Analysis of cells is fundamental to the the understanding of functioning biological systems from discovery of oncology drugs, to DMPK and toxicology studies for all pharmaceuticals. Cells contain thousands of compounds in constant metabolomic flux so capturing an accurate ‘snap-shot,’ requires fast analysis and minimal sample preparation. Liquid Chromatography-Mass Spectrometry (LC-MS) is used widely as HILIC separations capture polar metabolites however, 30 minute runs and significant sample preparation are not ideal. ZipChip enables fast separations and full MS data with minimal sample preparation – typically a simple protein crash and quick spin filter before direct injection onto the device.
Using ZipChip HS, metabolites are analyzed from raw cells, whole blood and a variety of other matrices with minimal prep, a common method and full MS data in under 3 minutes. Prep and background electrolyte are gentle on your lysates and gentle on your MS – confidence that your analysis is reliable and matches the state of the cells.
ZipChip™ uses integrated microfluidic technology to prepare, separate and electrospray biological samples directly into traditional mass spectrometers (MS).
In less than 3 minutes per sample, the cost-effective ZipChip analyzes a broad range of matrices from growth media to cell lysates, blood, plasma, urine and biopharma products. ZipChip delivers answers on analytes from small molecules and peptides up to intact proteins, antibodies and antibody drug conjugates; providing better separation quality than most liquid chromatography instruments — in a fraction of the time — all with full MS identification behind every separations peak. The ZipChip interface simply mounts onto your mass spectrometer for seamless integration with existing data collection and processing.