Instant PAT Implementation with Raman-based MAVERICK

MAVERICK enables real-time monitoring of critical process parameters like glucose, lactate, and biomass in bioprocesses without the need for complex setups or prior modeling. Unlike traditional Raman spectroscopy methods that require extensive configuration and expert knowledge, MAVERICK offers a plug-and-play solution that can be implemented quickly and effectively across various cell lines and culture media. The system utilizes a de novo algorithm that works straight out of the box, measuring both static and dynamic parameters during bioprocess runs. Results from experiments with CHO and HEK293 cell cultures demonstrated that MAVERICK provides accurate readings that align closely with at-line measurements. The technology simplifies the monitoring process and helps ensure optimal cell culture conditions, enhancing overall product quality and yield. Overall, MAVERICK represents a significant advancement in in-line process analytical technology (PAT) for biomanufacturing.