908 Devices @ #ASMS2023

Booth #603

71st ASMS Conference on Mass Spectrometry and Allied Topics


June 4-8, 2023
George R. Brown Convention Center
Houston, Texas

Let’s Meet in Houston!

We’re bringing a great team to this year’s gathering in Houston, and we want to show you how 908 Devices is making mass spec more accessible to more scientists. Come and “Join the Revolution.” Company executives, research scientists, and applications specialists will be on hand as well as our favorite devices: ZipChip, REBEL, and the new MAVEN.

Thank you to all that attended our
Breakfast Seminar

Monday, June 5
7:00-8:00AM
Room 342AB-George R. Brown Convention Center

Protein Characterization of Biologics using Microchip CE-MS: From mAbs to AAVs

Protein characterization is crucial to ensure the quality of biotherapeutics during the drug discovery and development process. A wide variety of analytical techniques are needed to achieve a thorough understanding of the critical product quality attributes impacting drug safety and efficacy. Capillary zone electrophoresis (CZE) is a separation technique that can produce highly efficient separations of a wide variety of biological molecules. The ZipChip (908 Devices) is a microfluidic device that seamlessly couples rapid & high resolution CZE separations to high resolution accurate mass (HRAM) mass spectrometry, making it a powerful analytical platform that can be used for a wide range of applications, ranging from biopharmaceutical drug product characterization, clinical diagnostics, cell and gene therapies, proteomics, and metabolomics.

Join us to hear Dr. Jonathan Bones and Dr. Josh Smith from the National Institute of Bioprocessing Research and Training (NIBRT) share application highlights of using microchip CE-MS for protein characterization. In the first part of this presentation, Dr. Bones will share data showing his lab’s use of ZipChip for multi-characterization of proteins in applications including Charge Variant Analysis, Peptide Mapping, and Released Glycan Analysis of therapeutic proteins. He will also discuss the key advantages of ZipChip such as versatility, high sensitivity, short analysis times and lack of method development as applicable in these workflows.

In the second part of this presentation, Dr. Smith will highlight the use of ZipChip for the analysis of the Adeno-Associated Viruses (AAVs). He will discuss the method development work, which went into successfully using the ZipChip/MS for rapid analysis of various serotypes of the AAV viral capsid proteins (VPs). He will also share the tips and tricks to rapidly characterize AAV capsid proteins using intact mass analysis and obtaining near 100% sequence coverage for VPs using the peptide mapping workflow.

Meet our speakers:

Jonathan is the principal investigator of the Characterization and Comparability Laboratory at NIBRT. An analytical chemist by training, Jonathan’s research group specializes in the development and application of analytical solutions for problems associated with the manufacture and characterization of biopharmaceuticals including recombinant proteins, monoclonal antibodies and advanced therapies including AAV based gene therapy, cell therapy and mRNA using their core excellence in analytical separations coupled to mass spectrometry.

Presentation PDF

Dr. Jonathan Bones
NIBRT

Josh is a Senior Research Scientist in the Characterization and Comparability Lab at NIBRT in Dublin, Ireland. He initially joined NIBRT to undertake his Ph.D. in analytical biochemistry in conjunction with Trinity College Dublin. His PhD studies focused on developing liquid chromatography-mass spectrometry omics platforms applied to in-depth serum characterization for early-stage biomarker discovery. Josh subsequently took a role evaluating the impact of production media quality on monoclonal antibody critical quality attributes, before transitioning to his current position where he develops and applies mass spectrometry workflows for the characterization of viral gene therapy products and their host cell protein contaminants.

Presentation PDF

Dr Josh Smith
NIBRT

JOIN US!

If you are planning to travel to Houston, we made a downloadable list below of our exciting scientific program. We look forward to seeing you there!

Oral Presentation by 908 Devices and Duke University

Thursday, June 8
3:30 – 5:30PM
Hall B3- George R. Brown Convention Center

Session THOAPMInstrumentation: Innovative Separation Approaches Coupled to MS

Unifying the Multi-Omics World with Microchip Capillary Electrophoresis: Discovering Secrets in Six Dimensions from One Drop of Dried Blood

Presented by Will Thompson, Principal Scientist Life Sciences, 908 Devices.

Presentation PDF


Poster Presentations by 908 Devices Scientists & Collaborators

Posters | Monday, June 5

MP 291Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility
Collaboration: 908 Devices, NIBRT
Download Poster
MP 547Use Of Microchip Capillary Electrophoresis – Mass Spectrometry for Automated Rapid Measurement of Enzyme Reaction Kinetics
Collaboration: 908 Devices, Weizmann Institute of Science
MP 548Combining Capillary Electrophoresis and Trapped Ion Mobility Spectrometry Mass Spectrometry to Analyze Epitranscriptomic Marks Mediating Virus-Host Interactions in Infectious Diseases
Collaboration: 908 Devices, University of Connecticut, Bruker
Download Poster
MP 550Exploring the Possibilities for Microchip SPE-CE-MS
Presented by 908 Devices
MP 619Peptide Mapping Workflow for Direct Microchip CE-MS Analysis of Biopharmaceuticals
Collaboration: 908 Devices, NIBRT
Download Poster

Posters | Tuesday, June 6

TP 384Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS
Collaboration: 908 Devices, Protein Metrics, Thermo Fischer Scientific
Download Poster
TP 398Amino Acid Quantitation of Cell Culture Media Matrices via an Integrated CE-MS Analyzer
Collaboration: 908 Devices, CPI Innovation Services
Download Poster
TP 489Determination of ATP, ADP, AMP, and Adenosine Levels by Microchip Capillary Electrophoresis Coupled with High Resolution Mass Spectrometry
Collaboration: 908 Devices, Avice Labs
Download Poster
TP 532Continuing the Investigation of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry in the Bottom-up Characterization of Progressively Larger RNAs
Collaboration: 908 Devices, University of Connecticut, Bruker
Download Poster
TP 544Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis – Mass Spectrometry (CE-MS)
Collaboration: 908 Devices, Ningbo University
Download Poster

Posters | Wednesday, June 7

WP 040Conformation of Native Antibody-Drug Conjugate Charge Variants Revealed by Microchip Capillary Electrophoresis Coupled with Trapped Ion Mobility
Collaboration: 908 Devices, University of Wisconsin-Madison, Bruker
Download Poster
WP 041Rapid Identification of Conjugation Sites in Antibody Drug Conjugates Using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
Collaboration: 908 Devices, Bruker
WP 045Investigation of Drug-To-Antibody Ratio for FORCE Oligonucleotide Conjugates Using Microchip CE-MS
Collaboration: 908 Devices, Dyne Therapeutics
Download Poster
WP 730In-depth Characterization of Adeno-Associated Viruses using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
Collaboration: 908 Devices, NIBRT
Download Poster

Posters | Thursday, June 8

THP 175Ultra-High-Throughput Microchip CE-MS Quantitative Glycomics Enabled by 18-plex Isobaric Multiplex Labeling Reagents for Carbonyl-Containing Compound (SUGAR) Tags
Collaboration: 908 Devices, University of Wisconsin-Madison
Download Poster
THP 248Multi-omic Analyses Enabled by Microchip Capillary Electrophoresis and Trapped Ion Mobility
Collaboration: 908 Devices, University of Wisconsin-Madison
Download Poster
THP 5755’ mRNA Analysis By Microchip CE-MS Using an Internal Cleavage Motif for RNase H Digestion
Collaboration: 908 Devices, Thermo Fischer Scientific
THP 609Improved Performance of Phosphopeptides Characterization using Online Capillary Electrophoresis Coupling with Ion Mobility Mass Spectrometry (CE-IM-MS)
Collaboration: 908 Devices, Ningbo University
Download Poster
THP 625Amino Acid Quantitation in Over 50 Mammalian Cell Culture Media with an Integrated CE-MS Analyzer
Presented by 908 Devices

Poster Presentations by our Customers

TP
019
Characterization of Therapeutic Antibody Charge Variants in Drug Development by Microfluidic Native Capillary Electrophoresis-Mass Spectrometry
Presented by Regeneron Pharmaceuticals
THP 729Microfluidic Capillary Electrophoresis-Mass Spectrometry Method Development for Quantitation of Spermidine in Whole Blood
Presented by University of Wisconsin-Madison

Learn more about the ASMS Annual Meeting.


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