Empowering Process Optimization for a mAb-Expressing CHO Cell Line
Coupling miniature mass spectrometry (MS) with microchip capillary electrophoresis (CE) fulfills an unmet need: simple, rapid at-line nutrient quantitation.
Using CE-HPMS For Accelerated Process Development of a mAb-Expressing Cell Line
The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for at-line amino acid quantitation.
Dynamic Range Optimization for Amino Acid Quantitation with an Integrated CE-MS Analyzer
The coupling of miniature mass spectrometry (MS) to a microchip capillary electrophoresis (CE) platform provides a simple solution for amino acid quantitation.
Rapid at line quantitation of key nutrients in cell culture media
This poster details the benefits of coupling of miniature mass spectrometry to a microchip capillary electrophoresis platform for characterizing cell media metabolites in fresh and spent media.
REBEL Customer Experience: Clemson University
Listen to Stephanie Klaubert, a graduate research assistant from Clemson University, as she shares how REBEL helps her with process development and cell culture optimization.
Conference Talk: Power Up Your Process Control (BPI 2022)
Graziella Piras spoke at BPI 2022 about how amino acids can present a goldilocks problem for bioprocessing: too little and they starve; too much and they favor growth over protein production.
Harness the Power of At-Line Spend Media Analysis to Optimize a CHO mAb Fed-Batch Process
This webcast shares a data-driven and accelerated cell culture media screening as well as the selection in the Ambr15 microbioreactor system.
Multi-Component At-Line Cell Culture Media Analysis
In this talk, Graziella Piras discusses a data-driven and accelerated media screening, selection, and optimization experiment leveraging REBEL.
Power up your process control with rapid at line MS-based key nutrient monitoring
Graziella Piras, bioprocess segment director for 908 Devices, spoke at BPI Europe 2022 on the benefits of at-line nutrient monitoring.
Biopharma 4.0: Finding Opportunities to Leverage New At-Line Data
Listen how REBEL users describe how they use better data acquisition, management platforms, and process modeling to implement process intensification.
Process Modeling with Researchers from Johns Hopkins University
Listen to a dynamic discussion on the highlights of a new peer-reviewed article exploring model-based approached to cell culture optimization
Process Intensification: Do You Have All the Data You Need When You Need It?
The need for process intensification and implementation of Bioprocess 4.0 requires extensive real time data acquisition and process modelling. At line MS-based technologies presented here provide key cellular metabolic and protein quality data in real time to support process intensification and modelling.
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