908 Devices, a pioneer of purpose-built analytical devices for chemical and biomolecular analysis, today announced  they’ve expanded compatibility of the ZipChip® platform to a broader base of industry-leading mass spectrometers including Thermo Fisher Scientific’s Fusion™ Lumos™ and TSQ mass spectrometer (MS) product lines, and the SCIEX Triple Quad and QTRAP® series instruments. The ZipChip platform radically improves sample separation and MS workflow efficiencies for both small and large molecule analysis in biopharmaceutical labs. The platform’s expanded reach lets even more MS researchers take advantage of its rapid, high-resolution separations. The company also introduced new extended-life chips and a Native Antibody Assay Kit to their ZipChip consumable line up.

The ZipChip platform lets scientists consolidate a host of time-consuming biotherapeutic, metabolomic and proteomic applications typically run on multiple instruments or configurations onto a single platform. Running more than one application in any given day with traditional chromatographic/liquid chromatography (LC) techniques isn’t always practical as the changeover can take several hours. With ZipChip, researchers can be up and running new applications in under 30 minutes with a simple chip switch.  Anything from large complex proteins to small molecules can be run with 3-minute separations and direct electrospray into the MS for analysis, resulting in in better separation quality than most LCs in a fraction of the time. The new ZipChip Native Antibody Kit utilizes a simple prep process and gentle conditions to separate charge variants, resulting in high-quality, fully-native mass spectra, and clean resolution of glycoforms. New extended-life ZipChips maximize MS efficiency allowing up to 250 samples per chip, compressing a typical 5-day process into less than 24 hours.

“We are excited to be opening the ZipChip platform to a wider audience of researchers, amplifying productivity for drug discovery labs involved in MS analysis,” said Dr. Trent Basarsky, VP and GM of Life Sciences, 908 Devices. “The expanded compatibility across more mass specs and the additional application diversity brings this enabling technology to a broader customer base, letting them generate higher quality data, solve more problems and maximize their MS efficiency.”

The new lineup was revealed Monday at the American Society of Mass Spectrometry (ASMS) conference in San Diego, CA.  908 Devices’ scientists as well as ZipChip users from AbbVie, Amgen, Boston University, Duke University, North Carolina State and Vertex will be presenting data on how ZipChip is helping them get more from their mass spec. Research topics include a wide range of applications from characterization of biotherapeutics, quantitation of mutagenic impurities, to screening for small molecule and protein biomarkers in newborns.