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Application Notes & Snapshots
Quick screening of intact antibody and antibody drug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry
This application note shows a method for rapid screening of the heterogeneity of monoclonal antibodies and antibody-drug conjugates by an integrated microfluidic capillary electrophoresis (CE) and mass spectrometry (MS) workflow.
A ZipChip Based CZE-MS Analysis for Quick Assessment of Biotherapeutics
From comprehensive characterization to monitoring product degradation characteristics
Charge Variant Analysis Coupled to a SCIEX TripleTOF® 6600+ System Mass Spectrometer
High-Throughput Intact Mass Analysis of mAb Based Therapeutics
Analysis of Reduced mAbs and ADCs
Rapid Characterization of Intact mAb-based Biotherapeutics
Quick screening of intact antibody and ADC
ZipChip for profiling and characterization of antibody charge heterogeneity
Sciex Flexible Solution for MAM with ZipChip
Sciex Presents Charge Heterogeneity of Monoclonal Antibodies with ZipChip
Snapshot: Charge Variant Analysis
Charge Variant Analysis of Native Antibodies for In-depth Characterization of mAb-based Biotherapeutics
Bioreactor Monitoring via ZipChip
Snapshot: High-Throughput Intact Mass
Snapshot: High Throughput Charge Variant Analysis
Snapshot: Cell Culture Analysis
Brochures & Flyers
Case Studies
Posters
Microchip CE-MS Analysis of Sialylated N-glycan Linkage Isomers
In this ASMS 2022 poster, Fudan University researchers show a ZipChip-based strategy for qualitative and quantitative analysis of sialylated N-glycan linkage isomers was developed.
Glycosylation Profiling of mAB Subunits With CZE-MS
This ASMS 2022 poster from Bruker shows ZipChip coupled with high resolution mass spectrometry providing charge-based selectivity which can assist with glycoforms separation.
Microchip CE-MS with Integrated Solid Phase Extraction
Fast Chip-CEMS for Characterization of Protein/PTM Changes
Characterization of ADCs using ZipChip
Fast and Efficient Biopharmaceutical Characterization
Characterization of charge heterogeneity of mAb
Rapid, Multi-level Analysis of Complex Proteins
Oligonucleotide Analysis via Microfluidic CE-MS
Advancing mAb Characterization with Microchip CE-MS Couples to a PASEF Enabled QTOF
Native Analysis of Monoclonal Antibodies
Characterization of Protein/PTM Changes
Native CE-MS for Biopharmaceutical Characterization
A Rapid Microfluidic Method for Molecular Weight Determination and Spent Media Analysis of an IgG1 Intact Protein in Growth Media
Bioprocessing of Monoclonal Antibody Based Therapies
NIBRT Presents Native MS for Charge Variants using ZipChip
NIBRT Presents ZipChip for Native Charge Heterogeneity
Published Articles
The Critical Role of CE-MS Methods for Biotherapeutic Characterization
Capillary electrophoresis (CE) methods play an important role in biomolecular characterization while microfluidic CE-mass spectrometry (MS) accelerates analytical workflows and improves development/commercialization timelines.
Identification of AAV capsid proteins
Characterization of a SRPK1/2 Inhibitor Complex
Characterizing Covalent CDK Inhibitor Complexes
Rapid Fingerprinting of a Highly Glycosylated Fusion Protein
Analysis of monosaccharides, oligosaccharides and glycopeptides
Metabolite Profiling Reveals Predictive Biomarkers
Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples
Characterizing Antiviral Protein-Inhibitor Complexes
Characterization of NIST mAb Proteoforms and Glycoforms
In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry
Comparative Elucidation of Cetuximab Heterogeneity on the Intact Protein Level
Characterization of Protein Assemblies Related to Cancer Proliferation
Analysis of alkaloids in plant cell cultures
Safety Data Sheet (SDS)
SDS – ZipChip Standard: Amino Acids
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Interface Tray Grease
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Acid: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip BGE: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
SDS – ZipChip Diluent: Metabolites
Download this Safety Data Sheet (SDS) for documentation related to the properties of each chemical in the product; the physical, health, and environmental health hazards; protective measures; and safety precautions for handling, storing, and transporting the product.
Specification Sheets
ZipChip Hardware Specification Sheet
The compact interface seamlessly integrates all fluidics and electronics. Just clip it on your mass spec and off you go!
ZipChip Consumables Specification Sheet
Premixed background electrolyte and sample diluent reduce preparation time for your samples. With ZipChip you just dilute and shoot!
Tech Notes
Performance Validation Study
Using the ZipChip Infusion Function
Using Field Strength Gradients
ZipChip and Detergents
ZipChip Protocols
We have compiled this list of concise protocols and technical notes to help you facilitate high-quality science with ZipChip. Simply log in to our customer support portal to view these files and more.
Evaluation of Sample Carryover
Videos
Interview: The Key to Unsolved Insights into RNA Characterization?
Recorded at ASMS 2022, Dan Fabris from the University of Connecticut shares his experience with RNA characterization using ZipChip.
Customer Experience: New England Biolabs
A Conversation with Sciex
Application Experience: Native Analysis of mAbs and ADCs
DYK: ZipChip Can See Charge Variants In Degraded Antibodies?
ZipChip Poster Chat
Application Experience: Oligonucleotides
Webinars
EPO Separation & Analysis
Straightforward separation and analysis of a highly glycosylated protein
Analysis of inhibitor-protein complexes and small molecules
Fast Therapeutic Protein Characterization
In-depth characterization of complex monoclonal antibodies and antibody-drug conjugates with native ZipChip CE-MS
Streamline Protein Characterization and Profiling with CE-ESI-MS
Why use capillary electrophoresis
Simultaneous monitoring of amino acids and protein titer
Redefine Bioprocess Analytics
Zip Through the Backlog
ZipChip for Rapid and Easy Nanospray Infusions
Summary: Streamlined protein characterization and profiling
Rapid, comprehensive biotherapeutics characterization
NIBRT presents ZipChip for biopharma characterization
White Papers
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