
[post_excerpt] => This study demonstrates the power of at-line cell culture analyzers such as the REBEL to gain process understanding quickly to adjust media components for improved cell culture performance. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 18.
[post_status] => publish
[comment_status] => closed
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[post_password] =>
[post_name] => improved-cell-growth-production-viral-vectors
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[post_modified] => 2024-03-21 09:09:37
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[post_content] =>
[post_title] => Optimization of Scalable rAAV Production for Gene Therapy
[post_excerpt] => This poster showcases spent media analysis leveraging REBEL, which requires only 10 μL per sample and 10 minutes analysis time.
[post_status] => publish
[comment_status] => closed
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[post_name] => rebel-ps-13
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[post_date] => 2022-09-22 15:04:14
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[post_content] =>
[post_title] => Empowering Process Optimization for a mAb-Expressing CHO Cell Line
[post_excerpt] => Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.
[post_status] => publish
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[post_date] => 2020-10-06 17:54:35
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[post_title] => Using genomic and spent media analysis to characterize stressed CHO cultures
[post_excerpt] =>
[post_status] => publish
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[post_name] => rebel_poster_clemson_rna-seq-to-characterize-underlying-gene-expressions-changes
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[post_title] => A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
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Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis.
This poster was a collaboration with Terumo Blood and Cell Technologies and was part of the poster program at the 2024 ISCT EU Conference.
[post_title] => Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
[post_excerpt] => The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding, characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
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Posters
Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding, characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
Optimization of Scalable rAAV Production for Gene Therapy – Utilizing At-Line Amino Acid Measurements for Bioprocess
The REBEL device enabled data-driven bioprocess development for rAAV manufacturing in HEK293 cells by accurately and precisely quantitating amino acids, leading to deeper process understanding. This poster was a collaboration with MIT and highlighted at the following 2024 Conferences-ASGCT, ISCT, ISCT EU and ESACT.
In-Line and On-Line Monitoring of Key Cell Culture Parameters for Robust Cell and Gene Therapy Bioprocess
The instant PAT implementation with MAVERICK, versatility, and sensitivity of MAVEN and point of need availability of amino acids analysis with REBEL, enable deeper knowledge and actionable information of Cell and GeneTherapy bioprocesses. Further, the devices informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization and control. This poster was highlighted at the 2024 ASGCT Conference.
Know Your Process: On-line and At-line Analytics for Upstream Bioprocess Key Nutrients
Bioprocess development requires analytics to monitor critical process parameters. This poster discusses two discuss two key technologies to characterize, optimize and control bioprocess. In 2024, this poster has been highlighted at BPI Europe and BPS Europe.
Amino Acid Quantitation in Over 50 Mammalian Cell Culture Media with an Integrated CE-MS Analyzer
Characterizing cell culture nutrients such as amino acids in growth media is critical for maximizing cell growth and improving key quality attributes of the cells. This poster was presented at ASMS 2023 as poster THP625.
Amino Acid Quantitation of Cell Culture Media Matrices via an Integrated CE-MS Analyzer
Optimization of cell culture media and process conditions are critical for achieving optimal cell growth, productivity, and product quality. This poster was presented at ASMS 2023 as poster TP 398.
Optimization of Scalable rAAV Production for Gene Therapy – Leveraging At-Line Amino AcidMeasurements for Bioprocess Modeling-Driven Approaches
Spent media analysis from an at-line analyzer, the REBEL, was used to further understanding of AAV production process and identify correlation between key nutrient consumptions and capsid titers in fed-batch and continuous processes. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 43.
Innovations in Analytical Technology for Cell & Gene Therapy Manufacturing
This poster highlights our at-, on-, and in-line analytical solutions that contribute to an enhanced understanding, characterization, and control of bioprocesses in the development and manufacturing of cell and gene therapies.
Raman-based Lactate Feeding Impact on Culture Characteristics and Product Quality in Mammalian Cell Cultures
This research explores Raman spectroscopy for real-time glucose monitoring and feeding strategies in CHO cell cultures, aiming to improve product quality.
Data-driven Feed Strategy Optimization and Scale-up of mAb-expressing CHO Cell Line Bioprocess
This poster explores utilizing micro-bioreactors for expedited biologics production development, highlighting challenges with limited sample volume for media analysis and proposing real-time, point-of-need analytical tools for efficient CCM optimization. This poster was created with CPI. In 2024 this poster has been highlighted at ESACT, the Bioprocessing Summit and BPI USA.
Spent Media Analysis Aids in Determining Metabolic Mechanisms of Superior CAR T-Cell Products
As the use of CAR T-cell therapies advances, testing different CAR T-cells, and associating metabolic characteristics to well-performing, desired phenotypes of CAR T-cells enables optimization of CAR constructs and manufacturing processes.
Open-sourced Production Platform for Raav in HEK Data-driven Cell Culture Media Optimization
This poster highlights the HEK-mediated adeno-associated virus (AAV) production process and the development of an open-source production platform incorporating a chemically defined serum-free medium.
Improving Cell and Gene Therapy Manufacturing Processes by Automated On-line and In-line Bioprocess Analytical Technologies
Recent advances in cell and gene therapy bioprocess analytical technology regimes, approaches to de novo analytical modeling/calibration of these systems, and how their informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 29. This poster was also on display as #843 at ISCT 2024.
Amino Acid Analysis Indicates Metabolic Differences in Multi-Cytokine Backpack – Manufactured CAR T-Cells
Novel reagents that aid in the consistent manufacturing of
Novel reagents that aid in consistent manufacturing of CAR T-cells with well-defined phenotypes are needed to improve treatment outcomes in patients. View poster #17 from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference.
Optimization of Cell Culture Media and Culture Conditions for HEK293 for Improved Cell Growth and Reduced Cell Clumping for the Effective Production of Viral Vectors
This study demonstrates the power of at-line cell culture analyzers such as the REBEL to gain process understanding quickly to adjust media components for improved cell culture performance. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 18.
Optimization of Scalable rAAV Production for Gene Therapy
This poster showcases spent media analysis leveraging REBEL, which requires only 10 μL per sample and 10 minutes analysis time.
Empowering Process Optimization for a mAb-Expressing CHO Cell Line
Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.
Using genomic and spent media analysis to characterize stressed CHO cultures
A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
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Published Articles
In-Process Analytics are Key to Successful Cell Therapy Process Optimization and Manufacturing
Considerable clinical activity and the approval of several autologous, patient-specific therapies has increased industry demand and has also highlighted bottlenecks in manufacturing workflows.
Harness the Power of At-Line Spent Media Analysis (BioPharm International)
Spent Media Analysis of CHO Grown in an Ammonia-Stressed Parallel Microbioreactor Platform
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Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Amino Acid Training Kit
BGE
Diluent: SMA
Diluent: SMA (EU)
Diluent: SMA (UK)
Diluent: SMA (USA)
IQOQ Standard: SMA
IQOQ Standard: SMA (EU)
IQOQ Standard: SMA (UK)
IQOQ Standard: SMA (USA)
Standard
Standard (EU)
Standard (UK)
Standard (USA)
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Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Amino Acid Training Kit
BGE
Diluent: SMA
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Diluent: SMA (UK)
Diluent: SMA (USA)
IQOQ Standard: SMA
IQOQ Standard: SMA (EU)
IQOQ Standard: SMA (UK)
IQOQ Standard: SMA (USA)
Standard
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[post_date] => 2019-09-11 15:09:41
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[post_content] =>
Get cell media analysis at-line, anytime.
The REBEL puts the control in your hands.
Its small, self-contained footprint fits right on your bench allowing you to run samples at-line in less than 10 minutes.
SAMPLE INFO
Get quantitative identification and analysis on a panel of 30+ analytes including key amino acids, biogenic amines, and water-soluble vitamins.
Analysis time:
<10 minutes per well
Volume and format:
10 µL minimum volume (prior to dilution)
96-well plate or chromatography vials
Cooled sample storage
Type:
Fresh or spent cell media from mammalian or microbial cultures and fermentations
Amino Acids: Alanine
Alanyl-Glutamine
Arginine
Asparagine
Aspartic acid
Betaine
Cystine
Glutamic Acid Glutamine
Glycine
Histidine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine Proline
Serine
Threonine
Tryptophan
Tyrosine
Valine Biogenic Amines: β-Alanine
L-Citrulline GABA
Hydroxyproline Methyl-L-histidine
Sarcosine Vitamins: Choline
Pyridoxine Nicotinamide
Thiamine Pyridoxal
THE DEVICE
Calibration:
Automated calibration and
QC with consumable kits
System Interfaces:
Ethernet, USB port (2)
COMPLIANCE
Safety/Compliance:
UL/CSA/IEC 61010-1
3rd Edition; CE marked;
EU & China RoHS; EU REACH
SOFTWARE INTEGRATION
Sartorius SIMCA multivariate data analysis Securecell Lucullus PIMS*
*driver license available directly
from Securecell Inc.
YOUR DATA
Output:
Concentration reported in “mM”
Report format:
CSV and PDF
SOFTWARE
Designed for operation in cGLP/cGMP, with support for 21 CFR Part 11-compliance
OPERATING CONDITIONS
Ambient temperature:
20–25°C
Ambient humidity:
20–80% RH (non-condensing)
Solvent waste collected in dedicated vessel with level sensing
Condensate (water) collected in dedicated vessel with level sensing
Power requirements:
100–240 VAC, 50–60 Hz
Physical dimensions:
Height (22 in./56 cm)
Width (13 in./33 cm)
Depth (27 in./69 cm)
Weight (83 lbs/38 kg)
[post_title] => REBEL Specifications Sheet
[post_excerpt] => Get quantitative identification and analysis on a panel of >30 analytes including key amino acids, biogenic amines, and water soluble vitamins.
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[post_content] =>
Get cell media analysis at-line, anytime.
The REBEL puts the control in your hands.
Its small, self-contained footprint fits right on your bench allowing you to run samples at-line in less than 10 minutes.
SAMPLE INFO
Get quantitative identification and analysis on a panel of 30+ analytes including key amino acids, biogenic amines, and water-soluble vitamins.
Analysis time:
<10 minutes per well
Volume and format:
10 µL minimum volume (prior to dilution)
96-well plate or chromatography vials
Cooled sample storage
Type:
Fresh or spent cell media from mammalian or microbial cultures and fermentations
Amino Acids: Alanine
Alanyl-Glutamine
Arginine
Asparagine
Aspartic acid
Betaine
Cystine
Glutamic Acid Glutamine
Glycine
Histidine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine Proline
Serine
Threonine
Tryptophan
Tyrosine
Valine Biogenic Amines: β-Alanine
L-Citrulline GABA
Hydroxyproline Methyl-L-histidine
Sarcosine Vitamins: Choline
Pyridoxine Nicotinamide
Thiamine Pyridoxal
THE DEVICE
Calibration:
Automated calibration and
QC with consumable kits
System Interfaces:
Ethernet, USB port (2)
COMPLIANCE
Safety/Compliance:
UL/CSA/IEC 61010-1
3rd Edition; CE marked;
EU & China RoHS; EU REACH
SOFTWARE INTEGRATION
Sartorius SIMCA multivariate data analysis Securecell Lucullus PIMS*
*driver license available directly
from Securecell Inc.
YOUR DATA
Output:
Concentration reported in “mM”
Report format:
CSV and PDF
SOFTWARE
Designed for operation in cGLP/cGMP, with support for 21 CFR Part 11-compliance
OPERATING CONDITIONS
Ambient temperature:
20–25°C
Ambient humidity:
20–80% RH (non-condensing)
Solvent waste collected in dedicated vessel with level sensing
Condensate (water) collected in dedicated vessel with level sensing
Power requirements:
100–240 VAC, 50–60 Hz
Physical dimensions:
Height (22 in./56 cm)
Width (13 in./33 cm)
Depth (27 in./69 cm)
Weight (83 lbs/38 kg)
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Host Rizwan Chaudhrey from RSK Media visited our Boston office bioprocessing lab. Check out this video lab tour with Senior Scientist Stephanie Klaubert and Product Manager Nick Randall as they discuss bioprocessing trends, including incorporating automated technologies into the lab and learn what makes 908 Devices unique and different.
[post_title] => RSK Media Interview: Bioprocessing Lab Tour with Nick and Steph
[post_excerpt] => In this interview with Nick and Steph, you will get to explore inside the 908 Devices bioprocessing lab set-up and see MAVEN, MAVERICK and REBEL.
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RSK Media, Rizwan Chaudhrey, interviews 908 Devices CEO and co-founder, Kevin J. Knopp. This interview highlights:
- A background on 908 Devices and why they started the company.
- What the key drivers are behind 908 Devices product launches.
- Why 908 Devices acquired RedWave Technology.
- Kevin J. Knopp provides his thoughts on the future for Life Science.
- Explains what differentiates 908 Devices from other companies.
[post_title] => Interview: RSK Media Interviews Kevin J. Knopp
[post_excerpt] => RSK Media, Rizwan Chaudhrey, visited Boston and met with 908 Devices CEO, Kevin J. Knopp. Topics included key business drivers, the RedWave Technology acquisition, and the future of life sciences.
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[post_title] => Ultimate Bioprocess Monitoring and Control
[post_excerpt] => Quickly get data at the point of need with our REBEL, MAVEN, and MAVERICK devices. Take control of your bioprocess and get to market faster.
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Controlling Essential Amino Acid Levels in CHO Cell Cultures Using A Genome-Scale Nutrient Minimization Forecast Algorithm
Our own Milla Neffling moderates a discussion with three authors of a recent peer-reviewed article in Biotechnology & Bioengineering. The 18-minute discussion ranges from the importance of process modeling to the critical role of new tools like REBEL.
Key Discussion Points:
- How media optimization strategies evolved to help the biopharma industry
- The benefit of genome-scale models
- The importance of input data quality
- The relevance of amino acids and their importance in genome-scale models
Speakers:
Michael Betenbaugh, Ph.D
Professor,
Johns Hopkins University
Yiqun Chen, Ph.D
Graduate Student,
Johns Hopkins University
Ji Young Anderson
Sr. Scientist,
908 Devices
Milla Neffling
Bioprocessing Segment Manager
908 Devices
[post_title] => Process Modeling with Researchers from Johns Hopkins University
[post_excerpt] => Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization
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Host Rizwan Chaudhrey from RSK Media visited our Boston office bioprocessing lab. Check out this video lab tour with Senior Scientist Stephanie Klaubert and Product Manager Nick Randall as they discuss bioprocessing trends, including incorporating automated technologies into the lab and learn what makes 908 Devices unique and different.
[post_title] => RSK Media Interview: Bioprocessing Lab Tour with Nick and Steph
[post_excerpt] => In this interview with Nick and Steph, you will get to explore inside the 908 Devices bioprocessing lab set-up and see MAVEN, MAVERICK and REBEL.
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Videos
RSK Media Interview: Bioprocessing Lab Tour with Nick and Steph
In this interview with Nick and Steph, you will get to explore inside the 908 Devices bioprocessing lab set-up and see MAVEN, MAVERICK and REBEL.
Interview: RSK Media Interviews Kevin J. Knopp
RSK Media, Rizwan Chaudhrey, visited Boston and met with 908 Devices CEO, Kevin J. Knopp. Topics included key business drivers, the RedWave Technology acquisition, and the future of life sciences.
Ultimate Bioprocess Monitoring and Control
Quickly get data at the point of need with our REBEL, MAVEN, and MAVERICK devices. Take control of your bioprocess and get to market faster.
Process Modeling with Researchers from Johns Hopkins University
Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization
REBEL Product Video
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About this Webinar
Overview:
Liquid chromatography-mass spectrometry (LC-MS) is used in various applications across the biotherapeutic protein manufacturing workflow pertaining to drug product quality. Mass spectrometry-based applications range from evaluating glycan distributions in monoclonal antibody products to optimization of the cell culture process development by monitoring amino acid and metabolite consumption. Given its analytical flexibility, LC-MS has the capacity to address complex questions; however, LC-MS instrumentation requires a high level of technical experience and more method development than other analytical procedures. Additionally, media development and feed studies in cell culture process optimization are labor-intensive and time-consuming. There is a growing interest in implementing efficient and simplified methods for cell culture media analysis to push for faster innovative processes in biomanufacturing. Newer analytical equipment does not attempt to address the complexity of LC-MS applications specifically targeted for high throughput media analysis of cell culture. This capillary electrophoresis-mass spectrometry (CE-MS)-based Amino Acid Analyzer is a device with simple procedures that provide a similar ability to the traditional LC-MS to specifically identify and quantitate an array of amino acids and several other important metabolites while providing a user-friendly interface and process.
Key Takeaways:
- Ascertain the capabilities and limitations of the Amino Acid Analyzer.
- Compare the Amino Acid Analyzer, a new generation of CE-MS analytical platform, against traditional LC-MS methods.
- Evaluate the data quality, trade-offs in operation, and resourcefulness of the analytical platforms.
Want to read a summary on the webinar? Download the resource.
[post_title] => Keeping up with New Emerging Analytical Technology
[post_excerpt] => Explore advancements in emerging analytical technologies like Process Analytical Technology (PAT) and mass spectrometry, improving drug development through enhanced bioprocess monitoring and control.
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About this Webinar
In this webcast, 908 Devices explores approaches to address these technological gaps. This involves utilizing engineered devices, mechanistic model predictions, high-throughput metabolic screening, and molecular biology techniques to facilitate cost-effective and scalable vector production at a personalized level.
The presentation by Prasanna Srinivasan, PhD and Graziella Piras, PhD will delve into strategies employing rapid and straightforward analytical tools at the point of use to swiftly assess key nutrient consumption, providing feedback to optimize feed and supplement addition strategies. Additionally, the use of continuous culture for rAAV production from the triple-plasmid transfection HEK293 system will be discussed.
Key Takeaways:
- Use of model-driven approach to design, predict, test, and optimize VV production processes.
- Benefit of using high-throughput metabolite screening to optimize AAV production using triple transfection method.
- Scale up and transfer to a continuous process at a bioreactor scale.
Want to read a summary on the webinar? Download the resource.
[post_title] => Moving Towards a Scalable AAV Vector Production at High Volumetric Efficiency
[post_excerpt] => In this on-demand webinar, Graziella Piras and Prasanna Srinivasan explore approaches to facilitate a cost-effective and scalable vector production at a personalized level. You will learn how you can get the data where and when you need it.
[post_status] => publish
[comment_status] => closed
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[post_name] => moving-towards-a-scalable-aav-vector-production-at-high-volumetric-efficiency
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[post_modified] => 2024-08-01 10:56:19
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[2] => WP_Post Object
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[ID] => 20719
[post_author] => 29
[post_date] => 2023-06-28 09:15:05
[post_date_gmt] => 2023-06-28 13:15:05
[post_content] =>
About this Webinar
Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieves a durable complete response (dCR). DCR has been correlated with CAR T cell products enriched with T cells of memory phenotypes. Therefore, reagents that consistently promote memory phenotypes during the manufacturing of CAR T cell products have the potential to significantly improve clinical outcomes. Researchers at Emory University, led by Dr. Sarwish Rafiq, have developed a novel modular multi-cytokine backpack (MCB) platform that combines the signals necessary for activation, co-stimulation, and cytokine support into a single “all-in-one” reagent for CAR T cell manufacturing.
This platform allows for the assembly and screening of compositionally diverse MCB libraries to identify formulations tailored to promote specific phenotypes with a high degree of flexibility. We leveraged this platform to identify unique MCB formulations that increase the proportion of memory phenotype CAR T cells. MCB-manufactured CAR T cell products exhibit increased proportions of memory-like phenotypes in diffuse large B cell lymphoma (DLBCL) patient CAR T cells and demonstrate superior anti-tumor efficacy in mouse models of lymphoma and ovarian cancer through enhanced persistence.
In addition, we saw indications of differences in the metabolism of the MCB-manufactured T cells through spent media amino acid analysis. This analysis was performed with 908 Devices REBEL at-line analyzer and showed nutrient consumption and metabolite accumulation profiles which may indicate different metabolic pathways being active in memory-like phenotype CAR T-cell products.
Our findings serve as a proof-of-principle of the powerful utility of the MCB platform to identify reagents that can improve the effectiveness of cell therapy products through optimal manufacturing.
Key Takeaways
- About a novel multi-cytokine backpack MCB activation, co-stimulation, ad cytokine support for effective CAR T cell product manufacturing
- A proof-of-principle of the powerful utility of the MCB platform to identify reagents that can improve the effectiveness of cell therapy products through optimal manufacturing
- Indications of differences in the metabolism of the MCB-manufactured T cells through spent media amino acid analysis
[post_title] => Engineering Functionally Improved CAR T cells with a Multi-Cytokine Backpack Platform with Insights into Metabolism
[post_excerpt] => Researchers at Emory University, led by Dr. Sarwish Rafiq, have developed a novel modular multi-cytokine backpack (MCB) platform that combines the signals necessary for activation, co-stimulation, and cytokine support into a single “all-in-one” reagent for CAR T cell manufacturing.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rebel-webinars-ls-rb-wb-0018
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[pinged] =>
[post_modified] => 2024-12-09 15:17:48
[post_modified_gmt] => 2024-12-09 20:17:48
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[post_date] => 2024-04-29 09:27:59
[post_date_gmt] => 2024-04-29 13:27:59
[post_content] =>
Improve Process Intensification
Process intensification requires a thorough understanding of the process to achieve desired yields while improving resource utilization and maintaining consistent product quality. Continuous monitoring of glucose and lactate provides deeper process understanding. Dynamic glucose control can lead to better cell viability, lower levels of lactate production, and therefore, higher titer and better control of quality attributes (CQAs) in fed-batch and intensified processes. Learn how you can make more informed decisions with in-line, on-line and at-line analytics of key process parameters
[post_title] => Data-driven Process Intensification – Utilizing Smart Analytics to Achieve your Bioprocess Goals
[post_excerpt] => This BPI presentation discusses process intensification and rapid analytics of critical parameters for cell culture, which is necessary to control the process and end product. See how fast and simple analytics significantly speed up the development and optimization processes.
[post_status] => publish
[comment_status] => closed
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[post_name] => data-driven-process-intensification-utilizing-smart-analytics-to-achieve-your-bioprocess-goals
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[post_modified] => 2024-09-11 10:58:39
[post_modified_gmt] => 2024-09-11 14:58:39
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[post_date] => 2023-11-30 15:13:07
[post_date_gmt] => 2023-11-30 20:13:07
[post_content] =>
About this Webinar
In today's bioprocessing industry, speeding up timelines and cutting costs are essential goals. However, it is crucial to maintain product quality when making changes to processes. Utilizing at-line and on-line technologies to monitor bioprocess parameters and cell-feeding strategies is necessary for creating efficient processes that produce top-notch products while also lowering production expenses.
The Centre for Process Innovation (CPI) collaborates with partners in various industries in the UK and globally to advance innovative technologies and help reduce the risks and costs of product development. Dr. Chris Schultz, at CPI, led a project in partnership with 908 Devices to enhance a CHO bioprocess. The main objective was to improve monoclonal antibody production and CHO cell health by making informed decisions when selecting and using suitable cell culture media and feeds. In this webinar, Schultz shares insights on utilizing at-line spent media analysis and online monitoring of glucose and lactate levels to optimize feeding strategies.
Key Takeaways
- Accelerate process development by data-driven decision making.
- Reduce manufacturing costs while improving process efficiency.
- Use at-line and on-line technology to characterize bioprocesses and improve product yield.
[post_title] => Accelerate Upstream Process Development with Data-driven Feeding Strategy Optimization
[post_excerpt] => At-line and on-line technologies that inform bioprocess parameters and cell-feeding strategies are needed to develop processes that deliver high-quality products while reducing manufacturing costs. In this webinar, Chris Schultz, PhD from CPI provides insights on using at-line spent media analysis and on-line glucose and lactate monitoring for the optimization of feeding strategy.
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[post_name] => rebel-maven-webinars-accelerate-upstream-process-development
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[post_modified] => 2024-10-02 04:56:29
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[post_date] => 2022-10-31 13:47:38
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[post_content] =>
[post_title] => Harness the Power of At-line Spend Media Analysis using the REBEL to Optimize a CHO mAb Fed-batch Process
[post_excerpt] => This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => rebel-webinar-biopharm-2022
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[post_modified] => 2024-10-02 05:00:09
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[post_date] => 2022-10-18 18:45:01
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[post_content] =>
[post_title] => Power Up Your Process Control with Rapid At-Line MS-based Metabolite Monitoring
[post_excerpt] => Graziella Piras spoke at BPI 2022 about how amino acids can present a goldilocks problem for bioprocessing: too little and they starve; too much and they favor growth over protein production.
[post_status] => publish
[comment_status] => closed
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[post_name] => rebel-power-up-your-process-control
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[post_modified] => 2024-05-24 00:06:42
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[post_date] => 2023-05-30 10:26:19
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[post_title] => Enabling Faster Feed Strategy Optimization with Rapid Spent Media Analysis and Data Visualization Tools
[post_excerpt] => Learn how to take charge of your bioprocess development via at-line amino acid analysis empowered by a dedicated bioprocess software tool.
[post_status] => publish
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[post_name] => rebel-webinars-ls-rb-wb-0017
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[post_modified] => 2024-08-01 12:22:13
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[post_date] => 2022-08-30 14:43:18
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[post_title] => Multi-Component At-Line Cell Culture Media Analysis for Accelerated Process Development of a mAb-Expressing Cell Line
[post_excerpt] => In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.
[post_status] => publish
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[ping_status] => closed
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[post_name] => rebel-webinar-multi-component-ccma
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[post_modified] => 2024-05-24 00:10:42
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[post_date] => 2022-06-09 18:41:48
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[post_content] =>
[post_title] => Biopharma 4.0 and Cell Media Optimization & At-line Methods for Cell Media Analysis
[post_excerpt] => Graziella Piras, bioprocess segment director for 908 Devices, spoke at BPI Europe 2022 on the benefits of at-line nutrient monitoring.
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[post_name] => rebel-bpi-europe-2022
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[post_modified] => 2024-05-24 00:11:06
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[post_date] => 2022-05-23 13:29:49
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[post_title] => The Critical Role of Cell Culture Media Analysis in Cell and Gene Therapies Development
[post_excerpt] => Does cell culture analysis matter for CGT development? This short webinar explores what is already known, reviews at-line methods for cell culture media analysis, and shares recent data from two case studies.
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[post_name] => rebel-webinar-bpi-cgt
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[post_modified] => 2024-08-01 12:21:19
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[post_title] => Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data
[post_excerpt] => Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.
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[post_name] => biopharma-4-0-finding-opportunities-to-leverage-new-at-line-data
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[post_title] => Ask the Expert: Bioprocess 101 - Cell Culture Media Analysis
[post_excerpt] =>
[post_status] => publish
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[post_name] => rebel-ask-the-expert-bioprocess-101-cell-culture-media-analysis
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[post_date] => 2021-09-16 18:20:12
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[post_title] => Conference Talk: 2021 Industrializing Cell-Based Meats & Seafood Summit
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[post_name] => conference-talk-2021-industrializing-cell-based-meats-seafood-summit
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[post_title] => The Importance of Cell Media Analysis in Upstream Bioprocess Development
[post_excerpt] => Watch this discussion with experts from industry and academia as they discuss bioprocessing trends relating to cell culture media analysis.
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[post_name] => rebel_webinar_the-importance-of-cell-media-analysis-in-upstream-bioprocess-development
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[post_date] => 2021-06-02 15:24:14
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[post_title] => Mass Spectrometry-Based Process Analytical Technologies for Cell Therapies
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[post_status] => publish
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[post_name] => rebel_webinar_mass-spectrometry-based-process-analytical-technologies-for-cell-therapies
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[post_title] => Unlocking Rapid Cell Culture Media Analysis for Cell and Gene Therapy Process Development
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[post_name] => rebel_webinar_unlocking-rapid-cell-culture-media-analysis-for-cell-and-gene-therapy-process-development
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[post_title] => Be a REBEL with Your Cell Media Analytics
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[post_status] => publish
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[post_name] => rebel-be-a-rebel-with-your-cell-media-analytics
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[post_title] => Rapid At-line Amino Acid and Nutrient Profiling from Bioprocess Media with the REBEL
[post_excerpt] =>
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[post_name] => rebel_webinar-bpi-digital-week
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[post_title] => How can we Accelerate PD Analytics?
[post_excerpt] =>
[post_status] => publish
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[post_name] => rebel_webinar-bpi-bio-bites
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[post_date] => 2024-09-24 12:24:35
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[post_content] =>
About this Webinar
Overview:
Liquid chromatography-mass spectrometry (LC-MS) is used in various applications across the biotherapeutic protein manufacturing workflow pertaining to drug product quality. Mass spectrometry-based applications range from evaluating glycan distributions in monoclonal antibody products to optimization of the cell culture process development by monitoring amino acid and metabolite consumption. Given its analytical flexibility, LC-MS has the capacity to address complex questions; however, LC-MS instrumentation requires a high level of technical experience and more method development than other analytical procedures. Additionally, media development and feed studies in cell culture process optimization are labor-intensive and time-consuming. There is a growing interest in implementing efficient and simplified methods for cell culture media analysis to push for faster innovative processes in biomanufacturing. Newer analytical equipment does not attempt to address the complexity of LC-MS applications specifically targeted for high throughput media analysis of cell culture. This capillary electrophoresis-mass spectrometry (CE-MS)-based Amino Acid Analyzer is a device with simple procedures that provide a similar ability to the traditional LC-MS to specifically identify and quantitate an array of amino acids and several other important metabolites while providing a user-friendly interface and process.
Key Takeaways:
- Ascertain the capabilities and limitations of the Amino Acid Analyzer.
- Compare the Amino Acid Analyzer, a new generation of CE-MS analytical platform, against traditional LC-MS methods.
- Evaluate the data quality, trade-offs in operation, and resourcefulness of the analytical platforms.
Want to read a summary on the webinar? Download the resource.
[post_title] => Keeping up with New Emerging Analytical Technology
[post_excerpt] => Explore advancements in emerging analytical technologies like Process Analytical Technology (PAT) and mass spectrometry, improving drug development through enhanced bioprocess monitoring and control.
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[post_name] => keeping-up-with-new-emerging-analytical-technology
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Webinars On Demand
Keeping up with New Emerging Analytical Technology
Explore advancements in emerging analytical technologies like Process Analytical Technology (PAT) and mass spectrometry, improving drug development through enhanced bioprocess monitoring and control.
Moving Towards a Scalable AAV Vector Production at High Volumetric Efficiency
In this on-demand webinar, Graziella Piras and Prasanna Srinivasan explore approaches to facilitate a cost-effective and scalable vector production at a personalized level. You will learn how you can get the data where and when you need it.
Engineering Functionally Improved CAR T cells with a Multi-Cytokine Backpack Platform with Insights into Metabolism
Researchers at Emory University, led by Dr. Sarwish Rafiq, have developed a novel modular multi-cytokine backpack (MCB) platform that combines the signals necessary for activation, co-stimulation, and cytokine support into a single “all-in-one” reagent for CAR T cell manufacturing.
Data-driven Process Intensification – Utilizing Smart Analytics to Achieve your Bioprocess Goals
This BPI presentation discusses process intensification and rapid analytics of critical parameters for cell culture, which is necessary to control the process and end product. See how fast and simple analytics significantly speed up the development and optimization processes.
Accelerate Upstream Process Development with Data-driven Feeding Strategy Optimization
At-line and on-line technologies that inform bioprocess parameters and cell-feeding strategies are needed to develop processes that deliver high-quality products while reducing manufacturing costs. In this webinar, Chris Schultz, PhD from CPI provides insights on using at-line spent media analysis and on-line glucose and lactate monitoring for the optimization of feeding strategy.
Harness the Power of At-line Spend Media Analysis using the REBEL to Optimize a CHO mAb Fed-batch Process
This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.
Power Up Your Process Control with Rapid At-Line MS-based Metabolite Monitoring
Graziella Piras spoke at BPI 2022 about how amino acids can present a goldilocks problem for bioprocessing: too little and they starve; too much and they favor growth over protein production.
Enabling Faster Feed Strategy Optimization with Rapid Spent Media Analysis and Data Visualization Tools
Learn how to take charge of your bioprocess development via at-line amino acid analysis empowered by a dedicated bioprocess software tool.
Multi-Component At-Line Cell Culture Media Analysis for Accelerated Process Development of a mAb-Expressing Cell Line
In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.
Biopharma 4.0 and Cell Media Optimization & At-line Methods for Cell Media Analysis
Graziella Piras, bioprocess segment director for 908 Devices, spoke at BPI Europe 2022 on the benefits of at-line nutrient monitoring.
The Critical Role of Cell Culture Media Analysis in Cell and Gene Therapies Development
Does cell culture analysis matter for CGT development? This short webinar explores what is already known, reviews at-line methods for cell culture media analysis, and shares recent data from two case studies.
Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data
Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.
Ask the Expert: Bioprocess 101 – Cell Culture Media Analysis
Conference Talk: 2021 Industrializing Cell-Based Meats & Seafood Summit
The Importance of Cell Media Analysis in Upstream Bioprocess Development
Watch this discussion with experts from industry and academia as they discuss bioprocessing trends relating to cell culture media analysis.
Mass Spectrometry-Based Process Analytical Technologies for Cell Therapies
Unlocking Rapid Cell Culture Media Analysis for Cell and Gene Therapy Process Development
Be a REBEL with Your Cell Media Analytics
Rapid At-line Amino Acid and Nutrient Profiling from Bioprocess Media with the REBEL
How can we Accelerate PD Analytics?
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