Rapid In-Depth Characterization of Biologics by Microchip CE-MS: mAbs, AAVs and Nucleic Acids
Microchip capillary electrophoresis (CE) coupled with mass spectrometry (MS) has revolutionized the characterization of therapeutic modalities in biopharmaceuticals. Here, we present the applications of an integrated workflow that couples the microfluidic CE system (ZipChip) with MS in characterization of biotherapeutics. This was poster A03 at BPS Europe 2024.
In-depth Characterization of Adeno-Associated Viruses using Microchip Capillary Electrophoresis Coupled with Mass Spectrometry
Rapid microchip CE-MS can be utilized for the in-depth characterization of AAVs including viral capsid protein analysis and peptide mapping. This poster was presented as a collaboration with NIBRT at ASMS 2023 as poster WP730.
Optimization of Scalable rAAV Production for Gene Therapy – Leveraging At-Line Amino Acid Measurements for Bioprocess Modeling-Driven Approaches
Spent media analysis from an at-line analyzer, the REBEL, was used to further understanding of AAV production process and identify correlation between key nutrient consumptions and capsid titers in fed-batch and continuous processes. View our poster from the 2024 Advanced Manufacturing Cell and Gene Therapies Conference. This was poster 43.
In-Depth Adeno-Associated Virus Characterization with Microchip Capillary Electrophoresis-Mass Spectrometry
This webinar consists of two parts: Dr. Adi Kulkarni from 908 Devices begins by providing a brief introduction to the ZipChip CE-MS technology, highlighting its features and benefits. In part two, Dr. Josh Smith from NIBRT, demonstrates how microchip CE-MS can be applied to the characterization of AAVs, specifically VP characterization and peptide mapping.
Multi-level Expeditious Characterization of Adeno-associated Virus (AAV) Capsid Proteins Using ZipChip Microfluidic CE Coupled with HRMS
In this poster from ASMS 2022, scientists from Thermo Fisher Scientific and 908 Devices present a novel approach using microchip CE-MS for the characterization of AAVs.
Identification of AAV capsid proteins
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