908 Devices @ #ASMS2023
Booth #603
71st ASMS Conference on Mass Spectrometry and Allied Topics
June 4-8, 2023
George R. Brown Convention Center
Houston, Texas
Let’s Meet in Houston!
We’re bringing a great team to this year’s gathering in Houston, and we want to show you how 908 Devices is making mass spec more accessible to more scientists. Come and “Join the Revolution.” Company executives, research scientists, and applications specialists will be on hand as well as our favorite devices: ZipChip, REBEL, and the new MAVEN.
Thank you to all that attended our
Breakfast Seminar
Monday, June 5
7:00-8:00AM
Room 342AB-George R. Brown Convention Center
Protein Characterization of Biologics using Microchip CE-MS: From mAbs to AAVs
Protein characterization is crucial to ensure the quality of biotherapeutics during the drug discovery and development process. A wide variety of analytical techniques are needed to achieve a thorough understanding of the critical product quality attributes impacting drug safety and efficacy. Capillary zone electrophoresis (CZE) is a separation technique that can produce highly efficient separations of a wide variety of biological molecules. The ZipChip (908 Devices) is a microfluidic device that seamlessly couples rapid & high resolution CZE separations to high resolution accurate mass (HRAM) mass spectrometry, making it a powerful analytical platform that can be used for a wide range of applications, ranging from biopharmaceutical drug product characterization, clinical diagnostics, cell and gene therapies, proteomics, and metabolomics.
Join us to hear Dr. Jonathan Bones and Dr. Josh Smith from the National Institute of Bioprocessing Research and Training (NIBRT) share application highlights of using microchip CE-MS for protein characterization. In the first part of this presentation, Dr. Bones will share data showing his lab’s use of ZipChip for multi-characterization of proteins in applications including Charge Variant Analysis, Peptide Mapping, and Released Glycan Analysis of therapeutic proteins. He will also discuss the key advantages of ZipChip such as versatility, high sensitivity, short analysis times and lack of method development as applicable in these workflows.
In the second part of this presentation, Dr. Smith will highlight the use of ZipChip for the analysis of the Adeno-Associated Viruses (AAVs). He will discuss the method development work, which went into successfully using the ZipChip/MS for rapid analysis of various serotypes of the AAV viral capsid proteins (VPs). He will also share the tips and tricks to rapidly characterize AAV capsid proteins using intact mass analysis and obtaining near 100% sequence coverage for VPs using the peptide mapping workflow.
Meet our speakers:

Jonathan is the principal investigator of the Characterization and Comparability Laboratory at NIBRT. An analytical chemist by training, Jonathan’s research group specializes in the development and application of analytical solutions for problems associated with the manufacture and characterization of biopharmaceuticals including recombinant proteins, monoclonal antibodies and advanced therapies including AAV based gene therapy, cell therapy and mRNA using their core excellence in analytical separations coupled to mass spectrometry.
Presentation PDF
Dr. Jonathan Bones
NIBRT

Josh is a Senior Research Scientist in the Characterization and Comparability Lab at NIBRT in Dublin, Ireland. He initially joined NIBRT to undertake his Ph.D. in analytical biochemistry in conjunction with Trinity College Dublin. His PhD studies focused on developing liquid chromatography-mass spectrometry omics platforms applied to in-depth serum characterization for early-stage biomarker discovery. Josh subsequently took a role evaluating the impact of production media quality on monoclonal antibody critical quality attributes, before transitioning to his current position where he develops and applies mass spectrometry workflows for the characterization of viral gene therapy products and their host cell protein contaminants.
Presentation PDF
Dr Josh Smith
NIBRT
JOIN US!
If you are planning to travel to Houston, we made a downloadable list below of our exciting scientific program. We look forward to seeing you there!
Oral Presentation by 908 Devices and Duke University
Thursday, June 8
3:30 – 5:30PM
Hall B3- George R. Brown Convention Center
Session THOAPM –Instrumentation: Innovative Separation Approaches Coupled to MS
Unifying the Multi-Omics World with Microchip Capillary Electrophoresis: Discovering Secrets in Six Dimensions from One Drop of Dried Blood
Presented by Will Thompson, Principal Scientist Life Sciences, 908 Devices.

Poster Presentations by 908 Devices Scientists & Collaborators
Posters | Monday, June 5
MP 291 | Rapid CE-MS Analysis of Released N-Glycan: Optimized Workflow for Direct CE Compatibility Collaboration: 908 Devices, NIBRT Download Poster |
MP 547 | Use Of Microchip Capillary Electrophoresis – Mass Spectrometry for Automated Rapid Measurement of Enzyme Reaction Kinetics Collaboration: 908 Devices, Weizmann Institute of Science |
MP 548 | Combining Capillary Electrophoresis and Trapped Ion Mobility Spectrometry Mass Spectrometry to Analyze Epitranscriptomic Marks Mediating Virus-Host Interactions in Infectious Diseases Collaboration: 908 Devices, University of Connecticut, Bruker Download Poster |
MP 550 | Exploring the Possibilities for Microchip SPE-CE-MS Presented by 908 Devices |
MP 619 | Peptide Mapping Workflow for Direct Microchip CE-MS Analysis of Biopharmaceuticals Collaboration: 908 Devices, NIBRT Download Poster |
Posters | Tuesday, June 6
TP 384 | Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS Collaboration: 908 Devices, Protein Metrics, Thermo Fischer Scientific Download Poster |
TP 398 | Amino Acid Quantitation of Cell Culture Media Matrices via an Integrated CE-MS Analyzer Collaboration: 908 Devices, CPI Innovation Services Download Poster |
TP 489 | Determination of ATP, ADP, AMP, and Adenosine Levels by Microchip Capillary Electrophoresis Coupled with High Resolution Mass Spectrometry Collaboration: 908 Devices, Avice Labs Download Poster |
TP 532 | Continuing the Investigation of Microchip Capillary Electrophoresis Coupled with Mass Spectrometry in the Bottom-up Characterization of Progressively Larger RNAs Collaboration: 908 Devices, University of Connecticut, Bruker Download Poster |
TP 544 | Fast Screening and Characterization of Therapeutic Peptide by Online Capillary Electrophoresis – Mass Spectrometry (CE-MS) Collaboration: 908 Devices, Ningbo University Download Poster |
Posters | Wednesday, June 7
WP 040 | Conformation of Native Antibody-Drug Conjugate Charge Variants Revealed by Microchip Capillary Electrophoresis Coupled with Trapped Ion Mobility Collaboration: 908 Devices, University of Wisconsin-Madison, Bruker Download Poster |
WP 041 | Rapid Identification of Conjugation Sites in Antibody Drug Conjugates Using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry Collaboration: 908 Devices, Bruker |
WP 045 | Investigation of Drug-To-Antibody Ratio for FORCE Oligonucleotide Conjugates Using Microchip CE-MS Collaboration: 908 Devices, Dyne Therapeutics Download Poster |
WP 730 | In-depth Characterization of Adeno-Associated Viruses using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry Collaboration: 908 Devices, NIBRT Download Poster |
Posters | Thursday, June 8
THP 175 | Ultra-High-Throughput Microchip CE-MS Quantitative Glycomics Enabled by 18-plex Isobaric Multiplex Labeling Reagents for Carbonyl-Containing Compound (SUGAR) Tags Collaboration: 908 Devices, University of Wisconsin-Madison Download Poster |
THP 248 | Multi-omic Analyses Enabled by Microchip Capillary Electrophoresis and Trapped Ion Mobility Collaboration: 908 Devices, University of Wisconsin-Madison Download Poster |
THP 575 | 5’ mRNA Analysis By Microchip CE-MS Using an Internal Cleavage Motif for RNase H Digestion Collaboration: 908 Devices, Thermo Fischer Scientific |
THP 609 | Improved Performance of Phosphopeptides Characterization using Online Capillary Electrophoresis Coupling with Ion Mobility Mass Spectrometry (CE-IM-MS) Collaboration: 908 Devices, Ningbo University Download Poster |
THP 625 | Amino Acid Quantitation in Over 50 Mammalian Cell Culture Media with an Integrated CE-MS Analyzer Presented by 908 Devices |
Poster Presentations by our Customers
TP 019 | Characterization of Therapeutic Antibody Charge Variants in Drug Development by Microfluidic Native Capillary Electrophoresis-Mass Spectrometry Presented by Regeneron Pharmaceuticals |
THP 729 | Microfluidic Capillary Electrophoresis-Mass Spectrometry Method Development for Quantitation of Spermidine in Whole Blood Presented by University of Wisconsin-Madison |
Learn more about the ASMS Annual Meeting.

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