MAVERICK is intended for bioprocessing applications in process development and biopharmaceutical manufacturing, enabling cell culture automation in biologic production for CHO or HEK293 mammalian cell line and media. For example, MAVERICK can help optimize viral vector titer in lentiviral vector production, AAV production, and other viral vector manufacturing applications.

MAVERICK works with CHO and HEK293 cell lines and media.

MAVERICK autoclavable immersion probe is 220 mm long with 12 mm outside diameter, making it compatible with most 250 mL to 10L bioreactors. The PG 13.5 compression fitting interfaces with the standard bioreactor sensor ports and enables adjustment of the immersion depth (minimum 40 mm immersion depth is required).

Yes. Each MAVERICK Hub connects and controls up to six Measurement Modules, supporting up to six individually or jointly operated bioreactors. Unlike other process Raman spectroscopy analyzers that employ optical switches or multi-channel design, MAVERICK preserves operational redundancy in multi-bioreactor applications.

The probe is calibrated using the two standards in the Calibration Kit. Calibration is performed prior to autoclaving the probe, before each bioreactor run. Each probe has a built-in memory chip that stores its calibration coefficients and verifies that the correct probe was re-attached post-sterilization.

On-board analog/digital controller offers optional direct control of feed pumps. Alternatively, the measured values can be sent to an existing bioreactor controller, SCADA, or data acquisition system via Analog outputs or OPC UA protocol.

Probe barrels are autoclavable or steam sterilizable and should be replaced after 10 autoclave cycles to ensure the probe maintains its integrity.

Normally, interpreting the spectrum from Raman spectroscopy requires the development of empirical multivariate calibration models (chemometric modeling) specific to analytes of interest. This requires multiple bioreactor runs to acquire real-time spectral data, manually collect numerous samples from the bioreactors for at-line/off-line analysis, and then utilize statistical analysis to correlate the Raman spectra to the at-line/off-line measurements. Naturally, this process is very time consuming, expensive, and complicated, making Raman-based bioprocess monitoring inaccessible to most biopharma labs.

MAVERICK purpose-built De Novo Model does not need to be trained on empirical process data. The model quantifies analyte concentration by accurately inferring peaks, associated with the analytes of interest based on a priori knowledge and the baseline from water, other mixture components, and instrumentation in the spectra.

MAVERICK devices and support are available for purchase directly from 908 Devices in North America and Europe, and through a network of distributors globally.