Illuminating the Edges

Analysis of proteins by digestion and peptide mapping is typically run with Liquid Chromatography Mass Spectrometry (LC-MS). There are limitations: Chromatography is both slow, often 30 minutes or more per sample, and depends on retention of analytes on a stationary phase – incompatible with some sample types. Small, polar peptides typically aren’t retained while large, ‘sticky’ peptides get trapped on column and don’t elute for analysis. ZipChip brings new technology that is both fast and, since it has no stationary phase, can typically see the peptides that LC misses. ZipChip also complements digest data by enabling direct MS analysis of the protein samples intact and in near native states.

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Proteins – The Big Picture

ZipChip HS offers a simple, cost effective analysis of peptide maps with high coverage and capturing the peptides not compatible with typical LC approaches. Each sample is run completes in 3 minutes and you can complement your digest experiments by adding ZipChip HR to see the intact proteins – separation of intact protein mixes and variants with full MS data behind every peak!


Life Sciences Events

American Society for Mass Spectrometry, Indianapolis, IN

06.04.17 - 06.08.17

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