Bioprocess International Europe is a leading event in Europe that brings together scientists and suppliers working in biopharmaceutical development and production. It is a great opportunity to learn about the latest innovations in the field.

The conference covers a wide range of topics, including:

  • Cell Line Development and Engineering
  • Cell Culture and Upstream Processing
  • Recovery & Purification
  • Cell & Gene Therapy Manufacturing
  • Manufacturing Strategy & Bioprocessing 4.0

Upstream/Cell Culture Track

Data-driven Process Intensification – Utilizing Smart Analytics to Achieve your Bioprocess Goals

Process intensification requires a thorough understanding of the process to achieve desired yields while improving resource utilization and maintaining consistent product quality. Due to the dynamic nature of cell culture, frequent and fast analytics of critical parameters are necessary to fully control the process and end product.

Continuous monitoring of glucose and lactate provides deeper process understanding. Dynamic glucose control can lead to better cell viability, lower levels of lactate production, and therefore, higher titer and better control of quality attributes (CQAs) in fed-batch and intensified processes.

Other key considerations in intensified processes are cost, manual labor and footprint reductions. In perfusion/intensified processes, media consumption is typically high and requires optimization to reduce the cost of goods. The media development process can be laborious, time-consuming and costly, but it can lead to significant cost savings. Fast and simple at-line analytics for key media components, such as amino acids, significantly speed up the development and optimization processes.

Key takeaways:

  • Process intensification enabled by process knowledge and understanding
  • Informed decision-making with in-line, on-line and at-line analytics of key process parameters

We discuss MAVERICK, a novel Raman-based in-line continuous monitoring of mammalian (CHO, HEK293) bioprocesses with a novel multivariate sensing technology that does not require process-specific chemometric modelling for implementation. This technology offers automated, non-destructive, and easy-to-integrate multi-parameter analysis with the ability to add a feedback control loop to key bioprocess parameters. We demonstrate applicability across cell culture media, CHO and HEK293 cell cultures and processes.

Key takeaways:

  • A new Raman-based sensing technology that enables monitoring of multiple key process parameters and overcomes major implementation hurdles of traditional Raman approaches.
  • Applicability of the technology to main mammalian (CHO, HEK293) cell cultures, across media and across scales.

Bioprocess development requires analytics to monitor critical process parameters. We discuss two key technologies to characterize, optimize and control bioprocess:  

  • The MAVEN enables automated on-line (sample-free) monitoring for glucose & lactate, and glucose feed control even to very low levels.  
  • The REBEL at-line analyzer quantitatively measures a panel of all amino acids, and other amines, in only ~10 min sample and requiring very little (~30 ul) sample. 

We discuss how the automated monitoring of glucose and lactate and glucose levels controlled at low levels, together with understanding the amino acid consumption profiles can lead to higher growth/viability, lower lactate, and decreased COGS.


On display at booth 317 will be our latest technology MAVERICK. Learn more about the Raman-based device for in-line monitoring and control of multiple key process parameters.