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MAVERICK enables real-time monitoring of critical process parameters like glucose, lactate, and biomass in bioprocesses without the need for complex setups or prior modeling. Unlike traditional Raman spectroscopy methods that require extensive configuration and expert knowledge, MAVERICK offers a plug-and-play solution that can be implemented quickly and effectively across various cell lines and culture media. The system utilizes a de novo algorithm that works straight out of the box, measuring both static and dynamic parameters during bioprocess runs. Results from experiments with CHO and HEK293 cell cultures demonstrated that MAVERICK provides accurate readings that align closely with at-line measurements. The technology simplifies the monitoring process and helps ensure optimal cell culture conditions, enhancing overall product quality and yield. Overall, MAVERICK represents a significant advancement in in-line process analytical technology (PAT) for biomanufacturing.


                    [post_title] => Instant PAT Implementation with Raman-based MAVERICK
                    [post_excerpt] => Learn about instant PAT implementation, where MAVERICK was used to monitor critical process parameters to create measurement chemometric models.
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                    [post_title] => Real-time Monitoring of Key Bioprocess Parameters Using MAVERICK In-line Device in Culture Biosciences’ Cloud-connected Bioreactors
                    [post_excerpt] => Bioprocessing 4.0 aims to leverage advanced digital technologies, automation, and data-driven approaches to transform biopharmaceutical production. The data generated utilizing Culture Bioscience’s bioreactors, cloud-based controllers and software console together with MAVERICK, a novel Raman spectroscopy powered in-line PAT device, was found to track closely with off-line measurements for multiple critical process parameters. The use of PAT in bioreactors provides in-line, continuous data about cell culture conditions, thereby enhancing process understanding and enabling precise bioprocess monitoring and control.
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                    [post_title] => Glucose and Lactate Raman-Based Monitoring with MAVERICK: Performance in Spent Media
                    [post_excerpt] => MAVERICK provides a plug-and-play, in-line, Raman based PAT solution for monitoring and control of glucose, lactate, and biomass in up to 6 bioreactors. This Application Snapshot shows the results from experiments to demonstrate the selectivity of glucose and lactate measurements from MAVERICK in complex spent media samples from CHO and HEK293 cultures.
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Faster Bioprocess Data Visualization



Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers rich, time-course data visualization in less than a minute for run and sample comparisons. Download from our customer support portal and visit JMP.com.















REBEL



Sample comparison, and time-course data visualization from multiple samples, for all analytes, in an instant.




Learn more














MAVERICK



Visualize time course data for glucose, lactate, and biomass and compare runs. Values are provided in 1-minute intervals.




Learn more














MAVEN



Visualize time course data for glucose and lactate, and display the glucose feed-pump speed for run duration to compare runs.




Learn more









Data Visualization for Actionable Insights













MAVEN data output from device



















MAVEN data output with JMP add-in tool






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IN-LINE BIOPROCESS ANALYZER





REAL-TIME. IN-LINE. REAL FAST.



MAVERICK



RAMAN-BASED MONITORING OF MULTIPLE CRITICAL PARAMETERS, READY TO GO IN MINUTES.













MEET MAVERICK



THE ONLY PLUG-AND-PLAY, READY IN MINUTES, IN-LINE MULTIPARAMETER PAT PLATFORM



MAVERICK is powered by Raman spectroscopy and purpose-built de novo model for simultaneous real-time measurements of multiple key process parameters in mammalian cell cultures without the costs, complexities, and risks of conventional methods. There’s no need to deal with complex empirical calibration models, reagents, or unreliable auto-sampling systems to implement in-line bioreactor monitoring.

It’s all in-line gain, with no modeling pain.





















Monitoring of multiple bioprocess parameters right out of the box.













Walk-away automation with integrated analog and digital feed controllers and optional secure remote monitoring.













Parallel and continuous monitoring of up to six bioreactors from a single hub.













Analog and OPC UA communication options for plug-and-play integration with automation and data acquisition systems.













Straightforward validation process and CFR 21 part 11 compliance-ready software enable seamless method tech transfer













MAVERICK’s de novo model will continue to evolve, with additional process parameters that can be added through software upgrades











INSTANT INSIGHTS WITH DE NOVO MODEL



QUANTIFICATION OF GLUCOSE, LACTATE AND TOTAL BIOMASS IN CELL CULTURE WITHOUT “BLACK BOX” EMPIRICAL RAMAN CALIBRATION MODELS













Raman spectrum is collected from the bioreactor



















Spectrum analyzed and interpreted in real-time by de novo model



















Process parameters are quantified and displayed automatically









A SIX BIOREACTOR MULTIPLEX FLEX





EASILY MONITOR AND CONTROL UP TO SIX BIOREACTORS SIMULTANEOUSLY






Control feeding pumps directly or send the measured parameters to an existing automation system



Securely monitor your bioprocess from anywhere with optional remote monitoring via a web browser














INSTANTLY ENHANCE UNDERSTANDING AND CONTROL OF YOUR BIOPROCESS











MEASURE AND CONTROL GLUCOSE CONCENTRATION



Dynamic control of feeding, enabled by real-time glucose measurements, helps optimize cell growth and productivity while minimizing accumulation of toxic metabolites and ensuring product quality



MONITOR LACTATE CONCENTRATION



Continuously monitoring lactate concentration is crucial to prevent potentially toxic effects that can compromise productivity and product quality



TRACK TOTAL BIOMASS



Tracking the biomass trend over the cell culture duration provides valuable insights on cell growth for process optimization and detection of deviations











TAKE IT OUT OF THE BOX AND YOU'RE HALFWAY DONE WITH THE SETUP PROCESS













BIOPROCESS INSIGHTS AT YOUR FINGERTIPS



Take your understanding of bioprocess to the next level by combining real time process insights offered by MAVERICK and at line spent media analysis provided by REBEL.











EVERYTHING YOU NEED TO GET STARTED









OPTICAL IMMERSION PROBE



— Autoclavable probe compatible with standard bioreactor ports

— Automatic probe identification and compliance traceability

— Magnetic probe coupling ensures secure attachment and proper alignment

— No optical isolation of bioreactor required





MEASUREMENT MODULE



— Autonomous operation

— Optional direct control of feed pumps

— Compact footprint

— Electrical interrupt switch for enhanced operator safety





HUB



— Simultaneous control of up to six measurement modules

— Data transfer over Ethernet or OPC UA 

High-resolution, color touchscreen interface supports:

— User authentication

— System configuration and operation

— Guided calibration of immersion probes

— Viewing system status, monitoring of real-time measurements and trends





SOFTWARE



— CFR 21 part 11 compliance ready

— Optional remote monitoring from any web browser

— Access to Raman spectral data





CALIBRATION KITS AND ACCESSORIES



— Two-point probe calibration standards

— Probe stand for convenient calibration and probe storage on the bench





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Faster Bioprocess Data Visualization



Expedite your 908 Devices bioprocess data visualization with the JMP add-in tool that delivers rich, time-course data visualization in less than a minute for run and sample comparisons. Download from our customer support portal and visit JMP.com.















REBEL



Sample comparison, and time-course data visualization from multiple samples, for all analytes, in an instant.




Learn more














MAVERICK



Visualize time course data for glucose, lactate, and biomass and compare runs. Values are provided in 1-minute intervals.




Learn more














MAVEN



Visualize time course data for glucose and lactate, and display the glucose feed-pump speed for run duration to compare runs.




Learn more









Data Visualization for Actionable Insights













MAVEN data output from device



















MAVEN data output with JMP add-in tool






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Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis.



This poster was a collaboration with Terumo Blood and Cell Technologies and was part of the poster program at the 2024 ISCT EU Conference.


                    [post_title] => Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
                    [post_excerpt] => The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding,  characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
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                    [post_title] => In-Line and On-Line Monitoring of Key Cell Culture Parameters for Robust Cell and Gene Therapy Bioprocess
                    [post_excerpt] => The instant PAT implementation with MAVERICK, versatility, and sensitivity of MAVEN and point of need availability of amino acids analysis with REBEL, enable deeper knowledge and actionable information of Cell and GeneTherapy bioprocesses. Further, the devices informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization and control. This poster was highlighted at the 2024 ASGCT Conference.
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                    [post_title] => Raman-based In-line Monitoring of Key Process Parameters in Mammalian Bioprocesses without the Need for Chemometric Model Building
                    [post_excerpt] => This poster describes a new technology called MAVERICK that uses Raman spectroscopy for continuous monitoring of mammalian cell cultures, specifically those using CHO and HEK293 cells. In 2024 this poster has been highlighted at BPI US West, BPS Europe, BPI Europe, BPI USA and most recently Advanced Therapies.
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Process intensification in biomanufacturing often involves increasing cell densities and product titers, which can lead to increased glucose consumption and potential accumulation of toxic metabolites. High glucose concentrations can also negatively impact protein quality attributes. To address these challenges, we developed MAVERICK, a novel Raman-based PAT approach that enables real-time monitoring and control of CHO cell cultures without the need for prior model building. This versatile approach can be applied across various cell lines, media systems, reactor scales, and culture modes. By implementing a continuous dynamic feeding strategy guided by MAVERICK, we can enhance process performance and improve protein quality attributes like glycosylation, glycation, and charge variants.



MAVERICK, a novel Raman-based PAT technology, was showcased at the ECI Integrated Continuous Biomanufacturing Conference 2024. This technology allows for immediate monitoring of critical process parameters like glucose, lactate, and biomass without the need for extensive preliminary work or model building. By implementing a continuous glucose feeding strategy guided by MAVERICK, researchers were able to significantly improve process titer, cell-specific productivity, and protein quality attributes. This straightforward approach highlights the potential of MAVERICK to revolutionize biomanufacturing processes.






                    [post_title] => Novel Approach for Instant Implementation of Raman-based PAT with Integrated Real-Time Process Control
                    [post_excerpt] => The innovative technology of Maverick allows for immediate monitoring of critical process parameters like glucose, lactate, and biomass without the need for extensive preliminary work or model building.
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Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis. This poster was developed with Terumo Blood and Cell Technologies and was showcased at BPI USA and Advanced Therapies 2024.


                    [post_title] => Innovations in Analytical Technology for Cell & Gene Therapy Manufacturing
                    [post_excerpt] => This poster highlights our at-, on-, and in-line analytical solutions that contribute to an enhanced understanding, characterization, and control of bioprocesses in the development and manufacturing of cell and gene therapies.
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Raman spectroscopy offers relatively non-invasive access to the estimation of critical quality attributes and parameters in bioprocesses. Current approaches to predicting these parameters rely heavily on latent variable/regularized empirical calibration methods, with partial least-squares (PLS) being the most dominant. Although one advantage of these approaches is that they require zero detailed understanding of the underlying system (physics/chemistry/biology), there are several significant disadvantages to modelling bioprocess under these frameworks. This was poster #391 at ESACT 2024.


                    [post_title] => De Novo Approaches for Bioprocess Parameter Estimation Using Raman Spectroscopy
                    [post_excerpt] => This research proposes a novel method for real-time bioprocess parameter prediction with de novo models using Raman spectroscopy. Unlike traditional methods, this approach requires no training data and offers a priori performance estimates.
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The power of Raman spectroscopy for bioprocess monitoring is well-known , but the expertise required to develop ROBUST and SUSTAINABLE multivariate models is a massive impediment. Our goal was to develop an in-line device, termed MAVERICK, that provides immediate value for glucose, lactate and biomass estimation without the need for cumbersome model training/re-training with an ease-of-use similar to that of a pH probe. This was poster # 390 at ESACT 2024.


                    [post_title] => New Era of Real-time Bioprocess Monitoring and Control –Raman-based Direct Measurements with De Novo Model
                    [post_excerpt] => MAVERICK offers real-time bioprocess monitoring of glucose, lactate, and biomass through a Raman-based sensor, eliminating the need for complex setup and training data.
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                    [post_title] => Improving Cell and Gene Therapy Manufacturing Processes by Automated On-line and In-line Bioprocess Analytical Technologies
                    [post_excerpt] => Recent advances in cell and gene therapy bioprocess analytical technology regimes, approaches to de novo analytical modeling/calibration of these systems, and how their informing power can be leveraged with the increasing sophistication of bioprocess metabolic models for predictive bioprocess optimization. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 29. This poster was also on display as #843 at ISCT 2024. 
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Advancements in bioprocess characterization technologies have progressed rapidly, broadening the range of readily accessible process information. While dissolved gases, pH, and temperature have been measurable in- or on-line for some time, crucial nutrients and metabolites are typically monitored via manual sampling and at- or off-line analysis.



This poster was a collaboration with Terumo Blood and Cell Technologies and was part of the poster program at the 2024 ISCT EU Conference.


            [post_title] => Enhancing Cell and Gene Therapy Manufacturing Processes by In-line, On-line and At-line Bioprocess Analytical Technologies
            [post_excerpt] => The 908 Devices, on-, and in-line analytical solutions contribute to an enhanced understanding,  characterization, and control of bioprocesses in development and manufacturing of cell and gene therapies.
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Intended Applications:
Monitoring of mammalian cell cultures in CHO or HEK293 media







Analytical Performance
Measurement / reporting period:
1 per minute







Glucose
Units of measurement:
Grams per liter (g/L)
Measurement range:
0 to 10 g/L
Measurement precision:
Approximately 0.1 g/L







Lactate
Units of measurement:
Grams per liter (g/L)
Measurement range:
0 to 5 g/L
Measurement precision:
Approximately 0.1 g/L







Total Biomass
Units of measurement:
Biomass units (BMUs)
Measurement range:
Equivalent of 0 to 25 x 106 cells/mL



















Measurement module connections:
6 with power and data over ethernet
User interface:
25.4 cm touch screen
Data export:
XLSX or CSV format via USB-C or USB-A port or over LAN
Digital communication protocol:
OPC UA
Networking:
Ethernet
Dimensions (H x W x D):
17 cm x 21 cm x 26 cm
Weight:
2 kg
Power requirements:
120/240 VAC, 50/60 Hz
Ingress protection rating:
IP 5X
Operating temperature range:
15°C to 25°C
Operating humidity range:
20-80% RH (non-condensing)
Software:
In accordance with GAMP 5 Category 3 guidelines and CFR 21 part 11 compliance ready















Excitation wavelength:
785 nm
Laser output power:
Approximately 450 mW (strictly less than 500 mW)
Spectral range:
200 cm^(–1) to 3,200 cm^(–1)
Spectral resolution:
Approximately 6 cm^(–1)
Fiber-optical cable length:
200 cm
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Analog outputs:
Two channel analog: 4 -20 mA or 0 -10 V
Dimensions (H x W x D):
8 cm x 20 cm x 26 cm
Weight:
2 kg
Operating temperature range:
15°C to 25°C
Operating humidity range:
20-80% RH (non-condensing)















Probe length and outside diameter:
220 mm length, 12 mm diameter
Minimum reactor wall clearance:
40 mm
Bioreactor connection:
Compression fitting; 12 mm I.D. ; PG-13.5 thread
Compatible sterilization methods:
Autoclave or steam sterilization
Maximum recommended sterilization temperature and pressure:
121°C, 15 psi
Wetted materials:
316L stainless steel with Ra 15 Electro-polish surface finish, sapphire, EPDM, and Bio-compatible ISO: 10993 certified lubricant



                    [post_title] => MAVERICK Product Specification Sheet
                    [post_excerpt] => Get all the MAVERICK specifications including applications, physical dimensions, and more.
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Intended Applications:
Monitoring of mammalian cell cultures in CHO or HEK293 media







Analytical Performance
Measurement / reporting period:
1 per minute







Glucose
Units of measurement:
Grams per liter (g/L)
Measurement range:
0 to 10 g/L
Measurement precision:
Approximately 0.1 g/L







Lactate
Units of measurement:
Grams per liter (g/L)
Measurement range:
0 to 5 g/L
Measurement precision:
Approximately 0.1 g/L







Total Biomass
Units of measurement:
Biomass units (BMUs)
Measurement range:
Equivalent of 0 to 25 x 106 cells/mL



















Measurement module connections:
6 with power and data over ethernet
User interface:
25.4 cm touch screen
Data export:
XLSX or CSV format via USB-C or USB-A port or over LAN
Digital communication protocol:
OPC UA
Networking:
Ethernet
Dimensions (H x W x D):
17 cm x 21 cm x 26 cm
Weight:
2 kg
Power requirements:
120/240 VAC, 50/60 Hz
Ingress protection rating:
IP 5X
Operating temperature range:
15°C to 25°C
Operating humidity range:
20-80% RH (non-condensing)
Software:
In accordance with GAMP 5 Category 3 guidelines and CFR 21 part 11 compliance ready















Excitation wavelength:
785 nm
Laser output power:
Approximately 450 mW (strictly less than 500 mW)
Spectral range:
200 cm^(–1) to 3,200 cm^(–1)
Spectral resolution:
Approximately 6 cm^(–1)
Fiber-optical cable length:
200 cm
Power requirements:
40 W power-over-ethernet (POE) supplied by Hub
Integrated controllers:
Hysteresis controller with configurable analog output
Ingress protection rating:
IP 5X
Laser classification:
Class IIIB laser; NOHD 10 cm from probe tip (equivalent to Class I beyond 10 cm)
Analog outputs:
Two channel analog: 4 -20 mA or 0 -10 V
Dimensions (H x W x D):
8 cm x 20 cm x 26 cm
Weight:
2 kg
Operating temperature range:
15°C to 25°C
Operating humidity range:
20-80% RH (non-condensing)















Probe length and outside diameter:
220 mm length, 12 mm diameter
Minimum reactor wall clearance:
40 mm
Bioreactor connection:
Compression fitting; 12 mm I.D. ; PG-13.5 thread
Compatible sterilization methods:
Autoclave or steam sterilization
Maximum recommended sterilization temperature and pressure:
121°C, 15 psi
Wetted materials:
316L stainless steel with Ra 15 Electro-polish surface finish, sapphire, EPDM, and Bio-compatible ISO: 10993 certified lubricant



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                    [post_title] => Bioprocessing International Interview
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Ready to easily start your bioprocess run?



Get fast, in-line analysis of critical process parameters in minutes. These videos show you how easy it is to set up MAVERICK and start your bioprocess run. MAVERICK is powered by Raman spectroscopy and a purpose-built de novo model that automatically processes spectra from a wide variety of media types and cell lines. There's no modeling or development required. With MAVERICK, you can quickly develop cell culture media and design feeding and control strategies.














Calibrate









Autoclave









Start Bioprocess Run




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                    [post_title] => MAVERICK: Raman-based Monitoring of Multiple Critical Parameters, Ready to Go in Minutes
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                    [post_title] => MAVERICK: Monitoring of Multiple Bioprocess Parameters Right Out of the Box
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Host Rizwan Chaudhrey from RSK Media visited our Boston office bioprocessing lab. Check out this video lab tour with Senior Scientist Stephanie Klaubert and Product Manager Nick Randall as they discuss bioprocessing trends, including incorporating automated technologies into the lab and learn what makes 908 Devices unique and different.








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RSK Media, Rizwan Chaudhrey, interviews 908 Devices CEO and co-founder, Kevin J. Knopp. This interview highlights:




A background on 908 Devices and why they started the company.



What the key drivers are behind 908 Devices product launches.



Why 908 Devices acquired RedWave Technology.



Kevin J. Knopp provides his thoughts on the future for Life Science.



 Explains what differentiates 908 Devices from other companies.













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                    [post_title] => Ultimate Bioprocess Monitoring and Control
                    [post_excerpt] => Quickly get data at the point of need with our REBEL, MAVEN, and MAVERICK devices. Take control of your bioprocess and get to market faster.
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About this Webinar







Understanding how bioprocess changes impact product quality is crucial for successful biopharmaceutical development. However, frequent data collection across the entire bioprocess can be a significant challenge for analytical teams.



This webinar explores a streamlined solution for acquiring critical mAb quality attributes, including charge variant profiles, sequence identity, glycosylation profiles, and glycation levels. We will demonstrate a simple "dilute-and-shoot" analysis utilizing ZipChip capillary electrophoresis coupled with high-resolution mass spectrometry.



Furthermore, we will present a case study comparing CHO fed-batch processes with traditional daily bolus glucose feeding and a 2g/L dynamic glucose feed strategy, enabled by MAVEN monitoring and control. This study highlights the clear impact of process feeding strategies on product quality profiles.



Presenters




Erin Redman, PhD, Principal Scientist, 908 Devices



Graziella Piras, PhD, Senior Director of Strategic Marketing, Life Science, 908 Devices












Key Takeaways:




Streamline mAb product quality assessment throughout bioprocess runs.



Gain insights into charge variant profiles, sequence identity, glycosylation profiles, and glycation levels.



Understand the link between process feeding strategies and product quality.



Learn how bioprocess monitoring enables control, such as stabilizing glucose levels at 2g/L via MAVEN control to reduce glycation.



Explore the benefits of both off-line analytical and on-line process analytical technology (PAT) solutions.



Discover the efficiency of the dilute-and-shoot ZipChip-MS CVA workflow for frequent measurements.



















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                    [post_excerpt] => Dilute-and-shoot ZipChip-MS CVA workflow enabling frequent measurements.
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Improve Process Intensification



Process intensification requires a thorough understanding of the process to achieve desired yields while improving resource utilization and maintaining consistent product quality. Continuous monitoring of glucose and lactate provides deeper process understanding. Dynamic glucose control can lead to better cell viability, lower levels of lactate production, and therefore, higher titer and better control of quality attributes (CQAs) in fed-batch and intensified processes. Learn how you can make more informed decisions with in-line, on-line and at-line analytics of key process parameters













                    [post_title] => Data-driven Process Intensification – Utilizing Smart Analytics to Achieve your Bioprocess Goals
                    [post_excerpt] => This BPI presentation discusses process intensification and rapid analytics of critical parameters for cell culture, which is necessary to control the process and end product. See how fast and simple analytics significantly speed up the development and optimization processes.
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About this Webinar



In this webinar, we discuss the implementation of MAVERICK for continuous CHO feed control, including novel feeding approach. While empirical Raman spectroscopy models are convenient due to their 'black box' properties, they may prove impractical and insufficiently robust for deployment as Process Analytical Technology (PAT) solutions in complex upstream bioprocesses. In contrast, the MAVERICK platform, based on Raman technology with a de novo approach, operates as effortlessly as a pH-meter, providing real-time measurements of key process parameters such as glucose, lactate, and biomass.










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About this Webinar



Drs. Chris Brown and Graziella Piras provide information about a new and transformative means to instantly implement in-line monitoring for multiple key process parameters, right out of the box. 



It’s been nearly 20 years since the FDA and EMA published guidelines on process analytical technologies (PAT) to drive the advancement of Biopharma 4.0, with the ultimate aim of predictive control and Quality by Design. Over the years several multivariate optical sensing technologies have demonstrated tremendous promise for in-line continuous monitoring of a range of parameters. These technologies offer the promise of hands-off, non-destructive, and easy-to-integrate multi-parameter analysis with feedback control loop. Yet, they often require substantial expert configuration and set-up time that can take months or years, and substantial expense. In this webinar, review the current state of several optical technology approaches and their associated strengths and limitations. A new platform that greatly accelerates successful implementation of in-line monitoring of key bioprocess parameters is discussed.



Key Takeaways:




Current state of state-of-the-art in-line upstream bioprocess analytics



A new solution overcoming major hurdles of implementation of in-line multivariate bioprocess analysis











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About this Webinar







Understanding how bioprocess changes impact product quality is crucial for successful biopharmaceutical development. However, frequent data collection across the entire bioprocess can be a significant challenge for analytical teams.



This webinar explores a streamlined solution for acquiring critical mAb quality attributes, including charge variant profiles, sequence identity, glycosylation profiles, and glycation levels. We will demonstrate a simple "dilute-and-shoot" analysis utilizing ZipChip capillary electrophoresis coupled with high-resolution mass spectrometry.



Furthermore, we will present a case study comparing CHO fed-batch processes with traditional daily bolus glucose feeding and a 2g/L dynamic glucose feed strategy, enabled by MAVEN monitoring and control. This study highlights the clear impact of process feeding strategies on product quality profiles.



Presenters




Erin Redman, PhD, Principal Scientist, 908 Devices



Graziella Piras, PhD, Senior Director of Strategic Marketing, Life Science, 908 Devices












Key Takeaways:




Streamline mAb product quality assessment throughout bioprocess runs.



Gain insights into charge variant profiles, sequence identity, glycosylation profiles, and glycation levels.



Understand the link between process feeding strategies and product quality.



Learn how bioprocess monitoring enables control, such as stabilizing glucose levels at 2g/L via MAVEN control to reduce glycation.



Explore the benefits of both off-line analytical and on-line process analytical technology (PAT) solutions.



Discover the efficiency of the dilute-and-shoot ZipChip-MS CVA workflow for frequent measurements.



















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Learn About Advantages Over Traditional Chemometrics Models



Read about the seven reasons why Raman spectroscopy with PLS models is challenging for bioprocess applications. Learn how MAVERICK's purpose-built de novo model eliminates the need for complex empirical calibration models, reagents, or unreliable auto-sampling systems for in-line bioreactor monitoring. This white paper is written in summary of the white paper “De novo Approaches for Bioprocess Parameter Estimation”. Please view the full version for detailed explanations, figures, and references.

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MAVERICK is powered by Raman spectroscopy and purpose-built de novo model for simultaneous real-time measurements of multiple key process parameters in mammalian cell cultures without the costs, complexities, and risks of conventional methods. There’s no need to deal with complex empirical calibration models, reagents, or unreliable auto-sampling systems to implement in-line bioreactor monitoring. Read this white paper summary to learn about de novo approaches for bioprocess parameter estimation. 

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            [post_content] => 
Learn About Advantages Over Traditional Chemometrics Models



Read about the seven reasons why Raman spectroscopy with PLS models is challenging for bioprocess applications. Learn how MAVERICK's purpose-built de novo model eliminates the need for complex empirical calibration models, reagents, or unreliable auto-sampling systems for in-line bioreactor monitoring. This white paper is written in summary of the white paper “De novo Approaches for Bioprocess Parameter Estimation”. Please view the full version for detailed explanations, figures, and references.

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