North Bethesda, MD | March 2-5
Process Analytical Technology (PAT) is a crucial and rapidly evolving field, addressing both current and future industrial challenges. The IFPAC Conference and Exhibition, comprised of Scientific Board leaders from industry, regulatory bodies, and academia, collaborates annually to develop a comprehensive program covering both established core topics and emerging trends, technologies, and applications in PAT.
Speaking Sessions
Colin Gavin
Principal Scientist
908 Devices
Raman-based Bioprocess Monitoring and Control Using de novo Modeling
Monday, March 3
Grand Ballroom G
2 – MON PM – Continuous Manufacturing in Biologics and Pharma
1:05-5:40PM
In this talk, we’ll discuss a modern Raman bioreactor control platform built to scale from early phase process development to GMP implementation facilitating turn-key monitoring of CPPs and control across diverse process conditions. Core to this platform is a de novo data analytic approach with far greater agility than traditional empirical multivariate calibration approaches, enabling generalization across cell lines, media systems, and reactor scales. We’ll discuss the key elements of de novo approaches from a foundational and practical perspective, along with their advantages and equally importantly, limitations. Case studies from multiple cell lines, media systems and scales will be leveraged to highlight figures of merit. We will also present studies leveraging this platform for closed-loop control of glucose and lactate concentrations and showcase the improvements to CQAs that can be achieved.
Accelerating Bioprocess Development with Advanced Metabolite Profiling through Micro-Scale Mass Spectrometry and PAT
Wednesday, March 5
Brookside B
9B – WED PM – Mass Spec/Process Spectroscopy
1:05-5:40PM
This presentation will discuss the critical value of metabolite profiling and metabolomics in bioprocess development and optimization. These methods have proven essential for enhancing cell metabolism understanding, enabling higher productivities, and improving process robustness through innovations in cell engineering and media/feed optimization. Despite their potential, the application of mass spectrometry (MS) in bioprocessing labs often faces significant challenges due to its complexity
In this talk, we will highlight contemporary approaches to rapid, at-line quantitative media characterization across highly multiplexed panels. We will also demonstrate the capabilities of miniature MS systems for at-line panel assays and delve into the advantages of deeper characterization enabled by high-performance, rapid MS methods. Attendees will gain insights into cutting-edge solutions that streamline the integration of metabolomics into bioprocess insights, learning and improvement.
Bioprocessing
Have you met MAVERICK?
Our latest innovation, MAVERICK, empowers real-time in-line bioprocess analysis (bioreactor monitoring) and control. Effortlessly monitor key process parameters in up to six bioreactors simultaneously. Experience Process Analytical Technology (PAT) made easy.